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Journal Articles

Whole-Genome CRISPR-Cas9 Screening Identifies Genes Required for Human and Mouse Erythroid Development

Greggory Myers, Ann Friedman, Lei Yu, Claire Kerpet, Masaki Ito, Rilie Saba, Ginette Balbin-Cuesta, Zesen Lin, Claire Drysdale, Ayse Bilge Ozel, James Engel, Rami Khoriaty

Blood (2023) 142 (Supplement 1): 3828.

https://doi.org/10.1182/blood-2023-181929

Published: 2023

Journal Articles

Identifying Novel Regulators of γ-Globin Expression Using a Genome-Scale CRISPR Activation Screen

Ginette Balbin-Cuesta, Greggory Myers, Zesen Lin, Claire Kerpet, Beth McGee, Katherine Rybkin, Richard King, Claire Drysdale, Ann Friedman, Lei Yu, Masaki Ito, Rilie Saba, Ayse Bilge Ozel, Rami Khoriaty

Blood (2023) 142 (Supplement 1): 1100.

https://doi.org/10.1182/blood-2023-182203

Published: 2023

Journal Articles

Whole-Genome CRISPR-Cas9 Screen Identifies ZBTB7A As a Potential Therapeutic Target for Cda-II

Lei Yu, Greggory Myers, Beth McGee, Xiaofang Liu, Gallagher Patrick, Richard King, Ann Friedman, Ginette Balbin-Cuesta, Zesen Lin, Claire Drysdale, Claire Kerpet, Singh Sharon, James Engel, Rami Khoriaty

Blood (2023) 142 (Supplement 1): 12.

https://doi.org/10.1182/blood-2023-182246

Published: 2023

Journal Articles

Identification of CNOT4 As a Positive Regulator of Erythroid Cell Growth Using a Genome Wide CRISPR Knock-out Screen

Claire Drysdale, Greggory Myers, Lei Yu, Ann Friedman, Claire Kerpet, Ginette Balbin-Cuesta, Zesen Lin, Ayse Bilge Ozel, James Engel, Rami Khoriaty

Blood (2023) 142 (Supplement 1): 2447.

https://doi.org/10.1182/blood-2023-182187

Published: 2023

Journal Articles

A Genome Scale CRISPR Screen Identifies Novel Genes That Regulate Erythropoietin Production

Zesen Lin, Ginette Balbin-Cuesta, Greggory Myers, Lei Yu, Claire Drysdale, Vi Tang, Ayse Bilge Ozel, Ann Friedman, Beth McGee, Masaki Ito, Rilie Saba, Claire Kerpet, Richard King, Gallagher Patrick, James Engel, Rami Khoriaty

Blood (2023) 142 (Supplement 1): 3820.

https://doi.org/10.1182/blood-2023-182427

Published: 2023

Journal Articles

The CDK-Inhibitor p27 Kip1 Regulates Fetal Hemoglobin Expression

Ginette Balbin-Cuesta, Greggory Myers, Claire Kerpet, Beth McGee, Katherine Rybkin, Zesen Lin, Claire Drysdale, Ann Friedman, Sharon A Singh, Lei Yu, Ayse Bilge Ozel, Rami Khoriaty

Blood (2023) 142 (Supplement 1): 556.

https://doi.org/10.1182/blood-2023-181197

Published: 2023

Journal Articles

A Genome Scale CRISPR Screen Identifies the ER Cargo Receptor That Facilitates the Efficient Secretion of Erythropoietin

Zesen Lin, B.S., Greggory Myers, Beth McGee, Richard King, MD, Vi Tang, B.S., Ann Friedman, B.S., Brian Emmer, MD, Rami Khoriaty

Blood (2019) 134 (Supplement_1): 340.

https://doi.org/10.1182/blood-2019-131208

Published: 2019

Journal Articles

Functional Overlap between the SEC23 Paralogs Suggests a Novel Treatment Paradigm for Congenital Dyserythropoietic Anemia Type II

Richard King, MD, Ann Friedman, BS, Zesen Lin, BS, Rami Khoriaty, MD

Blood (2019) 134 (Supplement_1): 2221.

https://doi.org/10.1182/blood-2019-129669

Published: 2019

Journal Articles

Donor T Cells Require Notch Signals but Not Alloantigen Presentation from Specialized Secondary Lymphoid Organ Fibroblasts to Drive Graft-Versus-Host Disease

Eric Perkey, BS, Léolène Carrington, PhD, Jooho Chung, MDPhD, David Granadier, BS, Alexander Dils, Ann Friedman, BS, Anastasia Tikhonova, PhD, Bruce R. Blazar, MD, Ute Koch, PhD, Nathalie Labrecque, PhD, Freddy Radtke, PhD, Chris Siebel, PhD BA, Iannis Aifantis, PhD, Ivan Maillard, MD PhD

Blood (2018) 132 (Supplement 1): 810.

https://doi.org/10.1182/blood-2018-99-110258

Published: 2018

Journal Articles

The PAF1c Subunit Cdc73 Is Essential for Hematopoiesis and Displays Differential Gene Regulation in MLL-AF9 Driven Leukemia

Nirmalya SAHA, PhD MSc, BSc, James Ropa, BS, Lili Chen, PhD, Hsiang-Yu Hu, BS, Maria Mysliwski, Ann Friedman, BS, Ivan Maillard, MD, Andrew G. Muntean, PhD

Blood (2018) 132 (Supplement 1): 1280.

https://doi.org/10.1182/blood-2018-99-118703

Published: 2018

Journal Articles

The Trithorax-Group Protein ASH1L Regulates Hematopoietic Stem Cell Homeostasis Independently of Its Histone Methyltransferase Activity

Gloria Jih, PhD, Jennifer Chase, PhD, Yile Zhou, MD PhD, Ann Friedman, BS, Xiaomin Feng, MD PhD, Manabu Nakayama, PhD, Haruhiko Koseki, PhD, Kenichi Nishioka, PhD, Gang Huang, PhD, Ivan Maillard, MD PhD

Blood (2018) 132 (Supplement 1): 1270.

https://doi.org/10.1182/blood-2018-99-117367

Published: 2018

Journal Articles

Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice

Vedran Radojcic, Katelyn Paz, Jooho Chung, Jing Du, Eric T. Perkey, Ryan Flynn, Sanja Ivcevic, Michael Zaiken, Ann Friedman, Minhong Yan, Maria A. Pletneva, Stefanie Sarantopoulos, Christian W. Siebel, Bruce R. Blazar, Ivan Maillard

Blood (2018) 132 (20): 2188–2200.

https://doi.org/10.1182/blood-2018-03-841155

Published: 2018

Includes: Supplemental data

Journal Articles

Notch Signaling Mediated By Dll1/4 Notch Ligands Controls the Pathogenesis of Both Multi-Organ System Non-Sclerodermatous and Sclerodermatous Chronic Graft-Versus-Host Disease

Vedran Radojcic, MD, Ryan P Flynn, PhD, Jooho Chung, BS, Jing Du, Eric Perkey, BS, Katelyn Paz, Michael Zaiken, Ann Friedman, Minhong Yan, PhD, Christian W. Siebel, PhD, Bruce R. Blazar, MD, Ivan Maillard, MD PhD

Blood (2016) 128 (22): 805.

https://doi.org/10.1182/blood.V128.22.805.805

Published: 2016

Journal Articles

Delta-like Ligands Expressed By Stromal Cells in Secondary Lymphoid Organs Deliver an Early Pulse of Notch Signaling and Drive T Cell Pathogenicity in Acute Graft-Versus-Host Disease

Jooho Chung, BS, Christen L. Ebens, MDMPH, Vedran Radojcic, MD, Ute Koch, PhD, Ann Friedman, BS, Ivy T. Tran, BS, Qian Chai, PhD, Lucas Onder, PhD, Minhong Yan, PhD, Pavan Reddy, MD, Bruce R. Blazar, MD, Burkhard Ludewig, PhD, Christian W. Siebel, PhD, Freddy Radtke, PhD, Ivan Maillard, MD PhD

Blood (2014) 124 (21): 841.

https://doi.org/10.1182/blood.V124.21.841.841

Published: 2014

Journal Articles

Delta-Like Notch Ligands Expressed By Host Non-Hematopoietic Radioresistant Cells Regulate Graft-Versus-Host Disease and Extrathymic T Cell Development After Bone Marrow Transplantation

Christen L Ebens, MD, MPH, Jooho Chung, BS, Ute Koch, PhD, Ivy T Tran, BS, Ashley R Sandy-Sloat, PhD, Ann Friedman, BS, Bruce R Blazar, MD, Pavan Reddy, MD, Minhong Yan, PhD, Christian W Siebel, PhD, Freddy Radtke, PhD, Ivan Maillard, MD, PhD

Blood (2013) 122 (21): 2003.

https://doi.org/10.1182/blood.V122.21.2003.2003

Published: 2013

Journal Articles

Notch Inhibition in Alloreactive CD4 + and CD8 + T Cells Blocks Graft-Versus-Host Disease by Inducing a Hyporesponsive Program with Features of T Cell Anergy

Ashley R Sandy, BS, Jooho Chung, BS, Ivy T Tran, BS, Gloria T Shan, BS, Ann Friedman, BS, Timothy S Blackwell, MD-PhD, Pavan Reddy, M.D., Philip D King, PhD, Ivan Maillard, MD, PhD

Blood (2012) 120 (21): 340.

https://doi.org/10.1182/blood.V120.21.340.340

Published: 2012

Journal Articles

The Trithorax Group Protein Ash1l Is An Essential Epigenetic Regulator of Adult Hematopoietic Stem Cell Maintenance

Morgan Jones, BS, MS, Michelle L Brinkmeier, PhD, Julien Schira, BS, MS, Ann Friedman, BS, Sami Malek, MD, Yali Dou, PhD, Sally A Camper, PhD, Ivan Maillard, MD, PhD

Blood (2011) 118 (21): 387.

https://doi.org/10.1182/blood.V118.21.387.387

Published: 2011

Journal Articles

In Vivo Blockade of Individual Notch Ligands and Receptors Provides a New Targeted Therapeutic Approach In Graft-Versus-Host Disease

Ivy T Tran, BS, Ashley R Sandy, BS, Alexis Carulli, BS, Gloria T Shan, BS, Vedran Radojcic, MD, Ann Friedman, BS, Amy Shelton, Linda C Samuelson, PhD, Minhong Yan, PhD, Christian W Siebel, PhD, Ivan Maillard, MD, PhD

Blood (2011) 118 (21): 819.

https://doi.org/10.1182/blood.V118.21.819.819

Published: 2011

Journal Articles

Ikaros-Notch axis in host hematopoietic cells regulates experimental graft-versus-host disease

Tomomi Toubai, Yaping Sun, Isao Tawara, Ann Friedman, Chen Liu, Rebecca Evers, Evelyn Nieves, Chelsea Malter, Peter Chockley, Ivan Maillard, Susan Winandy, Pavan Reddy

Blood (2011) 118 (1): 192–204.

https://doi.org/10.1182/blood-2010-12-324616

Published: 2011

Includes: Supplemental data

Journal Articles

Notch signaling is a critical regulator of allogeneic CD4 + T-cell responses mediating graft-versus-host disease

Yi Zhang, Ashley R. Sandy, Jina Wang, Vedran Radojcic, Gloria T. Shan, Ivy T. Tran, Ann Friedman, Koji Kato, Shan He, Shuaiying Cui, Elizabeth Hexner, Dale M. Frank, Stephen G. Emerson, Warren S. Pear, Ivan Maillard

Blood (2011) 117 (1): 299–308.

https://doi.org/10.1182/blood-2010-03-271940

Published: 2011

Includes: Supplemental data

NARROW

Whole-Genome CRISPR-Cas9 Screening Identifies Genes Required for Human and Mouse Erythroid Development

Identifying Novel Regulators of γ-Globin Expression Using a Genome-Scale CRISPR Activation Screen

Whole-Genome CRISPR-Cas9 Screen Identifies ZBTB7A As a Potential Therapeutic Target for Cda-II

Identification of CNOT4 As a Positive Regulator of Erythroid Cell Growth Using a Genome Wide CRISPR Knock-out Screen

A Genome Scale CRISPR Screen Identifies Novel Genes That Regulate Erythropoietin Production

The CDK-Inhibitor p27 Kip1 Regulates Fetal Hemoglobin Expression

A Genome Scale CRISPR Screen Identifies the ER Cargo Receptor That Facilitates the Efficient Secretion of Erythropoietin

Functional Overlap between the SEC23 Paralogs Suggests a Novel Treatment Paradigm for Congenital Dyserythropoietic Anemia Type II

Donor T Cells Require Notch Signals but Not Alloantigen Presentation from Specialized Secondary Lymphoid Organ Fibroblasts to Drive Graft-Versus-Host Disease

The PAF1c Subunit Cdc73 Is Essential for Hematopoiesis and Displays Differential Gene Regulation in MLL-AF9 Driven Leukemia

The Trithorax-Group Protein ASH1L Regulates Hematopoietic Stem Cell Homeostasis Independently of Its Histone Methyltransferase Activity

Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice

Notch Signaling Mediated By Dll1/4 Notch Ligands Controls the Pathogenesis of Both Multi-Organ System Non-Sclerodermatous and Sclerodermatous Chronic Graft-Versus-Host Disease

Delta-like Ligands Expressed By Stromal Cells in Secondary Lymphoid Organs Deliver an Early Pulse of Notch Signaling and Drive T Cell Pathogenicity in Acute Graft-Versus-Host Disease

Delta-Like Notch Ligands Expressed By Host Non-Hematopoietic Radioresistant Cells Regulate Graft-Versus-Host Disease and Extrathymic T Cell Development After Bone Marrow Transplantation

Notch Inhibition in Alloreactive CD4 + and CD8 + T Cells Blocks Graft-Versus-Host Disease by Inducing a Hyporesponsive Program with Features of T Cell Anergy

The Trithorax Group Protein Ash1l Is An Essential Epigenetic Regulator of Adult Hematopoietic Stem Cell Maintenance

In Vivo Blockade of Individual Notch Ligands and Receptors Provides a New Targeted Therapeutic Approach In Graft-Versus-Host Disease

Ikaros-Notch axis in host hematopoietic cells regulates experimental graft-versus-host disease

Notch signaling is a critical regulator of allogeneic CD4 + T-cell responses mediating graft-versus-host disease

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American Society of Hematology

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American Society of Hematology

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