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Journal Articles

The Novel Profiling Relative Inhibition Simultaneously in Mixtures (PRISM) Platform Identifies Synergistic Activity of Lanraplenib and Ruxolitinib in Hematological Malignancies

Akanksha Pandey, Luis A. Carvajal, Andrew S Boghossian, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Tressa Hood, Linlin Guo, Tamara D Hopkins, Nikolaus Obholzer, Michael R. McKeown, Jorge F. DiMartino, Charles Y. Lin

Blood (2023) 142 (Supplement 1): 2259.

https://doi.org/10.1182/blood-2023-174114

Published: 2023

Journal Articles

The Combination of Lanraplenib, a Selective SYK Inhibitor, and Gilteritinib, a FLT3 Inhibitor, Targets Aberrant Proliferation and Differentiation Blockade in Acute Myeloid Leukemia

Luis A. Carvajal, Michael R. McKeown, Tressa Hood, Linlin Guo, Charles Y. Lin, Jorge F. DiMartino

Blood (2023) 142 (Supplement 1): 5951.

https://doi.org/10.1182/blood-2023-186605

Published: 2023

Journal Articles

CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma

Blood (2023) 141 (23): 2841–2852.

https://doi.org/10.1182/blood.2022018885

Published: 2023

Includes: Supplemental data

Journal Articles

CDK7 Inhibition Targets Proliferative and Metabolic Oncogenic Vulnerabilities in Multiple Myeloma

Yao Yao, Jessica Fong Ng, Woojun D Park, Mehmet K. Samur, Eugenio Morelli, Nicholas P Kwiatkowski, Jessica Encinas Mayoral, Zuzana Chyra, Yan Xu, Behnam Nabet, Marta Chesi, Nathaniel Gray, Richard A. Young, Kenneth C. Anderson, Charles Y Lin, Nikhil C Munshi, Mariateresa Fulciniti

Blood (2022) 140 (Supplement 1): 9955–9956.

https://doi.org/10.1182/blood-2022-163811

Published: 2022

Journal Articles

Preclinical Activity of Selective SYK Inhibitors, Entospletinib and Lanraplenib, Alone or Combined with Targeted Agents in Ex Vivo AML Models with Diverse Mutational Backgrounds

Melinda A. L. Day, Philipp Sergeev, Caroline A. Heckman, Anna Schinzel, Nikolaus D. Obholzer, Charles Y. Lin, Pavan Kumar, Jorge DiMartino, Douglas C. Saffran

Blood (2021) 138 (Supplement 1): 3356.

https://doi.org/10.1182/blood-2021-146180

Published: 2021

Journal Articles

Targeting MM at the Nexus between Cell Cycle and Transcriptional Regulation Via CDK7 Inhibition

Yao Yao, Woojun D Park, Eugenio Morelli, MD, Mehmet Kemal Samur, PhD, Nicholas P Kwiatkowski, PhD, Yan Xu, MD, Chandraditya Chakraborty, PhD, Behnam Nabet, PhD, Marta Chesi, PhD, Herve Avet-Loiseau, Nathaniel Gray, Richard A. Young, PhD, Kenneth Anderson, MD, Charles Y Lin, PhD, Nikhil C. Munshi, MD, Mariateresa Fulciniti, PhD

Blood (2020) 136 (Supplement 1): 1–2.

https://doi.org/10.1182/blood-2020-142592

Published: 2020

Journal Articles

RNA Regulator of Lipogenesis (RROL) Is a Novel Lncrna Mediating Protein-Protein Interaction at Gene Regulatory Loci Driving Lipogenic Programs in Multiple Myeloma

Blood (2020) 136 (Supplement 1): 20–21.

https://doi.org/10.1182/blood-2020-142514

Published: 2020

Journal Articles

Mechanistic basis and efficacy of targeting the β-catenin–TCF7L2–JMJD6–c-Myc axis to overcome resistance to BET inhibitors

Blood (2020) 135 (15): 1255–1269.

https://doi.org/10.1182/blood.2019002922

Published: 2020

Includes: Supplemental data

Journal Articles

AMP-activated protein kinase links acetyl-CoA homeostasis to BRD4 recruitment in acute myeloid leukemia

Yajian Jiang, Tianyuan Hu, Tao Wang, Xiangguo Shi, Ayumi Kitano, Kenneth Eagle, Kevin A. Hoegenauer, Marina Y. Konopleva, Charles Y. Lin, Nicolas L. Young, Daisuke Nakada

Blood (2019) 134 (24): 2183–2194.

https://doi.org/10.1182/blood.2019001076

Published: 2019

Includes: Supplemental data

Journal Articles

An Oncogenic Enhancer Encodes Selective Selenium Dependency in AML

Charles Y Lin, PhD, Joanna S. Yi, MD, Yajian Jiang, MBBS, Daisuke Nakada, PhD, Monika Perez, BS, Jost Koren, M.S., Kenneth Eagle

Blood (2019) 134 (Supplement_1): 638.

https://doi.org/10.1182/blood-2019-129433

Published: 2019

Journal Articles

Integrating Enhancer Profiling and CRISPR Dropout Screen Revealed Selenoprotein Synthesis Pathway As a New Vulnerability in AML

Yajian Jiang, MBBS, Xiangguo Shi, PhD, Kenneth Eagle, Charles Y Lin, PhD, Daisuke Nakada, PhD

Blood (2019) 134 (Supplement_1): 639.

https://doi.org/10.1182/blood-2019-126904

Published: 2019

Journal Articles

Rara Is a Druggable Super-Enhancer Regulated Dependency in Pediatric AML

Alfred S. Daramola, MS, Monika Perez, BS, Oscar S. Sias-Garcia, MS, Maci S. Terrell, BS, Helen Y Wei, BS, Nikitha Cherayil, BS, Alexandra McLean Stevens, MD PhD, Charles Y Lin, PhD, Joanna S. Yi, MD

Blood (2019) 134 (Supplement_1): 281.

https://doi.org/10.1182/blood-2019-125425

Published: 2019

Journal Articles

Core Transcriptional Regulatory Circuitries in AML

Maxim Pimkin, MD PhD, Juliana Xavier Ferrucio, PhD, Neekesh Vijay Dharia, MD PhD, Taku Harada, Andrew Kossenkov, Selma Elsarrag, Jazmin Ewers, Charles Y Lin, PhD, Kimberly Stegmaier, MD, Stuart H. Orkin, MD

Blood (2019) 134 (Supplement_1): 280.

https://doi.org/10.1182/blood-2019-129297

Published: 2019

Journal Articles

Chromatin Accessibility Profiling Reveals Cis-Regulatory Heterogeneity and Novel Transcription Factor Dependencies in Multiple Myeloma

Christopher J. Ott, PhD, Raphael Szalat, MD, Matthew Lawlor, Mehmet Kemal Samur, PhD, Yan Xu, MD, Charles B Epstein, Charles Y Lin, PhD, Rao Prabhala, PhD, Nina Farrell, Lauren D Walter, Logan Schwartz, Kenneth Wen, BS, Yu-Tzu Tai, PhD, Mariateresa Fulciniti, PhD, Jinhua Wang, PhD, Nathanael Gray, PhD, Kenneth Anderson, MD, Richard A. Young, PhD, Nikhil Munshi, MD

Blood (2018) 132 (Supplement 1): 1313.

https://doi.org/10.1182/blood-2018-99-119941

Published: 2018

Journal Articles

Targeting Distinct Promoter- and Enhancer-Driven Dependencies in Multiple Myeloma

Chandraditya Chakraborty, PhD, Mehmet Kemal Samur, PhD, Richard A. Young, PhD, Kenneth Anderson, MD, Charles Y Lin, PhD, Mariateresa Fulciniti, PhD, Nikhil Munshi, MD

Blood (2018) 132 (Supplement 1): 3156.

https://doi.org/10.1182/blood-2018-99-112583

Published: 2018

Journal Articles

c-MPL provides tumor-targeted T-cell receptor-transgenic T cells with costimulation and cytokine signals

Christopher D. Nishimura, Daniel A. Brenner, Malini Mukherjee, Rachel A. Hirsch, Leah Ott, Meng-Fen Wu, Hao Liu, Olga Dakhova, Jordan S. Orange, Malcolm K. Brenner, Charles Y. Lin, Caroline Arber

Blood (2017) 130 (25): 2739–2749.

https://doi.org/10.1182/blood-2017-02-769463

Published: 2017

Includes: Supplemental data

Journal Articles

Mapping of the Multiple Myeloma Transcriptional Core Regulatory Circuitry Reveals TCF3 As a Novel Dependency and an Oncogenic Collaborator of MYC

Charles Y Lin, PhD, Mariateresa Fulciniti, PhD, Michael A Lopez, BS, Mehmet Kemal Samur, PhD, Raphael Szalat, MD, Christopher J. Ott, PhD, Charles Epstein, Richard A. Young, PhD, James Bradner, MD, Kenneth C Anderson, MD, Nikhil Munshi, MD

Blood (2017) 130 (Supplement 1): 64.

https://doi.org/10.1182/blood.V130.Suppl_1.64.64

Published: 2017

Journal Articles

Integrative Oncogenomic Analysis Combining Whole Genome, Transcriptome and Epigenome Identifies Altered Chromatin Accessibility Landscape in Multiple Myeloma

Raphael Szalat, MD, Mehmet Kemal Samur, PhD, Christopher J. Ott, PhD, Matthew Lawlor, Charles Epstein, Brian J Abraham, PhD, Charles Y Lin, PhD, Linying Zhang, Rao Prabhala, PhD, Nina Farrell, Kenneth Wes, Yu-Tzu Tai, PhD, Mariateresa Fulciniti, PhD, Giovanni Parmigiani, Richard A. Young, PhD, Kenneth C Anderson, MD, Nikhil Munshi, MD

Blood (2017) 130 (Supplement 1): 328.

https://doi.org/10.1182/blood.V130.Suppl_1.328.328

Published: 2017

Journal Articles

Discovery and Characterization of Promoter and Super-Enhancer-Associated Dependencies through E2F and BET Bromodomains in Multiple Myeloma

Mariateresa Fulciniti, Charles Y. Lin, Mehmet K Samur, PhD, Matthew Lawlor, Kenneth C Anderson, James E. Bradner, MD, Nikhil C. Munshi, MD

Blood (2015) 126 (23): 838.

https://doi.org/10.1182/blood.V126.23.838.838

Published: 2015

Journal Articles

Disruption of the Ikaros-Mediated Gene Expression Program in Multiple Myeloma with Immunomodulatory Agents

Christopher J. Ott, Gang Lu, Jaime Reyes, Charles Y. Lin, William G. Kaelin, MD, James E. Bradner

Blood (2014) 124 (21): 420.

https://doi.org/10.1182/blood.V124.21.420.420

Published: 2014

NARROW

The Novel Profiling Relative Inhibition Simultaneously in Mixtures (PRISM) Platform Identifies Synergistic Activity of Lanraplenib and Ruxolitinib in Hematological Malignancies

The Combination of Lanraplenib, a Selective SYK Inhibitor, and Gilteritinib, a FLT3 Inhibitor, Targets Aberrant Proliferation and Differentiation Blockade in Acute Myeloid Leukemia

CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma

CDK7 Inhibition Targets Proliferative and Metabolic Oncogenic Vulnerabilities in Multiple Myeloma

Preclinical Activity of Selective SYK Inhibitors, Entospletinib and Lanraplenib, Alone or Combined with Targeted Agents in Ex Vivo AML Models with Diverse Mutational Backgrounds

Targeting MM at the Nexus between Cell Cycle and Transcriptional Regulation Via CDK7 Inhibition

RNA Regulator of Lipogenesis (RROL) Is a Novel Lncrna Mediating Protein-Protein Interaction at Gene Regulatory Loci Driving Lipogenic Programs in Multiple Myeloma

Mechanistic basis and efficacy of targeting the β-catenin–TCF7L2–JMJD6–c-Myc axis to overcome resistance to BET inhibitors

AMP-activated protein kinase links acetyl-CoA homeostasis to BRD4 recruitment in acute myeloid leukemia

An Oncogenic Enhancer Encodes Selective Selenium Dependency in AML

Integrating Enhancer Profiling and CRISPR Dropout Screen Revealed Selenoprotein Synthesis Pathway As a New Vulnerability in AML

Rara Is a Druggable Super-Enhancer Regulated Dependency in Pediatric AML

Core Transcriptional Regulatory Circuitries in AML

Chromatin Accessibility Profiling Reveals Cis-Regulatory Heterogeneity and Novel Transcription Factor Dependencies in Multiple Myeloma

Targeting Distinct Promoter- and Enhancer-Driven Dependencies in Multiple Myeloma

c-MPL provides tumor-targeted T-cell receptor-transgenic T cells with costimulation and cytokine signals

Mapping of the Multiple Myeloma Transcriptional Core Regulatory Circuitry Reveals TCF3 As a Novel Dependency and an Oncogenic Collaborator of MYC

Integrative Oncogenomic Analysis Combining Whole Genome, Transcriptome and Epigenome Identifies Altered Chromatin Accessibility Landscape in Multiple Myeloma

Discovery and Characterization of Promoter and Super-Enhancer-Associated Dependencies through E2F and BET Bromodomains in Multiple Myeloma

Disruption of the Ikaros-Mediated Gene Expression Program in Multiple Myeloma with Immunomodulatory Agents

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American Society of Hematology

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American Society of Hematology

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