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Journal Articles

Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A - and NPM1 -altered leukemias

Min Chul Kwon, Jan Willem Thuring, Olivier Querolle, Xuedong Dai, Tinne Verhulst, Vineet Pande, Ann Marien, Dries Goffin, Daniela V. Wenge, Hong Yue, Jevon A. Cutler, Cyrus Jin, Florian Perner, Shanna M. Hogeling, Paul L. Shaffer, Frank Jacobs, Petra Vinken, Wei Cai, Vikki Keersmaekers, Filmon Eyassu, Balpreet Bhogal, Karin Verstraeten, Sara El Ashkar, Jennifer A. Perry, Prathiba Jayaguru, Laura Barreyro, Anna Kuchnio, Nicolas Darville, Daniel Krosky, Gregor Urbanietz, Bie Verbist, James P. Edwards, Glenn S. Cowley, Robert Kirkpatrick, Ruth Steele, Lucille Ferrante, Christina Guttke, Nikki Daskalakis, E. Christine Pietsch, David M. Wilson, Ricardo Attar, Yusri Elsayed, Eric S. Fischer, Jan Jacob Schuringa, Scott A. Armstrong, Kathryn Packman, Ulrike Philippar
Journal: Blood
Blood (2024) 144 (11): 1206–1220.
https://doi.org/10.1182/blood.2023022480
Published: 2024
Includes: Supplemental data
Journal Articles

Preclinical Efficacy of the Menin-KMT2A Inhibitor JNJ-75276617 in Combination with Venetoclax and Azacitidine in AML

Min Chul Kwon, Tinne Verhulst, Dries Goffin, Ann Marien, Bie Verbist, Christina Guttke, Jan Willem Thuring, Lucille Ferrante, Nikki Daskalakis, E. Christine Pietsch, Yusri Elsayed, Kathryn Packman, Ulrike Philippar
Journal: Blood
Blood (2023) 142 (Supplement 1): 4167.
https://doi.org/10.1182/blood-2023-186204
Published: 2023
Journal Articles

Discovery of a Novel, First-in-Class Bfl-1 BH3 Mimetic with Pro-Apoptotic Activity

Maarten Derks, Marian C. Bryan, Cindy Rockx, Tamara Schults, Tinne Verhulst, Beth Pietrak, Tatsuya Maehigashi, James C. Robertson, Andrew H. DeMaria, Kimberly Holt, Shaofei Ji, Victoria Wong, Ruud Bueters, Seong Joo Koo, Stefan Masure, Balpreet Bhogal, Christopher B. Kelly, Kaushik Mitra, Leopoldo Luistro, Paul L. Shaffer, Lawrence Szewczuk, Yusri Elsayed, Ulrike Philippar
Journal: Blood
Blood (2023) 142 (Supplement 1): 2824.
https://doi.org/10.1182/blood-2023-188516
Published: 2023
Journal Articles

Characterization of JNJ-79635322, a Novel BCMAxGPRC5DxCD3 T-Cell Redirecting Trispecific Antibody, for the Treatment of Multiple Myeloma

Ram Pillarisetti, Danlin Yang, Jianhong Yao, Melissa Smith, Leopoldo Luistro, Peter Vulfson, James Testa, Jr., Kathryn Packman, Scott Brodeur, Ricardo M. Attar, Yusri Elsayed, Ulrike Philippar
Journal: Blood
Blood (2023) 142 (Supplement 1): 456.
https://doi.org/10.1182/blood-2023-174941
Published: 2023
Journal Articles

Discovery of JNJ-88549968, a Novel, First-in-Class CALRmutxCD3 T-Cell Redirecting Antibody for the Treatment of Myeloproliferative Neoplasms

Anna Kuchnio, Elsie Samakai, Eva Hug, Meritxell Balmaña, Lut Janssen, Ricardo Amorim, Ivo Cornelissen, Andrea Majoros, Michaël Broux, Isha Taneja, Vince Torti, Azra Agic, Stefan Moritsch, Filippo Benedetti, Felix Rosebrock, Kathryn Packman, Janine Arts, Sonal Patel, Oliver Christopher Lomas, M. Phillip Deyoung, Oleh Zagrijtschuk, Yusri Elsayed, Stefan Constantinescu, Robert Kralovics, Ulrike Philippar
Journal: Blood
Blood (2023) 142 (Supplement 1): 1777.
https://doi.org/10.1182/blood-2023-173430
Published: 2023
Journal Articles

Pharmacological Characterization of JNJ-75276617, a Menin-KMT2A Inhibitor, As Targeted Treatment for KMT2A-Altered and NPM1-Mutant Acute Leukemia

Min Chul Kwon, Olivier Querolle, Xuedong Dai, Jan Willem Thuring, Tinne Verhulst, Ann Marien, Dries Goffin, Wei Cai, Vikki Keersmaekers, Filmon Eyassu, Karin Verstraeten, Sara El Ashkar, Shanna M Hogeling, Frank Jacob, Petra Vinken, Nicolas Darville, Vineet Pande, Daniel Krosky, Gregor Urbanietz, Bie Verbist, Lucille A. Ferrante, Christina Diane Drenberg, David Wilson, Ricardo M. Attar, Jan Jacob Schuringa, Nikki Daskalakis, Kathryn Packman, Christine Pietsch, Yusri Elsayed, Ulrike Philippar
Journal: Blood
Blood (2022) 140 (Supplement 1): 5928–5929.
https://doi.org/10.1182/blood-2022-168921
Published: 2022
Journal Articles

A T-cell–redirecting bispecific G-protein–coupled receptor class 5 member D x CD3 antibody to treat multiple myeloma

Kodandaram Pillarisetti, Suzanne Edavettal, Mark Mendonça, Yingzhe Li, Mark Tornetta, Alexander Babich, Nate Majewski, Matt Husovsky, Dara Reeves, Eileen Walsh, Diana Chin, Leopoldo Luistro, Jocelin Joseph, Gerald Chu, Kathryn Packman, Shoba Shetty, Yusri Elsayed, Ricardo Attar, François Gaudet
Journal: Blood
Blood (2020) 135 (15): 1232–1243.
https://doi.org/10.1182/blood.2019003342
Published: 2020
Includes: Supplemental data
Journal Articles

Development of a CD123xCD3 Bispecific Antibody (JNJ-63709178) for the Treatment of Acute Myeloid Leukemia (AML)

François Gaudet, Jennifer F Nemeth, Ronan McDaid, Yingzhe Li, Benjamin Harman, Hillary Millar, Alexey Teplyakov, John Wheeler, Jinquan Luo, Susan Tam, Sheng-Jiun Wu, Emily Chen, Stephen Rudnick, Gerald Chu, Anna Hughes, Leopoldo Luistro, Diana Chin, Alexander Babich, Anna Kalota, Indrajeet Singh, Mark Salvati, Yusri Elsayed, Ricardo M. Attar
Journal: Blood
Blood (2016) 128 (22): 2824.
https://doi.org/10.1182/blood.V128.22.2824.2824
Published: 2016
Journal Articles

The Impact of the Bone Marrow Microenvironment on T Cell Redirection Therapeutics

Priyanka Nair-Gupta, Stephen Rudnick, Leopoldo Luistro, Diana Chin, Melissa Smith, Ronan McDaid, Yingzhe Li, Kodandaram Pillarisetti, Eric Baldwin, Kathryn Packman, Yusri Elsayed, Ricardo M. Attar, François Gaudet
Journal: Blood
Blood (2016) 128 (22): 2752.
https://doi.org/10.1182/blood.V128.22.2752.2752
Published: 2016
Journal Articles

Development of a New BCMAxCD3 Duobody® Antibody for Multiple Myeloma

Kodandaram Pillarisetti, Eric Baldwin, Alexander Babich, Nate Majewski, Linda Barone, Yingzhe Li, Xiaochun Zhang, Diana Chin, Leopoldo Luistro, Mark Mendonça, Rupesh Nanjunda, Stephen Rudnick, Kevin Bellew, Yusri Elsayed, Ricardo M. Attar, François Gaudet
Journal: Blood
Blood (2016) 128 (22): 2116.
https://doi.org/10.1182/blood.V128.22.2116.2116
Published: 2016
Journal Articles

Phase 2 Multicenter Trial of Oral Quisinostat, a Histone Deacetylase Inhibitor, in Patients with Previously Treated Stage IB-IVA Cutaneous T-Cell Lymphoma

Fiona Child, MD, Pablo Ortiz Romero, Prof., Rute Alvarez, MD, Martine Bagot, Rudolf Stadler, MD, Michael Weichenthal, MD, Rosario Alves, MD, Maria Grazia Bernengo, Prof., Marie Beylot-Barry, Prof., Richard Cowan, Larisa J. Geskin, MD, Amparo Pérez Ferriols, Peter Hellemans, MD, Yusri Elsayed, MD, PhD, Charles Phelps, Ann Forslund, Makio Kamida, Pier Luigi Zinzani, MD
Journal: Blood
Blood (2012) 120 (21): 3676.
https://doi.org/10.1182/blood.V120.21.3676.3676
Published: 2012
Journal Articles

A Phase 3 Trial Comparing Bortezomib Plus Rituximab with Rituximab Alone In Patients with Relapsed, Rituximab-Naive or -Sensitive, Follicular Lymphoma

Bertrand Coiffier, MD, PhD, Evgenii Osmanov, MD, Xiaonan Hong, MD, Adriana Scheliga, MD, Jiri Mayer, MD, PhD, Fritz C Offner, MD, PhD, Simon A. Rule, MD, Adriana Teixeira, MD, Jan A Walewski, MD, PhD, DSc, Michael Crump, MD, FRCPC, Ofer Shpilberg, MD, MPH, Robert Hermann, MD, Sudha Parasuraman, MD, Eugene Zhu, PhD, Christopher Enny, BS, Panteli Theocharous, MSc, PhD, Helgi van de Velde, MD, PhD, Yusri Elsayed, MD, PhD, Pier Luigi Zinzani, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 857.
https://doi.org/10.1182/blood.V116.21.857.857
Published: 2010