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Journal Articles

Discovery of First-in-Class Small Molecule Inhibitors of the IRF4-PU.1/Spi-B Interaction

Mike P. Agius, Laura Hevenor, N Connor Payne, Ralph Mazitschek, Hyuk-Soo Seo, Sirano Dhe-Paganon, Jun Qi, Irene M. Ghobrial
Journal: Blood
Blood (2023) 142 (Supplement 1): 3635.
https://doi.org/10.1182/blood-2023-186864
Published: 2023
Journal Articles

Discovery of BT-114143, a Novel and Potent Small-Molecule Plasminogen Inhibitor for Hyperfibrinolysis

Jun Tang, Sen Ji, Xiao Hu, Yan Wang, Jun Qi, Xiao Wang, Hao Wang, Jianzong Li, Zhiqiang Li, Min Li, Shaomei Zeng, Xiong Yuan, Xiaodong Zhang
Journal: Blood
Blood (2023) 142 (Supplement 1): 1229.
https://doi.org/10.1182/blood-2023-185454
Published: 2023
Journal Articles

Targeting the Oncofetal Transcription Factor Protein SALL4 in Cancer By a Non-IMiD Degrader

Kim Anh L. Vu, Kalpana Kumari, Bee Hui Liu, Chong Gao, Feng Li, Jing Ping Tang, Danilo Maddalo, Xi Tian, Miao Liu, Mahmoud Adel Bassal, Shiva Moein, Viktoriia Iakovleva, Justin L. Tan, Alicia J. Stein, Qiling Zhou, Patrick D. Fischer, Logan H. Sigua, Jun Qi, Haribabu Arthanari, Daniel G. Tenen, Li Chai
Journal: Blood
Blood (2023) 142 (Supplement 1): 7144.
https://doi.org/10.1182/blood-2023-184502
Published: 2023
Journal Articles

PHF19 Inhibits Multiple Myeloma Cell Response to Immunotherapy Via Promoting Immunosuppressive Microenvironment

Tengteng Yu, Mu Hao, Hailin Chen, Kenneth Wen, Tingjian Wang, Thomas C.M Smits, Mehmet K. Samur, Eugenio Morelli, Lijie Xing, Liang Lin, Jun Qi, Gang An, Nikhil C Munshi, Yu-Tzu Tai, Lugui Qiu, Kenneth C. Anderson
Journal: Blood
Blood (2022) 140 (Supplement 1): 854–855.
https://doi.org/10.1182/blood-2022-159137
Published: 2022
Journal Articles

BRD9 Is Essential for Ribosome Biogenesis and the Survival of Multiple Myeloma Cells

Keiji Kurata, Mehmet K. Samur, Priscilla Liow, Kenneth Wen, Leona Yamamoto, Jiye Liu, Eugenio Morelli, Annamaria Gulla, Yu-Tzu Tai, Jun Qi, Teru Hideshima, Kenneth C. Anderson
Journal: Blood
Blood (2022) 140 (Supplement 1): 596–597.
https://doi.org/10.1182/blood-2022-162445
Published: 2022
Journal Articles

BET-bromodomain and EZH2 inhibitor–treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes

Michael C. Zaiken, Ryan Flynn, Katelyn G. Paz, Stephanie Y. Rhee, Sujeong Jin, Fathima A. Mohamed, Asim Saha, Govindarajan Thangavelu, Paul M. C. Park, Matthew L. Hemming, Peter T. Sage, Arlene H. Sharpe, Michel DuPage, Jeffrey A. Bluestone, Angela Panoskaltsis-Mortari, Corey S. Cutler, John Koreth, Joseph H. Antin, Robert J. Soiffer, Jerome Ritz, Leo Luznik, Ivan Maillard, Geoffrey R. Hill, Kelli P. A. MacDonald, David H. Munn, Jonathan S. Serody, William J. Murphy, Leslie S. Kean, Yi Zhang, James E. Bradner, Jun Qi, Bruce R. Blazar
Journal: Blood
Blood (2022) 139 (19): 2983–2997.
https://doi.org/10.1182/blood.2021014557
Published: 2022
Includes: Supplemental data
Journal Articles

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Angela Su, Frank Ling, Camille Vaganay, Bryann Pardieu, Lina Benajiba, MD/PhD, Gaetano Sodaro, Justine Pasanisi, Kevin H Lin, BS, Justine Rutter, PhD, Christopher F. Bassil, Iléana Antony-Debre, PhD, Gabriela Alexe, PhD, Jean-François Benoist, MD, Yana Pikman, MD, Jun Qi, PhD, Herve Dombret, MD PhD, Claude Preudhomme, PharmD, PhD, Nina Fenouille, Hava M. Golan, Kimberly Stegmaier, MD, Camille Lobry, Kris C Wood, PhD, Raphael Itzykson, Alexandre Puissant, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 877.
https://doi.org/10.1182/blood-2019-131255
Published: 2019
Journal Articles

Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease

Brief Report
Katelyn Paz, Ryan Flynn, Jing Du, Jun Qi, Leo Luznik, Ivan Maillard, Kelli P. MacDonald, Geoffrey R. Hill, Jonathan S. Serody, William J. Murphy, Peter T. Sage, Arlene H. Sharpe, David Miklos, Corey S. Cutler, John Koreth, Joseph H. Antin, Robert J. Soiffer, Jerome Ritz, James E. Bradner, Ari M. Melnick, Bruce R. Blazar
Journal: Blood
Blood (2019) 133 (1): 94–99.
https://doi.org/10.1182/blood-2018-03-839993
Published: 2019
Journal Articles

Arginine Methylation Mediated By PRMT5 Has Significant Biological and Clinical Impact in Multiple Myeloma

Annamaria Gulla, MD, Teru Hideshima, MD PhD, Giada Bianchi, MD, Mariateresa Fulciniti, PhD, Mehmet K. Samur, PhD, Yu-Tzu Tai, PhD, Jun Qi, PhD, Takeshi Harada, MD PhD, Eugenio Morelli, MD, Nicola Amodio, PhD, Ruben D. Carrasco, MD PhD, Pierosandro Tagliaferri, MD, Nikhil C. Munshi, MD, Pierfrancesco Tassone, MD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2016) 128 (22): 1140.
https://doi.org/10.1182/blood.V128.22.1140.1140
Published: 2016
Journal Articles

An Epigenetic Regulator Screen Identifies Novel Targets That Sensitize MLL -Rearranged Leukemia to DOT1L Inhibition

Chun-Wei David Chen, PhD, Christopher Delaney, BS, Haiming Xu, PhD, Richard Koche, PhD, Amaya Lujambio Goizueta, PhD, Takayuki Hoshii, PhD, Monica Cusan, MD PhD, Jonathan Chabon, BS, Daria Gianina Valerio, MD, Michael Kuehn, MD, Xi Wang, BS, Sheng Cai, MD PhD, S. Haihua Chu, PhD, Yining Kevin Chen, Justin He, Chun-Hao Huang, PhD, Zhaohui Feng, BM, BS, Andrei Krivtsov, PhD, Jun Qi, PhD, James E. Bradner, MD, Scott W. Lowe, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 571.
https://doi.org/10.1182/blood.V128.22.571.571
Published: 2016
Journal Articles

Leukemia-Specific Delivery of Mutant NOTCH1 Targeted Therapy

Giovanni Roti, MD PhD, Jun Qi, PhD, Samuel Kitara, Anthony C. Varca, Marta Sanchez-Martin, PhD, Andrew L. Kung, MD PhD, Adolfo A. Ferrando, MD PhD, James E. Bradner, MD, Kimberly Stegmaier, MD
Journal: Blood
Blood (2016) 128 (22): 889.
https://doi.org/10.1182/blood.V128.22.889.889
Published: 2016
Journal Articles

Genome-Wide Mapping Reveals BRD4 in Regulation of Tumor-Driver Genes in Cutaneous T-Cell Lymphoma

Anjali Mishra, PhD, Alex Hartlage, BS, Laura Sullivan, Leah Grinshpun, Sonya Kwiatkowski, Jun Qi, PhD, James E. Bradner, MD, Pierluigi Porcu, MD, Michael A. Caligiuri, MD
Journal: Blood
Blood (2015) 126 (23): 589.
https://doi.org/10.1182/blood.V126.23.589.589
Published: 2015
Journal Articles

Targeted Treatment of FLT3 -Overexpressing Acute Myeloid Leukemia with MiR-150 Nanoparticles Guided By Conjugated FLT3 Ligand Peptides

Xi Jiang, PhD, Jason Bugno, Chao Hu, Yang Yang, PhD, Tobias Herold, MD, Jun Qi, PhD, Ping Chen, Sandeep Gurbuxani, MBBS, PhD, Stephen Arnovitz, Bryan Ulrich, Hengyou Weng, PhD, Yungui Wang, PhD, Hao Huang, PhD, Shenglai Li, Jennifer Strong, Mary Beth Neilly, Richard A. Larson, MD, Michelle M. Le Beau, PhD, Stefan K. Bohlander, MD, Jie Jin, MD PhD, Zejuan Li, MD PhD, James E. Bradner, MD, Seungpyo Hong, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2015) 126 (23): 3784.
https://doi.org/10.1182/blood.V126.23.3784.3784
Published: 2015
Journal Articles

Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib

Baohua Sun, Bhavin Shah, Warren Fiskus, Jun Qi, Kimal Rajapakshe, Cristian Coarfa, Li Li, Santhana G. T. Devaraj, Sunil Sharma, Liang Zhang, Michael L. Wang, Dyana T. Saenz, Stephanie Krieger, James E. Bradner, Kapil N. Bhalla
Journal: Blood
Blood (2015) 126 (13): 1565–1574.
https://doi.org/10.1182/blood-2015-04-639542
Published: 2015
Includes: Supplemental data
Journal Articles

Selectively Targeting Mutated NOTCH1 with a Folate-Thapsigargin Derivative

Giovanni Roti, MD, Jun Qi, PhD, Angela Su, B.S., Antony Varca, B.S., Jon C Aster, MD PhD, James E. Bradner, Kimberly Stegmaier, MD
Journal: Blood
Blood (2014) 124 (21): 2158.
https://doi.org/10.1182/blood.V124.21.2158.2158
Published: 2014
Journal Articles

Mechanistic Role of HEXIM1 Induction in BRD4-Antagonist Mediated Growth Inhibition, Differentiation and in Vivo Lethal Activity Against Human AML Blast Progenitor Cells

Santhana G. T. Devaraj, PhD, Warren Fiskus, PhD, Bhavin Shah, Sunil Sharma, Jun Qi, PhD, Baohua Sun, MD PhD, Saikat Saha, PhD, Swaminathan Padmanabhan Iyer, MD, Youli Zu, MD PhD, James Bradner, MD, Kapil N. Bhalla, MD
Journal: Blood
Blood (2014) 124 (21): 3534.
https://doi.org/10.1182/blood.V124.21.3534.3534
Published: 2014
Journal Articles

Targeting BCL6 and Germinal Centers (GCs) in Chronic Graft-Versus-Host Disease (cGVHD) Using Direct and Epigenomic Therapies

Ryan P Flynn, Katelyn Goodman, Jun Qi, PhD, Du Jing, Angela Panoskaltsis-Mortari, PhD, Zhang Yi, Chen Dong, PhD, Xindong Liu, Kelli P A MacDonald, PhD, Geoffrey R Hill, MD, Jonathan S Serody, MD, William J Murphy, PhD, Leo Luznik, MD, Ivan Maillard, MD PhD, John Koreth, MBBS, DPhil, Corey S Cutler, MD MPH, Robert J Soiffer, MD, Joseph H. Antin, MD, Jerome Ritz, MD, Ari M Melnick, MD, James E. Bradner, MD, Bruce R. Blazar, MD
Journal: Blood
Blood (2014) 124 (21): 535.
https://doi.org/10.1182/blood.V124.21.535.535
Published: 2014
Journal Articles

Eradication of Chronic Myelogenous Leukemia By Inactivation of the Polycomb Group Protein EZH2

Huafeng Xie, PhD, Cong Peng, PhD, Jun Qi, PhD, Giullia Cheloni, Partha Das, PhD, Jialiang Huang, PhD, Minh Nguyen, Shaoguang Li, MD PhD, James E. Bradner, MD, Stuart H. Orkin, MD
Journal: Blood
Blood (2014) 124 (21): 778.
https://doi.org/10.1182/blood.V124.21.778.778
Published: 2014
Journal Articles

Superior Pre-Clinical Activity of BET (Bromodomain and Extra terminal) Protein Antagonist Combined with Ibrutinib, Panobinostat or Carfilzomib Against Human Mantle Cell Lymphoma (MCL) Cells

Baohua Sun, MD PhD, Warren Fiskus, PhD, Bhavin Shah, Jun Qi, PhD, Santhana G. T. Devaraj, PhD, Swaminathan Padmanabhan Iyer, MD, Sunil Sharma, James Bradner, MD, Youli Zu, MD PhD, Kapil N. Bhalla, MD
Journal: Blood
Blood (2014) 124 (21): 918.
https://doi.org/10.1182/blood.V124.21.918.918
Published: 2014
Journal Articles

SALL4 Is a Key Factor in HDAC Inhibitor Mediated Ex Vivo Expansion of Human Peripheral Blood Mobilized Stem/Progenitor CD34+CD90+ Cells

Hiro Tatetsu, MD PhD, Fei Wang, Chong Gao, MD PhD, Shikiko Ueno, MD PhD, Xi Tian, BS, Myriam Armant, PhD, Alex Federation, Jun Qi, PhD, James E. Bradner, Daniel G. Tenen, MD, Li Chai, MD
Journal: Blood
Blood (2014) 124 (21): 1566.
https://doi.org/10.1182/blood.V124.21.1566.1566
Published: 2014