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Govindarajan Thangavelu
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Journal Articles

Mitochondrial Pyruvate Carrier Inhibition Mitigates Murine Chronic Graft Versus Host Disease By Attenuating the Germinal Center Reaction

Fathima A Mohamed, Stephanie Y Rhee, Joanna Ly, Ethan G Aguilar, Haley Melin, Peter T Sage, Tanner Schumacher, Govindarajan Thangavelu, Michael C Zaiken, Juan Liu, Venkatram Mereddy, Jason W Locasale, Bruce R Blazar
Journal: Blood
Blood (2023) 142 (Supplement 1): 459.
https://doi.org/10.1182/blood-2023-185200
Published: 2023
Journal Articles

Prevention of acute GVHD using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T cells in vivo

Teresa L. Ramos, Sara Bolivar-Wagers, Sujeong Jin, Govindarajan Thangavelu, Federico Simonetta, Po-Yu Lin, Toshihito Hirai, Asim Saha, Brent Koehn, Leon L. Su, Lora K. Picton, Jeanette Baker, Juliane K. Lohmeyer, Megan Riddle, Cindy Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, John E. Wagner, K. Christopher Garcia, Robert S. Negrin, Bruce R. Blazar
Journal: Blood
Blood (2023) 141 (11): 1337–1352.
https://doi.org/10.1182/blood.2022018440
Published: 2023
Includes: Supplemental data
Journal Articles

BET-bromodomain and EZH2 inhibitor–treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes

Michael C. Zaiken, Ryan Flynn, Katelyn G. Paz, Stephanie Y. Rhee, Sujeong Jin, Fathima A. Mohamed, Asim Saha, Govindarajan Thangavelu, Paul M. C. Park, Matthew L. Hemming, Peter T. Sage, Arlene H. Sharpe, Michel DuPage, Jeffrey A. Bluestone, Angela Panoskaltsis-Mortari, Corey S. Cutler, John Koreth, Joseph H. Antin, Robert J. Soiffer, Jerome Ritz, Leo Luznik, Ivan Maillard, Geoffrey R. Hill, Kelli P. A. MacDonald, David H. Munn, Jonathan S. Serody, William J. Murphy, Leslie S. Kean, Yi Zhang, James E. Bradner, Jun Qi, Bruce R. Blazar
Journal: Blood
Blood (2022) 139 (19): 2983–2997.
https://doi.org/10.1182/blood.2021014557
Published: 2022
Includes: Supplemental data
Journal Articles

Corticosteroid Treatment Impairs Epithelial Regeneration, Limiting Intestinal Recovery in Experimental Graft Vs Host Disease

Viktor Arnhold, Suze A Jansen, Winston Chang, Govindarajan Thangavelu, Paola Vinci, Shuichiro Takashima, Anastasiya Egorova, Jason Kuttiyara, Marliek van Hoesel, Chen Liu, Marco Calafiore, Bruce R. Blazar, Caroline Lindemans, Alan M Hanash
Journal: Blood
Blood (2021) 138 (Supplement 1): 88.
https://doi.org/10.1182/blood-2021-154500
Published: 2021
Journal Articles

Repurposing a novel anti-cancer RXR agonist to attenuate murine acute GVHD and maintain graft-versus-leukemia responses

Govindarajan Thangavelu, Chao Wang, Michael Loschi, Asim Saha, Mark J. Osborn, Scott N. Furlan, Kazutoshi Aoyama, Cameron McDonald-Hyman, Ethan G. Aguilar, Amanda S. Janesick, Roshantha A. Chandraratna, Yosef Refaeli, Angela Panoskaltsis-Mortari, Kelli P. MacDonald, Geoffrey R. Hill, Robert Zeiser, Ivan Maillard, Jonathan S. Serody, William J. Murphy, David H. Munn, Bruce Blumberg, Chrysothemis Brown, Vijay Kuchroo, Leslie S. Kean, Keli L. Hippen, Randolph J. Noelle, Bruce R. Blazar
Journal: Blood
Blood (2021) 137 (8): 1090–1103.
https://doi.org/10.1182/blood.2020005628
Published: 2021
Includes: Supplemental data
Journal Articles

Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease

Govindarajan Thangavelu, Jing Du, Katelyn G. Paz, Michael Loschi, Michael C. Zaiken, Ryan Flynn, Patricia A. Taylor, Andrew Kemal Kirchmeier, Angela Panoskaltsis-Mortari, Leo Luznik, Kelli P. MacDonald, Geoffrey R. Hill, Ivan Maillard, David H. Munn, Jonathan S. Serody, William J. Murphy, David Miklos, Corey S. Cutler, John Koreth, Joseph H. Antin, Robert J. Soiffer, Jerome Ritz, Carol Dahlberg, Andrew T. Miller, Bruce R. Blazar
Journal: Blood
Blood (2020) 135 (1): 28–40.
https://doi.org/10.1182/blood.2019000032
Published: 2020
Includes: Supplemental data
Journal Articles

Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD

Brent H. Koehn, Asim Saha, Cameron McDonald-Hyman, Michael Loschi, Govindarajan Thangavelu, Lie Ma, Michael Zaiken, Josh Dysthe, Walker Krepps, Jamie Panthera, Keli Hippen, Stephen C. Jameson, Jeffrey S. Miller, Matthew A. Cooper, Christopher J. Farady, Takao Iwawaki, Jenny P.-Y. Ting, Jonathan S. Serody, William J. Murphy, Geoffrey R. Hill, Peter J. Murray, Vincenzo Bronte, David H. Munn, Robert Zeiser, Bruce R. Blazar
Journal: Blood
Blood (2019) 134 (19): 1670–1682.
https://doi.org/10.1182/blood.2019001950
Published: 2019
Journal Articles

Invariant natural killer T cells ameliorate murine chronic GVHD by expanding donor regulatory T cells

Brief Report
Jing Du, Katelyn Paz, Govindarajan Thangavelu, Dominik Schneidawind, Jeanette Baker, Ryan Flynn, Omar Duramad, Colby Feser, Angela Panoskaltsis-Mortari, Robert S. Negrin, Bruce R. Blazar
Journal: Blood
Blood (2017) 129 (23): 3121–3125.
https://doi.org/10.1182/blood-2016-11-752444
Published: 2017
Journal Articles

Critical Roles of Retinoic Acid Signaling in Combating Acute Graft Versus Host Disease

Govindarajan Thangavelu, PhD, Asim Saha, PhD, Kazutoshi Aoyama, MD PhD, Cameron McDonald-Hyman, BA, Yu-Chi Lee, MSc, Chrysothemis Brown, MBBS, PhD, Angela Panoskaltsis-Mortari, PhD, Mark J. Osborn, PhD, Roshantha A Chandraratna, PhD, Randolph Noelle, PhD, Bruce R. Blazar, MD
Journal: Blood
Blood (2016) 128 (22): 4534.
https://doi.org/10.1182/blood.V128.22.4534.4534
Published: 2016
Journal Articles

Loss of Programmed Death Ligand-1 Expression on Donor T Cells Lessens Acute Graft-Versus-Host Disease Lethality

Asim Saha, PhD, Roddy S. O'Connor, PhD, Govindarajan Thangavelu, PhD, Scott B. Lovitch, MD PhD, Durga Bhavani Dandamudi, Caleph B. Wilson, PhD, Benjamin G. Vincent, MD, Kazutoshi Aoyama, Patricia A. Taylor, DVM, Angela Panoskaltsis-Mortari, PhD, Rocio Foncea, PhD, Joel S. Burrill, Lili Guo, Catarina Sacristan, PhD, Scott N. Furlan, MD, Nathaniel W. Snyder, PhDMPH, Ian A. Blair, PhD, Michael C. Milone, MD PhD, Michael L. Dustin, PhD, James L. Riley, PhD, David A. Bernlohr, PhD, Laurence A. Turka, MD, William J. Murphy, PhD, Brian T. Fife, PhD, David H. Munn, MD, Jeffrey S. Miller, MD, Jonathan S. Serody, MD, Leslie Kean, MD PhD, Gordon J. Freeman, PhD, Arlene H. Sharpe, MDPhD, Bruce R. Blazar, MD
Journal: Blood
Blood (2015) 126 (23): 147.
https://doi.org/10.1182/blood.V126.23.147.147
Published: 2015
Journal Articles

Protein Kinase C-Theta Interacts with mTORC2 and Vimentin to Limit Regulatory T-Cell Function

Cameron McDonald-Hyman, BA, Govindarajan Thangavelu, PhD, James Muller, Guoan Zhang, PhD, Sudha Kumari, PhD, Asim Saha, PhD, Brent H. Koehn, PhD, Jason S. Mitchell, PhD, Brian T Fife, PhD, Jonathan S. Serody, MD, Mark J. Osborn, PhD, Keli L. Hippen, PhD, Ameeta Kelekar, PhD, David H. Munn, MD, Amnon Altman, PhD, Thomas A. Neubert, PhD, Michael L. Dustin, PhD, Bruce R. Blazar, MD
Journal: Blood
Blood (2015) 126 (23): 849.
https://doi.org/10.1182/blood.V126.23.849.849
Published: 2015