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Journal Articles

NSD2 inhibition suppresses t(4;14) gene expression and oncogenic signaling to impair proliferation in multiple myeloma

Robert Chavez, Jonathan Patton, James Ackley, Mala Shanmugam, Constantine Mitsiades, Arun Wiita, Jonathan Licht, Erin Flynt, Terry Connolly, Karen Conneely, Sagar Lonial, Lawrence Boise, Benjamin Barwick

Blood (2025) 146 (Supplement 1): 3956.

https://doi.org/10.1182/blood-2025-3956

Published: 2025

Journal Articles

Inhibition of NSD2 in t(4;14) myeloma induces changes in mitochondrial priming

Shannon Matulis, Jonathan Patton, Rebecca Owens, Robert Chavez, Arun Wiita, Mala Shanmugam, Constantine Mitsiades, Vikas Gupta, Jonathan Licht, Benjamin Barwick, Lawrence Boise

Blood (2025) 146 (Supplement 1): 2177.

https://doi.org/10.1182/blood-2025-2177

Published: 2025

Journal Articles

Preclinical evaluation of SWI/SNF targeting agents in multiple myeloma including t(4;14) subtypes

Yusuke Yamashita, Jonathan Patton, Yuliza Shotts, Megan Du, Meaghen Sharik, Kirsten Pfeffer, Yuan Zhu, Chang-Xin Shi, Caleb Stein, Erin Meermeier, Marta Chesi, Lanbo Xiao, Arul Chinnaiyan, Benjamin Barwick, P. Leif Bergsagel

Blood (2025) 146 (Supplement 1): 2138.

https://doi.org/10.1182/blood-2025-2138

Published: 2025

Journal Articles

NSD2 expression remodels DNA methylation, creating a targetable epigenetic dependency in t(4;14) multiple myeloma

Anna Baj, Jonathan Patton, Robert Chavez, Shannon Matulis, Doris Powell, Mala Shanmugam, Arun Wiita, Constantine Mitsiades, Jonathan Keats, Jonathan Licht, Sagar Lonial, Lawrence Boise, Benjamin Barwick

Blood (2025) 146 (Supplement 1): 572.

https://doi.org/10.1182/blood-2025-572

Published: 2025