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Journal Articles

Real-World Experience of Ropeginterferon-Alfa Treatment of PV and ET - Two Centers Experience

Tsewang Tashi, Brandi N. Reeves, Soo Jin Kim, Hyewon Jeong, Sheh-Li Chen, Brynn Parsegov, Josef T. Prchal
Journal: Blood
Blood (2023) 142 (Supplement 1): 6397.
https://doi.org/10.1182/blood-2023-191268
Published: 2023
Journal Articles

Predictive Value of Elevated Tryptase and Mediator Symptoms in Systemic Mastocytosis - a Single Center Experience

Tsewang Tashi, Laura Bickel
Journal: Blood
Blood (2023) 142 (Supplement 1): 6395.
https://doi.org/10.1182/blood-2023-191117
Published: 2023
Journal Articles

Elenestinib, an Investigational, Next Generation KIT D816V Inhibitor, Reduces Mast Cell Burden, Improves Symptoms, and Has a Favorable Safety Profile in Patients with Indolent Systemic Mastocytosis: Analysis of the Harbor Trial

Tsewang Tashi, Olivier Hermine, Mariana Castells, Mar Guilarte, Vito Sabato, Marcus Maurer, Jens Panse, Ivan Alvarez-Twose, Renata Cabral, Robert Bird, Stéphane Barete, Laurence Bouillet, Maud Hermans, Paul Van Daele, David González-De-Olano, Elizabeth A. Griffiths, Joseph Jurcic, Ingunn Dybedal, Gandhi Laurent Damaj, Philippe Schafhausen, Chiara Elena, Tse-Chieh Teh, Pankit Vachhani, Caroline Labe, Saranya Venugopal, Kevin He, Javier Muñoz-González, Ben Lampson, Robyn Scherber, Prithviraj Bose, Clive Grattan, Thanai Pongdee, Tracy I. George, Cristina Bulai Livideanu
Journal: Blood
Blood (2023) 142 (Supplement 1): 76.
https://doi.org/10.1182/blood-2023-188904
Published: 2023
Journal Articles

Exploratory Study on Impact of Comorbid Sleep Apnea Treatment in Patients with Polycythemia Vera and Essential Thrombocythemia

Krishna Sundar, Jihyun Song, Soo Jin Kim, Binal Shah, Kimberly Workman, Braxton Smith, Ellen Brooks, Gabrielle Matinkhah, Srinivas K. Tantravahi, Tsewang Tashi, Victor R. Gordeuk, Josef T. Prchal, Brynn Parsegov
Journal: Blood
Blood (2023) 142 (Supplement 1): 6414.
https://doi.org/10.1182/blood-2023-182884
Published: 2023
Journal Articles

Safety and Efficacy of Bezuclastinib (CGT9486), a Novel, Highly Selective, Potent KIT D816V Tyrosine Kinase Inhibitor, in Patients with Advanced Systemic Mastocytosis (AdvSM): Results from Part 1 of the Phase 2 Apex Trial

Pankit Vachhani, Tsewang Tashi, Gary J. Schiller, Stephanie Lee, Miguel Piris Villaespesa, Helena Pomares, Cristina Bulai Livideanu, Jonathan Lambert, Anthony M. Hunter, Tracy I. George, Cristina Papayannidis, Khalid Shoumariyeh, Rita Petroro, Jenna Zhang, Amanda Pilla, Hina Jolin, Rachael Easton, Vinod Pullarkat
Journal: Blood
Blood (2023) 142 (Supplement 1): 4567.
https://doi.org/10.1182/blood-2023-178885
Published: 2023
Journal Articles

A Phase 1 Study of Avapritinib in Combination with Decitabine in Patients with Systemic Mastocytosis with an Associated Hematologic Neoplasm

Andrew T. Kuykendall, Somedeb Ball, Jason Gotlib, Cecilia Y. Arana Yi, Tsewang Tashi, Raajit K. Rampal, Daniel J. DeAngelo, Virginia O. Volpe, Kristen Marie Pettit, Rami S. Komrokji, Eric Padron
Journal: Blood
Blood (2023) 142 (Supplement 1): 6441.
https://doi.org/10.1182/blood-2023-184652
Published: 2023
Journal Articles

A Phase 3b, Randomized, Open-Label, Parallel Group, Multicenter Study to Assess Efficacy, Safety, and Tolerability of Two Dosing Regimens of Ropeginterferon Alfa-2b-Njft (P1101) in Adult Patients with Polycythemia Vera

John Mascarenhas, Tsewang Tashi, Firas El Chaer, Victor Priego, Oleh Zagrijtschuk, Albert Qin, Jewell Jessup, Craig Zimmerman, Ray Urbanski, Lucia Masarova
Journal: Blood
Blood (2023) 142 (Supplement 1): 6444.
https://doi.org/10.1182/blood-2023-189912
Published: 2023
Journal Articles

Preliminary Safety and Efficacy from Apex, a Phase 2 Study of Bezuclastinib (CGT9486), a Novel, Highly Selective, Potent KIT D816V Tyrosine Kinase Inhibitor, in Adults with Advanced Systemic Mastocytosis (AdvSM)

Daniel J. DeAngelo, Vinod A. Pullarkat, Miguel Piris-Villaespesa, Tracy I. George, Jay L. Patel, Celalettin Ustun, Prithviraj Bose, Mark L Heaney, Jessica Sachs, Lei Sun, Amanda Pilla, Benjamin Exter, Hina A. Jolin, Tsewang Tashi
Journal: Blood
Blood (2022) 140 (Supplement 1): 1512–1513.
https://doi.org/10.1182/blood-2022-156311
Published: 2022
Journal Articles

Development of a Comprehensive Program for Evaluation of Hereditary Predisposition to Hematologic Malignancies

Jennie Vagher, Bryan D. Huber, Luke Maese, Archana M Agarwal, Afaf Osman, Ami B. Patel, Tsewang Tashi, Paul J Shami, Tibor Kovacsovics, Julie D. Asch, Charles J. Parker, Srinivas K. Tantravahi
Journal: Blood
Blood (2022) 140 (Supplement 1): 11468–11470.
https://doi.org/10.1182/blood-2022-170000
Published: 2022
Journal Articles

Disease Characteristics of AML Patients with Germline DDX41 Variants

Jennie Vagher, Shobi Venkatachalam, Peng Li, Julie D. Asch, Bryan D. Huber, Tsewang Tashi, Paul J Shami, Tibor Kovacsovics, Luke Maese, Charles J. Parker, Srinivas K. Tantravahi
Journal: Blood
Blood (2021) 138 (Supplement 1): 3384.
https://doi.org/10.1182/blood-2021-154117
Published: 2021
Journal Articles

A Phase 2 Study of Bezuclastinib (CGT9486), an Oral, Selective, and Potent KIT D816V Inhibitor, in Adult Patients with Advanced Systemic Mastocytosis (AdvSM)

Jason Gotlib, Tracy I. George, Michael W. Deininger, Tsewang Tashi, Vinod A. Pullarkat, Prithviraj Bose, Francis Payumo, Amanda Pilla, Hina Jolin, Jessica Sachs, Daniel J. DeAngelo
Journal: Blood
Blood (2021) 138 (Supplement 1): 3636.
https://doi.org/10.1182/blood-2021-145928
Published: 2021
Journal Articles

Pioneer Part 2: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Evaluate Safety and Efficacy of Avapritinib in Indolent Systemic Mastocytosis

Cem Akin, MDPhD, Hanneke Oude Elberink, MD PhD, Jason Gotlib, MD MS, Vito Sabato, MD PhD, Karin Hartmann, MD, Sigurd Broesby-Olsen, MD, Mariana Castells, MD PhD, Tsewang Tashi, MD, Mark L Heaney, MD, Tracy I. George, MD, Frank Siebenhaar, MD, Deepti H. Radia, MRCPI, FRCPath, Massimo Triggiani, MD PhD, Paul van Daele, MD, Daniel J. DeAngelo, MD PhD, Iván Alvarez-Twose, MD PhD, Andreas Reiter, MD, Peter Vadas, MD PhD, Patrizia Bonadonna, MD, Paggy Hew, MS, Hui-Min Lin, PhD, Maria Roche, MS, Marcus Maurer, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 41–42.
https://doi.org/10.1182/blood-2020-136632
Published: 2020
Journal Articles

Phlebotomy-Induced Iron Deficiency Increases the Expression of Prothrombotic Genes

Jihyun Song, PhD, Adelina Sergueeva, MD, Galina Miasnikova, MD, Soo Jin Kim, MS, Binal N. Shah, PhD, Tsewang Tashi, MD, Xu Zhang, PhD, Perumal Thiagarajan, MD, Victor R. Gordeuk, MD, Josef T. Prchal, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
https://doi.org/10.1182/blood-2020-141374
Published: 2020
Journal Articles

Downregulated KLF2 in PV and ET May Induce Prothrombotic Gene Expression

Jihyun Song, PhD, Jahnavi Gollamudi, MD, Soo Jin Kim, MS, Radhika Gangaraju, MD, Tsewang Tashi, MD, Victor R. Gordeuk, MD, Perumal Thiagarajan, MD, Josef T. Prchal, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–14.
https://doi.org/10.1182/blood-2020-140852
Published: 2020
Journal Articles

Pegylated Interferon-Alfa Suppresses Clonal Hematopoiesis in Polycythemia Vera and Essential Thrombocythemia and Is Associated with Immune Responses to Tumor Antigens

Tsewang Tashi, MD, Tim Luetkens, MD, Stephanie Avila, Soo Jin Kim, MS, Josef T. Prchal, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1691.
https://doi.org/10.1182/blood-2019-131974
Published: 2019
Journal Articles

Normal Hemoglobin Concentrations in Obstructive Sleep Apnea and Associated Neocytolysis-Mediated Hemolysis and Inflammation Mediated Suppression of Expected Elevated Hemoglobin

Jihyun Song, PhD, Krishna M Sundar, MD, Monika Horvathova, MSc, PhD, Tsewang Tashi, MD, Carsten Lundby, PhD, Tomas Ganz, MD PhD, Josef T. Prchal, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3507.
https://doi.org/10.1182/blood-2019-131269
Published: 2019
Journal Articles

Compassionate Use of Ropeginterferon-Alfa-2b/P1101 for Treatment of High Risk Polycythemia Vera and Essential Thrombocythemia Patients Previously Controlled on Pegylated Interferon-Alfa-2a/ Pegasys ®

Jeffrey A Gilreath, PharmD, Tsewang Tashi, MD, Soo Jin Kim, MS, Kimberly Hickman, BS, Josef T. Prchal, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5459.
https://doi.org/10.1182/blood-2018-99-116852
Published: 2018
Journal Articles

Synergistic Effect of Imatinib and Ruxolitinib in a Patient with JAK2 V617F positive Myelofibrosis and Concomitant BCR-ABL1 positive Chronic Myeloid Leukemia

Srinivas K. Tantravahi, MBBS, Soo Jin Kim, MS, Jeffrey A Gilreath, PharmD, Anthony D. Pomicter, MS, Tsewang Tashi, MD, Michael W. Deininger, MD PhD, Josef T. Prchal, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5482.
https://doi.org/10.1182/blood-2018-99-119745
Published: 2018
Journal Articles

Tibetan Gain-of-Function Variant of Prolyl Hydroxylase 2 ( EGLN1) and Selected SNPs of HIF-2-Alpha ( EPAS1) Are Associated with Lower Hemoglobin Values in Tibetans

Tsewang Tashi, MD, N. Scott Reading, PhD, Anna Shestakova, MD PhD, Tatiana Burjanivova, PhD, Tanna Uran, MD PhD, Felipe R Lorenzo V, MD, PhD, Hao Hu, PhD, Chad Huff, PhD, Lorna Moore, PhD, Parvaiz Koul, MD, Carl T Wittwer, MD PhD, Victor R. Gordeuk, MD, Re-Li Ge, MD PhD, Josef T. Prchal, MD
Journal: Blood
Blood (2015) 126 (23): 3332.
https://doi.org/10.1182/blood.V126.23.3332.3332
Published: 2015
Journal Articles

Tibetan PHD2 D4E High Altitude Adapted Gene Can be Rapidly Detected By High Resolution Melting Assay

Anna Shestakova, PhD, Felipe Lorenzo, MD/PhD, Tsewang Tashi, MD, Lucie Lanikova, PhD, Carl T Wittwer, MD/PhD, Josef T. Prchal, MD
Journal: Blood
Blood (2014) 124 (21): 4875.
https://doi.org/10.1182/blood.V124.21.4875.4875
Published: 2014