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Vrajesh Karkhanis
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Journal Articles

Mechanistic basis and efficacy of targeting the β-catenin–TCF7L2–JMJD6–c-Myc axis to overcome resistance to BET inhibitors

Dyana T. Saenz, Warren Fiskus, Christopher P. Mill, Dimuthu Perera, Taghi Manshouri, Bernardo H. Lara, Vrajesh Karkhanis, Sunil Sharma, Stephen K. Horrigan, Prithviraj Bose, Tapan M. Kadia, Lucia Masarova, Courtney D. DiNardo, Gautam Borthakur, Joseph D. Khoury, Koichi Takahashi, Srividya Bhaskara, Charles Y. Lin, Michael R. Green, Cristian Coarfa, Craig M. Crews, Srdan Verstovsek, Kapil N. Bhalla
Journal: Blood
Blood (2020) 135 (15): 1255–1269.
https://doi.org/10.1182/blood.2019002922
Published: 2020
Includes: Supplemental data
Journal Articles

Mechanistic Basis and Efficacy of Targeting β-Catenin-TCF7L2-JMJD6-MYC Axis to Overcome Resistance to BET Inhibitors

Christopher Peter Mill, PhD BA, Warren Fiskus, BSc,PhD, Dyana T. Saenz, PhD, Bernardo H Lara, Vrajesh Karkhanis, PhD, Taghi Manshouri, PhD, Isean Bhalla, Nancy Shao, James V Maher, Srdan Verstovsek, MD PhD, Kapil N. Bhalla, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 538.
https://doi.org/10.1182/blood-2019-125142
Published: 2019
Journal Articles

Efficacy of Targeted Therapy in Novel Pre-Clinical in Vitro and In Vivo Models of Richter Transformation-Diffuse Large B-Cell Lymphoma (RT-DLBCL)

Vrajesh Karkhanis, PhD, Warren Fiskus, BSc,PhD, Christopher Peter Mill, PhD BA, Abhishek Maiti, MBBS, Bernardo H Lara, James V Maher, Isean Bhalla, Nancy Shao, Michael R Green, PhD, Joseph D. Khoury, MD, Kapil N. Bhalla, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3961.
https://doi.org/10.1182/blood-2019-132041
Published: 2019
Journal Articles

Pre-Clinical Efficacy of Co-Treatment with KDM1A (LSD1) Inhibitor and Ruxolitinib or BET Inhibitor Against Post-MPN-sAML Blast Progenitor Cells

Warren Fiskus, BSc,PhD, Christopher Peter Mill, PhD BA, Vrajesh Karkhanis, PhD, Bernardo H Lara, Prithviraj Bose, MD, Lucia Masarova, Tapan M. Kadia, MD, Nancy Shao, Isean Bhalla, James V Maher, Joseph D. Khoury, MD, Sunil Sharma, MD, Taghi Manshouri, PhD, Srdan Verstovsek, MD PhD, Kapil N. Bhalla, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1274.
https://doi.org/10.1182/blood-2019-130783
Published: 2019
Journal Articles

Protein Arginine Methyltransferase 5 Regulates WNT/β-Catenin Target Gene Expression in at Multiple Levels

Jihyun Chung, PhD, Vrajesh Karkhanis, PhD, Sif Said, PhD, Robert A Baiocchi, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4106.
https://doi.org/10.1182/blood.V128.22.4106.4106
Published: 2016
Journal Articles

PRMT5 Transgenic Mice Develop Aggressive Lymphoblastic Lymphomas

Porsha L. Smith, PhD, Fengting Yan, MD PhD, John T. Patton, PhD, Lapo Alinari, MD PhD, Vrajesh Karkhanis, PhD, Leona Ayers, MD, Natarajan Muthusamy, DVM, PhD, Anjali Mishra, PhD, Elshafa Ahmed, DVM, Said Sif, PhD, Rosa Lapalombella, PhD, Robert A Baiocchi, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2936.
https://doi.org/10.1182/blood.V128.22.2936.2936
Published: 2016
Journal Articles

PRMT5 Targets Tumor Suppressor Micro RNAs to Regulate Cyclin D1 and c-MYC in Mantle Cell Lymphoma

Vrajesh Karkhanis, PhD, Lapo Alinari, MD PhD, Bethany Mundy, MD, Michael Caliguri, MD, Selina Chen-Kiang, PhD, Olivier Elemento, PhD, Sif Said, PhD, Robert A Baiocchi, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2937.
https://doi.org/10.1182/blood.V128.22.2937.2937
Published: 2016
Journal Articles

Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation

Lapo Alinari, Kiran V. Mahasenan, Fengting Yan, Vrajesh Karkhanis, Ji-Hyun Chung, Emily M. Smith, Carl Quinion, Porsha L. Smith, Lisa Kim, John T. Patton, Rosa Lapalombella, Bo Yu, Yun Wu, Satavisha Roy, Alessandra De Leo, Stefano Pileri, Claudio Agostinelli, Leona Ayers, James E. Bradner, Selina Chen-Kiang, Olivier Elemento, Tasneem Motiwala, Sarmila Majumder, John C. Byrd, Samson Jacob, Said Sif, Chenglong Li, Robert A. Baiocchi
Journal: Blood
Blood (2015) 125 (16): 2530–2543.
https://doi.org/10.1182/blood-2014-12-619783
Published: 2015
Includes: Supplemental data
Journal Articles

Protein Arginine Methyltransferase 5 Supports MYC, Survivin and Cyclin D1 Activity in Aggressive Lymphomas By Regulating the WNT/β-Catenin Pathway

Jihyun Chung, PhD, Vrajesh Karkhanis, PhD, Said Sif, PhD, Robert A. Baiocchi, MD PhD
Journal: Blood
Blood (2014) 124 (21): 58.
https://doi.org/10.1182/blood.V124.21.58.58
Published: 2014
Journal Articles

Protein Arginine Methyltransferase 5 Directly Targets and Epigenetically Silences microRNAs miR33b and miR96 to Support Constitutive Cyclin D1 Activity in Non-Hodgkin’s Lymphoma

Vrajesh Karkhanis, PhD, Olivier Elemento, PhD, Maurizio Di Liberto, PhD, Selina Chen-Kiang, PhD, Said Sif, PhD, Robert A. Baiocchi, MD PhD
Journal: Blood
Blood (2014) 124 (21): 60.
https://doi.org/10.1182/blood.V124.21.60.60
Published: 2014
Journal Articles

Developing a Novel Class of Drug to Inhibit Protein Arginine Methyltransferase 5 (PRMT5) Enzyme Dysregulation in Mantle Cell Lymphoma

Fengting Yan, M.D., Ph.D., Porsha Smith, Lapo Alinari, MD., Ph.D., John Ryu, Bo Yu, Ph.D., Vrajesh Karkhanis, Ph.D., Sookil Tae, Ph.D., John T. Patton, Emily E. Wilding, Kate Gordon, Kiran Mahasenan, Ph.D., Deepak Bhasin, Ph.D., Claudio Agostinelli, M.D., Ph.D., Stefano A. Pileri, M.D., John C. Byrd, MD, Said Sif, Ph.D., Pui-kai Li, Ph.D., Chenglong Li, Ph.D., Robert A. Baiocchi, M.D., Ph.D.
Journal: Blood
Blood (2011) 118 (21): 595.
https://doi.org/10.1182/blood.V118.21.595.595
Published: 2011