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Bill H. Chang
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Journal Articles

Project Evolve, Evaluation of Lineage Switch (LS), an International Initiative: Preliminary Results Reveal Dismal Outcomes in Patients with LS

Sara K. Silbert, Cynthia Harrison, D. Nathan Biery, Alexandra Semchenkova, Elena Zerkalenkova, Anna Alonso-Saladrigues, Kaylyn Utley, Ibrahim Aldoss, Liping Zhao, Sneha Fernandes, Jeremy D. Rubinstein, Naomi Torres Carapia, Bill H. Chang, Anant Vatsayan, Barbara De Moerloose, Holly L. Pacenta, Dennis John Kuo, Gabriele Escherich, Benjamin J. Lee, Michele S. Redell, Mandi R. Fitzjohn, Daniel P. Larson, Nicolas Duployez, Raymund S. Cuevo, Rui Rochelle He, David Dickens, Firas El Chaer, Kelly Reed, Matthias Wolfl, Sunil S. Raikar, Süreyya Savaşan, Latika Puri, Zhubin J. Gahvari, Aimee C. Talleur, Hisham Abdel-Azim, Aghiad Chamdin, Marlie R.M. Provost, Vanessa A. Fabrizio, Kerstin Mezger, Alexandra McLean Stevens, Emily M. Hsieh, Hao-Wei Wang, Constance M. Yuan, Ulrich A. Duffner, Jing Pan, Sara Ghorashian, Susana Rives, Chloe Hoang, Kara L. Davis, Elad Jacoby, Alexander Popov, Adam Lamble, Nirali N. Shah
Journal: Blood
Blood (2023) 142 (Supplement 1): 4202.
https://doi.org/10.1182/blood-2023-182293
Published: 2023
Journal Articles

Risk Stratified Treatment for Patients with Newly Diagnosed Juvenile Myelomonocytic Leukemia: A Phase 1/2 Non-Randomized Study of Trametinib and Azacitidine with or without Chemotherapy

Elliot Stieglitz, Yueh-Yun Chi, Bill H. Chang, Sarah K. Tasian, Marielle Yohe, Christopher C Dvorak, Erica Southworth, Janel R. Long-Boyle, Jessica Van Ziffle, Zied Abdullaev, Roy Leong, Alan S. Wayne, Deepa Bhojwani, Mignon L. Loh
Journal: Blood
Blood (2023) 142 (Supplement 1): 3210.
https://doi.org/10.1182/blood-2023-177838
Published: 2023
Journal Articles

Outcome of Infants Treated on Total Therapy for Infants with Acute Lymphoblastic Leukemia I: Results from a Non-Randomized Multi-Center Study

Tanja A. Gruber, Minxuan Huang, Sima Jeha, Rebecca J. Deyell, Victor A. Lewis, Bill H. Chang, Eric J. Lowe, Jamie Frediani, Catherine Vezina, Bruno Michon, Nathan Gossai, Erin H. Breese, Thai Hoa Tran, Norman J. Lacayo, Christine Bolen, Sunil J. Desai, Jennifer L. Pauley, Emily Ashcraft, Cheng Cheng, Kirk R. Schultz, Krysta Schils, Linda C. Stork, Van Thu Huynh, Michael Richards, Yoav H. Messinger, Henrique Bittencourt, Terzah M. Horton, Uma Athale, Duncan Stearns, Deborah E. Schiff, Paul S. Gaynon
Journal: Blood
Blood (2023) 142 (Supplement 1): 823.
https://doi.org/10.1182/blood-2023-177798
Published: 2023
Journal Articles

Mouse Model of Combination Targeted Therapy in PTPN11 Driven Leukemia

Karina Thiel-Klare, Alexander Rogers, Ryan Boston, Jeffrey W. Tyner, Bill H. Chang
Journal: Blood
Blood (2022) 140 (Supplement 1): 10687–10688.
https://doi.org/10.1182/blood-2022-160358
Published: 2022
Journal Articles

Phase I Study of Tagraxofusp with or without Chemotherapy in Pediatric Patients with Relapsed or Refractory CD123-Expressing Hematologic Malignancies: A Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) Consortium Trial

Adam J. Lamble, Yueh-Yun Chi, Bill H. Chang, Anupam Verma, Kelly E Faulk, Alexandra McLean Stevens, Lauren Pommert, Sarah Tucker, Benjamin Brookhart, Nirali N. Shah, Christopher L. Brooks, Tariq I. Mughal, Alan S. Wayne, Soheil Meshinchi, Todd M. Cooper
Journal: Blood
Blood (2022) 140 (Supplement 1): 6102–6103.
https://doi.org/10.1182/blood-2022-163503
Published: 2022
Journal Articles

Defining Clinical and Molecular Biomarkers for Venetoclax-Based Drug Combinations to Augment AML Therapy

Christopher A. Eide, Stephen E. Kurtz, Andy Kaempf, Nicola Long, Sunil K Joshi, Tamilla Nechiporuk, Ariane Huang, Charles Dibb, Daniel Bottomly, Shannon K. McWeeney, Bill H. Chang, Brian J. Druker, Jeffrey W. Tyner
Journal: Blood
Blood (2022) 140 (Supplement 1): 1025–1027.
https://doi.org/10.1182/blood-2022-159264
Published: 2022
Journal Articles

Vincristine Sulfate Liposome Injection (VSLI, Marqibo®) in Combination with UK ALL-R3 Induction Chemotherapy for Children, Adolescents and Young Adults with Relapsed Acute Lymphoblastic Leukemia (ALL): A Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) Consortium Trial

Nirali N. Shah, Eric S Schafer, Kenneth Matthew Heym, Andrew E. Place, Melissa A. Burns, Nathan Gossai, Peter Shaw, Michael J. Burke, Bill H. Chang, Michelle L. Hermiston, Reuven J Schore, Teresa Rushing, Paul F Jarosinski, Richard Sposto, Ellynore Florendo, Jemily Malvar, Yueh-Yun Chi, James A. Whitlock, Lewis B. Silverman, Deepa Bhojwani, Alan S. Wayne
Journal: Blood
Blood (2021) 138 (Supplement 1): 3402.
https://doi.org/10.1182/blood-2021-149365
Published: 2021
Journal Articles

Concomitant use of a dual Src/ABL kinase inhibitor eliminates the in vitro efficacy of blinatumomab against Ph + ALL

Brief Report
Jessica T. Leonard, Yoko Kosaka, Pavani Malla, Dorian LaTocha, Adam Lamble, Brandon Hayes-Lattin, Kaelan Byrd, Brian J. Druker, Jeffrey W. Tyner, Bill H. Chang, Evan Lind
Journal: Blood
Blood (2021) 137 (7): 939–944.
https://doi.org/10.1182/blood.2020005655
Published: 2021
Journal Articles

Simultaneous Kinase Inhibition with Ibrutinib and BCL2 Inhibition with Venetoclax As a Therapeutic Strategy for Acute Lymphoblastic Leukemia

Christopher A. Eide, Stephen E Kurtz, PhD, Andy Kaempf, MS, Nicola Long, Jessica Leonard, MD, Bill H. Chang, MD PhD, Motomi Mori, PhD, Brian J. Druker, Jeffrey W. Tyner
Journal: Blood
Blood (2019) 134 (Supplement_1): 3950.
https://doi.org/10.1182/blood-2019-131288
Published: 2019
Journal Articles

Significant In Vivo Sensitivity to Aurora Kinase Inhibition in TCF3-Hlf rearranged Acute Lymphoblastic Leukemia

Bill H. Chang, MD PhD, Jessica Leonard, MD, Joelle Wolf, Michelle Degnin, BS, Kyle Lenz, MD, Beth Wilmot, PhD, Charles G. Mullighan, MBBS, MD, Mignon L. Loh, MD, Stephen P. Hunger, MD, Jeffrey W. Tyner, PhD, Brian J. Druker, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4026.
https://doi.org/10.1182/blood-2018-99-115706
Published: 2018
Journal Articles

T-Cell Suppression By Src/ABL Kinase Inhibitors When Combined with Blinatumomab in Ph+ Acute Lymphoblastic Leukemia

Jessica Leonard, MD, Yoko Kosaka, PhD, Pavani Malla, MS, Brandon Hayes-Lattin, MD, Adam J. Lamble, MD, Brian J. Druker, MD, Jeffrey W. Tyner, PhD, Bill H. Chang, MD PhD, Evan F. Lind, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2694.
https://doi.org/10.1182/blood-2018-99-119301
Published: 2018
Journal Articles

Altered T Cell Subsets and Function in Patients with Acute Lymphoblastic Leukemia

Jessica Leonard, MD, Yoko Kosaka, PhD, Matthew T Newman, BS, Adam J. Lamble, MD, Pavani Malla, MS, Brian J. Druker, MD, Jeffrey W. Tyner, PhD, Bill H. Chang, MD PhD, Evan F. Lind, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1547.
https://doi.org/10.1182/blood-2018-99-119409
Published: 2018
Journal Articles

Targeting of Glutamine Pathways Restores Sensitivity in Venetoclax Resistant Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

Jessica T Leonard, MD, Bill H. Chang, MD PhD, Jeffrey W. Tyner, PhD, Brian J. Druker, MD, Marc Loriaux, MD PhD, Pavani Malla, MS
Journal: Blood
Blood (2017) 130 (Supplement 1): 1264.
https://doi.org/10.1182/blood.V130.Suppl_1.1264.1264
Published: 2017
Journal Articles

Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia

e-blood
Viktoras Frismantas, Maria Pamela Dobay, Anna Rinaldi, Joelle Tchinda, Samuel H. Dunn, Joachim Kunz, Paulina Richter-Pechanska, Blerim Marovca, Orrin Pail, Silvia Jenni, Ernesto Diaz-Flores, Bill H. Chang, Timothy J. Brown, Robert H. Collins, Sebastian Uhrig, Gnana P. Balasubramanian, Obul R. Bandapalli, Salome Higi, Sabrina Eugster, Pamela Voegeli, Mauro Delorenzi, Gunnar Cario, Mignon L. Loh, Martin Schrappe, Martin Stanulla, Andreas E. Kulozik, Martina U. Muckenthaler, Vaskar Saha, Julie A. Irving, Roland Meisel, Thomas Radimerski, Arend Von Stackelberg, Cornelia Eckert, Jeffrey W. Tyner, Peter Horvath, Beat C. Bornhauser, Jean-Pierre Bourquin
Journal: Blood
Blood (2017) 129 (11): e26–e37.
https://doi.org/10.1182/blood-2016-09-738070
Published: 2017
Includes: Supplemental data
Journal Articles

Selective Targeting Cyclin-Dependent Kinase-9 (CDK9) Downmodulates c-MYC and Induces Apoptosis in Diffuse Large B-Cell Lymphoma (DLBCL) Cells

Taylor Rowland, Cody Paiva, BS, Joelle Rowley, Andy Chen, MD PhD, Lisa Drew, PhD, Peter Hurlin, Bill H. Chang, MD PhD, Alexey V Danilov, MD PhD
Journal: Blood
Blood (2016) 128 (22): 289.
https://doi.org/10.1182/blood.V128.22.289.289
Published: 2016
Journal Articles

Novel Targets Identified By in Vitro Screening of Patient Samples with Adult Acute Lymphoblastic Leukemia

Jessica T Leonard, MD, Bill H. Chang, MD PhD, Jeffrey W. Tyner, PhD, Brandon Hayes-Lattin, MD, Marc M. Loriaux, Brian J. Druker, Uma Borate, MD
Journal: Blood
Blood (2016) 128 (22): 2811.
https://doi.org/10.1182/blood.V128.22.2811.2811
Published: 2016
Journal Articles

Venetoclax Resistant Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Cells Are Also Resistant to ABL Inhibitors, Which Can be Overcome By Targeting the PI3K/AKT/ mTOR Pathway

Jessica T Leonard, MD, Jeffrey W. Tyner, PhD, Joelle Rowley, Marc M. Loriaux, Brian J. Druker, Bill H. Chang, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1583.
https://doi.org/10.1182/blood.V128.22.1583.1583
Published: 2016
Journal Articles

PTPN11 Mutations in JMML Confer Dasatinib Sensitivity in a TNK2-Dependent Manner

Chelsea Jenkins, B.S., Samuel B Luty, BS, Julia E. Maxson, PhD, Christopher A. Eide, Bill H. Chang, MD PhD, Jeffrey W. Tyner
Journal: Blood
Blood (2016) 128 (22): 3154.
https://doi.org/10.1182/blood.V128.22.3154.3154
Published: 2016
Journal Articles

ROR1 Protein Expression Is Regulated By UHRF1 in t(1;19) Pre B-Cell ALL

Marilynn Chow, MS,BS, Jason D. MacManiman, Vincent T. Bicocca, PhD, Lina Gao, PhD, Joshi A. Alumkal, MD, Bill H. Chang, MD PhD, Jeffrey W. Tyner, PhD
Journal: Blood
Blood (2015) 126 (23): 3648.
https://doi.org/10.1182/blood.V126.23.3648.3648
Published: 2015
Journal Articles

Dual Targeting of Ph+ ALL with Dasatinib and ABT-199 (Venetoclax)

Jessica Leonard, MD, Joelle Rowley, Brandon Hayes-Lattin, MD, Jeffrey W. Tyner, PhD, Marc Loriaux, MD PhD, Brian J. Druker, MD, Bill H Chang, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1329.
https://doi.org/10.1182/blood.V126.23.1329.1329
Published: 2015