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Kathleen M. Sakamoto
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Journal Articles

Small Molecule Inhibitor Targeting Nemo-like Kinase Improves Erythropoiesis in Human and Mouse Models of Diamond Blackfan Anemia

Aya Shibuya, Lucy Liu, Mark C Wilkes, Nan Wang, Leonardo Daniels, Jayla Taylor, Bertil Glader, Kathleen M. Sakamoto
Journal: Blood
Blood (2023) 142 (Supplement 1): 2728.
https://doi.org/10.1182/blood-2023-182445
Published: 2023
Journal Articles

Roles of Ribosomal S6 Kinases in Acute Leukemia and Normal Hematopoiesis

Kailen Mark, Minyoung Youn, Madalsa Singh, Kathleen M. Sakamoto
Journal: Blood
Blood (2023) 142 (Supplement 1): 1429.
https://doi.org/10.1182/blood-2023-179588
Published: 2023
Journal Articles

Uridine Synthesis Is the Metabolic Vulnerability in Relapse-Associated B-ALL Cells with Active Pre-BCR Signaling

Yuxuan Liu, Haowen Jiang, Lucille Stuani, Jolanda Sarno, Pablo Domizi, Milton Merchant, Dorra Jedoui, Astraea Jager, Min Huang, Norman J. Lacayo, Kathleen M. Sakamoto, Jiangbin Ye, Kara L. Davis
Journal: Blood
Blood (2023) 142 (Supplement 1): 4340.
https://doi.org/10.1182/blood-2023-186925
Published: 2023
Journal Articles

Novel Mouse Model That Recapitulates the Hematologic Phenotype of Diamond Blackfan Anemia

Y. Lucy Liu, Nan Wang, Nicholas Neoman, Carolyn Wong, Bertil Glader, Raymond T. Doty, Mark C Wilkes, Janis L. Abkowitz, Kathleen M. Sakamoto
Journal: Blood
Blood (2023) 142 (Supplement 1): 944.
https://doi.org/10.1182/blood-2023-187734
Published: 2023
Journal Articles

Niclosamide Inhibits Proliferation of Leukemia Cells and Synergizes with Chemotherapy

Kailen Mark, Marilee Robbins, Anna Gamble, Hee-Don Chae, Michael Bassik, Kyuho Han, Kathleen M. Sakamoto
Journal: Blood
Blood (2022) 140 (Supplement 1): 8870–8871.
https://doi.org/10.1182/blood-2022-167429
Published: 2022
Journal Articles

Novel Small Molecule and Peptide Inhibitors of CREB in Leukemia Cells

John Dalloul, Minyoung Youn, Kailen Mark, Alexander Powers, Ron Dror, Soichi Wakatsuki, Kathleen M. Sakamoto
Journal: Blood
Blood (2022) 140 (Supplement 1): 4949–4950.
https://doi.org/10.1182/blood-2022-163739
Published: 2022
Journal Articles

Aberrant Histone Landscape in Juvenile Myelomonocytic Leukemia

Roshani Sinha, Mai Dvorak, Charlotte M. Niemeyer, Kathleen M. Sakamoto, Rachana Patil, Paul J Utz, Y. Lucy Liu, Alex Kuo, Alice Bertaina
Journal: Blood
Blood (2021) 138 (Supplement 1): 4328.
https://doi.org/10.1182/blood-2021-152074
Published: 2021
Journal Articles

Nutritional Supplements, Ginseng and Leucine, Increase Erythropoiesis in Diamond Blackfan Anemia Models through Inhibition of Nemo-like Kinase

Mark C Wilkes, Aya Shibuya, Jacqueline D Mercado, Anupama Narla, Bert Glader, Kathleen M. Sakamoto
Journal: Blood
Blood (2021) 138 (Supplement 1): 1129.
https://doi.org/10.1182/blood-2021-153728
Published: 2021
Journal Articles

Gene Expression Analysis of CML Patients across the Age Spectrum

Minyoung Youn, Stephanie M. Smith, Alex Gia Lee, Hee-Don Chae, Elizabeth Spiteri, Jason Erdmann, Ilana Galperin, Lara C. Murphy, Michele Donato, Parveen Abidi, Henrique Bittencourt, Norman J. Lacayo, Gary Dahl, Catherine Aftandilian, Kara L. Davis, Jairo A. Matthews, Steven M. Kornblau, Min Huang, Nathan Sumarsono, Michele Redell, Cecilia H. Fu, I-Ming L Chen, Todd A. Alonzo, Elizabeth A. Eklund, Jason Gotlib, Purvesh Khatri, Alejandro Sweet-Cordero, Nobuko Hijiya, Kathleen M. Sakamoto
Journal: Blood
Blood (2021) 138 (Supplement 1): 1473.
https://doi.org/10.1182/blood-2021-148701
Published: 2021
Journal Articles

The Serine Threonine Kinase Inhibitor Ots-167 Improves Erythropoiesis through Suppression of Nlk Activity in Diamond Blackfan Anemia Models

Aya Shibuya, Mark C Wilkes, Manuel Serrano, Johan Flygare, Bert Glader, Anupama Narla, Kathleen M. Sakamoto
Journal: Blood
Blood (2021) 138 (Supplement 1): 2179.
https://doi.org/10.1182/blood-2021-150070
Published: 2021
Journal Articles

SATB1 Regulates Chromatin Organization and HSP70 Expression in Early Erythropoiesis and Is Downregulated in Models of Diamond Blackfan Anemia

Mark C Wilkes, Aya Shibuya, Vanessa M Scanlon, Hee-Don Chae, Anupama Narla, Kathleen M. Sakamoto
Journal: Blood
Blood (2021) 138 (Supplement 1): 2189.
https://doi.org/10.1182/blood-2021-153814
Published: 2021
Journal Articles

Activated natural killer cells predict poor clinical prognosis in high-risk B- and T-cell acute lymphoblastic leukemia

Caroline Duault, Anil Kumar, Adeleh Taghi Khani, Sung June Lee, Lu Yang, Min Huang, Christian Hurtz, Bryan Manning, Lucy Ghoda, Tinisha McDonald, Norman J. Lacayo, Kathleen M. Sakamoto, Martin Carroll, Sarah K. Tasian, Guido Marcucci, Jianhua Yu, Michael A. Caligiuri, Holden T. Maecker, Srividya Swaminathan
Journal: Blood
Blood (2021) 138 (16): 1465–1480.
https://doi.org/10.1182/blood.2020009871
Published: 2021
Includes: Supplemental data
Journal Articles

Genetic Modulators of Niclosamide Sensitivity and Resistance in Acute Myeloid Leukemia

Anna Wojcicki, BS, Hee-Don Chae, PhD, Kyuho Han, PhD, Minyoung Youn, PhD, Mark C Wilkes, PhD, Norman J. Lacayo, MD, Michael Bassik, PhD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29.
https://doi.org/10.1182/blood-2020-137340
Published: 2020
Journal Articles

Metformin Upregulates Mir-26a to Improve Erythropoiesis in Preclinical Models of Diamond Blackfan Anemia through Suppression of Nlk Expression

Mark C Wilkes, PhD, Kavitha Siva, PhD, Jacqueline D Mercado, Ethan Patrick Wentworth, Mallika Saxena, Jun Chen, MD PhD, Anupama Narla, MD, Bertil Glader, MD PhD, Shuo Lin, PhD, Manuel Serrano, PhD, Johan Flygare, MD PhD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 7.
https://doi.org/10.1182/blood-2020-137170
Published: 2020
Journal Articles

SATB1 Regulates GATA1 Protein Expression in Early Hematopoiesis and Is Deregulated in Diamond Blackfan Anemia

Mark C Wilkes, PhD, Hee-Don Chae, PhD, Ethan Patrick Wentworth, Toshinobu Nishimura, PhD, Anupama Narla, MD, Bertil Glader, MD PhD, Hiromitsu Nakauchi, Joanna Wysocka, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3.
https://doi.org/10.1182/blood-2020-140437
Published: 2020
Journal Articles

Targeting of Calbindin 1 (CALB1) Rescues Erythropoiesis in a Human Model of Diamond Blackfan Anemia: Implications for Novel Therapies

Nan of Wang, PhD, Corinne Marie Lavasseur, BA, Hongxia Yan, MS, Scott Younger, PhD, Bertil Glader, MD PhD, Kathleen M. Sakamoto, MD PhD, Lionel Blanc, PhD, Anupama Narla, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4.
https://doi.org/10.1182/blood-2020-139823
Published: 2020
Journal Articles

Comparison of the Transcriptomic Signatures in Pediatric and Adult CML

Minyoung Youn, PhD, Hee-Don Chae, PhD, Stephanie M. Smith, MD, Alex Gia Lee, PhD, Lara C. Murphy, MD, Michele Donato, PhD, Alejandro Sweet-Cordero, Parveen Abidi, PhD, Henrique Bittencourt, MD PhD, Norman J. Lacayo, MD, Gary Dahl, Catherine Aftandilian, MD, Kara L Davis, DO, Jairo A. Matthews, Steven M. Kornblau, MD, Min Huang, PhD, Nathan Sumarsono, BS, Michele Redell, MD, Cecilia H. Fu, MD, I-Ming L Chen, Todd A. Alonzo, PhD, Elizabeth A. Eklund, MD, Jason Gotlib, MD MS, Purvesh Khatri, PhD, Nobuko Hijiya, MD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
https://doi.org/10.1182/blood-2020-142270
Published: 2020
Journal Articles

Pp90RSK Isoforms Play Distinct Roles during Hematopoiesis

Minyoung Youn, PhD, Hee-Don Chae, PhD, Jesus Omar Gomez, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13.
https://doi.org/10.1182/blood-2020-142251
Published: 2020
Journal Articles

Activated Natural Killer Cells Are Associated with Poor Clinical Prognosis in High-Risk B- and T- Cell Acute Lymphoblastic Leukemia

Caroline Duault, PharmD, PhD, Anil Kumar, PhD, Adeleh Taghi Khani, PhD, Sung June Lee, BA, Lu Yang, PhD, Min Huang, PhD, Christian Hurtz, PhD, Bryan Manning, BS, Lucy Ghoda, PhD, Tinisha McDonald, BS, Norman J. Lacayo, MD, Kathleen M. Sakamoto, MD PhD, Martin P. Carroll, MD, Guido Marcucci, MD, Jianhua Yu, PhD, Michael A. Caligiuri, MD, Holden T. Maecker, PhD, Srividya Swaminathan, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39.
https://doi.org/10.1182/blood-2020-140044
Published: 2020
Journal Articles

Pharmacological Inhibition of Nemo-like Kinase Rescues mTOR-Mediated Translation and Primes Progenitors for Leucine-Stimulated Erythroid Expansion in Pre-Clinical Models of Diamond Blackfan Anemia

Mark C Wilkes, PhD, Jacqueline D Mercado, Mallika Saxena, Jun Chen, MD PhD, Kavitha Siva, PhD, Hee-Don Chae, PhD, Minyoung Youn, PhD, Ethan Patrick Wentworth, Kevin Jung, Ryan Sathianathen, Hiral Patel, Bertil Glader, MD PhD, Anupama Narla, MD, Claire E Repellin, PhD, Hanna T Gazda, MD PhD, Manuel Serrano, PhD, Johan Flygare, MD PhD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 455.
https://doi.org/10.1182/blood-2019-129570
Published: 2019