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Journal Articles

BET-bromodomain and EZH2 inhibitor–treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes

Blood (2022) 139 (19): 2983–2997.

https://doi.org/10.1182/blood.2021014557

Published: 2022

Includes: Supplemental data

Journal Articles

Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease

Blood (2020) 135 (1): 28–40.

https://doi.org/10.1182/blood.2019000032

Published: 2020

Includes: Supplemental data

Journal Articles

Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells

Ranjeet K. Sinha, Ryan Flynn, Michael Zaiken, Katelyn Paz, Amanda L. Gavin, David Nemazee, José A. Fernández, Xiao Xu, John H. Griffin, Bruce R. Blazar

Blood (2019) 134 (9): 776–781.

https://doi.org/10.1182/blood.2019001259

Published: 2019

Journal Articles

Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease

Blood (2019) 133 (1): 94–99.

https://doi.org/10.1182/blood-2018-03-839993

Published: 2019

Journal Articles

Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice

Vedran Radojcic, Katelyn Paz, Jooho Chung, Jing Du, Eric T. Perkey, Ryan Flynn, Sanja Ivcevic, Michael Zaiken, Ann Friedman, Minhong Yan, Maria A. Pletneva, Stefanie Sarantopoulos, Christian W. Siebel, Bruce R. Blazar, Ivan Maillard

Blood (2018) 132 (20): 2188–2200.

https://doi.org/10.1182/blood-2018-03-841155

Published: 2018

Includes: Supplemental data

Journal Articles

Murine chronic graft-versus-host disease proteome profiling discovers CCL15 as a novel biomarker in patients

Jing Du, Ryan Flynn, Katelyn Paz, Hong-Gang Ren, Yuko Ogata, Qing Zhang, Philip R. Gafken, Barry E. Storer, Nathan H. Roy, Janis K. Burkhardt, Wendy Mathews, Jakub Tolar, Stephanie J. Lee, Bruce R. Blazar, Sophie Paczesny

Blood (2018) 131 (15): 1743–1754.

https://doi.org/10.1182/blood-2017-08-800623

Published: 2018

Includes: Supplemental data

Journal Articles

Invariant natural killer T cells ameliorate murine chronic GVHD by expanding donor regulatory T cells

Jing Du, Katelyn Paz, Govindarajan Thangavelu, Dominik Schneidawind, Jeanette Baker, Ryan Flynn, Omar Duramad, Colby Feser, Angela Panoskaltsis-Mortari, Robert S. Negrin, Bruce R. Blazar

Blood (2017) 129 (23): 3121–3125.

https://doi.org/10.1182/blood-2016-11-752444

Published: 2017

Journal Articles

Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production

Blood (2017) 129 (18): 2570–2580.

https://doi.org/10.1182/blood-2017-01-758854

Published: 2017

Includes: Supplemental data

Journal Articles

Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner

Cameron McDonald-Hyman, Ryan Flynn, Angela Panoskaltsis-Mortari, Nicholas Peterson, Kelli P. A. MacDonald, Geoffrey R. Hill, Leo Luznik, Jonathan S. Serody, William J. Murphy, Ivan Maillard, David H. Munn, Laurence A. Turka, John Koreth, Corey S. Cutler, Robert J. Soiffer, Joseph H. Antin, Jerome Ritz, Bruce R. Blazar

Blood (2016) 128 (7): 1013–1017.

https://doi.org/10.1182/blood-2016-05-715896

Published: 2016

Journal Articles

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism

Blood (2016) 127 (17): 2144–2154.

https://doi.org/10.1182/blood-2015-10-678706

Published: 2016

Includes: Supplemental data

Journal Articles

Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease

Blood (2015) 125 (26): 4085–4094.

https://doi.org/10.1182/blood-2014-08-595470

Published: 2015

Includes: Supplemental data

Journal Articles

B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality

Rachelle G. Veenstra, Ryan Flynn, Katharina Kreymborg, Cameron McDonald-Hyman, Asim Saha, Patricia A. Taylor, Mark J. Osborn, Angela Panoskaltsis-Mortari, Annette Schmitt-Graeff, Elisabeth Lieberknecht, William J. Murphy, Jonathan S. Serody, David H. Munn, Gordon J. Freeman, James P. Allison, Tak W. Mak, Marcel van den Brink, Robert Zeiser, Bruce R. Blazar

Blood (2015) 125 (21): 3335–3346.

https://doi.org/10.1182/blood-2014-09-603357

Published: 2015

Includes: Supplemental data

Journal Articles

Therapeutic activity of multiple common γ-chain cytokine inhibition in acute and chronic GVHD

Anne-Kathrin Hechinger, Benjamin A. H. Smith, Ryan Flynn, Kathrin Hanke, Cameron McDonald-Hyman, Patricia A. Taylor, Dietmar Pfeifer, Björn Hackanson, Franziska Leonhardt, Gabriele Prinz, Heide Dierbach, Annette Schmitt-Graeff, Jiri Kovarik, Bruce R. Blazar, Robert Zeiser

Blood (2015) 125 (3): 570–580.

https://doi.org/10.1182/blood-2014-06-581793

Published: 2015

Includes: Supplemental data

Journal Articles

A Selective and Potent Rock 2 Inhibitor (KD025) Decreases Human STAT3-Dependent IL-21 and IL-17 Production and Experimental Chronic Graft-Versus-Host Disease (cGVHD)

Alexandra Zanin-Zhorov, PhD, Ryan Flynn, Leo Luznik, MD, Angela Panoskaltsis-Mortari, PhD, Du Jing, Katelyn Goodman, Jonathan Weiss, PhD, Melanie Nyuydzefe, Wei Chen, PhD, Jonathan S Serody, MD, Kelli PA MacDonald, Geoffrey R Hill, John O'Shea, MD, Maria Roche, Sara Weiss, PhD, Samuel Waksal, PhD, Bruce R. Blazar, MD

Blood (2014) 124 (21): 540.

https://doi.org/10.1182/blood.V124.21.540.540

Published: 2014

Journal Articles

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

Blood (2014) 123 (25): 3988–3998.

https://doi.org/10.1182/blood-2014-03-562231

Published: 2014

Includes: Supplemental data

Journal Articles

Germinal Center Generation and Maintenance By T Follicular Helper Cells Is Required For The Development Of Chronic Gvhd Associated Bronchiolitis Obliterans In a Preclinical Model

Blood (2013) 122 (21): 292.

https://doi.org/10.1182/blood.V122.21.292.292

Published: 2013

Journal Articles

Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells

Rachelle G. Veenstra, Patricia A. Taylor, Qing Zhou, Angela Panoskaltsis-Mortari, Mitsuomi Hirashima, Ryan Flynn, Derek Liu, Ana C. Anderson, Terry B. Strom, Vijay K. Kuchroo, Bruce R. Blazar

Blood (2012) 120 (3): 682–690.

https://doi.org/10.1182/blood-2011-10-387977

Published: 2012

Includes: Supplemental data

Journal Articles

Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans

Mathangi Srinivasan, Ryan Flynn, Andrew Price, Ann Ranger, Jeffrey L. Browning, Patricia A. Taylor, Jerome Ritz, Joseph H. Antin, William J. Murphy, Leo Luznik, Mark J. Shlomchik, Angela Panoskaltsis-Mortari, Bruce R. Blazar

Blood (2012) 119 (6): 1570–1580.

https://doi.org/10.1182/blood-2011-07-364414

Published: 2012

Includes: Supplemental data

Journal Articles

Donor B-Cell Alloantibody Deposition and Germinal Center Formation Are Required for the Development of Murine Chronic Gvhd and Bronchiolitis Obliterans

Mathangi Srinivasan, PhD, Ryan Flynn, Andrew Price, Ann Ranger, PhD, Jeffrey L Browning, Patricia A Taylor, DVM, Jerome Ritz, MD, Joseph H. Antin, MD, William J Murphy, PhD, Leo Luznik, Mark Shlomchik, MD, PhD, Angela Panoskaltsis-Mortari, PhD, Bruce R. Blazar, MD

Blood (2011) 118 (21): 307.

https://doi.org/10.1182/blood.V118.21.307.307

Published: 2011

NARROW

BET-bromodomain and EZH2 inhibitor–treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes

Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease

Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells

Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease

Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice

Murine chronic graft-versus-host disease proteome profiling discovers CCL15 as a novel biomarker in patients

Invariant natural killer T cells ameliorate murine chronic GVHD by expanding donor regulatory T cells

Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production

Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism

Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease

B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality

Therapeutic activity of multiple common γ-chain cytokine inhibition in acute and chronic GVHD

A Selective and Potent Rock 2 Inhibitor (KD025) Decreases Human STAT3-Dependent IL-21 and IL-17 Production and Experimental Chronic Graft-Versus-Host Disease (cGVHD)

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

Germinal Center Generation and Maintenance By T Follicular Helper Cells Is Required For The Development Of Chronic Gvhd Associated Bronchiolitis Obliterans In a Preclinical Model

Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells

Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans

Donor B-Cell Alloantibody Deposition and Germinal Center Formation Are Required for the Development of Murine Chronic Gvhd and Bronchiolitis Obliterans

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American Society of Hematology

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American Society of Hematology

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