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Paul J Shami
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Journal Articles

Revumenib Monotherapy in Patients with Relapsed/Refractory KMT2Ar Acute Leukemia: Topline Efficacy and Safety Results from the Pivotal Augment-101 Phase 2 Study

Ibrahim Aldoss, Ghayas C. Issa, Michael Thirman, John DiPersio, Martha Arellano, James S. Blachly, Gabriel N. Mannis, Alexander Perl, David S. Dickens, Christine M. McMahon, Elie Traer, C. Michel Zwaan, Carolyn Grove, Richard Stone, Paul J. Shami, Ioannis Mantzaris, Matthew Greenwood, Neerav Shukla, Branko Cuglievan, Yu Gu, Rebecca G. Bagley, Kate Madigan, Soujanya Sunkaraneni, Huy Van Nguyen, Nicole McNeer, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 2): LBA-5.
https://doi.org/10.1182/blood-2023-192042
Published: 2023
Journal Articles

Revumenib Monotherapy in Patients with Relapsed/Refractory KMT2Ar Acute Leukemias: Efficacy and Safety Results from the Augment-101 Phase 1/2 Study

Ibrahim Aldoss, Ghayas C. Issa, Michael J Thirman, John DiPersio, Martha Arellano, James S. Blachly, Gabriel Mannis, Alexander Perl, David Dickens, Christine M. McMahon, Elie Traer, C. Michel Zwaan, Carolyn Grove, Richard Stone, Paul J Shami, Ioannis Mantzaris, Matthew Greenwood, Neerav Shukla, Branko Cuglievan, Yu Gu, Rebecca G Bagley, Kate Madigan, Soujanya Sunkaraneni, Huy Van Nguyen, Nicole McNeer, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 1): 2907.
https://doi.org/10.1182/blood-2023-189762
Published: 2023
Journal Articles

An 8-year pragmatic observation evaluation of the benefits of allogeneic HCT in older and medically infirm patients with AML

Clinical Trials & Observations
Mohamed L. Sorror, Ted A. Gooley, Barry E. Storer, Aaron T. Gerds, Mikkael A. Sekeres, Bruno C. Medeiros, Eunice S. Wang, Paul J. Shami, Kehinde Adekola, Selina Luger, Maria R. Baer, David A. Rizzieri, Tanya M. Wildes, Jamie Koprivnikar, Julie Smith, Mitchell Garrison, Kiarash Kojouri, Tammy A. Schuler, Wendy M. Leisenring, Lynn E. Onstad, Pamela S. Becker, Jeannine S. McCune, Stephanie J. Lee, Brenda M. Sandmaier, Frederick R. Appelbaum, Elihu H. Estey
Journal: Blood
Blood (2023) 141 (3): 295–308.
https://doi.org/10.1182/blood.2022016916
Published: 2023
Includes: Supplemental data
Journal Articles

Novel Data Analytics Identify Predictors of Quality-of-Life Trajectories in Patients with AML or High-Risk Myeloid Neoplasms

Jordan Gauthier, Bianca Furtuna, Jacopo Mangiavacchi, Shahrzad Gholami, Juan Lavista Ferres, Rahul Dodhia, Amir T. Fathi, Andrew M. Brunner, Aaron T. Gerds, Mikkael A. Sekeres, Bruno C. Medeiros, Eunice S. Wang, Paul J Shami, Kehinde Adekola, Selina M. Luger, Maria R. Baer, David A Rizzieri, Tanya Wildes, Jamie L. Koprivnikar, Julie Smith, Mitchell A. Garrison, Kiarash Kojouri, Frederick R. Appelbaum, Mary-Elizabeth M. Percival, Stephanie J. Lee, Mohamed L. Sorror
Journal: Blood
Blood (2022) 140 (Supplement 1): 5254–5257.
https://doi.org/10.1182/blood-2022-165437
Published: 2022
Journal Articles

Development of a Comprehensive Program for Evaluation of Hereditary Predisposition to Hematologic Malignancies

Jennie Vagher, Bryan D. Huber, Luke Maese, Archana M Agarwal, Afaf Osman, Ami B. Patel, Tsewang Tashi, Paul J Shami, Tibor Kovacsovics, Julie D. Asch, Charles J. Parker, Srinivas K. Tantravahi
Journal: Blood
Blood (2022) 140 (Supplement 1): 11468–11470.
https://doi.org/10.1182/blood-2022-170000
Published: 2022
Journal Articles

Disease Characteristics of AML Patients with Germline DDX41 Variants

Jennie Vagher, Shobi Venkatachalam, Peng Li, Julie D. Asch, Bryan D. Huber, Tsewang Tashi, Paul J Shami, Tibor Kovacsovics, Luke Maese, Charles J. Parker, Srinivas K. Tantravahi
Journal: Blood
Blood (2021) 138 (Supplement 1): 3384.
https://doi.org/10.1182/blood-2021-154117
Published: 2021
Journal Articles

Tolerability and Single Agent Anti-Neoplastic Activity of the CD3xCD123 Bispecific Antibody APVO436 in Patients with Relapsed/Refractory AML or MDS

Justin M Watts, Tara L. Lin, Alice S. Mims, Prapti Patel, Paul J Shami, Elizabeth H. Cull, Christopher R. Cogle, Cynthia Lee, Fatih Uckun
Journal: Blood
Blood (2021) 138 (Supplement 1): 3415.
https://doi.org/10.1182/blood-2021-149337
Published: 2021
Journal Articles

Risk and Severity of Cytokine Release Syndrome in Patients with Relapsed/Refractory (R/R) AML or MDS Treated with CD3xCD123 Bispecific Antibody APVO436

Tara L. Lin, Justin M Watts, Alice S. Mims, Prapti Patel, Paul J Shami, Elizabeth H. Cull, Christopher R. Cogle, Cynthia Lee, Fatih Uckun
Journal: Blood
Blood (2021) 138 (Supplement 1): 3416.
https://doi.org/10.1182/blood-2021-149366
Published: 2021
Journal Articles

Multisite 11-year experience of less-intensive vs intensive therapies in acute myeloid leukemia

Clinical Trials & Observations
Mohamed L. Sorror, Barry E. Storer, Amir T. Fathi, Andrew Brunner, Aaron T. Gerds, Mikkael A. Sekeres, Sudipto Mukherjee, Bruno C. Medeiros, Eunice S. Wang, Pankit Vachhani, Paul J. Shami, Esteban Peña, Mahmoud Elsawy, Kehinde Adekola, Selina Luger, Maria R. Baer, David Rizzieri, Tanya M. Wildes, Jamie Koprivnikar, Julie Smith, Mitchell Garrison, Kiarash Kojouri, Wendy Leisenring, Lynn Onstad, Jennifer E. Nyland, Pamela S. Becker, Jeannine S. McCune, Stephanie J. Lee, Brenda M. Sandmaier, Frederick R. Appelbaum, Elihu H. Estey
Journal: Blood
Blood (2021) 138 (5): 387–400.
https://doi.org/10.1182/blood.2020008812
Published: 2021
Includes: Supplemental data
Journal Articles

Preliminary Results from a Phase 1 Study of APVO436, a Novel Anti-CD123 x Anti-CD3 Bispecific Molecule, in Relapsed/Refractory Acute Myeloid Leukemia and Myelodysplastic Syndrome

Justin M. Watts, MD, Tara Lin, MD, Eunice S. Wang, MD, Alice S. Mims, MD, Elizabeth H. Cull, MD, Prapti A. Patel, MD, Paul J. Shami, MD, Roland B. Walter, MDPhDMS, Christopher R. Cogle, Ruth A. Chenault, MS, Bret Macpherson, MSc, MBA, Allison Given Chunyk, Catherine J. McMahan, Jane A. Gross, PhD, Scott Stromatt, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
https://doi.org/10.1182/blood-2020-141619
Published: 2020
Journal Articles

Prevalence of Inherited Cancer Predisposition Mutations in a Cohort of Older AML Patients Enrolled on the Beat AML Master Trial

Uma Borate, MD, Fei Yang, MD, Richard D. Press, MD PhD, Dean Pavlick, Luke Juckett, BSc, BA, MSc, Anupriya Agarwal, PhD, Amy Burd, PhD, Alice S. Mims, MD, Eytan M. Stein, MD, Prapti A. Patel, MD, Maria R. Baer, MD, Wendy Stock, MD, Gary J. Schiller, MD, William Blum, MD, Paul J Shami, MD, Mark Litzow, MD, James M. Foran, MD, Nyla A. Heerema, PhD, Leonard Rosenberg, Sonja Marcus, MPH, Ashley Owen Yocum, PhD, Mona Stefanos, MBChB, John C. Byrd, MD, Brian J. Druker, Jo-Anne Vergilio, MD, Ross L. Levine, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 373.
https://doi.org/10.1182/blood-2019-131925
Published: 2019
Journal Articles

Safety of Gemtuzumab Ozogamicin As Monotherapy or Combination Therapy in an Expanded-Access Protocol for Patients with Relapsed or Refractory Acute Myeloid Leukemia

Eunice S. Wang, MD, Richard Aplenc, MD PhD, Deborah Chirnomas, Michael John Dugan, MD, Salman Fazal, MD, Swaminathan Iyer, Tara L Lin, MD, Sucha Nand, MD, Kristen J Pierce, Paul J Shami, MD, Jennifer J Vermette, Camille N Abboud, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3979.
https://doi.org/10.1182/blood-2018-99-110804
Published: 2018
Journal Articles

Survival Differences Among Patients (pts) with Acute Myeloid Leukemia (AML) Treated with Allogeneic Hematopoietic Cell Transplantation (HCT) Versus Non-HCT Therapies: A Large Real-Time Multi-Center Prospective Longitudinal Observational Study

Mohamed L. Sorror, MD MSc, Barry E. Storer, PhD, Aaron T. Gerds, MDMS, Bruno C. Medeiros, MD, Paul J Shami, MD, John P. Galvin, MDMS,MPH, Kehinde U. Adekola, MBBS,MS, Selina Luger, MD, Maria R. Baer, MD, David A. Rizzieri, MD, Tanya M. Wildes, MD MSCI, Eunice S. Wang, MD, Stefan Faderl, MD, Jamie L. Koprivnikar, MD, Mikkael A. Sekeres, MD MS, Sudipto Mukherjee, MDPhDMPH, Julie Smith, MD, Mitchell Garrison, MD, Kiarash Kojouri, MD, Jennifer E. Nyland, PhD, Rachelle R. Moore, BS, Sophie L. Fleuret, BS, Ylinne Lynch, MD, Pamela S. Becker, MD, Mary-Elizabeth M. Percival, MD MS, Brenda M. Sandmaier, MD, Frederick R. Appelbaum, MD, Elihu H. Estey, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 207.
https://doi.org/10.1182/blood-2018-99-113094
Published: 2018
Journal Articles

Drug-Free Macromolecular Therapeutics Induce Apoptosis in Cells Isolated from Patients with B Cell Malignancies with Enhanced Apoptosis Induction By Pretreatment with Gemcitabine

Jiawei Wang, Lian Li, PhD, Jiyuan Yang, PhD, Phillip M. Clair, MS, Martha Glenn, MD, Deborah M. Stephens, D. Christopher Radford, PhDCandidate, Ken M. Kosak, Michael W. Deininger, MD PhD, Paul J Shami, MD, Jindřich Kopeček, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4426.
https://doi.org/10.1182/blood-2018-99-112001
Published: 2018
Journal Articles

Limitations to Receiving Allogeneic Hematopoietic Cell Transplantation for Treatment of Acute Myeloid Leukemia: A Large Multi-Center Prospective Longitudinal Observational Study

Mohamed L. Sorror, MD MSc, Barry E. Storer, PhD, Aaron T. Gerds, MDMS, Bruno C. Medeiros, MD, Paul J Shami, MD, John P. Galvin, MDMS,MPH, Kehinde U. Adekola, MBBS,MS, Selina Luger, MD, Maria R. Baer, MD, David A. Rizzieri, MD, Tanya M. Wildes, MD MSCI, Eunice S. Wang, MD, Stefan Faderl, MD, Jamie L. Koprivnikar, MD, Mikkael A. Sekeres, MD MS, Sudipto Mukherjee, MDPhDMPH, Julie Smith, MD, Mitchell Garrison, MD, Kiarash Kojouri, MD, Jennifer E. Nyland, PhD, Rachelle R. Moore, BS, Sophie L. Fleuret, BS, Ylinne Lynch, MD, Pamela S. Becker, MD, Mary-Elizabeth M. Percival, MD, Brenda M. Sandmaier, MD, Frederick R. Appelbaum, MD, Elihu H. Estey, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1388.
https://doi.org/10.1182/blood-2018-99-112672
Published: 2018
Journal Articles

Emerging Real-World Midostaurin Treatment Patterns and Outcomes in FLT3-Mutated Acute Myeloid Leukemia at a Comprehensive Cancer Center

Connor Willis, PharmD, Jyothi Menon, PhD, Sudhir Unni, PhD, Trang Au, PharmD, Briana Ndife, MPH, George J Joseph, BPharm, MS, PhD, Gaetano J Bonifacio, MD, Eytan M. Stein, MD, Srinivas K. Tantravahi, MBBS, Paul J Shami, MD, Tibor Kovacsovics, MD, Diana Brixner, PhD, David Dean Stenehjem, PharmD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4745.
https://doi.org/10.1182/blood-2018-99-115009
Published: 2018
Journal Articles

Healthcare Utilization and Imputed Costs of Acute Myeloid Leukemia Patients By FLT3 Status and Early Midostaurin Use at a Comprehensive Cancer Center

Minkyoung Yoo, Jyothi Menon, PhD, Connor Willis, PharmD, Sudhir Unni, PhD, Trang Au, PharmD, Joseph Biskupiak, PhD, Briana Ndife, MPH, George J Joseph, BPharm, MS, PhD, Gaetano J Bonifacio, MD, Eytan M. Stein, MD, Srinivas K. Tantravahi, MBBS, Paul J. Shami, MD, Tibor Kovacsovics, MD, Diana Brixner, PhD, David Dean Stenehjem, PharmD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5857.
https://doi.org/10.1182/blood-2018-99-113479
Published: 2018
Journal Articles

Comorbidities Are Major Drivers of Overall Survival of Chronic Myelomonocytic Leukemia

Tyson Broadbent, MD, Srinivas K. Tantravahi, MBBS, Sowmya Ravulapati, MBBS, Morgan Ward, Alexandra Asay, Ananth Peddinti, MS, Isaac Kunz, MS, Paul J Shami, MD, Tibor Kovacsovics, MD, Samir Courdy, MBA, Ken Boucher, PhD, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5521.
https://doi.org/10.1182/blood-2018-99-119339
Published: 2018
Journal Articles

Intensive Versus Non-Intensive Induction Therapy for Patients (Pts) with Newly Diagnosed Acute Myeloid Leukemia (AML) Using Two Different Novel Prognostic Models

Mohamed L. Sorror, MD MSc, Barry E. Storer, PhD, Mahmoud Elsawy, MD MSc, Amir T. Fathi, MD, Andrew M. Brunner, MD, Aaron T. Gerds, MD MS, Mikkael A. Sekeres, MD MS, Sudipto Mukherjee, MD, PhD, M.P.H., Bruno C. Medeiros, MD, Eunice S. Wang, MD, Pankit Vachhani, MD, Paul J Shami, MD, Esteban Peña, MD, Shylo Wardyn, MS, Jenny Whitten, MPH, Rachelle Moore, BS, Pamela S. Becker, MD PhD, Jeannine McCune, PharmD, Stephanie J. Lee, MD, Brenda M. Sandmaier, MD, Frederick R. Appelbaum, Elihu H. Estey, MD
Journal: Blood
Blood (2016) 128 (22): 216.
https://doi.org/10.1182/blood.V128.22.216.216
Published: 2016
Journal Articles

The Nitric Oxide-Generating Prodrug Js-K Is Selectively Toxic Towards AML Compared to Normal Human Hematopoietic Cells

Kristi J. Smock, MD, William L. Heaton, MS, Anthony D. Pomicter, MS, Ronda A Crist, MT, Ken M Kosak, BS, Kenneth M Boucher, PhD, George M. Rodgers, MD PhD, Thomas O'Hare, PhD, Michael W. Deininger, MD PhD, Paul J Shami, MD
Journal: Blood
Blood (2016) 128 (22): 5217.
https://doi.org/10.1182/blood.V128.22.5217.5217
Published: 2016