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Journal Articles

Abatacept for acute graft-versus-host disease prophylaxis after unrelated donor hematopoietic cell transplantation

Leslie S. Kean, Linda J. Burns, Tzuyung D. Kou, Roxanne Kapikian, Karissa Lozenski, Amelia Langston, John T. Horan, Benjamin Watkins, Muna Qayed, Brandi Bratrude, Kayla Betz, Xiao-Ying Tang, Mei-Jie Zhang, Sean E. Connolly, Martin Polinsky, Brian Gavin, Andres Gomez-Caminero, Marcelo C. Pasquini

Blood (2024) 144 (17): 1834–1845.

https://doi.org/10.1182/blood.2023023660

Published: 2024

Includes: Supplemental data

Journal Articles

Higher abatacept exposure after transplant decreases acute GVHD risk without increasing adverse events

Blood (2023) 142 (8): 700–710.

https://doi.org/10.1182/blood.2023020035

Published: 2023

Includes: Supplemental data

Journal Articles

Targeting CNS Lymphoma with Intravenous Axicabtagene Ciloleucel: Evidence for Transcriptional Evolution Towards a Prominent Interferon Signature in CAR-T Cells Trafficking to the Tumor Site

Ulrike Gerdemann, James Kaminski, Alexandre Albanese, Paula Keskula, Lorenzo Cagnin, Kayla Betz, Jillian Zavistaski, Ryan A Fleming, Caroline Falvey, Riemke Bouvier, Julia Jones, Soumya Poddar, Mike Mattie, Ugonma Chukwueke, Alexandra Torres, Caron A. Jacobson, Lakshmi Nayak, Leslie S. Kean

Blood (2022) 140 (Supplement 1): 408–409.

https://doi.org/10.1182/blood-2022-166645

Published: 2022

Journal Articles

Single-Cell RNA-Seq Reveals an Interferon-Driven Inflammatory CD4 Naïve T Cell Subpopulation at Day 100 in Hematopoietic Stem Cell Transplant Patients That Ultimately Develop Chronic Gvhd

Alexandre Albanese, Edward Chen, Jillian Zavistaski, Kayla Betz, Yvonne Suessmuth, Lorenzo Cagnin, Paula Keskula, Kyle Kimler, James Kaminski, Bruce R. Blazar, Benjamin Watkins, Leslie S. Kean

Blood (2022) 140 (Supplement 1): 270–271.

https://doi.org/10.1182/blood-2022-170214

Published: 2022

Journal Articles

Early Breakthrough T Cell Proliferation Despite CNI/MTX Prophylaxis Is a Harbinger of Acute Gvhd (AGVHD) and Is Controlled By Abatacept: Mechanism of Success of the ABA2 Agvhd Prevention Trial

Alexandre Albanese, Alal Eran, Yvonne Suessmuth, Kayla Betz, Brandi Bratrude, Paula Keskula, Lorenzo Cagnin, Amelia Langston, Muna Qayed, John T. Horan, Bruce R. Blazar, Benjamin Watkins, Leslie S. Kean

Blood (2022) 140 (Supplement 1): 274–275.

https://doi.org/10.1182/blood-2022-170693

Published: 2022

Journal Articles

Abatacept for the Prevention of Gvhd in Pediatric and Adult Patients Receiving 7/8 HLA-Mismatched Unrelated Transplant for Hematologic Malignancies: A Real-World Analysis

Sharmila Raghunandan, Lev Gorfinkel, Michael Graiser, Brandi Bratrude, Kayla Betz, Yvonne Suessmuth, Scott Gillespie, Adrianna Lynn Westbrook, Kirsten M. Williams, Michelle Schoettler, Amelia Langston, Leslie Kean, Muna Qayed, John T. Horan, Benjamin Watkins

Blood (2022) 140 (Supplement 1): 7653–7655.

https://doi.org/10.1182/blood-2022-163627

Published: 2022

Journal Articles

Predicting Immune Pathology after Hematopoietic Stem Cell Transplant with Transcriptomics: Naïve CD4 T Cell Expansion at Day 100 Predicts Patients with De Novo Chronic Gvhd

Ben Watkins, MD, James Kaminski, Muna Qayed, MDMSc, Kayla Betz, BS, Yvonne Suessmuth, PhD, Brandi Bratrude, Alison Yu, PhD, Victor Tkachev, PhD, Kathryn Pellegrini, Steven Bosinger, PhD, Bruce R. Blazar, MD, John T. Horan, MDMPH, Amelia Langston, MD, Leslie Kean, MD PhD

Blood (2020) 136 (Supplement 1): 38–39.

https://doi.org/10.1182/blood-2020-139488

Published: 2020

Journal Articles

Potent Interaction between CMV Reactivation and Gvhd: Immunologic Evidence for Blunting of CMV-Driven Immune Reconstitution in the Setting of Gvhd

Yvonne Suessmuth, PhD, Kayla Betz, BS, Alison Yu, PhD, Brandi Bratrude, Benjamin Watkins, MD, Muna Qayed, MDMSc, John T. Horan, MDMPH, Leslie Kean, MD PhD, Amelia Langston, MD

Blood (2020) 136 (Supplement 1): 50.

https://doi.org/10.1182/blood-2020-141856

Published: 2020

Journal Articles

Transcriptomic Analysis of CD4+ T Cell Dysfunction during Gvhd: Evidence for Profound Reprograming of T Cell Signaling during Acute Gvhd That Is Controlled during CD28:CD80/86 Costimulation Blockade with Abatacept

Benjamin Watkins, Yvonne Suessmuth, Kayla Betz, BS, Alison Yu, PhD, Brandi Bratrude, Muna Qayed, MD MSc, Kathryn Pellegrini, Steven Bosinger, Amelia Langston, MD, John T. Horan, MDMPH, Bruce R. Blazar, MD, Leslie Kean, MD PhD

Blood (2019) 134 (Supplement_1): 596.

https://doi.org/10.1182/blood-2019-131955

Published: 2019

Journal Articles

Uncovering the Molecular Signature of Pathogenic Tissue-Infiltrating T Cells during Acute Graft-Versus-Host Disease

Victor Tkachev, PhD, Scott N Furlan, MD, E. Lake Potter, Hengqi Zheng, MD, Daniel J Hunt, Lucrezia Colonna, PhD, Agne Taraseviciute, MD PhD, Judith M Carlson, BS, Kayla Betz, Alison Yu, PhD, Michelle Hoffman, MS, Audrey Baldessari, DVM, Sarah Herrin, Joe Olvera, Chad Littlewood, Christopher English, Bruce R. Blazar, MD, Mario Roederer, PhD, Leslie Kean, MD PhD

Blood (2018) 132 (Supplement 1): 805.

https://doi.org/10.1182/blood-2018-99-113652

Published: 2018

Journal Articles

Pharmacologic Blockade of Notch/Delta-like Ligand 4 Signaling Protects from Gastrointestinal Acute Graft-Versus-Host Disease in Non-Human Primates

Victor Tkachev, PhD, Frank Kuhnert, PhD, Scott N Furlan, MD, Hengqi Zheng, MD, Daniel J Hunt, Lucrezia Colonna, PhD, Judith M Carlson, BS, Agne Taraseviciute, MD PhD, Angela Panoskaltsis-Mortari, PhD, Virginia Hoglund, Kayla Betz, Alison Yu, PhD, Bruce R. Blazar, MD, Steve Carpenter, MD PhD, Olivier Harari, MD PhD, Gavin Thurston, PhD, Ivan Maillard, MD PhD, Leslie Kean, MD PhD

Blood (2018) 132 (Supplement 1): 2027.

https://doi.org/10.1182/blood-2018-99-110030

Published: 2018

Journal Articles

IL2 and Rapamycin Enhance Persistence of Adoptively-Transferred Ex-Vivo Expanded T Regulatory Cells

Scott N Furlan, MD, Christina Lopez, PhD, Victor Tkachev, PhD, Kayla Betz, Daniel J Hunt, James Hibbard, PhD, Bruce R. Blazar, MD, Cole Trapnell, PhD, Leslie Kean, MD PhD

Blood (2018) 132 (Supplement 1): 2049.

https://doi.org/10.1182/blood-2018-99-120254

Published: 2018

Journal Articles

T Cell Costimulation Blockade with Abatacept Nearly Eliminates Early Severe Acute Graft Versus Host Disease after HLA-Mismatched (7/8 HLA Matched) Unrelated Donor Transplant, with a Favorable Impact on Disease-Free and Overall Survival

Blood (2017) 130 (Supplement 1): 212.

https://doi.org/10.1182/blood.V130.Suppl_1.212.212

Published: 2017

Journal Articles

Striking Clinical, Molecular and Immunological Outcomes in Non-Human Primate Hematopoietic Stem Cell Transplantation Using a Novel OX40L Blockade Agent, KY1005, Combined with Rapamycin

Victor Tkachev, PhD, Scott N. Furlan, MD, Ben Watkins, MD, Betty Zheng, MD, Daniel Hunt, Angela Panoskaltsis-Mortari, PhD, Kayla Betz, Melanie Brown, Katie Zeleski, Alison Yu, PhD, Bruce R. Blazar, MD, Duncan Casson, Ian Kirby, Phil Bland-Ward, Leslie Kean, MD PhD

Blood (2016) 128 (22): 3341.

https://doi.org/10.1182/blood.V128.22.3341.3341

Published: 2016

Journal Articles

Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells

Scott N. Furlan, Benjamin Watkins, Victor Tkachev, Sarah Cooley, Angela Panoskaltsis-Mortari, Kayla Betz, Melanie Brown, Daniel J. Hunt, John B. Schell, Katie Zeleski, Alison Yu, Cynthia R. Giver, Edmund K. Waller, Jeffrey S. Miller, Bruce R. Blazar, Leslie S. Kean

Blood (2016) 128 (21): 2568–2579.

https://doi.org/10.1182/blood-2016-07-726547

Published: 2016

Includes: Supplemental data

Journal Articles

Th17/Th22 Cells Mediate Breakthrough Graft-Versus-Host-Disease

Scott N. Furlan, MD, Victor Tkachev, PhD, Ben Watkins, MD, Kayla Betz, Angela Panoskaltsis-Mortari, PhD, Bruce R. Blazar, MD, Leslie Kean, MD PhD

Blood (2015) 126 (23): 1878.

https://doi.org/10.1182/blood.V126.23.1878.1878

Published: 2015

NARROW

Abatacept for acute graft-versus-host disease prophylaxis after unrelated donor hematopoietic cell transplantation

Higher abatacept exposure after transplant decreases acute GVHD risk without increasing adverse events

Targeting CNS Lymphoma with Intravenous Axicabtagene Ciloleucel: Evidence for Transcriptional Evolution Towards a Prominent Interferon Signature in CAR-T Cells Trafficking to the Tumor Site

Single-Cell RNA-Seq Reveals an Interferon-Driven Inflammatory CD4 Naïve T Cell Subpopulation at Day 100 in Hematopoietic Stem Cell Transplant Patients That Ultimately Develop Chronic Gvhd

Early Breakthrough T Cell Proliferation Despite CNI/MTX Prophylaxis Is a Harbinger of Acute Gvhd (AGVHD) and Is Controlled By Abatacept: Mechanism of Success of the ABA2 Agvhd Prevention Trial

Abatacept for the Prevention of Gvhd in Pediatric and Adult Patients Receiving 7/8 HLA-Mismatched Unrelated Transplant for Hematologic Malignancies: A Real-World Analysis

Predicting Immune Pathology after Hematopoietic Stem Cell Transplant with Transcriptomics: Naïve CD4 T Cell Expansion at Day 100 Predicts Patients with De Novo Chronic Gvhd

Potent Interaction between CMV Reactivation and Gvhd: Immunologic Evidence for Blunting of CMV-Driven Immune Reconstitution in the Setting of Gvhd

Transcriptomic Analysis of CD4+ T Cell Dysfunction during Gvhd: Evidence for Profound Reprograming of T Cell Signaling during Acute Gvhd That Is Controlled during CD28:CD80/86 Costimulation Blockade with Abatacept

Uncovering the Molecular Signature of Pathogenic Tissue-Infiltrating T Cells during Acute Graft-Versus-Host Disease

Pharmacologic Blockade of Notch/Delta-like Ligand 4 Signaling Protects from Gastrointestinal Acute Graft-Versus-Host Disease in Non-Human Primates

IL2 and Rapamycin Enhance Persistence of Adoptively-Transferred Ex-Vivo Expanded T Regulatory Cells

T Cell Costimulation Blockade with Abatacept Nearly Eliminates Early Severe Acute Graft Versus Host Disease after HLA-Mismatched (7/8 HLA Matched) Unrelated Donor Transplant, with a Favorable Impact on Disease-Free and Overall Survival

Striking Clinical, Molecular and Immunological Outcomes in Non-Human Primate Hematopoietic Stem Cell Transplantation Using a Novel OX40L Blockade Agent, KY1005, Combined with Rapamycin

Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells

Th17/Th22 Cells Mediate Breakthrough Graft-Versus-Host-Disease

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American Society of Hematology

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American Society of Hematology

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