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Christian W. Siebel
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Journal Articles

Stroma-Driven Notch2 Signaling Controls Naïve B Cell Fate By Regulating Microenvironmental Positioning within the Spleen

Anneka Allman, Brian Gaudette, Samantha Kelly, Nagham Alouche, Leolene Carrington, Eric Perkey, Riley Outen, Ashley Vanderbeck, Katlyn Lederer, Tanner F. Robertson, Janis K. Burkhardt, Anastasia N. Tikhonova, Iannis Aifantis, Ute Koch, Freddy Radtke, Burkhard Ludewig, Lena Tveriakhina, Achim Gossler, Christian W. Siebel, Daniela Gomez Atria, Sanjiv Luther, David Allman, Ivan Maillard
Journal: Blood
Blood (2023) 142 (Supplement 1): 2549.
https://doi.org/10.1182/blood-2023-186941
Published: 2023
Journal Articles

Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice

Vedran Radojcic, Katelyn Paz, Jooho Chung, Jing Du, Eric T. Perkey, Ryan Flynn, Sanja Ivcevic, Michael Zaiken, Ann Friedman, Minhong Yan, Maria A. Pletneva, Stefanie Sarantopoulos, Christian W. Siebel, Bruce R. Blazar, Ivan Maillard
Journal: Blood
Blood (2018) 132 (20): 2188–2200.
https://doi.org/10.1182/blood-2018-03-841155
Published: 2018
Includes: Supplemental data
Journal Articles

An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD

Jonathan C. Poe, Wei Jia, Hsuan Su, Sarah Anand, Jeremy J. Rose, Prasanthi V. Tata, Amy N. Suthers, Corbin D. Jones, Pei Fen Kuan, Benjamin G. Vincent, Jonathan S. Serody, Mitchell E. Horwitz, Vincent T. Ho, Steven Z. Pavletic, Frances T. Hakim, Kouros Owzar, Dadong Zhang, Bruce R. Blazar, Christian W. Siebel, Nelson J. Chao, Ivan Maillard, Stefanie Sarantopoulos
Journal: Blood
Blood (2017) 130 (19): 2131–2145.
https://doi.org/10.1182/blood-2017-05-782466
Published: 2017
Includes: Supplemental data
Journal Articles

Notch Signaling Mediated By Dll1/4 Notch Ligands Controls the Pathogenesis of Both Multi-Organ System Non-Sclerodermatous and Sclerodermatous Chronic Graft-Versus-Host Disease

Vedran Radojcic, MD, Ryan P Flynn, PhD, Jooho Chung, BS, Jing Du, Eric Perkey, BS, Katelyn Paz, Michael Zaiken, Ann Friedman, Minhong Yan, PhD, Christian W. Siebel, PhD, Bruce R. Blazar, MD, Ivan Maillard, MD PhD
Journal: Blood
Blood (2016) 128 (22): 805.
https://doi.org/10.1182/blood.V128.22.805.805
Published: 2016
Journal Articles

All- Trans Retinoic Acid (ATRA) Targets IRF4 Deficient, NOTCH2-Activated B Cells from Chronic Gvhd Patients

Jonathan C. Poe, PhD, Wei Jia, MD, Hsuan Su, MS, Zhiguo Li, PhD, Frances T. Hakim, PhD, Steven Z. Pavletic, MD, Jeremy J. Rose, MS, David A Rizzieri, MD, Yiping Yang, MD PhD, Benny J. Chen, MD, Sarah Anand, MD, Jerome Ritz, MD, Christian W. Siebel, PhD, Nelson J. Chao, MD, Ivan Maillard, MD PhD, Stefanie Sarantopoulos, MD PhD
Journal: Blood
Blood (2016) 128 (22): 669.
https://doi.org/10.1182/blood.V128.22.669.669
Published: 2016
Journal Articles

Targeting the Human Notch 2-BCR Axis: A Driver of B-Cell Hyper-Responsiveness in Active Chronic Graft-Versus Host Disease (cGVHD)

Jonathan C. Poe, PhD, Wei Jia, MD, Zhiguo Li, PhD, Frances T. Hakim, PhD, Steven Z. Pavletic, MD, Jeremy J. Rose, BA, David A. Rizzieri, MD, Yiping Yang, MD PhD, Benny J. Chen, MD, Michael Green, MD, Sarah Anand, MD, Christian W. Siebel, PhD, Ivan Maillard, MD PhD, Nelson J. Chao, MD, Stefanie Sarantopoulos, MD PhD
Journal: Blood
Blood (2015) 126 (23): 145.
https://doi.org/10.1182/blood.V126.23.145.145
Published: 2015
Journal Articles

Delta-like Ligands Expressed By Stromal Cells in Secondary Lymphoid Organs Deliver an Early Pulse of Notch Signaling and Drive T Cell Pathogenicity in Acute Graft-Versus-Host Disease

Jooho Chung, BS, Christen L. Ebens, MDMPH, Vedran Radojcic, MD, Ute Koch, PhD, Ann Friedman, BS, Ivy T. Tran, BS, Qian Chai, PhD, Lucas Onder, PhD, Minhong Yan, PhD, Pavan Reddy, MD, Bruce R. Blazar, MD, Burkhard Ludewig, PhD, Christian W. Siebel, PhD, Freddy Radtke, PhD, Ivan Maillard, MD PhD
Journal: Blood
Blood (2014) 124 (21): 841.
https://doi.org/10.1182/blood.V124.21.841.841
Published: 2014
Journal Articles

Loss of Notch Receptor-Ligand Engagement Leads to Increased Hematopoietic Stem and Progenitor Cell Egress and Mobilization

Lan Zhou, MD PhD, Weihuan Wang, MD PhD, Grant Zimmerman, Jay Myers, MS, Yuanshuai Huang, MD PhD, Vionnie W.C. Yu, PhD, Dan Huang, MD PhD, Shuiliang Yu, PhD, Yiwei Wang, MD PhD, Xiaoran Huang, MD, Jeongsup Shim, PhD, Minhong Yan, PhD, John Lowe, MD, Wei Xin, MD PhD, Pamela Stanley, PhD BSc, David T. Scadden, MD, Alex Y Huang, MD PhD, Christian W. Siebel, PhD
Journal: Blood
Blood (2014) 124 (21): 652.
https://doi.org/10.1182/blood.V124.21.652.652
Published: 2014
Journal Articles

Delta-Like Notch Ligands Expressed By Host Non-Hematopoietic Radioresistant Cells Regulate Graft-Versus-Host Disease and Extrathymic T Cell Development After Bone Marrow Transplantation

Christen L Ebens, MD, MPH, Jooho Chung, BS, Ute Koch, PhD, Ivy T Tran, BS, Ashley R Sandy-Sloat, PhD, Ann Friedman, BS, Bruce R Blazar, MD, Pavan Reddy, MD, Minhong Yan, PhD, Christian W Siebel, PhD, Freddy Radtke, PhD, Ivan Maillard, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2003.
https://doi.org/10.1182/blood.V122.21.2003.2003
Published: 2013
Journal Articles

In Vivo Blockade of Individual Notch Ligands and Receptors Provides a New Targeted Therapeutic Approach In Graft-Versus-Host Disease

Ivy T Tran, BS, Ashley R Sandy, BS, Alexis Carulli, BS, Gloria T Shan, BS, Vedran Radojcic, MD, Ann Friedman, BS, Amy Shelton, Linda C Samuelson, PhD, Minhong Yan, PhD, Christian W Siebel, PhD, Ivan Maillard, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 819.
https://doi.org/10.1182/blood.V118.21.819.819
Published: 2011
Journal Articles

The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development

Kyle Niessen, Gu Zhang, John Brady Ridgway, Hao Chen, Ganesh Kolumam, Christian W. Siebel, Minhong Yan
Journal: Blood
Blood (2011) 118 (7): 1989–1997.
https://doi.org/10.1182/blood-2010-11-319129
Published: 2011
Includes: Supplemental data