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Brian Leber
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Journal Articles

Transform-1: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, International Phase 3 Study of Navitoclax in Combination with Ruxolitinib Versus Ruxolitinib Plus Placebo in Patients with Untreated Myelofibrosis

Naveen Pemmaraju, Adam J Mead, Tim CP Somervaille, James K McCloskey, Francesca Palandri, Steffen Koschmieder, David Lavie, Brian Leber, Su-Peng Yeh, Maria Teresa Gómez-Casares, Emanuele Ammatuna, Ho-Jin Shin, Keita Kirito, Eric Jourdan, Timothy Devos, Hun S Chuah, Atanas Radinoff, Andrija Bogdanovic, Rastislav Moskal, Qi Jiang, Avijeet S Chopra, Elektra Papadopoulos, Jalaja Potluri, Francesco Passamonti
Journal: Blood
Blood (2023) 142 (Supplement 1): 620.
https://doi.org/10.1182/blood-2023-173509
Published: 2023
Journal Articles

Analysis of the Impact of Whole Blood and T-Cell Donor Chimerism after Allogeneic Stem Cell Transplant

Michael Radford, Alejandro Garcia-Horton, Rohail Badami, Elaine Jin, Nida Javed Usmani, Daria Grafodatskaya, Elizabeth McCready, Dina Khalaf, Irwin Walker, Brian Leber, Kylie L. Lepic, Gregory Pond, Tobias Berg
Journal: Blood
Blood (2023) 142 (Supplement 1): 2211.
https://doi.org/10.1182/blood-2023-187458
Published: 2023
Journal Articles

Reclassification of Ascertain (ASTX727-02) Myelodysplastic Syndrome (MDS) Patients: Outcomes Including Clinical Response, Overall Survival (OS), and Leukemia Free Survival (LFS) Based on IPSS-R and IPSS-M Scoring Systems

Guillermo Garcia-Manero, James McCloskey, Elizabeth A. Griffiths, Amer M. Zeidan, Karen W.L. Yee, Aref Al-Kali, H. Joachim Deeg, Prapti A. Patel, Mitchell Sabloff, Mary-Margaret Keating, Nancy Zhu, Nashat Y. Gabrail, Salman Fazal, Joseph J. Maly, Olatoyosi Odenike, Hagop M. Kantarjian, Amy E. DeZern, Casey L. O'Connell, Gail J. Roboz, Lambert Busque, Rena Buckstein, Harsh Amin, Jasleen K. Randhawa, Brian Leber, Shannon Lee, Winny Chan, Sonia Souza, Yuri Sano, Harold N. Keer, Michael R. Savona
Journal: Blood
Blood (2023) 142 (Supplement 1): 4619.
https://doi.org/10.1182/blood-2023-188258
Published: 2023
Journal Articles

Ureaplasma -Induced Hyperammonemia Syndrome - an Acute Complication Post Allogeneic Stem Cell Transplant

Rohail Badami, Kylie L. Lepic, Dina Khalaf, Alejandro Garcia-Horton, Tobias Berg, Brian Leber, Irwin Walker, Michael Radford
Journal: Blood
Blood (2023) 142 (Supplement 1): 6988.
https://doi.org/10.1182/blood-2023-182897
Published: 2023
Journal Articles

LSD1 Inhibition Synergizes with Venetoclax in Acute Myeloid Leukemia By Targeting Cellular Metabolism

Kanwaldeep Singh, Emily Hartung, Christina Muhs, Islam Alshamleh, Monisha Divakaran, Anna Dvorkin-Gheva, Sara Pishyar, Pradhariny Prabagaran, Dina Khalaf, Alejandro Garcia-Horton, Stephen Ronan Foley, Brian Leber, Irwin Walker, Kylie Lepic, Harald Schwalbe, Hubert Serve, Maria Kleppe, Hugh Young Rienhoff, Jr., Tobias Berg
Journal: Blood
Blood (2023) 142 (Supplement 1): 4156.
https://doi.org/10.1182/blood-2023-189515
Published: 2023
Journal Articles

LSD1 Inhibition Enhances Antigen Presentation and Co-Stimulation in AML to Promote T Cell-Mediated Anti-Leukemia Immune Responses

Yu Yan, Kanwaldeep Singh, Emily Hartung, Brendan Lee, Pradhariny Prabagaran, Dina Khalaf, Alejandro Garcia-Horton, Brian Leber, Irwin Walker, Kylie L. Lepic, Maria Kleppe, Hugh Young Young Rienhoff Jr., Jr., Jonathan Bramson, Tobias Berg
Journal: Blood
Blood (2023) 142 (Supplement 1): 6793.
https://doi.org/10.1182/blood-2023-188472
Published: 2023
Journal Articles

Prolonged Survival in Bi-Allelic TP53 -Mutated ( TP53 mut) MDS Subjects Treated with Oral Decitabine/Cedazuridine in the Ascertain Trial (ASTX727-02)

Michael R. Savona, James K McCloskey, Elizabeth A. Griffiths, Karen Yee, Amer M. Zeidan, Aref Al-Kali, Joachim Deeg, Prapti Patel, Mitchell Sabloff, Mary-Margaret Keating, Kim-Hien Dao, Nancy Zhu, Nashat Y. Gabrail, Salman Fazal, Joseph J. Maly, Olatoyosi Odenike, Hagop Kantarjian, Amy E. DeZern, Casey L. O'Connell, Gail J. Roboz, Lambert Busque, Rena Buckstein, Harshad Amin, Jasleen K. Randhawa, Brian Leber, Aram Oganesian, Winny Chan, Yong Hao, Mohammad Azab, Guillermo Garcia-Manero
Journal: Blood
Blood (2022) 140 (Supplement 1): 2066–2069.
https://doi.org/10.1182/blood-2022-163841
Published: 2022
Journal Articles

A Retrospective Cohort Study of Donor Cell Leukemia

Brittany Salter, Omar Raslan, Suzanne Demczuk, Brian Leber, Alejandro Garcia-Horton, Irwin Walker, Tobias Berg, Darci Butcher, Kylie L. Lepic, Elizabeth McCready, Parveen Wasi, Dina Khalaf
Journal: Blood
Blood (2022) 140 (Supplement 1): 12916–12917.
https://doi.org/10.1182/blood-2022-164643
Published: 2022
Journal Articles

The LSC17 Score Correlates with the ELN 2022 Classification of AML and Is an Independent Predictor of Detectable Measurable Residual Disease after Induction Chemotherapy

Tracy Murphy, Stanley W.K. Ng, Ian King, Tong Zhang, Andrea Arruda, Jaime Claudio, Kristele Pan, Chantal Rockwell, Zhibin Lu, Natalie Stickle, Carl Virtanen, Vikas Gupta, Dawn Maze, Caroline McNamara, Aaron D. Schimmer, Andre C. Schuh, Hassan Sibai, Karen Yee, Dina Khalaf, Brian Leber, Mitchell Sabloff, Anne Tierens, Mark D. Minden, Tracy L. Stockley, Steven Chan, Jean C.Y. Wang
Journal: Blood
Blood (2022) 140 (Supplement 1): 9122–9124.
https://doi.org/10.1182/blood-2022-171107
Published: 2022
Journal Articles

Ex Vivo Generation and Infusion of Anti-Minor Histocompatibility Antigen Expanded T Cells for Patients Who Relapse after Allogeneic HLA-Matched Stem Cell Transplantation

Denis-Claude Roy, Jean-Sébastien Delisle, Imran Ahmad, Brian Leber, Félix Couture, Stephanie Thiant, Natasha Kekre, Radia Sidi Boumedine, Cédric Carli, Ann Brasey, Nadia M. Bambace, Léa Bernard, Sandra Cohen, Thomas L. Kiss, Jean Roy, Guy Sauvageau, Olivier Veilleux, Claude Perreault, Lambert Busque, Silvy Lachance
Journal: Blood
Blood (2022) 140 (Supplement 1): 1601–1603.
https://doi.org/10.1182/blood-2022-170147
Published: 2022
Journal Articles

Risk Factor Analysis for Second Treatment-Free Remission Failure from the Canadian TKI Discontinuation (TRAD) Trial in CML Patients: Treatment-Free Remission Accomplished By Dasatinib

Maria Agustina Perusini, Eshetu G. Atenafu, Donna L. Forrest, Bence-Bruckler Isabelle, Lynn Savoie, Mary-Margaret Keating, Lambert Busque, Robert Delage, Anargyros Xenocostas, Elena Liew, Pierre Laneuville, Kristjan Paulson, Tracy L. Stockley, Jeffrey H. Lipton, Brian Leber, Dennis Dong Hwan Kim
Journal: Blood
Blood (2022) 140 (Supplement 1): 6778–6779.
https://doi.org/10.1182/blood-2022-167581
Published: 2022
Journal Articles

Oral Decitabine/Cedazuridine in Patients with Lower Risk Myelodysplastic Syndrome: A Longer-Term Follow-up of from the Ascertain Study

Guillermo Garcia-Manero, James K McCloskey, Elizabeth A. Griffiths, Karen Yee, Amer M. Zeidan, Aref Al-Kali, H. Joachim Deeg, Prapti Patel, Mitchell Sabloff, Mary-Margaret Keating, Kim-Hien Dao, Nancy Zhu, Nashat Y. Gabrail, Salman Fazal, Joseph Maly, Olatoyosi Odenike, Hagop Kantarjian, Amy E. DeZern, Casey L. O'Connell, Gail J. Roboz, Lambert Busque, Richard A. Wells, Harshad Amin, Jasleen K. Randhawa, Brian Leber, Yong Hao, Harold N. Keer, Mohammad Azab, Michael R. Savona
Journal: Blood
Blood (2021) 138 (Supplement 1): 66.
https://doi.org/10.1182/blood-2021-144648
Published: 2021
Journal Articles

Fitness Assessment of Elderly Patients with AML and Outcomes

Tony HT Chen, Joshua Xu, Hassan Zahreddine, Brian Leber, Irwin Walker, Tobias Berg, Kylie L. Lepic, Parveen Wasi, Tom Kouroukis, Christopher M. Hillis, Justin Y. Lee, Dina Khalaf
Journal: Blood
Blood (2021) 138 (Supplement 1): 3379.
https://doi.org/10.1182/blood-2021-152612
Published: 2021
Journal Articles

The Impact of Oral Hypoglycemics and Statins on Outcomes in Myelodysplastic Syndromes

Eugene Brailovski, Qing Li, Ning Liu, Brian Leber, Dina Khalaf, Mitchell Sabloff, Grace Christou, Karen Yee, Lisa Chodirker, Anne Parmentier, Mohammed Siddiqui, Alexandre Mamedov, Liying Zhang, Ying Liu, Craig C. Earle, Matthew Cheung, Nicole Mittman, Rena J. Buckstein, Lee Mozessohn
Journal: Blood
Blood (2021) 138 (Supplement 1): 3064.
https://doi.org/10.1182/blood-2021-149855
Published: 2021
Journal Articles

A Real-World Canadian Experience of Asciminib Use in Chronic Myeloid Leukemia (CML) Patients Who Failed Multiple Lines of Tyrosine Kinase Inhibitor (TKI) Therapy

Fatima Khadadah, Anargyros Xenocostas, Lambert Busque, Kareem Jamani, Sonia Cerquozzi, Philip Kuruvilla, Brian Leber, Rayan Kaedbey, Sarit Assouline, Dennis Dong Hwan Kim
Journal: Blood
Blood (2021) 138 (Supplement 1): 3610.
https://doi.org/10.1182/blood-2021-149588
Published: 2021
Journal Articles

Efficacy of Oral Decitabine/Cedazuridine (ASTX727) in the CMML Subgroup from the Ascertain Phase 3 Study

Michael R. Savona, James K McCloskey, Elizabeth A. Griffiths, Karen Yee, Amer M. Zeidan, Aref Al-Kali, H. Joachim Deeg, Prapti Patel, Mitchell Sabloff, Mary-Margaret Keating, Kim-Hien Dao, Nancy Zhu, Nashat Gabrail, Salman Fazal, Joseph Maly, Olatoyosi Odenike, Hagop Kantarjian, Amy E. DeZern, Casey L. O'Connell, Gail J. Roboz, Lambert Busque, Richard A. Wells, Harshad Amin, Jasleen K. Randhawa, Brian Leber, Yong Hao, Harold N. Keer, Mohammad Azab, Guillermo Garcia-Manero
Journal: Blood
Blood (2021) 138 (Supplement 1): 3682.
https://doi.org/10.1182/blood-2021-154179
Published: 2021
Journal Articles

RBC-Enhance: A Randomized Pilot Feasibility Trial of Red Cell Transfusion Thresholds in Myelodysplastic Syndromes

Rena J. Buckstein, MD FRCPC, Anca Prica, MD, Brian Leber, MD, Nancy Heddle, MSc, Karen W.L. Yee, MD, Simon J. Stanworth, MD, David Bowen, MD, Lisa Chodirker, MD, Jennifer Gallagher, Anne Parmentier, BA, Liying Zhang, PhD, Alexandre Mamedov, Yulia Lin, MD, Jeannie L Callum, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–4.
https://doi.org/10.1182/blood-2020-140165
Published: 2020
Journal Articles

Preliminary Results from a Phase 1 Study of Cfi-400495, a PLK4 Inhibitor, in Patients with Acute Myeloid Leukemia and High Risk MDS

Tracy Murphy, MDFRCP,FRCPath, Brian Leber, MD, Mark R Bray, Steven M Chan, MD PhD, Vikas Gupta, MD FRCP, FRCPath, Dina Khalaf, BSc, MSc, MD, Dawn Maze, MDFRCPC,MSc, Caroline J McNamara, MBBS, Aaron D Schimmer, MD PhD, Andre C. Schuh, Hassan Sibai, MBBS, Graham Fletcher, Debbie Valiquette, Kylie Martin, BSc, RN, BSN, Mark D. Minden, Karen W.L. Yee, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
https://doi.org/10.1182/blood-2020-138822
Published: 2020
Journal Articles

Fatigue, However Measured, Continues to Refine Prognosis in Higher Risk MDS: An MDS-CAN Study

Irina Amitai, MD, Michelle Geddes, MD, Nancy Zhu, MD, Mary-Margaret Keating, MD FRCPC, Mitchell Sabloff, Grace Christou, MD, Brian Leber, MD, Dina Khalaf, BSc, MSc, MD, Heather A. Leitch, MD, Eve St-Hilaire, MD, Nicholas Finn, MD, April Shamy, MD, Karen W.L. Yee, MD, John M. Storring, MD, Thomas J. Nevill, MD, Robert Delage, MD, Mohamed Elemary, MD, Versha Banerji, MD, Lisa Chodirker, MD, Lee Mozessohn, MD, Anne Parmentier, BA, Mohammed Siddiqui, Alexandre Mamedov, Liying Zhang, PhD, Rena J. Buckstein, MD FRCPC
Journal: Blood
Blood (2020) 136 (Supplement 1): 41–43.
https://doi.org/10.1182/blood-2020-141635
Published: 2020
Journal Articles

BCR-ABL1 Transcript Doubling Time after Imatinib Discontinuation for Treatment-Free Remission in Chronic Myeloid Leukemia in Chronic Phase: Predictor for Treatment-Free Remission Failure

Dennis Dong Hwan Kim, MD, Igor Nicolas Novitzky-Basso, MDPhDMRCP,FRCPath, Taehyung Kim, MSc, Eshetu G Atenafu, M.Sc., P.Stat, Donna L. Forrest, MD, Lynn Savoie, MD, Isabelle Bence-Bruckler, MD, Mary-Margaret Keating, MD FRCPC, Lambert Busque, MD, Robert Delage, MD, Anargyros Xenocostas, MD FRCPC, Elena Liew, MDBSc,FRCPC, Kristjan Paulson, MD, Tracy L. Stockley, PhD FCCMG, FACMG, Pierre Laneuville, MD FRCPC, Jeffrey H. Lipton, MD PhD, Suzanne Kamel-Reid, BA, MA, PhD FACMG, Brian Leber, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–41.
https://doi.org/10.1182/blood-2020-136162
Published: 2020