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Journal Articles

Prolonged CXCR4 Receptor Occupancy By Motixafortide Following a Single Subcutaneous Injection Is Associated with Extended Mobilization of CD34+ Cells in Peripheral Blood for > 24 Hours

Zachary David Crees, Keith Stockerl-Goldstein, Ella Sorani, Debby Ickowicz, Liron Darvish, John F. DiPersio
Journal: Blood
Blood (2023) 142 (Supplement 1): 5777.
https://doi.org/10.1182/blood-2023-184608
Published: 2023
Journal Articles

Use of Combination Premedication Prior to Motixafortide Administration Reduced Severity and Frequency of AEs in the Phase 3 Genesis Trial - a Single Center Analysis

Zachary David Crees, Keith Stockerl-Goldstein, Mark A. Schroeder, Ravi Vij, Ella Sorani, Irit Gliko Kabir, Inbal Goldstein, Tzipi Lustig, Shaul Kadosh, John F. DiPersio
Journal: Blood
Blood (2023) 142 (Supplement 1): 3522.
https://doi.org/10.1182/blood-2023-181452
Published: 2023
Journal Articles

Double-Blind, Placebo Controlled, Randomized, Multicenter, Phase II Study to Assess the Efficacy of the High Affinity CXCR4 Inhibitor BL-8040 As Addition to Consolidation Therapy in AML By the SAL and OSHO Leukemia Study Groups

Sonia Jaramillo Segura, Maxi Wass, Judith Schaffrath, Kathrin Rieger, Axel Nogai, Mathias Haenel, Regina Herbst, Friedrich Stoelzel, Christoph Röllig, Edgar Jost, Richard F. Schlenk, Richard Noppeney, Christian H. Brandts, Utz Krug, Katharina S. Goetze, Sebastian Buske, Axel Florschütz, Jörg Schubert, Bernhard Opitz, Martin Mohren, Eva Eßeling, Stephan von Witzendorff, Marion Subklewe, Martin Kaufmann, Norbert Frickhofen, Christian W Scholz, Kerstin Schäfer-Eckart, Volker Kunzmann, Martin Schmidt-Hieber, Herbert G. Sayer, Andreas Rank, Philipp Hemmati, Frank Schueler, Simone Kowoll, Marina Scheller, Jörg Steighardt, Bayram Edemir, Lutz Peter Mueller, Irit Gliko-Kabir, Beatrice Ludwig-Kraus, Sabine Edemir, Ella Sorani, Mascha Binder, Abi Vainstein, Shaul Kadosh, Cora Gromann, Andreas Wienke, Claudia D. Baldus, Uwe Platzbecker, Hubert Serve, Martin Bornhaeuser, Christian Junghanss, Carsten Mueller-Tidow
Journal: Blood
Blood (2022) 140 (Supplement 1): 3338–3340.
https://doi.org/10.1182/blood-2022-166748
Published: 2022
Journal Articles

A Phase I Safety and Feasibility Study to Evaluate Motixafortide (CXCR4/SDF-1 Inhibition) and Natalizumab (VLA-4/VCAM-1 Inhibition) As a Novel Regimen to Mobilize CD34+ Hematopoietic Stem Cells for Gene Therapy in Sickle Cell Disease

Zachary D. Crees, Michael P. Rettig, Reyka G. Jayasinghe, Peter Ruminski, Abi Vainstein, Ella Sorani, Allison A. King, John F. DiPersio
Journal: Blood
Blood (2022) 140 (Supplement 1): 10432–10433.
https://doi.org/10.1182/blood-2022-165454
Published: 2022
Journal Articles

Immunophenotypic and Single-Cell Transcriptional Profiling of CD34+ Hematopoietic Stem and Progenitor Cells Mobilized with Motixafortide (BL-8040) and G-CSF Versus Plerixafor and G-CSF Versus Placebo and G-CSF: A Correlative Study of the Genesis Trial

Zachary D. Crees, Michael Retting, Reyka G Jayasinghe, Keith E. Stockerl-Goldstein, Abi Vainstein, Ella Sorani, Debby Ickowicz, Liron Shemesh-Darvish, Shaul Kadosh, John F. DiPersio
Journal: Blood
Blood (2021) 138 (Supplement 1): 3816.
https://doi.org/10.1182/blood-2021-144297
Published: 2021
Journal Articles

Hematopoietic Cell Transplantation of Higher CD34+ Cell Doses and Specific CD34+ Subsets Mobilized with Motixafortide and/or G-CSF Is Associated with Rapid Engraftment - a Post-Hoc Analysis of the Genesis Trial

Zachary D. Crees, Keith E. Stockerl-Goldstein, Michael Retting, Sarah M Larson, Arpad Illes, Giuseppe Milone, Massimo Martino, Patrick Stiff, Douglas W. Sborov, Denise L. Pereira, Ivana N. Micallef, Gemma Moreno Jiménez, Gábor Mikala, Maria Liz Paciello Coronel, Udo Holtick, John W. Hiemenz, Muzaffar H. Qazilbash, Nancy M. Hardy, Tahir Latif, Irene García-Cadenas, Ella Sorani, Liron Shemesh-Darvish, Abi Vainstein, Shaul Kadosh, John F. DiPersio
Journal: Blood
Blood (2021) 138 (Supplement 1): 2849.
https://doi.org/10.1182/blood-2021-146783
Published: 2021
Journal Articles

The High Affinity CXCR4 Inhibitor, BL-8040, Impairs the Infiltration, Migration, Viability, and Differentiation of Regulatory T Cells

Michal Abraham, Inbal Mishalian, Abi Vainstein, Liron Shemesh-Darvish, Ella Sorani, Orly Eizenberg, Amnon Peled
Journal: Blood
Blood (2021) 138 (Supplement 1): 2804.
https://doi.org/10.1182/blood-2021-147142
Published: 2021
Journal Articles

Motixafortide (BL-8040) and G-CSF Versus Placebo and G-CSF to Mobilize Hematopoietic Stem Cells for Autologous Stem Cell Transplantation in Patients with Multiple Myeloma: The Genesis Trial

Zachary D. Crees, Keith E. Stockerl-Goldstein, Sarah Larson, Árpád Illés, Giuseppe Milone, Massimo Martino, Patrick Stiff, Douglas W. Sborov, Denise L. Pereira, Ivana N. Micallef, Gemma Moreno Jiménez, Gábor Mikala, Maria liz paciello Coronel, Udo Holtick, John W. Hiemenz, Muzaffar H. Qazilbash, Nancy M. Hardy, Tahir Latif, Irene García-Cadenas, Abi Vainstein, Ella Sorani, Irit Gliko-Kabir, Inbal Goldstein, Shaul Kadosh, John F. DiPersio
Journal: Blood
Blood (2021) 138 (Supplement 1): 475.
https://doi.org/10.1182/blood-2021-144296
Published: 2021
Journal Articles

Combined Inhibition of CXCR4 Signaling and System x c - Transporter Activity Induces Synthetic Lethality in T-ALL Cells By Suppressing Gsh and Inducing Ferroptosis

Jun Xia, PhD, Stephanie Sun, Matthew RM Jotte, Geoffrey L Uy, MD, Ella Sorani, PhD, Abi Vainstein, Liron Shemesh Davish, Katherine E Caldwell, William G Hawkins, Daniel C. Link, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37.
https://doi.org/10.1182/blood-2020-142735
Published: 2020
Journal Articles

CXCR4 Inhibition with BL-8040 in Combination with Nelarabine in Patients with Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia / Lymphoblastic Lymphoma

Geoffrey L. Uy, MD, Tapan M. Kadia, MD, Wendy Stock, MD, Jonathan E Brammer, MD, Osnat Bohana-Kashtan, PhD, Abi Vainstein, Ella Sorani, PhD, Hemda Chen, PharmD, John F. DiPersio, MD PhD, Daniel C. Link, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2630.
https://doi.org/10.1182/blood-2019-127121
Published: 2019
Journal Articles

CXCR4 Blockade By BL-8040 in T Cell Acute Lymphoblastic Leukemia Decreases Mitochondrial Mass and Induces Non-Apoptotic Cell Death

Jun Xia, PhD, Stephanie Sun, Matthew RM Jotte, Geoffrey L. Uy, MD, Osnat Bohana-Kashtan, PhD, Ella Sorani, PhD, Abi Vainstein, Amnon Peled, PhD, Daniel C. Link, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2745.
https://doi.org/10.1182/blood-2019-128881
Published: 2019
Journal Articles

The CXCR4 Antagonist, BL8040, Is Highly Active Against Human T-ALL in Preclinical Models

Jun Xia, PhD, Matthew RM Jotte, Stephanie Sun, Geoffrey L. Uy, MD, Abi Vainstein, Ella Sorani, PhD, Osnat Bohana-Kashtan, PhD, Stephen Shaw, PhD, Daniel C. Link, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2700.
https://doi.org/10.1182/blood-2018-99-117213
Published: 2018
Journal Articles

Phase II Study Evaluating the Safety and Efficacy of BL-8040 for the Mobilization of Donor Hematopoietic Stem and Progenitor Cells for Allogeneic Hematopoietic Cell Transplantation and Phenotypic Characterization of the Leukapheresis Product

Michael P. Rettig, PhD, Geoffrey L. Uy, MD, Asad Bashey, MD PhD, Steven Devine, Samantha Jaglowski, MDMPH, Abi Vainstein, MD, Ella Sorani, PhD, Hemda Chen, PharmD, Osnat Bohana-Kashtan, PhD, Stephen Shaw, PhD, Peter Westervelt, MDPhD, John F. DiPersio, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 118.
https://doi.org/10.1182/blood-2018-99-109701
Published: 2018