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Journal Articles

Drug Response Profiling Informs Personalized Bridging to Cell Therapy for Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia

Fabio D. Steffen, Andrej Lissat, Julia Alten, Cornelia Eckert, Nicole Bodmer, Bodil E. Thorhauge Als-Nielsen, Adriana Balduzzi, Barbara Buldini, Sarah Elitzur, Andras Kriston, Gergely Nyiri, Imre Västrik, Ferenc Kovacs, Francesco Ceppi, Lucie Sramkova, Larissa Schori, Arianna Arpagaus, Silvia Gutnik, Andishe Attarbaschi, Birgitte Klug Albertsen, Jeanette Greiner, Marc Ansari, Judith M. Boer, Elad Jacoby, Martin Stanulla, Uri Ilan, Peter M. Hoogerbrugge, Tim Lammens, Barbara De Moerloose, Petter Svenberg, Nicolas von der Weid, David O'Connor, Hélène Cavé, Franco Locatelli, Martin Schrappe, André Baruchel, Andreas Kulozik, Kjeld Schmiegelow, Gunnar Cario, Arend von Stackelberg, Peter Horvath, Beat Bornhauser, Jean-Pierre Bourquin
Journal: Blood
Blood (2023) 142 (Supplement 1): 4350.
https://doi.org/10.1182/blood-2023-179306
Published: 2023
Journal Articles

Multinational Retrospective Analysis of Bridging Therapy Prior to Chimeric Antigen Receptor T Cells for Relapsed/Refractory Acute Lymphoblastic Leukemia in Children and Young Adults

Maike Breidenbach, Peter Bader, Andishe Attarbaschi, Claudia Rossig, Roland Meisel, Markus Metzler, Marion Subklewe, Fabian Mueller, Paul-Gerhardt Schlegel, Irene Teichert von Lüttichau, Jean-Pierre Bourquin, Gabriele Escherich, Gunnar Cario, Peter Lang, Ramona Krauss, Arend von Stackelberg, Semjon Willier, Christina Peters, Tobias Feuchtinger
Journal: Blood
Blood (2023) 142 (Supplement 1): 2135.
https://doi.org/10.1182/blood-2023-190117
Published: 2023
Journal Articles

Real-World Data Suggest Effectiveness of Allogeneic Mesenchymal Stromal (MSC-FFM) Cells in Ruxolitinib-Refractory Acute Graft-Versus-Host Disease

Peter Bader, Mareike Verbeek, Peter Herhaus, Lavinia Pachzelt, Gernot Beutel, Christoph Schmid, Nadine Müller, Gesine Bug, Arend von Stackelberg, Johanna Tischer, Francis A. Ayuk, Gerald G. Wulf, Lisa-Marie Pfeffermann, Bernd Jahrsdörfer, Hubert Schrezenmeier, Selim Kuci, Zyrafete Kuci, Anke Zens, Michael Tribanek, Robert Zeiser, Sabine Huenecke, Halvard Bonig
Journal: Blood
Blood (2023) 142 (Supplement 1): 4927.
https://doi.org/10.1182/blood-2023-174492
Published: 2023
Journal Articles

Pediatric Patients with High-Risk B-Cell ALL in First Complete Remission May Benefit from Less Toxic Immunotherapy with Blinatumomab - Results from Randomized Controlled Phase 3 Trial AIEOP-BFM ALL 2017

Martin Schrappe, Franco Locatelli, Maria Grazia Valsecchi, Gunnar Cario, Michaela Vossen-Gajcy, Jan Stary, Andishe Attarbaschi, Nicole Bodmer, Draga Barbaric, Sarah Elitzur, Daniela Silvestri, Alexandra Kolenova, Anja Möricke, Jean-Pierre Bourquin, Luciano Dalla-Pozza, Martin Stanulla, Shai Izraeli, Carmelo Rizzari, Fiona Poyer, Arend von Stackelberg, Valentino Conter, Martin Zimmermann, Andrea Biondi
Journal: Blood
Blood (2023) 142 (Supplement 1): 825.
https://doi.org/10.1182/blood-2023-181524
Published: 2023
Journal Articles

ALL-REZ BFM 2002 Is Associated with Improved Outcome as Compared to ALL-R3 Strategy in Children with Standard Risk Isolated CNS Relapse of Acute Lymphoblastic Leukemia, while Maintaining Comparable Efficacy in Patients with Bone Marrow Relapse. Results of the Multi-National, Multi-Center Trial IntReALL SR 2010

Arend von Stackelberg, Jean-Pierre Bourquin, Martin Zimmermann, Tamas Revesz, Andishe Attarbaschi, Alina Ferster, Lucie Sramkova, Thomas Leth Frandsen, Päivi Maria Lähteenmäki, Ronit Elhasid, Hidemi Toyoda, Peter M. Hoogerbrugge, Inga M. Johannsdottir, Ximo Duarte, Denise Bonney, Vaskar Saha, Ingo G. Steffen, Andrej Lissat, Christiane Chen-Santel, Cornelia Eckert, Andre Baruchel, Arnaud Petit, Hélène Cavé, Carmelo Rizzari, Giovanni Cazzaniga, Luciana Vinti, Pierre Rohrlich, Franco Locatelli
Journal: Blood
Blood (2022) 140 (Supplement 1): 3247–3249.
https://doi.org/10.1182/blood-2022-166234
Published: 2022
Journal Articles

Hypersensitivity Reactions to Native E. coli L-Asparaginase in Children with Acute Lymphoblastic Leukemia May Vary By Treatment Schedule and Type of Glucocorticoid in Induction: Results of Trial ALL-BFM 2000

Anja Möricke, Martin Schrappe, Carmelo Rizzari, Julia Alten, Andishe Attarbaschi, Rita Beier, Andrea Biondi, Birgit Burkhardt, Nicole Bodmer, Joachim Boos, Gunnar Cario, Valentino Conter, Christian Flotho, Andreas E. Kulozik, Claudia Lanvers-Kaminsky, Georg Mann, Felix Niggli, Daniela Silvestri, Arend von Stackelberg, Martin Stanulla, Maria Grazia Valsecchi, Martin Zimmermann
Journal: Blood
Blood (2022) 140 (Supplement 1): 11676–11678.
https://doi.org/10.1182/blood-2022-163142
Published: 2022
Journal Articles

CD19-CAR-T Cells Are Effective and Safe Treatment of Post-Transplant Relapse in Pediatric and Young Adult Patients with B-Lineage ALL: Real-World Data from Germany

Peter Bader, Claudia Rossig, Martin Hutter, Francis A. Ayuk, Claudia D. Baldus, Veit L Buecklein, Halvard Bonig, Gunnar Cario, Hermann Einsele, Udo Holtick, Christian Koenecke, Annette Künkele, Roland Meisel, Fabian Mueller, Ingo Müller, Olaf Penack, Eva Rettinger, Martin G. Sauer, Paul-Gerhardt Schlegel, Jan Soerensen, Arend von Stackelberg, Tobias Feuchtinger, Andrea Jarisch
Journal: Blood
Blood (2022) 140 (Supplement 1): 10407–10409.
https://doi.org/10.1182/blood-2022-156775
Published: 2022
Journal Articles

Superior Overall Survival with Blinatumomab Versus Chemotherapy As Pre-Transplant Consolidation Treatment in Children with High-Risk First-Relapse B-Cell Precursor Acute Lymphoblastic Leukemia (B-ALL): Longer Follow-up (FU) of a Phase 3 Randomized Controlled Trial (RCT)

Franco Locatelli, Gerhard Zugmaier, Carmelo Rizzari, Joan D Morris, Bernd Gruhn, Thomas Klingebiel, Rosanna Parasole, Christin Linderkamp, Christian Flotho, Arnaud Petit, Concetta Micalizzi, Yi Zeng, Deepali Dilip Pilankar, William N Kormany, Cornelia Eckert, Anja Moericke, Mary Sartor, Ondrej Hrusak, Christina Peters, Vaskar Saha, Luciana Vinti, Arend von Stackelberg
Journal: Blood
Blood (2021) 138 (Supplement 1): 1231.
https://doi.org/10.1182/blood-2021-145476
Published: 2021
Journal Articles

Prognostic Relevance of Protocol Deviations in Children with Relapsed ALL Treated in the ALL-REZ BFM 2002 Trial

Eleni Argyriadi, Ingo G. Steffen, Guenter Henze, Christiane Chen-Santel, Arend von Stackelberg
Journal: Blood
Blood (2021) 138 (Supplement 1): 365.
https://doi.org/10.1182/blood-2021-150467
Published: 2021
Journal Articles

Safety and Efficacy of CD19 CAR T-Cells for Pediatric Relapsed Acute Lymphoblastic Leukemia with Active CNS Involvement

Elad Jacoby, MD, Sara Ghorashian, FRCPath, PhD, Britta Julia Vormoor, MD, Barbara De Moerloose, MD, Nicole Bodmer, Michael Maschan, MD, Asaf David Yanir, MD, Bella Bielorai, MD, Srdan Rogosic, Olga Molostova, MD, Claudia Rossig, Amos Toren, MD PhD, Arend von Stackelberg, MD, Jean-Pierre Bourquin, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1.
https://doi.org/10.1182/blood-2020-141940
Published: 2020
Journal Articles

A Phase II Study of Single-Agent Inotuzumab Ozogamicin in Pediatric CD22-Positive Relapsed/Refractory Acute Lymphoblastic Leukemia: Results of the ITCC-059 Study

Erica Brivio, MD, Franco Locatelli, MD, Adriana Thano, Arnaud Petit, MD PhD, Britta Julia Vormoor, MD, Susana Rives, Bella Bielorai, MD, Claudia Rossig, Carmelo Rizzari, Vincent H.J. Van Der Velden, PhD, Anneke C.J. Ammerlaan, Monique L. Den Boer, PhD, Barbara Sleight, MD, Gernot Engstler, Jan Stary, MD PhD, Francisco José Bautista Sirvent, MD PhD, Christiane Chen-Santel, Bénédicte Bruno, MD, Yves Bertrand, MD, Fanny Rialland, MD, Geneviève Plat, Dirk Reinhardt, MD, Luciana Vinti, MD, Arend von Stackelberg, MD, Christian Michel Zwaan
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-134774
Published: 2020
Journal Articles

In Vitro Drug Response Profiling in BCP- and T-ALL Primary Samples Adds a Robust Functional Layer Enabling Optimized Guidance of Individualized Therapy in Relapsed and Refractory Pediatric Acute Leukemia Patients

Andrej Lissat, Despina Maniotis, Michael Nosswitz, Julia Alten, MD, Silvia Jenni, PhD, Yi-Chien Tsai, Gunnar Cario, MD PhD, Roberta La Starza, MDPhD, Ondrej Hrusak, MD PhD, Andreas E. Kulozik, MD PhD, Olaf Witt, Martin Stanulla, MD, Martin Schrappe, MDPhD, Christian M. Zwaan, MD PhD, Cornelia Eckert, PhD, Arend von Stackelberg, MD, Andre Baruchel, Elad Jacoby, MD, Axel Karow, Francesco Ceppi, MD, Beat Bornhauser, Jean-Pierre Bourquin, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 15–16.
https://doi.org/10.1182/blood-2020-142314
Published: 2020
Journal Articles

Subclonal NT5C2 mutations are associated with poor outcomes after relapse of pediatric acute lymphoblastic leukemia

Clinical Trials & Observations
Malwine J. Barz, Jana Hof, Stefanie Groeneveld-Krentz, Jui Wan Loh, Annabell Szymansky, Kathy Astrahantseff, Arend von Stackelberg, Hossein Khiabanian, Adolfo A. Ferrando, Cornelia Eckert, Renate Kirschner-Schwabe
Journal: Blood
Blood (2020) 135 (12): 921–933.
https://doi.org/10.1182/blood.2019002499
Published: 2020
Includes: Supplemental data
Journal Articles

Osteonecrosis after Allogeneic HSCT in Children with High-Risk or Relapsed ALL Treated in the ALL-SCT 2003 Trial

Michaela Kuhlen, MD, Michael H. Albert, Peter Bader, MD PhD, Karoline Ehlert, MD, Tayfun Guengoer, Thomas Klingebiel, MD, Peter J. Lang, MD, Martin Schrappe, MD PhD, Johanna Schrum, MD, Ansgar S. Schulz, MD, Arend von Stackelberg, MD, Brigitte Strahm, PD Dr., Karl-Walter Sykora, MD, Irene Teichert-von Luettichau, MD, Arndt Borkhardt, Prof MD, Roland Meisel, MD, Ulrike Poetschger, Evgenia Glogova, Christina Peters, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2004.
https://doi.org/10.1182/blood.V130.Suppl_1.2004.2004
Published: 2017
Journal Articles

Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia

e-blood
Viktoras Frismantas, Maria Pamela Dobay, Anna Rinaldi, Joelle Tchinda, Samuel H. Dunn, Joachim Kunz, Paulina Richter-Pechanska, Blerim Marovca, Orrin Pail, Silvia Jenni, Ernesto Diaz-Flores, Bill H. Chang, Timothy J. Brown, Robert H. Collins, Sebastian Uhrig, Gnana P. Balasubramanian, Obul R. Bandapalli, Salome Higi, Sabrina Eugster, Pamela Voegeli, Mauro Delorenzi, Gunnar Cario, Mignon L. Loh, Martin Schrappe, Martin Stanulla, Andreas E. Kulozik, Martina U. Muckenthaler, Vaskar Saha, Julie A. Irving, Roland Meisel, Thomas Radimerski, Arend Von Stackelberg, Cornelia Eckert, Jeffrey W. Tyner, Peter Horvath, Beat C. Bornhauser, Jean-Pierre Bourquin
Journal: Blood
Blood (2017) 129 (11): e26–e37.
https://doi.org/10.1182/blood-2016-09-738070
Published: 2017
Includes: Supplemental data
Journal Articles

Dexamethasone vs prednisone in induction treatment of pediatric ALL: results of the randomized trial AIEOP-BFM ALL 2000

Clinical Trials & Observations
Anja Möricke, Martin Zimmermann, Maria Grazia Valsecchi, Martin Stanulla, Andrea Biondi, Georg Mann, Franco Locatelli, Giovanni Cazzaniga, Felix Niggli, Maurizio Aricò, Claus R. Bartram, Andishe Attarbaschi, Daniela Silvestri, Rita Beier, Giuseppe Basso, Richard Ratei, Andreas E. Kulozik, Luca Lo Nigro, Bernhard Kremens, Jeanette Greiner, Rosanna Parasole, Jochen Harbott, Roberta Caruso, Arend von Stackelberg, Elena Barisone, Claudia Rössig, Valentino Conter, Martin Schrappe
Journal: Blood
Blood (2016) 127 (17): 2101–2112.
https://doi.org/10.1182/blood-2015-09-670729
Published: 2016
Includes: Supplemental data
Journal Articles

Activation of Simultaneous Apoptosis and Necroptosis to Eradicate Drug Resistant Leukemia

Scott McComb, PhD, Julia Aguadé-Gorgorió, Blerim Marovca, Lena Harder, Gunnar Cario, Cornelia Eckert, Martin Schrappe, MD PhD, Martin Stanulla, MD, Arend von Stackelberg, MD, Jean-Pierre Bourquin, MD PhD, Beat Bornhauser, PhD
Journal: Blood
Blood (2015) 126 (23): 1283.
https://doi.org/10.1182/blood.V126.23.1283.1283
Published: 2015
Journal Articles

De Novo Purine Biosynthesis in Drug Resistance and Tumor Relapse of Childhood ALL

Hui Li, PhD, Benshang Li, Fan Yang, Caiwen Duan, Yun Bai, Jun J Yang, PhD, Jing Chen, MD PhD, Arend von Stackelberg, MD, Hongzhuan Chen, PhD, JingYan Tang, MD, Adolfo A. Ferrando, MD PhD, Jinghui Zhang, PhD, Shengyue Wang, Renate Kirschner-Schwabe, PhD, Bin-Bing S. Zhou, PhD
Journal: Blood
Blood (2015) 126 (23): 2627.
https://doi.org/10.1182/blood.V126.23.2627.2627
Published: 2015
Journal Articles

Initial Results from a Phase 2 Study of Blinatumomab in Pediatric Patients with Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia

Lia Gore, Franco Locatelli, Gerhard Zugmaier, Christian M. Zwaan, Deepa Bhojwani, Rupert Handgretinger, Peter Bader, Maureen M. O'Brien, Tanya M. Trippett, Benoît Brethon, Carmelo Rizzari, Steven G. DuBois, Paul Gerhardt Schlegel, Phillip Barnette, Chiara Messina, Kuolung Hu, Noemi Mergen, Anja Fischer, James Whitlock, Arend von Stackelberg
Journal: Blood
Blood (2014) 124 (21): 3703.
https://doi.org/10.1182/blood.V124.21.3703.3703
Published: 2014
Journal Articles

Clinical Significance of NT5C2 Mutations in Children with First Relapse of B-Cell Precursor Acute Lymphoblastic Leukemia

Jana Hof, MSc, Annabell Szymansky, MSc, Arend von Stackelberg, MD, Cornelia Eckert, PhD, Renate Kirschner-Schwabe, PhD
Journal: Blood
Blood (2014) 124 (21): 3789.
https://doi.org/10.1182/blood.V124.21.3789.3789
Published: 2014