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James E. Bradner
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Journal Articles

Targeted Degradation of the Wiz Transcription Factor for Gamma Globin De-Repression

Pamela Y Ting, Sneha Borikar, John Ryan Kerrigan, Noel M Thomsen, Eamon Aghania, Amelia E Hinman, Nicolas Pizzato, Alejandro Reyes, Barna D Fodor, Fabian Wu, Muluken S Belew, Xiaohong Mao, Jian Wang, Shripad Chitnis, Peter Ashcroft, Wei Niu, Amanda Hachey, Jennifer S Cobb, Nikolas A Savage, Ashley Burke, Joshiawa Paulk, Dustin Dovala, James Lin, Matthew C Clifton, Elizabeth Ornelas, Xiaolei Ma, Nathaniel F Ware, Carina C Sanchez, Remi Terranova, Judith Knehr, Marc Altorfer, S. Whitney Barnes, John Taraszka, Danuta Lubicka, James R Manning, Sonia R Miranda, Rohan EJ Beckwith, Jonathan M Solomon, William Forrester, Gregory Hollingworth, Natalie A Dales, Andrew W Patterson, Tewis Bouwmeester, Juergen Wagner, Glenn Dranoff, Susan C Stevenson, James E Bradner
Journal: Blood
Blood (2023) 142 (Supplement 1): 2.
https://doi.org/10.1182/blood-2023-179331
Published: 2023
Journal Articles

BET-bromodomain and EZH2 inhibitor–treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes

Michael C. Zaiken, Ryan Flynn, Katelyn G. Paz, Stephanie Y. Rhee, Sujeong Jin, Fathima A. Mohamed, Asim Saha, Govindarajan Thangavelu, Paul M. C. Park, Matthew L. Hemming, Peter T. Sage, Arlene H. Sharpe, Michel DuPage, Jeffrey A. Bluestone, Angela Panoskaltsis-Mortari, Corey S. Cutler, John Koreth, Joseph H. Antin, Robert J. Soiffer, Jerome Ritz, Leo Luznik, Ivan Maillard, Geoffrey R. Hill, Kelli P. A. MacDonald, David H. Munn, Jonathan S. Serody, William J. Murphy, Leslie S. Kean, Yi Zhang, James E. Bradner, Jun Qi, Bruce R. Blazar
Journal: Blood
Blood (2022) 139 (19): 2983–2997.
https://doi.org/10.1182/blood.2021014557
Published: 2022
Includes: Supplemental data
Journal Articles

Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease

Brief Report
Katelyn Paz, Ryan Flynn, Jing Du, Jun Qi, Leo Luznik, Ivan Maillard, Kelli P. MacDonald, Geoffrey R. Hill, Jonathan S. Serody, William J. Murphy, Peter T. Sage, Arlene H. Sharpe, David Miklos, Corey S. Cutler, John Koreth, Joseph H. Antin, Robert J. Soiffer, Jerome Ritz, James E. Bradner, Ari M. Melnick, Bruce R. Blazar
Journal: Blood
Blood (2019) 133 (1): 94–99.
https://doi.org/10.1182/blood-2018-03-839993
Published: 2019
Journal Articles

Diminished microRNA-29b level is associated with BRD4-mediated activation of oncogenes in cutaneous T-cell lymphoma

Rebecca Kohnken, Jing Wen, Bethany Mundy-Bosse, Kathleen McConnell, Ashleigh Keiter, Leah Grinshpun, Alex Hartlage, Max Yano, Betina McNeil, Nitin Chakravarti, Basem William, James E. Bradner, Michael A. Caligiuri, Pierluigi Porcu, Anjali Mishra
Journal: Blood
Blood (2018) 131 (7): 771–781.
https://doi.org/10.1182/blood-2017-09-805663
Published: 2018
Includes: Supplemental data
Journal Articles

BET Bromodomain Degradation As a Therapeutic Strategy in Multiple Myeloma

Geoffrey M. Matthews, PhD, Sara Gandolfi, MD, Johanna Bruggentheis, Ricardo De Matos Simoes, PhD, Dennis L Buckley, PhD, Yiguo Hu, MD PhD, Michal Sheffer, PhD, Hayley Poarch, James E. Bradner, MD, Constantine S Mitsiades, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1062.
https://doi.org/10.1182/blood.V128.22.1062.1062
Published: 2016
Journal Articles

An Epigenetic Regulator Screen Identifies Novel Targets That Sensitize MLL -Rearranged Leukemia to DOT1L Inhibition

Chun-Wei David Chen, PhD, Christopher Delaney, BS, Haiming Xu, PhD, Richard Koche, PhD, Amaya Lujambio Goizueta, PhD, Takayuki Hoshii, PhD, Monica Cusan, MD PhD, Jonathan Chabon, BS, Daria Gianina Valerio, MD, Michael Kuehn, MD, Xi Wang, BS, Sheng Cai, MD PhD, S. Haihua Chu, PhD, Yining Kevin Chen, Justin He, Chun-Hao Huang, PhD, Zhaohui Feng, BM, BS, Andrei Krivtsov, PhD, Jun Qi, PhD, James E. Bradner, MD, Scott W. Lowe, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 571.
https://doi.org/10.1182/blood.V128.22.571.571
Published: 2016
Journal Articles

Leukemia-Specific Delivery of Mutant NOTCH1 Targeted Therapy

Giovanni Roti, MD PhD, Jun Qi, PhD, Samuel Kitara, Anthony C. Varca, Marta Sanchez-Martin, PhD, Andrew L. Kung, MD PhD, Adolfo A. Ferrando, MD PhD, James E. Bradner, MD, Kimberly Stegmaier, MD
Journal: Blood
Blood (2016) 128 (22): 889.
https://doi.org/10.1182/blood.V128.22.889.889
Published: 2016
Journal Articles

Gene expression–based discovery of atovaquone as a STAT3 inhibitor and anticancer agent

Michael Xiang, Haesook Kim, Vincent T. Ho, Sarah R. Walker, Michal Bar-Natan, Melodi Anahtar, Suhu Liu, Patricia A. Toniolo, Yasmin Kroll, Nichole Jones, Zachary T. Giaccone, Lisa N. Heppler, Darwin Q. Ye, Jason J. Marineau, Daniel Shaw, James E. Bradner, Traci Blonquist, Donna Neuberg, Claudio Hetz, Richard M. Stone, Robert J. Soiffer, David A. Frank
Journal: Blood
Blood (2016) 128 (14): 1845–1853.
https://doi.org/10.1182/blood-2015-07-660506
Published: 2016
Includes: Supplemental data
Journal Articles

Genome-Wide Mapping Reveals BRD4 in Regulation of Tumor-Driver Genes in Cutaneous T-Cell Lymphoma

Anjali Mishra, PhD, Alex Hartlage, BS, Laura Sullivan, Leah Grinshpun, Sonya Kwiatkowski, Jun Qi, PhD, James E. Bradner, MD, Pierluigi Porcu, MD, Michael A. Caligiuri, MD
Journal: Blood
Blood (2015) 126 (23): 589.
https://doi.org/10.1182/blood.V126.23.589.589
Published: 2015
Journal Articles

High Throughput Screening Identifies Potential Inhibitors of WHSC1/MMSET, a Histone Methyltransferase Oncoprotein in Multiple Myeloma and Acute Lymphocytic Leukemia

Christine M Will, MS, Michael Scholle, MS, Roodolph St. Pierre, BS, Gary Schiltz, PhD, James E. Bradner, MD, Milan Mrksich, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2015) 126 (23): 3251.
https://doi.org/10.1182/blood.V126.23.3251.3251
Published: 2015
Journal Articles

Targeted Treatment of FLT3 -Overexpressing Acute Myeloid Leukemia with MiR-150 Nanoparticles Guided By Conjugated FLT3 Ligand Peptides

Xi Jiang, PhD, Jason Bugno, Chao Hu, Yang Yang, PhD, Tobias Herold, MD, Jun Qi, PhD, Ping Chen, Sandeep Gurbuxani, MBBS, PhD, Stephen Arnovitz, Bryan Ulrich, Hengyou Weng, PhD, Yungui Wang, PhD, Hao Huang, PhD, Shenglai Li, Jennifer Strong, Mary Beth Neilly, Richard A. Larson, MD, Michelle M. Le Beau, PhD, Stefan K. Bohlander, MD, Jie Jin, MD PhD, Zejuan Li, MD PhD, James E. Bradner, MD, Seungpyo Hong, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2015) 126 (23): 3784.
https://doi.org/10.1182/blood.V126.23.3784.3784
Published: 2015
Journal Articles

Dose-Dependent Role of the Cohesin Complex in Normal and Malignant Hematopoiesis

Aaron D. Viny, MD MS, Christopher J. Ott, PhD, Barbara Spitzer, MD, Martin A Rivas, PhD, Cem Meydan, Efthymia Papalexi, Dana Yelin, MD, Kaitlyn Shank, BS, Jaime Reyes, April Chiu, MD, Swapna Thota, MD, Jaroslaw P Maciejewski, MD PhD FACP, Ari Melnick, MD, James E. Bradner, MD, Ross L. Levine, MD
Journal: Blood
Blood (2015) 126 (23): 435.
https://doi.org/10.1182/blood.V126.23.435.435
Published: 2015
Journal Articles

Enhancer Landscapes Reveal Transcription Factor Network Dependencies in Chronic Lymphocytic Leukemia

Christopher J. Ott, PhD, Alexander J. Federation, PhD, Siddha Kasar, PhD, Josephine L. Klitgaard, MSc,PhD, Stacey M. Fernandes, Jennifer R. Brown, MD PhD, James E. Bradner, MD
Journal: Blood
Blood (2015) 126 (23): 436.
https://doi.org/10.1182/blood.V126.23.436.436
Published: 2015
Journal Articles

JQ1, a Selective Bromodomain Inhibitor, Augment the Immunogenicity of Mantle Cell Lymphoma By Influencing the Expression of PD-L1

Hongwei Wang, MD, Fengdong Cheng, MD, Jie Cheng, PhD, Alejandro Villagra, PhD, Jianguo Tao, MD PhD, James E. Bradner, MD, Eduardo M. Sotomayor, MD
Journal: Blood
Blood (2015) 126 (23): 822.
https://doi.org/10.1182/blood.V126.23.822.822
Published: 2015
Journal Articles

Discovery and Characterization of Promoter and Super-Enhancer-Associated Dependencies through E2F and BET Bromodomains in Multiple Myeloma

Mariateresa Fulciniti, Charles Y. Lin, Mehmet K Samur, PhD, Matthew Lawlor, Kenneth C Anderson, James E. Bradner, MD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2015) 126 (23): 838.
https://doi.org/10.1182/blood.V126.23.838.838
Published: 2015
Journal Articles

Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib

Baohua Sun, Bhavin Shah, Warren Fiskus, Jun Qi, Kimal Rajapakshe, Cristian Coarfa, Li Li, Santhana G. T. Devaraj, Sunil Sharma, Liang Zhang, Michael L. Wang, Dyana T. Saenz, Stephanie Krieger, James E. Bradner, Kapil N. Bhalla
Journal: Blood
Blood (2015) 126 (13): 1565–1574.
https://doi.org/10.1182/blood-2015-04-639542
Published: 2015
Includes: Supplemental data
Journal Articles

Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation

Lapo Alinari, Kiran V. Mahasenan, Fengting Yan, Vrajesh Karkhanis, Ji-Hyun Chung, Emily M. Smith, Carl Quinion, Porsha L. Smith, Lisa Kim, John T. Patton, Rosa Lapalombella, Bo Yu, Yun Wu, Satavisha Roy, Alessandra De Leo, Stefano Pileri, Claudio Agostinelli, Leona Ayers, James E. Bradner, Selina Chen-Kiang, Olivier Elemento, Tasneem Motiwala, Sarmila Majumder, John C. Byrd, Samson Jacob, Said Sif, Chenglong Li, Robert A. Baiocchi
Journal: Blood
Blood (2015) 125 (16): 2530–2543.
https://doi.org/10.1182/blood-2014-12-619783
Published: 2015
Includes: Supplemental data
Journal Articles

Eradication of Chronic Myelogenous Leukemia By Inactivation of the Polycomb Group Protein EZH2

Huafeng Xie, PhD, Cong Peng, PhD, Jun Qi, PhD, Giullia Cheloni, Partha Das, PhD, Jialiang Huang, PhD, Minh Nguyen, Shaoguang Li, MD PhD, James E. Bradner, MD, Stuart H. Orkin, MD
Journal: Blood
Blood (2014) 124 (21): 778.
https://doi.org/10.1182/blood.V124.21.778.778
Published: 2014
Journal Articles

Selectively Targeting Mutated NOTCH1 with a Folate-Thapsigargin Derivative

Giovanni Roti, MD, Jun Qi, PhD, Angela Su, B.S., Antony Varca, B.S., Jon C Aster, MD PhD, James E. Bradner, Kimberly Stegmaier, MD
Journal: Blood
Blood (2014) 124 (21): 2158.
https://doi.org/10.1182/blood.V124.21.2158.2158
Published: 2014
Journal Articles

Structure-Guided Design of DOT1L Methyltransferase Inhibitors By a Novel, Label Free Assay Platform

Joanna S. Yi, MD, Alex Federation, Jun Qi, PhD, Sirano Dhe-Paganon, PhD, Michael Hadler, MSc, Xiang Xu, PhD, Anthony Varca, Roodolph St. Pierre, Scott A. Armstrong, MD PhD, James E. Bradner
Journal: Blood
Blood (2014) 124 (21): 4811.
https://doi.org/10.1182/blood.V124.21.4811.4811
Published: 2014