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Journal Articles

Translatome Proteomics Identifies Autophagy As a Resistance Mechanism to on-Target FLT3 Inhibitors in Acute Myeloid Leukemia

Sebastian E. Koschade, Kevin Klann, Shabnam Shaid, Binje Vick, Jan A. Stratmann, Marlyn Thölken, Laura M. Meyer, The Duy Nguyen, Julia Campe, Laura M. Moser, Susanna Hock, Fatima Baker, Christian Meyer, Frank Wempe, Hubert Serve, Evelyn Ullrich, Irmela Jeremias, Christian Münch, Christian H. Brandts

Blood (2022) 140 (Supplement 1): 3100.

https://doi.org/10.1182/blood-2022-168824

Published: 2022

Journal Articles

Double-Blind, Placebo Controlled, Randomized, Multicenter, Phase II Study to Assess the Efficacy of the High Affinity CXCR4 Inhibitor BL-8040 As Addition to Consolidation Therapy in AML By the SAL and OSHO Leukemia Study Groups

Sonia Jaramillo Segura, Maxi Wass, Judith Schaffrath, Kathrin Rieger, Axel Nogai, Mathias Haenel, Regina Herbst, Friedrich Stoelzel, Christoph Röllig, Edgar Jost, Richard F. Schlenk, Richard Noppeney, Christian H. Brandts, Utz Krug, Katharina S. Goetze, Sebastian Buske, Axel Florschütz, Jörg Schubert, Bernhard Opitz, Martin Mohren, Eva Eßeling, Stephan von Witzendorff, Marion Subklewe, Martin Kaufmann, Norbert Frickhofen, Christian W Scholz, Kerstin Schäfer-Eckart, Volker Kunzmann, Martin Schmidt-Hieber, Herbert G. Sayer, Andreas Rank, Philipp Hemmati, Frank Schueler, Simone Kowoll, Marina Scheller, Jörg Steighardt, Bayram Edemir, Lutz Peter Mueller, Irit Gliko-Kabir, Beatrice Ludwig-Kraus, Sabine Edemir, Ella Sorani, Mascha Binder, Abi Vainstein, Shaul Kadosh, Cora Gromann, Andreas Wienke, Claudia D. Baldus, Uwe Platzbecker, Hubert Serve, Martin Bornhaeuser, Christian Junghanss, Carsten Mueller-Tidow

Blood (2022) 140 (Supplement 1): 3338–3340.

https://doi.org/10.1182/blood-2022-166748

Published: 2022

Journal Articles

SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma

Blood (2022) 139 (4): 538–553.

https://doi.org/10.1182/blood.2021012081

Published: 2022

Includes: Supplemental data

Journal Articles

Development and Exploitation of a Fully Human and Modular Organotypic Bone Marrow Niche Model to Study the Role of Stroma-Produced Factors in Human MDS

Alexander Schaeffer, Ewelina Czlonka, Irene Tirado-González, Thomas Böse, Jennifer Beauvarlet, Ivan Kur, Aline Bözec, Halvard Bönig, Christian H. Brandts, MD, Uwe Platzbecker, Katharina S. Götze, Hind Medyouf

Blood (2020) 136 (Supplement 1): 23.

https://doi.org/10.1182/blood-2020-142782

Published: 2020

Journal Articles

Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy

The Duy Nguyen, Shabnam Shaid, Olesya Vakhrusheva, Sebastian E. Koschade, Kevin Klann, Marlyn Thölken, Fatima Baker, Jing Zhang, Thomas Oellerich, Duran Sürün, Anja Derlet, Isabella Haberbosch, Stefan Eimer, Heinz D. Osiewacz, Christian Behrends, Christian Münch, Ivan Dikic, Christian H. Brandts

Blood (2019) 133 (2): 168–179.

https://doi.org/10.1182/blood-2018-02-833475

Published: 2019

Includes: Supplemental data

Journal Articles

The Addition of Sorafenib to Standard AML Treatment Results in a Substantial Reduction in Relapse Risk and Improved Survival. Updated Results from Long-Term Follow-up of the Randomized-Controlled Soraml Trial

Christoph Rollig, MD MSC, Hubert Serve, Andreas Hüttmann, MD, Richard Noppeney, MD, Carsten Müller-Tidow, Utz Krug, Claudia D. Baldus, MD, Christian H. Brandts, MD, Volker Kunzmann, MD PhD, Hermann Einsele, Alwin Krämer, MD, Kerstin Schäfer-Eckart, MD, Andreas Neubauer, MD, Andreas Burchert, MD, Aristoteles Giagounidis, MD, Stefan W. Krause, Andreas Mackensen, MD, Walter E. Aulitzky, MD, Regina Herbst, MD, Mathias Hänel, MD, Alexander Kiani, Norbert Frickhofen, MD, Johannes Kullmer, Ulrich Kaiser, MD, Hartmut Link, MD PhD, Thomas Geer, MD, Albrecht Reichle, MD, Christian Junghanss, MD, Roland Repp, MD, Frank Heits, MD, Heinz Albert Durk, Thomas Illmer, Martin Bornhäuser, MD, Markus Schaich, MD, Stefani Barbara Parmentier, MD, Martin Goerner, MD, Christian Thiede, MD, Malte von Bonin, MD, Johannes Schetelig, MD, Michael Kramer, M.Sc., Wolfgang E. Berdel, Gerhard Ehninger

Blood (2017) 130 (Supplement 1): 721.

https://doi.org/10.1182/blood.V130.Suppl_1.721.721

Published: 2017

Journal Articles

Selinexor, ARA-C and Idarubicin: An Effective and Tolerable Combination in Patients with Relapsed/Refractory AML: A Multicenter Phase II Study

Walter Fiedler, MD, Jörg Chromik, Maxim Kebenko, Felicitas Thol, MD, Arne Trummer, MD, Chirstoph Schünemann, Christian H. Brandts, MD, Anne Köhler, Vera Schlipfenbacher, Carsten Bokemeyer, MD, Susann Theile, Anne L. Kranich, Michael Heuser, MD

Blood (2015) 126 (23): 3789.

https://doi.org/10.1182/blood.V126.23.3789.3789

Published: 2015

Journal Articles

Cost-Effectiveness Analysis of Arsenic Trioxide in Combination with All-Trans Retinoic Acid in Acute Promyelocytic Leukemia with Pretreatment White Blood Counts <10G/L

Blood (2014) 124 (21): 2636.

https://doi.org/10.1182/blood.V124.21.2636.2636

Published: 2014

Journal Articles

Sorafenib Versus Placebo in Addition to Standard Therapy in Younger Patients with Newly Diagnosed Acute Myeloid Leukemia: Results from 267 Patients Treated in the Randomized Placebo-Controlled SAL-Soraml Trial

Blood (2014) 124 (21): 6.

https://doi.org/10.1182/blood.V124.21.6.6

Published: 2014

Journal Articles

Improved Outcome with ATRA-Arsenic Trioxide Compared to ATRA-Chemotherapy in Non-High Risk Acute Promyelocytic Leukemia – Updated Results of the Italian-German APL0406 Trial on the Extended Final Series

Uwe Platzbecker, MD, Giuseppe Avvisati, MD, Gerhard Ehninger, MD, Laura Cicconi, MD, Christian Thiede, MD, Felicetto Ferrara, MD, Sonia Maria Orlando, B.Sc., Marco Vignetti, MD, Giorgina Specchia, MD, Marco Sborgia, Eros Di Bona, MD, Massimo Breccia, MD, Elisa Cerqui, MD, Konstanze Döhner, MD, Walter Fiedler, MD, Marie von Lilienfeld-Toal, MD, Bernd Hertenstein, MD, Helmut R. Salih, MD, Mohammed Wattad, MD, Michael Lübbert, Christian H. Brandts, MD, Mathias Hänel, MD, Norbert Schmitz, MD, Hartmut Link, MDPhD, Mariadomenica Divona, B.Sc., Chiara Frairia, MD, Enrico Maria Pogliani, MD, Claudio Fozza, MD, Alfonso Maria D'Arco, MD, Nicola Di Renzo, MD, Agostino Cortelezzi, MD, Francesco Fabbiano, MD, Paola Fazi, MD, Johannes Kullmer, MD, Walter E. Aulitzky, MD, Stefan W. Krause, MD, Hans Salwender, MD, Kerstin Schäfer-Eckart, MD, Markus P. Radsak, MD, Arnold Ganser, Hartmut Döhner, MD, Sergio Amadori, MD, Franco Mandelli, MD, Richard F. Schlenk, MD, Francesco Lo-Coco, MD

Blood (2014) 124 (21): 12.

https://doi.org/10.1182/blood.V124.21.12.12

Published: 2014

Journal Articles

STS1 and STS2 Are Important Regulators Of Hematopoietic Stem Cells

Jing Zhang, PhD, Hubert Serve, MD, Christian H. Brandts, MD

Blood (2013) 122 (21): 1186.

https://doi.org/10.1182/blood.V122.21.1186.1186

Published: 2013

Journal Articles

The Role Of SOCS1 In BCR-ABL Mediated Transformation and Leukemogenesis

Özlem Demirel, PhD, Olivier Balló, MD, Hubert Serve, MD, Christian H. Brandts, MD

Blood (2013) 122 (21): 2507.

https://doi.org/10.1182/blood.V122.21.2507.2507

Published: 2013

Journal Articles

Interferon-γ impairs proliferation of hematopoietic stem cells in mice

Alexander M. de Bruin, Özlem Demirel, Berend Hooibrink, Christian H. Brandts, Martijn A. Nolte

Blood (2013) 121 (18): 3578–3585.

https://doi.org/10.1182/blood-2012-05-432906

Published: 2013

Includes: Supplemental data

Journal Articles

Sorafenib Versus Placebo in Addition to Standard Therapy in Adult Patients ≥60 Years with Newly Diagnosed Acute Myeloid Leukemia: Results From the Randomized-Controlled Soraml Trial

Blood (2012) 120 (21): 144.

https://doi.org/10.1182/blood.V120.21.144.144

Published: 2012

Journal Articles

A Unique Case of a Donor Cell Acute Myeloid Leukemia Reveals Complex Kinetics of Mutations and Evolution of the Disease

Sylvia Herold, PhD, Matthias Kuhn, Uwe Platzbecker, MD, Stange Thoralf, Jörgen Radke, MD, Caroline Heiderich, Lange Thoralf, MD, Kerstin Gutsche, MD, Johannes Schetelig, Stefani Parmentier, MD, Brigitte Mohr, PhD, Markus Schaich, MD, Hubert Serve, Prof. Dr. med., Christian H. Brandts, Martin Bornhäuser, Gerhard Ehninger, Christian Thiede

Blood (2012) 120 (21): 886.

https://doi.org/10.1182/blood.V120.21.886.886

Published: 2012

Journal Articles

ATRA and Arsenic Trioxide (ATO) Versus ATRA and Idarubicin (AIDA) for Newly Diagnosed, Non High-Risk Acute Promyelocytic Leukemia (APL): Results of the Phase III, Prospective, Randomized, Intergroup APL0406 Study by the Italian-German Cooperative Groups Gimema-SAL-AMLSG

Blood (2012) 120 (21): 6.

https://doi.org/10.1182/blood.V120.21.6.6

Published: 2012

Journal Articles

SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control

Pavankumar N. G. Reddy, Bülent Sargin, Chunaram Choudhary, Stefan Stein, Manuel Grez, Carsten Müller-Tidow, Wolfgang E. Berdel, Hubert Serve, Christian H. Brandts

Blood (2012) 120 (8): 1691–1702.

https://doi.org/10.1182/blood-2010-08-301416

Published: 2012

Includes: Supplemental data

Journal Articles

SOCS1 Cooperates with FLT3-ITD In the Development of Myeloproliferative Disease by Promoting the Escape From External Cytokine Control.

Christian H. Brandts, Pavankumar Reddy, Bülent Sargin, Chunaram Choudhary, Carsten Muller-Tidow, Wolfgang E. Berdel, Hubert Serve

Blood (2010) 116 (21): 1054.

https://doi.org/10.1182/blood.V116.21.1054.1054

Published: 2010

Journal Articles

Constitutive Activation of Akt and mTOR by Flt3 Internal Tandem Duplications Mediates Myeloid Leukemogenesis and Can Be Inhibited by Rapamycin.

Christian H. Brandts, MD, Bulent Sargin, MD, Miriam Rode, MS, Christoph Biermann, Beate Lindtner, Joachim Schwable, MD, Horst Buerger, MD, Carsten Muller-Tidow, MD, Chunaram Choudhary, Martin McMahon, PhD, Wolfgang E. Berdel, MD, Hubert L. Serve, MD

Blood (2004) 104 (11): 2532.

https://doi.org/10.1182/blood.V104.11.2532.2532

Published: 2004

NARROW

Translatome Proteomics Identifies Autophagy As a Resistance Mechanism to on-Target FLT3 Inhibitors in Acute Myeloid Leukemia

Double-Blind, Placebo Controlled, Randomized, Multicenter, Phase II Study to Assess the Efficacy of the High Affinity CXCR4 Inhibitor BL-8040 As Addition to Consolidation Therapy in AML By the SAL and OSHO Leukemia Study Groups

SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma

Development and Exploitation of a Fully Human and Modular Organotypic Bone Marrow Niche Model to Study the Role of Stroma-Produced Factors in Human MDS

Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy

The Addition of Sorafenib to Standard AML Treatment Results in a Substantial Reduction in Relapse Risk and Improved Survival. Updated Results from Long-Term Follow-up of the Randomized-Controlled Soraml Trial

Selinexor, ARA-C and Idarubicin: An Effective and Tolerable Combination in Patients with Relapsed/Refractory AML: A Multicenter Phase II Study

Cost-Effectiveness Analysis of Arsenic Trioxide in Combination with All-Trans Retinoic Acid in Acute Promyelocytic Leukemia with Pretreatment White Blood Counts <10G/L

Sorafenib Versus Placebo in Addition to Standard Therapy in Younger Patients with Newly Diagnosed Acute Myeloid Leukemia: Results from 267 Patients Treated in the Randomized Placebo-Controlled SAL-Soraml Trial

Improved Outcome with ATRA-Arsenic Trioxide Compared to ATRA-Chemotherapy in Non-High Risk Acute Promyelocytic Leukemia – Updated Results of the Italian-German APL0406 Trial on the Extended Final Series

STS1 and STS2 Are Important Regulators Of Hematopoietic Stem Cells

The Role Of SOCS1 In BCR-ABL Mediated Transformation and Leukemogenesis

Interferon-γ impairs proliferation of hematopoietic stem cells in mice

Sorafenib Versus Placebo in Addition to Standard Therapy in Adult Patients ≥60 Years with Newly Diagnosed Acute Myeloid Leukemia: Results From the Randomized-Controlled Soraml Trial

A Unique Case of a Donor Cell Acute Myeloid Leukemia Reveals Complex Kinetics of Mutations and Evolution of the Disease

ATRA and Arsenic Trioxide (ATO) Versus ATRA and Idarubicin (AIDA) for Newly Diagnosed, Non High-Risk Acute Promyelocytic Leukemia (APL): Results of the Phase III, Prospective, Randomized, Intergroup APL0406 Study by the Italian-German Cooperative Groups Gimema-SAL-AMLSG

SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control

SOCS1 Cooperates with FLT3-ITD In the Development of Myeloproliferative Disease by Promoting the Escape From External Cytokine Control.

Constitutive Activation of Akt and mTOR by Flt3 Internal Tandem Duplications Mediates Myeloid Leukemogenesis and Can Be Inhibited by Rapamycin.

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American Society of Hematology

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American Society of Hematology

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