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Journal Articles

Radiation and Busulfan-Free Hematopoietic Stem Cell Transplantation Using Briquilimab (JSP191) Anti-CD117 Antibody-Conditioning, Transient Immunosuppression and TCRαβ + T-Cell/CD19 + B-Cell Depleted Haploidentical Grafts in Patients with Fanconi Anemia

Blood (2023) 142 (Supplement 1): 229.

https://doi.org/10.1182/blood-2023-178400

Published: 2023

Journal Articles

JSP191 As a Single-Agent Conditioning Regimen Results in Successful Engraftment, Donor Myeloid Chimerism, and Production of Donor Derived Naïve Lymphocytes in Patients with Severe Combined Immunodeficiency (SCID)

Blood (2021) 138 (Supplement 1): 554.

https://doi.org/10.1182/blood-2021-153074

Published: 2021

Journal Articles

An All Antibody Approach for Conditioning Bone Marrow for Hematopoietic Stem Cell Transplantation with Anti-cKIT and Anti-CD47 in Non-Human Primates

Kristopher D Marjon, PhD, James Y Chen, MD PhD, Jiaqi Duan, MS, Timothy S Choi, BS, Kavitha Sompalli, MS, Dongdong Feng, PhD, Ofelia Mata, Sharline Chen, B.S., Leslie Kean, MD PhD, Mwe Mwe Chao, MD, Mark Chao, MD PhD, Chris H Takimoto, MD PhD, Balaji Agoram, PhD, Cynthia E. Dunbar, MD, Ravi Majeti, MD PhD, Irving L Weissman, MD, Jie Liu, PhD MD, Jens-Peter Volkmer, MD

Blood (2019) 134 (Supplement_1): 4428.

https://doi.org/10.1182/blood-2019-131490

Published: 2019

Journal Articles

Non-Genotoxic Anti-CD117 Antibody Conditioning Results in Successful Hematopoietic Stem Cell Engraftment in Patients with Severe Combined Immunodeficiency

Rajni Agarwal, MD, Christopher C. Dvorak, MD, Hye-Sook Kwon, PhD, Janel R Long-Boyle, PharmD, PhD, Susan S Prohaska, PhD MS, Janice W Brown, MD, Anne Le, Alyssa Guttman-Klein, Irving L Weissman, MD, Morton J Cowan, MD, Aaron C. Logan, MD PhD, Kenneth I. Weinberg, MD, Robertson Parkman, MD, Maria-Grazia Roncarolo, MD, Judith A Shizuru, MD PhD

Blood (2019) 134 (Supplement_1): 800.

https://doi.org/10.1182/blood-2019-126239

Published: 2019

Journal Articles

Anti-human CD117 antibody-mediated bone marrow niche clearance in nonhuman primates and humanized NSG mice

Hye-Sook Kwon, Aaron C. Logan, Akanksha Chhabra, Wendy W. Pang, Agnieszka Czechowicz, Keri Tate, Alan Le, Jessica Poyser, Roger Hollis, Benjamin V. Kelly, Donald B. Kohn, Irving L. Weissman, Susan S. Prohaska, Judith A. Shizuru

Blood (2019) 133 (19): 2104–2108.

https://doi.org/10.1182/blood-2018-06-853879

Published: 2019

Includes: Supplemental data

Journal Articles

Anti-CD117 antibody depletes normal and myelodysplastic syndrome human hematopoietic stem cells in xenografted mice

Wendy W. Pang, Agnieszka Czechowicz, Aaron C. Logan, Rashmi Bhardwaj, Jessica Poyser, Christopher Y. Park, Irving L. Weissman, Judith A. Shizuru

Blood (2019) 133 (19): 2069–2078.

https://doi.org/10.1182/blood-2018-06-858159

Published: 2019

Includes: Supplemental data

Journal Articles

RBC-Specific CD47 Pruning Confers Protection and Underlies the Transient Anemia in Patients Treated with Anti-CD47 Antibody 5F9

James Y Chen, MD PhD, Kelly Marie McKenna, BS, Timothy S Choi, BS, Jiaqi Duan, MS, Lynette Brown, MSc, Jennifer J Stewart, PhD, Kavitha Sompalli, MS, Paresh Vyas, Stanley Schrier, MD, Ravindra Majeti, MD PhD, Irving L Weissman, MD, Kyle Elrod, BS, Mark Ping Chao, MD PhD, Chris H Takimoto, MD PhD, Jie Liu, PhD MD, Jens-Peter Volkmer, MD

Blood (2018) 132 (Supplement 1): 2327.

https://doi.org/10.1182/blood-2018-99-115674

Published: 2018

Journal Articles

Combination Treatment with 5F9 and Azacitidine Enhances Phagocytic Elimination of Acute Myeloid Leukemia

Dongdong Feng, PhD, Phung Gip, PhD, Kelly Marie McKenna, BS, Feifei Zhao, Ofelia Mata, Timothy S Choi, BS, Jiaqi Duan, MS, Kavitha Sompalli, MS, Ravi Majeti, MD PhD, Irving L Weissman, MD, Chris H Takimoto, MD PhD, Mark Ping Chao, MD PhD, James Y Chen, MD PhD, Jie Liu, PhD MD, Jens-Peter Volkmer, MD

Blood (2018) 132 (Supplement 1): 2729.

https://doi.org/10.1182/blood-2018-99-120170

Published: 2018

Journal Articles

High Resolution Mapping of Human Lymphopoiesis Reveals a Common Lymphoid Progenitor (CLP) Population

Nivedita Shankar Saxena, BA, Kara L. Davis, DO, Matthew Arthur Inlay, PhD BA, Astraea Junger, Yujun Yang, Mark L. Krampf, MS, Beruh Dejene, Garry P. Nolan, Prof, PhD, Irving L Weissman, MD, Kenneth I. Weinberg, MD

Blood (2016) 128 (22): 1473.

https://doi.org/10.1182/blood.V128.22.1473.1473

Published: 2016

Journal Articles

Super Cross-Presentation of Tumor Antigens to Elicit Anti-Lymphoma Immunity By Synthetic Design of an Anti-Phosphatidylserine Bridge Protein

Daniel Corey, MD, Irving L Weissman, MD

Blood (2016) 128 (22): 1844.

https://doi.org/10.1182/blood.V128.22.1844.1844

Published: 2016

Journal Articles

Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation

Blood (2015) 125 (2): 249–260.

https://doi.org/10.1182/blood-2014-04-572255

Published: 2015

Includes: Multimedia, Supplemental data

Journal Articles

β7 Integrin Regulates Intra-Marrow Trafficking of Hematopoietic Stem Cells

Jodi Murakami, Baohui Xu, Christopher B. Franco, Xingbin Hu, Stephen J. Galli, Irving L Weissman, MD, Ching-Cheng Chen

Blood (2014) 124 (21): 2899.

https://doi.org/10.1182/blood.V124.21.2899.2899

Published: 2014

Journal Articles

Successful Engraftment of Hematopoietic Stem Cells into Immunocompetent Recipients Using Only Anti-CD117 Antibody and CD47 Blockade As Conditioning

Akanksha Chhabra, PhD, Aaron M Ring, MS, Kipp Weiskopf, PhD, Irving L Weissman, MD, Judith A. Shizuru, MD PhD

Blood (2014) 124 (21): 2410.

https://doi.org/10.1182/blood.V124.21.2410.2410

Published: 2014

Journal Articles

Direct SIRPa Blockade Augments Macrophage Responses to Therapeutic Anticancer Antibodies

Kipp Weiskopf, M.Phil, Aaron M Ring, MS, Nan Guo, BS, Peter J Schnorr, Roy Louis Maute, PhD BA, MA, MPhil, Jens-Peter Volkmer, MD, Irving L Weissman, MD

Blood (2014) 124 (21): 2729.

https://doi.org/10.1182/blood.V124.21.2729.2729

Published: 2014

Journal Articles

In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice

S. Christopher Derderian, P. Priya Togarrati, Charmin King, Patriss W. Moradi, Damien Reynaud, Agnieszka Czechowicz, Irving L. Weissman, Tippi C. MacKenzie

Blood (2014) 124 (6): 973–980.

https://doi.org/10.1182/blood-2014-02-550327

Published: 2014

Includes: Supplemental data

Journal Articles

BLT-humanized C57BL/6 Rag2 −/− γ c −/− CD47 −/− mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection

Kerry J. Lavender, Wendy W. Pang, Ronald J. Messer, Amanda K. Duley, Brent Race, Katie Phillips, Dana Scott, Karin E. Peterson, Charles K. Chan, Ulf Dittmer, Timothy Dudek, Todd M. Allen, Irving L. Weissman, Kim J. Hasenkrug

Blood (2013) 122 (25): 4013–4020.

https://doi.org/10.1182/blood-2013-06-506949

Published: 2013

Includes: Supplemental data

Journal Articles

Prospective Isolation Of Human Erythroid Lineage-Committed Progenitors

Yasuo Mori, M.D., Ph.D., Jun Seita, M.D., Ph.D., John V. Pluvinage, James Y. Chen, Irving L. Weissman, MD

Blood (2013) 122 (21): 3418.

https://doi.org/10.1182/blood.V122.21.3418.3418

Published: 2013

Journal Articles

In Utero Depletion Of Fetal Host Hematopoietic Stem Cells Improves Engraftment Following Neonatal Transplantation In Mice

Chris Derderian, MD, Charmin King, MS, Priya Togarrati, PhD, Agnieszka Czechowicz, MD, PhD, Ninnia Lescano, MS, Damien Reynaud, PhD, Emmanuelle Passegue, PhD, Irving L Weissman, MD, Tippi MacKenzie, MD

Blood (2013) 122 (21): 3240.

https://doi.org/10.1182/blood.V122.21.3240.3240

Published: 2013

Journal Articles

Unexplained Anemia In The Elderly Is Due To An Intrinsic Defect In Hematopoietic Stem Cells

Wendy W. Pang, M.D., Ph.D., John V. Pluvinage, Yasuo Mori, M.D., Ph.D., Elizabeth Price, MD, MPH, Amittha Wickrema, PhD, Oyebimpe Adensina, M.D., Andrew Artz, MD, Irving L. Weissman, MD, Stanley L. Schrier, MD

Blood (2013) 122 (21): 2187.

https://doi.org/10.1182/blood.V122.21.2187.2187

Published: 2013

Journal Articles

The Unique Ontogeny Of Natural Killer Cells As Revealed By Genetic Barcoding In The Nonhuman Primate Model

Chuanfeng Wu, PhD, Jan K. Davidson-Moncada, MD, PhD, Rong Lu, PhD, Brian Li, Allen E. Krouse, Mark E. Metzger, Robert E. Donahue, Irving L. Weissman, MD, Richard Childs, MD, Cynthia E. Dunbar, MD

Blood (2013) 122 (21): 15.

https://doi.org/10.1182/blood.V122.21.15.15

Published: 2013

NARROW

Radiation and Busulfan-Free Hematopoietic Stem Cell Transplantation Using Briquilimab (JSP191) Anti-CD117 Antibody-Conditioning, Transient Immunosuppression and TCRαβ + T-Cell/CD19 + B-Cell Depleted Haploidentical Grafts in Patients with Fanconi Anemia

JSP191 As a Single-Agent Conditioning Regimen Results in Successful Engraftment, Donor Myeloid Chimerism, and Production of Donor Derived Naïve Lymphocytes in Patients with Severe Combined Immunodeficiency (SCID)

An All Antibody Approach for Conditioning Bone Marrow for Hematopoietic Stem Cell Transplantation with Anti-cKIT and Anti-CD47 in Non-Human Primates

Non-Genotoxic Anti-CD117 Antibody Conditioning Results in Successful Hematopoietic Stem Cell Engraftment in Patients with Severe Combined Immunodeficiency

Anti-human CD117 antibody-mediated bone marrow niche clearance in nonhuman primates and humanized NSG mice

Anti-CD117 antibody depletes normal and myelodysplastic syndrome human hematopoietic stem cells in xenografted mice

RBC-Specific CD47 Pruning Confers Protection and Underlies the Transient Anemia in Patients Treated with Anti-CD47 Antibody 5F9

Combination Treatment with 5F9 and Azacitidine Enhances Phagocytic Elimination of Acute Myeloid Leukemia

High Resolution Mapping of Human Lymphopoiesis Reveals a Common Lymphoid Progenitor (CLP) Population

Super Cross-Presentation of Tumor Antigens to Elicit Anti-Lymphoma Immunity By Synthetic Design of an Anti-Phosphatidylserine Bridge Protein

Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation

β7 Integrin Regulates Intra-Marrow Trafficking of Hematopoietic Stem Cells

Successful Engraftment of Hematopoietic Stem Cells into Immunocompetent Recipients Using Only Anti-CD117 Antibody and CD47 Blockade As Conditioning

Direct SIRPa Blockade Augments Macrophage Responses to Therapeutic Anticancer Antibodies

In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice

BLT-humanized C57BL/6 Rag2 −/− γ c −/− CD47 −/− mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection

Prospective Isolation Of Human Erythroid Lineage-Committed Progenitors

In Utero Depletion Of Fetal Host Hematopoietic Stem Cells Improves Engraftment Following Neonatal Transplantation In Mice

Unexplained Anemia In The Elderly Is Due To An Intrinsic Defect In Hematopoietic Stem Cells

The Unique Ontogeny Of Natural Killer Cells As Revealed By Genetic Barcoding In The Nonhuman Primate Model

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American Society of Hematology

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ASH Publications

American Society of Hematology

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