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Journal Articles

NSD2 expression remodels DNA methylation, creating a targetable epigenetic dependency in t(4;14) multiple myeloma

Anna Baj, Jonathan Patton, Robert Chavez, Shannon Matulis, Doris Powell, Mala Shanmugam, Arun Wiita, Constantine Mitsiades, Jonathan Keats, Jonathan Licht, Sagar Lonial, Lawrence Boise, Benjamin Barwick

Blood (2025) 146 (Supplement 1): 572.

https://doi.org/10.1182/blood-2025-572

Published: 2025

Journal Articles

NSD2 inhibition suppresses t(4;14) gene expression and oncogenic signaling to impair proliferation in multiple myeloma

Robert Chavez, Jonathan Patton, James Ackley, Mala Shanmugam, Constantine Mitsiades, Arun Wiita, Jonathan Licht, Erin Flynt, Terry Connolly, Karen Conneely, Sagar Lonial, Lawrence Boise, Benjamin Barwick

Blood (2025) 146 (Supplement 1): 3956.

https://doi.org/10.1182/blood-2025-3956

Published: 2025

Journal Articles

A human IL-6–Expressing PDX model of multiple myeloma recapitulates clinical features and supports patient-derived tumor engraftment

Bonell Patino-Escobar, Natasha Mariathasan, Jose Rivera, Jessica Ramadhin, Fernando Salangsang, Paul Phojanakong, Juan Camara-Serrano, Yan Zeng, Veronica Steri, Elliot Stieglitz, Arun Wiita

Blood (2025) 146 (Supplement 1): 3943.

https://doi.org/10.1182/blood-2025-3943

Published: 2025

Journal Articles

Inhibition of NSD2 in t(4;14) myeloma induces changes in mitochondrial priming

Shannon Matulis, Jonathan Patton, Rebecca Owens, Robert Chavez, Arun Wiita, Mala Shanmugam, Constantine Mitsiades, Vikas Gupta, Jonathan Licht, Benjamin Barwick, Lawrence Boise

Blood (2025) 146 (Supplement 1): 2177.

https://doi.org/10.1182/blood-2025-2177

Published: 2025

Journal Articles

Identification of novel “driver” genes of multiple myeloma through genome-scale CRISPR activation studies

Huihui Tang, Ricardo De Matos Simoes, Torsten Steinbrunn, Ryosuke Shirasaki, Olga Dashevsky, Eleni Anastasakou, Oliver Bohorquez, Shizuka Yamano, Evangelos Papadopoulos, Lisa Leypoldt, Arun Wiita, Olwyn Mahon, Vikas Gupta, Jonathan Licht, Benjamin Barwick, Lawrence Boise, Constantine Mitsiades

Blood (2025) 146 (Supplement 1): 2173.

https://doi.org/10.1182/blood-2025-2173

Published: 2025

Journal Articles

Integrative genomic, single-cell, and functional profiling uncovers immune consequences of the CD48–CD244 axis in NK cells in multiple myeloma

Bonell Patino-Escobar, Torsten Steinbrunn, Lucy Perez-Lugo, Sham Rampersaud, Huimin Geng, Fernando Salangsang, Paul Phojanakong, Juan Camara-Serrano, Yan Zeng, Veronica Steri, Oscar Aguilar, Constantine Mitsiades, Arun Wiita

Blood (2025) 146 (Supplement 1): 687.

https://doi.org/10.1182/blood-2025-687

Published: 2025

Journal Articles

Unbiased in-depth surfaceome profiling of Acute Myeloid Leukemia reveals novel immunotherapy targets beyond canonical membrane proteins

Blood (2025) 146 (Supplement 1): 385.

https://doi.org/10.1182/blood-2025-385

Published: 2025

Journal Articles

Machine learning-guided optimization of anti-CD70 natural ligand-based CAR-lymphocytes for Acute Myeloid Leukemia

Ruyan Rahnama, Amrik Kang, Radhika Dalal, Sujata Walunj, Mingcheng Li, Samika Arun, Tanja Kortemme, Justin Eyquem, Arun Wiita

Blood (2025) 146 (Supplement 1): 5914.

https://doi.org/10.1182/blood-2025-5914

Published: 2025

Journal Articles

Profiling the Cell Surface of MPN Blast Phase Suggests Unique Biology and Therapeutic Targets

Emilio Ramos, Arun Wiita

Blood (2022) 140 (Supplement 1): 6735–6736.

https://doi.org/10.1182/blood-2022-159092

Published: 2022

Journal Articles

Defining Primary Marrow Microenvironment-Induced Synthetic Lethality and Resistance for 2,684 Approved Drugs Across Molecularly Distinct Forms of Multiple Myeloma

Megan Murnane, M.Sc., Eugen Dhimolea, PhD, Ruojing Li, BS, Megan A. Bariteau, BSc, Diamond D. Wheeler, BS, Rosemary J. Akhurst, PhD, Aaron C. Logan, MD PhD, Pamela Munster, MD, Arun Wiita, MD PhD, Thomas G. Martin, III, MD, Jeffrey L. Wolf, MD PhD, Jun O. Liu, PhD, Constantine S. Mitsiades, MD PhD, Blake T. Aftab, PhD

Blood (2015) 126 (23): 503.

https://doi.org/10.1182/blood.V126.23.503.503

Published: 2015

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NSD2 expression remodels DNA methylation, creating a targetable epigenetic dependency in t(4;14) multiple myeloma

NSD2 inhibition suppresses t(4;14) gene expression and oncogenic signaling to impair proliferation in multiple myeloma

A human IL-6–Expressing PDX model of multiple myeloma recapitulates clinical features and supports patient-derived tumor engraftment

Inhibition of NSD2 in t(4;14) myeloma induces changes in mitochondrial priming

Identification of novel “driver” genes of multiple myeloma through genome-scale CRISPR activation studies

Integrative genomic, single-cell, and functional profiling uncovers immune consequences of the CD48–CD244 axis in NK cells in multiple myeloma

Unbiased in-depth surfaceome profiling of Acute Myeloid Leukemia reveals novel immunotherapy targets beyond canonical membrane proteins

Machine learning-guided optimization of anti-CD70 natural ligand-based CAR-lymphocytes for Acute Myeloid Leukemia

Profiling the Cell Surface of MPN Blast Phase Suggests Unique Biology and Therapeutic Targets

Defining Primary Marrow Microenvironment-Induced Synthetic Lethality and Resistance for 2,684 Approved Drugs Across Molecularly Distinct Forms of Multiple Myeloma

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American Society of Hematology

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American Society of Hematology

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