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Cristina E. Tognon
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Journal Articles

Novel Combination Therapy of Venetoclax and Ruxolitinib in the Treatment of Patients with Relapsed/Refractory Acute Myeloid Leukemia

Uma Borate, Jennifer N. Saultz, Andy Kaempf, Jessica Minnier, Cristina E. Tognon, Stephen E. Kurtz, Christopher A. Eide, Prapti A. Patel, Yazan F. Madanat, Peter Clement, Sammantha Avaylon, Shikha Misra, Brian J. Druker, Jeffrey W. Tyner
Journal: Blood
Blood (2021) 138 (Supplement 1): 2333.
https://doi.org/10.1182/blood-2021-152903
Published: 2021
Journal Articles

Patterns of Venetoclax Sensitivity in Chronic Lymphocytic Leukemia

James T Dibb, DO, Nicola Long, Christopher A. Eide, Stephen E Kurtz, PhD, Cristina E. Tognon, PhD, Jeffrey W. Tyner, PhD, Brian J. Druker, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12–14.
https://doi.org/10.1182/blood-2020-137674
Published: 2020
Journal Articles

Evolution of Gilteritinib Resistance from Residual Disease to Relapse

Sunil K Joshi, BA, Tamilla Nechiporuk, PhD, Daniel Bottomly, Paul Piehowski, Paul.Piehowski@pnnl.gov, Julie Reisz, PhD, Janét Pittsenbarger, BA, Sara J Gosline, Andy Kaempf, MS, Yi-Ting Wang, Jamie Moon, Özgün Babur, Kevin M Watanabe-Smith, PhD, Emek Demir, Liu Tao, BS, PhD, Cristina E. Tognon, PhD, Angelo D'Alessandro, PhD, Jeffrey W. Tyner, PhD, Shannon K. McWeeney, PhD, Karin Rodland, rodland@ohsu.edu, Brian J. Druker, MD, Elie Traer
Journal: Blood
Blood (2020) 136 (Supplement 1): 4–5.
https://doi.org/10.1182/blood-2020-139084
Published: 2020
Journal Articles

Discovery and characterization of targetable NTRK point mutations in hematologic neoplasms

Sunil K. Joshi, Kristin Qian, William H. Bisson, Kevin Watanabe-Smith, Ariane Huang, Daniel Bottomly, Elie Traer, Jeffrey W. Tyner, Shannon K. McWeeney, Monika A. Davare, Brian J. Druker, Cristina E. Tognon
Journal: Blood
Blood (2020) 135 (24): 2159–2170.
https://doi.org/10.1182/blood.2019003691
Published: 2020
Includes: Supplemental data
Journal Articles

Framework to Identify and Prioritize Candidate Inherited Myeloid Malignancy Germline Variants Leveraging the BEAT AML Cohort

Daniel Bottomly, Nicola Long, Fei Yang, MD, Tiffany Lee, MD, Uma Borate, MD, Beth Wilmot, PhD, Adam S DuVall, MD, Andrea Monteblanco, BS, Karina Thiel-Klare, Gabby Dewson, BA, Richard D. Press, MD PhD, Cristina E. Tognon, Brian J. Druker, Jeffrey W. Tyner, Shannon K. McWeeney, PhD, Anupriya Agarwal, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1407.
https://doi.org/10.1182/blood-2019-132224
Published: 2019
Journal Articles

Discovery & Characterization of Therapeutically Targetable Ntrk Point Mutations in Leukemia

Sunil K Joshi, BA, William Bisson, PhD, Kristin Qian, Ariane Huang, Kevin Watanabe-Smith, PhD, Jeffrey W. Tyner, Monika Ashok Davare, PhD, Shannon K. McWeeney, PhD, Cristina E. Tognon, Brian J. Druker
Journal: Blood
Blood (2019) 134 (Supplement_1): 1256.
https://doi.org/10.1182/blood-2019-125908
Published: 2019
Journal Articles

Combining the Allosteric ABL1 Inhibitor Asciminib (ABL001) with Ponatinib Suppresses Emergence of and Restores Efficacy Against Highly Resistant BCR-ABL1 Compound Mutants

Christopher A. Eide, Matthew S. Zabriskie, Samantha L. Savage, Orlando Antelope, Nadeem A. Vellore, Hein Than, Anna Reister Schultz, Phillip M. Clair, Amber D. Bowler, Anthony D. Pomicter, Dongqing Yan, Anna V. Senina, Qiang Wang, Todd W. Kelley, Philippe Szankasi, Michael C. Heinrich, Jeffrey W. Tyner, Delphine Rea, MD, Jean-Michel Cayuela, Dong-Wook Kim, Cristina E. Tognon, Thomas O'Hare, PhD, Brian J. Druker, Michael W. Deininger
Journal: Blood
Blood (2019) 134 (Supplement_1): 188.
https://doi.org/10.1182/blood-2019-131781
Published: 2019
Journal Articles

Patterns of Sensitivity Exhibited By Venetoclax-Inclusive Drug Combinations in Acute Myeloid Leukemia

Stephen E Kurtz, PhD, Christopher A. Eide, Andy Kaempf, MS, Nicola Long, Anupriya Agarwal, PhD, Cristina E. Tognon, Motomi Mori, PhD, Brian J. Druker, Jeffrey W. Tyner
Journal: Blood
Blood (2019) 134 (Supplement_1): 878.
https://doi.org/10.1182/blood-2019-126020
Published: 2019
Journal Articles

Comparative Analysis of Independent Ex Vivo functional Drug Screens Identifies Predictive Biomarkers of BCL-2 Inhibitor Response in AML

Brian S. White, PhD, Suleiman A. Khan, PhD, Muhammad Ammad-ud-din, PhD, Swapnil Potdar, MSc, Mike J Mason, PhD, Cristina E. Tognon, PhD, Brian J. Druker, MD, Caroline A Heckman, PhD, Olli Kallioniemi, MD PhD, Stephen E Kurtz, PhD, Kimmo Porkka, MD PhD, Jeffrey W. Tyner, PhD, Tero Aittokallio, PhD, Krister Wennerberg, PhD, Justin Guinney, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2763.
https://doi.org/10.1182/blood-2018-99-111916
Published: 2018
Journal Articles

Combining p38MAPK Inhibitors with a Second Targeted Agent Enhances Blockade of Inflammatory Signaling-Mediated Survival in Acute Myeloid Leukemia Cells

Stephen E Kurtz, PhD, Christopher A. Eide, Narain P. Dubey, Andy Kaempf, Shannon K. McWeeney, PhD, Cristina E. Tognon, PhD, Motomi Mori, PhD, Brian J. Druker, MD, Jeffrey W. Tyner, PhD, Anupriya Agarwal, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2726.
https://doi.org/10.1182/blood-2018-99-117537
Published: 2018
Journal Articles

Characterizing Population Heterogeneity and Signaling Changes in Chronic Myeloid Leukemia Stem and Progenitor Cells upon Combined Treatment with Imatinib and MEK Inhibitors Using Quantitative Single Cell Phospho-Imaging

Anna Reister Schultz, BS, Thomas Jacob, Christopher A. Eide, Samantha L Savage, Motomi Mori, PhD, Jeffrey W. Tyner, PhD, Cristina E. Tognon, PhD, Tania Q. Vu, Brian J. Druker, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4248.
https://doi.org/10.1182/blood-2018-99-115387
Published: 2018
Journal Articles

RGL4 over Expression Correlates with Variation in Midostaurin Response in FLT3-ITD Mutant AML Samples

Mara Rosenberg, BS, Cristina E. Tognon, PhD, Kevin M Watanabe-Smith, PhD, Uma Borate, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1365.
https://doi.org/10.1182/blood-2018-99-120296
Published: 2018
Journal Articles

Dual Inhibition of Bruton's Tyrosine Kinase and BCL2: A Promising Therapeutic Strategy for Myeloid and Lymphoid Leukemias

Christopher A. Eide, Stephen E Kurtz, PhD, Andy Kaempf, Cristina E. Tognon, PhD, Motomi Mori, PhD, Max J. Gordon, MD, Jeffrey W. Tyner, PhD, Alexey V Danilov, MD PhD, Brian J. Druker, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 214.
https://doi.org/10.1182/blood-2018-99-117468
Published: 2018
Journal Articles

Predicting Response to BET Inhibitor in Combination with Palbociclib / Sorafenib Using a Computational Model and Its Validation: A Beat AML Project Study

Jeffrey W. Tyner, PhD, Brian J. Druker, MD, Stephen E Kurtz, PhD, Cristina E. Tognon, PhD, Leylah M. Drusbosky, PhD, Robinson Vidva, B.Tech, Yugandhara Narvekar, M.Sc., Ashish Kumar Agrawal, B.V.Sc, A.H., Saji Gera, M.Tech, Samiksha Avinash Prasad, M.Sc., Vijayashree P Shyamasundar, M.Sc., Gaurav Singh Tunwer, M.Sc., Taher Abbasi, MS, MBA, Shireen Vali, PhD, Christopher R. Cogle, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1540.
https://doi.org/10.1182/blood-2018-99-115284
Published: 2018
Journal Articles

Predicting Response to Dasatinib Using a Computational Model and Its Validation: A Beat AML Project Study

Jeffrey W. Tyner, PhD, Brian J. Druker, MD, Cristina E. Tognon, PhD, Stephen E Kurtz, PhD, Leylah M. Drusbosky, PhD, Diwyanshu Sahu, M.Sc., Robinson Vidva, B.Tech, Shweta Kapoor, M.Sc., Humera Azam, M.Sc., Rajeev Kumar, B.Tech, Padmagiri G Chickdipatti, B.E, Nithya T Raveendaran, M.Tech, Reshma P Gopi, M.Sc., Taher Abbasi, MS, MBA, Shireen Vali, PhD, Christopher R. Cogle, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1541.
https://doi.org/10.1182/blood-2018-99-115678
Published: 2018
Journal Articles

Metformin Reduces Tumor Burden and Splenomegaly in JAK2 V617F Murine Models

João Agostinho Machado-Neto, BSc, Renata Scopim Ribeiro, BSc, MSc, Juan Luiz Coelho-Silva, BSc, MSc, Christopher A. Eide, Bruna Alves Fenerich, BSc, Jaqueline Cristina Fernandes, BSc, MSc, Ana Paula Nunes Rodrigues Alves, MSc, Priscila S Scheucher, PhD, Cristina E. Tognon, PhD, Lorena Lobo Figueiredo-Pontes, MD PhD, Brian J. Druker, MD, Eduardo Magalhães Rego, MDPhD, Fabiola Traina, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4222.
https://doi.org/10.1182/blood.V130.Suppl_1.4222.4222
Published: 2017
Journal Articles

A Genomic Signature Predicting Venetoclax Treatment Response in Acute Myeloid Leukemia (AML) Identified By Protein Network Mapping and Validated By Ex Vivo Ddrug Sensitivity Testing

Leylah M. Drusbosky, PhD, Kimberly E. Hawkins, PhD BS, Helen L. Leather, Hemant S. Murthy, MD, Nosha Farhadfar, MD, John R. Wingard, MD, Maxim Norkin, MD, Randy A. Brown, MD, John W. Hiemenz, MD, Paul Castillo, MD, Biljana N. Horn, MD, Ansu Kumar, MS, Neeraj Kumar Singh, B.Tech, Chandan Kumar, MT, Sumanth Vasista, BE, Taher Abbasi, MS, MBA, Shireen Vali, PhD, Cristina E. Tognon, PhD, Stephen E Kurtz, PhD, Brian J. Druker, MD, Jeffrey W. Tyner, PhD, Daniel A. Pollyea, MD, Christopher R. Cogle, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2707.
https://doi.org/10.1182/blood.V130.Suppl_1.2707.2707
Published: 2017
Journal Articles

DNMT3A Is Highly Expressed in Bone Marrow Cells from Acute Myeloid Leukemia Patients

Renata Scopim Ribeiro, BSc, MSc, João Agostinho Machado-Neto, BSc, Paula De Melo Campos, MD PhD, Christopher A. Eide, Samantha L Savage, Irene Lorand-Metze, MD PhD, Cristina E. Tognon, PhD, Fernando Ferreira Costa, MD PhD, Brian J. Druker, MD, Sara Teresinha Olalla Saad, MD PhD, Fabiola Traina, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3969.
https://doi.org/10.1182/blood.V130.Suppl_1.3969.3969
Published: 2017
Journal Articles

Therapeutically Targetable Activating c-ABL1 Mutations in Philadelphia Chromosome-Negative Leukemias

Samantha L Savage, Julia E. Maxson, PhD, Christopher A. Eide, Chelsea Jenkins, B.S., Melissa L Abel, Anna M. Reister Schultz, Daniel Bottomly, Beth Wilmot, PhD, Shannon Mcweeney, PhD, Cristina E. Tognon, PhD, Jeffrey W. Tyner, PhD, Brian J. Druker, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3930.
https://doi.org/10.1182/blood.V130.Suppl_1.3930.3930
Published: 2017
Journal Articles

Predicting Response to IDH1/IDH2 Inhibitors Beyond IDH Mutations Using a Computational Model and Its Validation: A Beat AML Project Study

Leylah M. Drusbosky, PhD, Robinson Vidva, BT, Saji Gera, MT, Arko Das, MS, Krishna K Tiwari, BT, Vishwas Joseph, MS, Subrat Mohapatra, MS, Neelesh Lunkad, MT, Taher Abbasi, MS, MBA, Shireen Vali, PhD, Cristina E. Tognon, PhD, Stephen E Kurtz, PhD, Jeffrey W. Tyner, PhD, Brian J. Druker, MD, Christopher R. Cogle, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3907.
https://doi.org/10.1182/blood.V130.Suppl_1.3907.3907
Published: 2017