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Journal Articles

Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response

Blood (2018) 132 (3): 307–320.

https://doi.org/10.1182/blood-2017-10-810986

Published: 2018

Includes: Supplemental data

Journal Articles

Heterotrimeric G-Proteins Are Indispensable for FLT3-ITD autophosphorylation and Oncogenic Function

Maike Rehage, PhD, Susanne Wingert, PhD, Nadine Haetscher, PhD, Sabrina Bothur, Hubert Serve, MD, Manuel Grez, PhD, Joachim Schwaeble, MD, Michael A Rieger, PhD

Blood (2016) 128 (22): 2712.

https://doi.org/10.1182/blood.V128.22.2712.2712

Published: 2016

Journal Articles

Improving Hematopoietic Stem Cell Based Gene Therapy By Targeting CD133+ Cells

Benjamin Goebel, MD, Christian Brendel, PhD, Daniela Abriss, Sabrina Kneissl, PhD, Martijn Brugman, PhD, Christian J. Buchholz, PhD, Hubert Serve, MD, Manuel Grez, PhD

Blood (2013) 122 (21): 4202.

https://doi.org/10.1182/blood.V122.21.4202.4202

Published: 2013

Journal Articles

Disturbed Endothelial Blood-Bone Marrow-Barrier In Nox4 Deficient Mice

Maren Weisser, Kerstin B. Kaufmann, Tomer Itkin, PhD, Linping Chen-Wichmann, PhD, Tsvee Lapidot, PhD, Manuel Grez, PhD

Blood (2013) 122 (21): 1169.

https://doi.org/10.1182/blood.V122.21.1169.1169

Published: 2013

Journal Articles

SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control

Pavankumar N. G. Reddy, Bülent Sargin, Chunaram Choudhary, Stefan Stein, Manuel Grez, Carsten Müller-Tidow, Wolfgang E. Berdel, Hubert Serve, Christian H. Brandts

Blood (2012) 120 (8): 1691–1702.

https://doi.org/10.1182/blood-2010-08-301416

Published: 2012

Includes: Supplemental data

Journal Articles

Engineered factor IX variants bypass FVIII and correct hemophilia A phenotype in mice

Peter Milanov, Lacramioara Ivanciu, Daniela Abriss, Patricia Quade-Lyssy, Wolfgang Miesbach, Sonja Alesci, Torsten Tonn, Manuel Grez, Erhard Seifried, Jörg Schüttrumpf

Blood (2012) 119 (2): 602–611.

https://doi.org/10.1182/blood-2011-05-353672

Published: 2012

Journal Articles

Use of the in Vitro Immortalization Assay to Quantify the Impact of Integration Spectrum and Vector Design on Insertional Mutagenesis

Ute Modlich, DVM, PhD, Julia Sürth, Daniela Zychlinski, PhD, Johann Meyer, PhD, Christian Brendel, Manuel Grez, PhD, Paritha Arumugam, PhD, Punam Malik, MD, Elke Grassman, PhD, Axel Schambach, MD PhD, Christopher Baum, MD

Blood (2011) 118 (21): 3123.

https://doi.org/10.1182/blood.V118.21.3123.3123

Published: 2011

Journal Articles

Dimer-tetramer transition controls RUNX1/ETO leukemogenic activity

Christian Wichmann, Yvonne Becker, Linping Chen-Wichmann, Vitali Vogel, Anna Vojtkova, Julia Herglotz, Sandra Moore, Joachim Koch, Jörn Lausen, Werner Mäntele, Holger Gohlke, Manuel Grez

Blood (2010) 116 (4): 603–613.

https://doi.org/10.1182/blood-2009-10-248047

Published: 2010

Includes: Supplemental data

Journal Articles

The Clonal Inventory of Gene Corrected Hematopoiesis in Three Successful Clinical Gene Therapy Trials

Kerstin Schwarzwaelder, PhD, Manfred Schmidt, PhD, Annette Deichmann, Steven J. Howe, PhD, Marion G. Ott, MD, Stefan Stein, PhD, Ulrich Siler, MD, Salima Hacein-Bey-Abina, PhD, Hanno Glimm, MD, Dieter Hoelzer, MD, Marina Cavazzana-Calvo, MD, PhD, Adrian J. Thrasher, MD, PhD, Reinhard Seger, MD, Manuel Grez, PhD, Christof von Kalle, MD

Blood (2007) 110 (11): 3733.

https://doi.org/10.1182/blood.V110.11.3733.3733

Published: 2007

Journal Articles

The NHR2 Oligomerization Domain of AML1/ETO as a Novel Therapeutic Target Structure in t(8;21) Positive Leukemias.

Christian Wichmann, MD, Yvonne Becker, Manuel Grez, PhD

Blood (2007) 110 (11): 210.

https://doi.org/10.1182/blood.V110.11.210.210

Published: 2007

Journal Articles

Phase I/II Gene Therapy Study for Chronic Granulomatous Disease: Results, Lessons and Perspectives.

Blood (2007) 110 (11): 503.

https://doi.org/10.1182/blood.V110.11.503.503

Published: 2007

Journal Articles

Biased Engraftment of Retrovirus-Transduced Marrow in Murine X-CGD Following Submyeloablative Conditioning.

Mohammed Sadat, Sara Dirscherl, Nancy Pech, Robert Getty, Scott Cross, Cecilia Barese, W. Scott Goebel, Mervin C. Yoder, Sean Mooney, Manuel Grez, Kenneth Cornetta, Mary C. Dinauer

Blood (2006) 108 (11): 3285.

https://doi.org/10.1182/blood.V108.11.3285.3285

Published: 2006

Journal Articles

Long-Term Clinical Follow-Up and Safety/Toxicity Analysis in 3 X-CGD Patients Treated by Gene Therapy and Non-Myeloablative Conditioning.

Marion G. Ott, MD, Manfred Schmidt, PhD, Stefan Stein, PhD, Kerstin Schwarzwaelder, Ulrich Siler, PhD, Ulrike Koehl, PhD, Klaus Kuehlcke, PhD, Andrea Schilz, PhD, Christoph v. Kalle, PhD, Dieter Hoelzer, MD, Reinhard Seger, MD, Manuel Grez, PhD

Blood (2006) 108 (11): 199.

https://doi.org/10.1182/blood.V108.11.199.199

Published: 2006

Journal Articles

Insertional Activation of MDS1/EVI1, PRDM16 and SETBP1 in a Successful Chronic Granulomatous Disease (CGD) Gene Therapy Trial.

Kerstin Schwarzwaelder, Manfred Schmidt, PhD, Annette Deichmann, Marion G. Ott, MD, Stefan Stein, PhD, Hanno Glimm, MD, Ulrich Siler, MD, Dieter Hoelzer, MD, Reinhard Seger, MD, Manuel Grez, PhD, Christof von Kalle, MD

Blood (2006) 108 (11): 3274.

https://doi.org/10.1182/blood.V108.11.3274.3274

Published: 2006

Journal Articles

Myeloid Expansion after Insertional Activation of MDS1/EVI1, PRDM16 and SETBP1 in a Successful Chronic Granulomatous Gene Therapy Trial.

Kerstin Schwarzwaelder, Manfred Schmidt, PhD, Marion G. Ott, MD, Stefan Stein, PhD, Hanno Glimm, MD, Annette Deichmann, Marlene Fischer, Claudia Ball, Ingo Pilz, Sonja Schmidt, Claudia Prinz, Sylvia Fessler, Manuela Wissler, Silke Klingenberg, Dieter Hoelzer, MD, Reinhard Seger, MD, Manuel Grez, PhD, Christof von Kalle, MD

Blood (2005) 106 (11): 198.

https://doi.org/10.1182/blood.V106.11.198.198

Published: 2005

Journal Articles

Long-Term Follow-Up of Patients Treated by Gene Therapy for X-Linked Chronic Granulomatous Disease.

Marion G. Ott, MD, Manuel Grez, PhD, Stefan Stein, PhD, Ulrich Siler, PhD, Ulrike Koehl, PhD, Klaus Kuehlcke, PhD, Manfred Schmidt, MD, Andrea Schilz, PhD, Hana Kunkel, Sonja Naundorf, PhD, Andrea Brinkmann, Moustapha Hassan, PhD, Christof von Kalle, MD, Adrian Trasher, MD, Reinhard Seger, MD, Dieter Hoelzer, MD

Blood (2005) 106 (11): 194.

https://doi.org/10.1182/blood.V106.11.194.194

Published: 2005

Journal Articles

Reconstitution of Neutrophil NADPH Oxidase Activity in Murine X-CGD Following Transplantation of Retrovirus-Transduced Marrow: Potential Impact of Submyeloablative Conditioning.

Mohammed Sadat, MBBS, PhD, Cecilia Barese, MD, Nancy Pech, W. Scott Goebel, MD, PhD, Mervin C. Yoder, MD, Sean Mooney, PhD, Kenneth Cornetta, MD, Manuel Grez, PhD, Mary C. Dinauer, MD, PhD

Blood (2005) 106 (11): 3050.

https://doi.org/10.1182/blood.V106.11.3050.3050

Published: 2005

Journal Articles

Gene Therapy for X-Linked Chronic Granulomatous Disease.

Marion G. Ott, MD, Stefan Stein, PhD, Ulrike Koehl, PhD, Andrea Schilz, PhD, Klaus Kuhlcke, PhD, Manfred Schmidt, PhD, Christof von Kalle, MD, Moustapha Hassan, MD, Ulrich Siler, PhD, Dieter Hoelzer, MD, Reinhard Seger, MD, Manuel Grez, PhD

Blood (2004) 104 (11): 409.

https://doi.org/10.1182/blood.V104.11.409.409

Published: 2004

Journal Articles

The Stat5-RARα fusion protein represses transcription and differentiation through interaction with a corepressor complex

Alexander B. Maurer, Christian Wichmann, Alexandra Gross, Hana Kunkel, Thorsten Heinzel, Martin Ruthardt, Bernd Groner, Manuel Grez

Blood (2002) 99 (8): 2647–2652.

https://doi.org/10.1182/blood.V99.8.2647

Published: 2002

Journal Articles

Lentiviral gene transfer into peripheral blood–derived CD34 + NOD/SCID-repopulating cells

Michaela Scherr, Karin Battmer, Ulrike Blömer, Bernd Schiedlmeier, Arnold Ganser, Manuel Grez, Matthias Eder

Blood (2002) 99 (2): 709–712.

https://doi.org/10.1182/blood.V99.2.709

Published: 2002

NARROW

Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response

Heterotrimeric G-Proteins Are Indispensable for FLT3-ITD autophosphorylation and Oncogenic Function

Improving Hematopoietic Stem Cell Based Gene Therapy By Targeting CD133+ Cells

Disturbed Endothelial Blood-Bone Marrow-Barrier In Nox4 Deficient Mice

SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control

Engineered factor IX variants bypass FVIII and correct hemophilia A phenotype in mice

Use of the in Vitro Immortalization Assay to Quantify the Impact of Integration Spectrum and Vector Design on Insertional Mutagenesis

Dimer-tetramer transition controls RUNX1/ETO leukemogenic activity

The Clonal Inventory of Gene Corrected Hematopoiesis in Three Successful Clinical Gene Therapy Trials

The NHR2 Oligomerization Domain of AML1/ETO as a Novel Therapeutic Target Structure in t(8;21) Positive Leukemias.

Phase I/II Gene Therapy Study for Chronic Granulomatous Disease: Results, Lessons and Perspectives.

Biased Engraftment of Retrovirus-Transduced Marrow in Murine X-CGD Following Submyeloablative Conditioning.

Long-Term Clinical Follow-Up and Safety/Toxicity Analysis in 3 X-CGD Patients Treated by Gene Therapy and Non-Myeloablative Conditioning.

Insertional Activation of MDS1/EVI1, PRDM16 and SETBP1 in a Successful Chronic Granulomatous Disease (CGD) Gene Therapy Trial.

Myeloid Expansion after Insertional Activation of MDS1/EVI1, PRDM16 and SETBP1 in a Successful Chronic Granulomatous Gene Therapy Trial.

Long-Term Follow-Up of Patients Treated by Gene Therapy for X-Linked Chronic Granulomatous Disease.

Reconstitution of Neutrophil NADPH Oxidase Activity in Murine X-CGD Following Transplantation of Retrovirus-Transduced Marrow: Potential Impact of Submyeloablative Conditioning.

Gene Therapy for X-Linked Chronic Granulomatous Disease.

The Stat5-RARα fusion protein represses transcription and differentiation through interaction with a corepressor complex

Lentiviral gene transfer into peripheral blood–derived CD34 + NOD/SCID-repopulating cells

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American Society of Hematology

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American Society of Hematology

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