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Shannon McSain
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Journal Articles

CAR T cell-driven induction of iNOS in tumor associated macrophages promotes CAR T cell resistance in B cell lymphoma

Free
Sae Bom Lee, Yun Pyo Kang, Justin Boucher, Jay Mandula, Darwin Chang, Nolan Beatty, Payal Goala, Allan Pavy, Meredith Stone, Rosa Sierra-Mondragon, Min Liu, John Koomen, Xuefeng Wang, Rawan Faramand, Michael Jain, Frederick Locke, Paulo Rodriguez, Cooper Sailer, Shannon McSain, Showkat Hamid, Muhammad Junaid Tariq, Marco Davila
Journal: Blood
Blood (2025) 146 (Supplement 1): 558.
https://doi.org/10.1182/blood-2025-558
Published: 2025
Journal Articles

In-depth, quantitative characterization of important regulators and predictive biomarkers for CAR T-cell therapy induced toxicities in a clinical cohort

Free
Min Ma, Muhammad Junaid Tariq, Showkat Hamid, Shannon McSain, Ming Zhang, Maosheng Wei, Erfei Shang, Yingyi Lian, Meredith Stone, Spencer Rosario, Jun Qu, Marco Davila
Journal: Blood
Blood (2025) 146 (Supplement 1): 4141.
https://doi.org/10.1182/blood-2025-4141
Published: 2025
Journal Articles

Temporal control of CAR expression enables thymic generation of autoreactive T cells targeting tumor-associated antigens

Free
Manpreet Bariana, Michael Mcguire, Andrea Tuckett, Shaina Anuncio, Elena Cassella, Sara Mina, Sharoni Avtalion, Mathias Konstandin, Nicolai Bogert, Justin Boucher, Nolan Beatty, Shannon McSain, Wei Hu, Hai-Hui Xue, Marco Davila, Johannes Zakrzewski
Journal: Blood
Blood (2025) 146 (Supplement 1): 4107.
https://doi.org/10.1182/blood-2025-4107
Published: 2025
Journal Articles

CD83 CAR T overcome CD19 antigen loss in B cell malignancies after CD19-directed therapy

Free
Brian Betts, Constanza Savid-Frontera, Shannon McSain, Kelly Walton, Nolan Beatty, Payal Goala, Shernan Holtan, Meredith Stone, Frederick Locke, Anne Eaton, Michael Linden, Renier Brentjens, Marco Davila
Journal: Blood
Blood (2025) 146 (Supplement 1): 4098.
https://doi.org/10.1182/blood-2025-4098
Published: 2025
Journal Articles

IL-2 mutein-mediated improvement of CAR T function in Relapsed/Refractory diffuse B cell lymphoma

Free
Allan Pavy, Cooper Sailer, Shannon McSain, Tania Carmenate, Kalet Leon, Alex Niu, Meredith Stone, Circe Mesa, Marco Davila
Journal: Blood
Blood (2025) 146 (Supplement 1): 5880.
https://doi.org/10.1182/blood-2025-5880
Published: 2025
Journal Articles

JAK2/mTOR inhibition fails to prevent acute GVHD despite reduced Th1/Th17 cells: final phase 2 trial results

Free
Clinical Trials & Observations
Joseph Pidala, Shernan G. Holtan, Kelly Walton, Jongphil Kim, Biwei Cao, Hany Elmariah, Asmita Mishra, Nelli Bejanyan, Taiga Nishihori, Farhad Khimani, Lia Perez, Rawan G. Faramand, Marco L. Davila, Shannon McSain, Jordan Pleskow, Jeffrey Baron, Claudio Anasetti, Carlos Moran Segura, Daniel J. Weisdorf, Bruce R. Blazar, Jeffrey S. Miller, Veronika Bachanova, Najla El Jurdi, Brian C. Betts
Journal: Blood
Blood (2024) 144 (22): 2295–2307.
https://doi.org/10.1182/blood.2024024789
Published: 2024
Includes: Supplemental data
Journal Articles

Correlation of Serum Inflammatory State and Macrophage Phenotype with CAR T Cell Expansion and Clinical Outcomes

Free
Showkat Hamid, Muhammad Junaid Tariq, SaeBom Lee, Payal Goala, Shannon McSain, Cooper Sailer, Nolan Beatty, Marco Davila
Journal: Blood
Blood (2024) 144 (Supplement 1): 3432.
https://doi.org/10.1182/blood-2024-212112
Published: 2024
Journal Articles

Newly Diagnosed AML Exhibits Significant Differences in Immune Metabolic Pathways and Inflammatory States in Contrast to Patients with Relapsed/Refractory Disease

Free
Amanda C. Przespolewski, Spencer Rosario, Hua-Hsin Hsiao, Nicholas Rutland, Shannon McSain, Tara Cronin, Melissa Fos, Sarah Burke, Emily Najmulski, Krystin Mantione, Marco Davila
Journal: Blood
Blood (2023) 142 (Supplement 1): 6015.
https://doi.org/10.1182/blood-2023-188980
Published: 2023