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Karen McGovern
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Journal Articles

The Aryl Hydrocarbon Receptor Defines a Unique Genomic and Immune Signature in AML Characterized By Monocytic Differentiation, Venetoclax Resistance and Is Targetable By Ahr Antagonist

Jennifer N. Saultz, Daniel Bottomly, Faith Burns, Kaelan Byrd, Yoko Kosaka, Shannon K. McWeeney, Stephen E. Kurtz, Guang Fan, Andy Kaempf, Karen McGovern, Lei Wang, Marta Sanchez-Martin, Dan S Kaufman, Evan F. Lind, Jeffrey W. Tyner
Journal: Blood
Blood (2022) 140 (Supplement 1): 3071–3072.
https://doi.org/10.1182/blood-2022-163166
Published: 2022
Journal Articles

Aryl Hydrocarbon Receptor (AHR) Gene Expression in AML Is Associated with FLT3-ITD+ AML and HLA-E Induced Immune Resistance Reversed By Ik-364

Jennifer N. Saultz, Evan F. Lind, Jeffrey W. Tyner, Kaelan Byrd, Shannon K. McWeeney, Yoko Kosaka, Karen McGovern, Lei Wang, Marta Sanchez-Martin
Journal: Blood
Blood (2021) 138 (Supplement 1): 1161.
https://doi.org/10.1182/blood-2021-147589
Published: 2021
Journal Articles

Dual Inhibition of PI3K-Delta and Gamma By Duvelisib (IPI-145) Impairs CLL B- and T-Cell Migration, Survival and Proliferation in a Murine Xenograft Model Using Primary Chronic Lymphocytic Leukemia Cells

Shih-Shih Chen, PhD, Steven Ham, Kanti R. Rai, MD, Karen McGovern, PhD, Jeffery L. Kutok, MD PhD, Nicholas Chiorazzi, MD
Journal: Blood
Blood (2015) 126 (23): 1753.
https://doi.org/10.1182/blood.V126.23.1753.1753
Published: 2015
Journal Articles

Duvelisib (IPI-145) Inhibits Malignant B-Cell Proliferation and Disrupts Signaling from the Tumor Microenvironment through Mechanisms That Are Dependent on PI3K-δ and PI3K-γ

Marisa Peluso, MS, Kerrie Faia, MS, David Winkler, PhD, Nidhi Patel, MS, Erin Brophy, BS, Kerry White, BA, Mark Douglas, MS, Howard M. Stern, MD PhD, Vito Palombella, PhD, Karen McGovern, PhD, Jeffery L. Kutok, MD PhD
Journal: Blood
Blood (2014) 124 (21): 328.
https://doi.org/10.1182/blood.V124.21.328.328
Published: 2014
Journal Articles

The Potent PI3K-δ,γ Inhibitor, IPI-145, Exhibits Preclinical Activity In Murine and Human T-Cell Acute Lymphoblastic Leukemia

Xiaoyan Huang, MD., MSc, Jennifer Proctor, B.S., Yaling Yang, PhD, Xiuhua Gao, MD, PhD, Weihong Zhang, M.D., Shenjiao Huang, MD, PhD, Paul Changelian, PhD, Jeffery L. Kutok, MD, PhD, Karen McGovern, PhD, M. James You, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1438.
https://doi.org/10.1182/blood.V122.21.1438.1438
Published: 2013
Journal Articles

Inhibition Of PI3K-δ and -γ Isoforms By IPI-145 In Chronic Lymphocytic Leukemia Overcomes Signals From PI3K/AKT/S6 Pathway and Promotes Apoptosis

Kumudha Balakrishnan, Marisa Peluso, Min Fu, Nathalie Y. Rosin, PhD, Jan A. Burger, MD, PhD, William G. Wierda, MD, PhD, Michael J. Keating, MD, Kerrie Faia, MS, Susan O'Brien, MD, Jeff Kutok, Karen McGovern, PhD, Varsha Gandhi, PhD
Journal: Blood
Blood (2013) 122 (21): 4167.
https://doi.org/10.1182/blood.V122.21.4167.4167
Published: 2013
Journal Articles

The Potent PI3K-δ,γ Inhibitor IPI-145 Exhibits Differential Activity In Diffuse Large B-Cell Lymphoma (DLBCL) Cell Lines

Veronica Campbell, BS, Ryan Thompson, PhD, Vivian Villegas, MS, Jennifer Proctor, B.S., Karen McGovern, PhD, Jeffery L. Kutok, MD, PhD, Howard M. Stern, M.D., Ph.D.
Journal: Blood
Blood (2013) 122 (21): 1832.
https://doi.org/10.1182/blood.V122.21.1832.1832
Published: 2013
Journal Articles

Evidence That Activated Hedgehog Signaling Predicts for Poor Clinical Outcome in Acute Myeloid Leukemia

Veronica Campbell, BS, Eleni Tholouli, MD, PhD, M. Travis Quigley, MS, John Keilty, MS, Patrick Kelly, MD, Karen McGovern, PhD, Margaret Read, PhD, Jeffery L. Kutok, MD, PhD, Richard Byers, PhD, MBChB
Journal: Blood
Blood (2012) 120 (21): 1441.
https://doi.org/10.1182/blood.V120.21.1441.1441
Published: 2012
Journal Articles

Aberrant Hedgehog Signaling Represents a Novel Therapeutic Target in B Cell Lymphomas.

Qiuju Wang, MS, Craig Peacock, PhD, Kortney Hensley, Sarah Brennan, Akil Merchant, MD, Evan Jones, Irwin Freed, Richard Ambinder, MD, Karen McGovern, Martin Tremblay, D. Neil Watkins, MD, PhD, William Matsui, MD
Journal: Blood
Blood (2007) 110 (11): 3582.
https://doi.org/10.1182/blood.V110.11.3582.3582
Published: 2007