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Samantha L. Savage
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Journal Articles

Combining the Allosteric ABL1 Inhibitor Asciminib (ABL001) with Ponatinib Suppresses Emergence of and Restores Efficacy Against Highly Resistant BCR-ABL1 Compound Mutants

Christopher A. Eide, Matthew S. Zabriskie, Samantha L. Savage, Orlando Antelope, Nadeem A. Vellore, Hein Than, Anna Reister Schultz, Phillip M. Clair, Amber D. Bowler, Anthony D. Pomicter, Dongqing Yan, Anna V. Senina, Qiang Wang, Todd W. Kelley, Philippe Szankasi, Michael C. Heinrich, Jeffrey W. Tyner, Delphine Rea, MD, Jean-Michel Cayuela, Dong-Wook Kim, Cristina E. Tognon, Thomas O'Hare, PhD, Brian J. Druker, Michael W. Deininger
Journal: Blood
Blood (2019) 134 (Supplement_1): 188.
https://doi.org/10.1182/blood-2019-131781
Published: 2019
Journal Articles

Characterizing Population Heterogeneity and Signaling Changes in Chronic Myeloid Leukemia Stem and Progenitor Cells upon Combined Treatment with Imatinib and MEK Inhibitors Using Quantitative Single Cell Phospho-Imaging

Anna Reister Schultz, BS, Thomas Jacob, Christopher A. Eide, Samantha L Savage, Motomi Mori, PhD, Jeffrey W. Tyner, PhD, Cristina E. Tognon, PhD, Tania Q. Vu, Brian J. Druker, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4248.
https://doi.org/10.1182/blood-2018-99-115387
Published: 2018
Journal Articles

Identification of Effective Combinations of Targeted Drugs for DNMT3A and NPM1 Mutated Acute Myeloid Leukemia

Stephen E Kurtz, PhD, Christopher A. Eide, Andy Kaempf, Samantha L Savage, Anna M. Reister Schultz, Beth Wilmot, PhD, Shannon Mcweeney, PhD, Motomi Mori, PhD, Elie Traer, MD PhD, Brian J. Druker, MD, Jeffrey W. Tyner, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2068.
https://doi.org/10.1182/blood.V130.Suppl_1.2068.2068
Published: 2017
Journal Articles

DNMT3A Is Highly Expressed in Bone Marrow Cells from Acute Myeloid Leukemia Patients

Renata Scopim Ribeiro, BSc, MSc, João Agostinho Machado-Neto, BSc, Paula De Melo Campos, MD PhD, Christopher A. Eide, Samantha L Savage, Irene Lorand-Metze, MD PhD, Cristina E. Tognon, PhD, Fernando Ferreira Costa, MD PhD, Brian J. Druker, MD, Sara Teresinha Olalla Saad, MD PhD, Fabiola Traina, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3969.
https://doi.org/10.1182/blood.V130.Suppl_1.3969.3969
Published: 2017
Journal Articles

Therapeutically Targetable Activating c-ABL1 Mutations in Philadelphia Chromosome-Negative Leukemias

Samantha L Savage, Julia E. Maxson, PhD, Christopher A. Eide, Chelsea Jenkins, B.S., Melissa L Abel, Anna M. Reister Schultz, Daniel Bottomly, Beth Wilmot, PhD, Shannon Mcweeney, PhD, Cristina E. Tognon, PhD, Jeffrey W. Tyner, PhD, Brian J. Druker, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3930.
https://doi.org/10.1182/blood.V130.Suppl_1.3930.3930
Published: 2017
Journal Articles

Combining the Allosteric ABL1 Tyrosine Kinase Inhibitor ABL001 with ATP-Competitive Inhibitors to Suppress Resistance in Chronic Myeloid Leukemia

Christopher A. Eide, Samantha L. Savage, Michael C. Heinrich, Anna M. Reister Schultz, Jeffrey W. Tyner, Cristina E. Tognon, Brian J. Druker
Journal: Blood
Blood (2016) 128 (22): 2747.
https://doi.org/10.1182/blood.V128.22.2747.2747
Published: 2016
Journal Articles

Characterization of the Genomic Landscape of BCR-ABL1 Kinase-Independent Mechanisms of Resistance to ABL1 Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia

Christopher A. Eide, Daniel Bottomly, Samantha L. Savage, Libbey White, Beth Wilmot, Anna M. Reister Schultz, Kimberly A. Uchida, Anupriya Agarwal, Elie Traer, MD, Lan Beppu, Olga Sala-Torra, Jerald P. Radich, Garrett Eickelberg, Richard D. Press, Marc M. Loriaux, Srinivas K. Tantravahi, MD, Anthony D. Pomicter, MS, Matthew S. Zabriskie, Michael W. Deininger, MD PhD, Thomas O'Hare, PhD, Jeffrey W. Tyner, Shannon K. McWeeney, Cristina E. Tognon, Brian J. Druker
Journal: Blood
Blood (2016) 128 (22): 1119.
https://doi.org/10.1182/blood.V128.22.1119.1119
Published: 2016
Journal Articles

Identification of Effective Combinations of Targeted Drugs for Hematologic Malignancies

Stephen E Kurtz, PhD, Christopher A. Eide, Andy Kaempf, Vishesh Khanna, BS, Samantha L. Savage, Angela Rofelty, Isabel English, Hibery Ho, Motomi Mori, PhD, Elie Traer, MD, Brian J. Druker, MD, Jeffrey W. Tyner, PhD
Journal: Blood
Blood (2016) 128 (22): 836.
https://doi.org/10.1182/blood.V128.22.836.836
Published: 2016
Journal Articles

Activating Mutations of Insulin Receptor Substrate 2 (IRS2) in Patients with Tyrosine Kinase Inhibitor-Refractory Chronic Myeloid Leukemia

Samantha L Savage, Christopher A. Eide, Kyle F Concannon, Daniel Bottomly, MS, Beth Wilmot, PhD, Shannon K. McWeeney, PhD, Julia Elizabeth Maxson, PhD, Jeffrey W. Tyner, PhD, Cristina E. Tognon, PhD, Brian J. Druker, MD
Journal: Blood
Blood (2015) 126 (23): 2461.
https://doi.org/10.1182/blood.V126.23.2461.2461
Published: 2015
Journal Articles

Activating Mutations Observed in De Novo Acute Myeloid Leukemia Are Also Present in a Subset of Philadelphia Chromosome (Ph)-Positive Leukemia Patients with BCR-ABL1-Independent Resistance to ABL1 Kinase Inhibitors

Christopher A. Eide, Samantha L. Savage, Anupriya Agarwal, Daniel Bottomly, Beth Wilmot, Shannon K. McWeeney, Stephen E. Kurtz, Thomas O'Hare, Michael W. Deininger, Marc M. Loriaux, Cristina E. Tognon, Jeffrey W. Tyner, Brian J. Druker
Journal: Blood
Blood (2014) 124 (21): 4514.
https://doi.org/10.1182/blood.V124.21.4514.4514
Published: 2014
Journal Articles

Philadelphia Chromosome (Ph)-Positive Leukemia Patients Who Fail ABL1 Tyrosine Kinase Inhibitors Without BCR-ABL1 Kinase Domain Point Mutations Demonstrate Sensitivity To PI3-K/AKT Inhibitors

Christopher A. Eide, Samantha L. Savage, Jade Bryant, Anupriya Agarwal, Daniel Bottomly, Beth Wilmot, Shannon K. McWeeney, Thomas O'Hare, Michael W. Deininger, Marc M. Loriaux, Cristina E. Tognon, Jeffrey W. Tyner, Brian J. Druker
Journal: Blood
Blood (2013) 122 (21): 3994.
https://doi.org/10.1182/blood.V122.21.3994.3994
Published: 2013