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Journal Articles

Effects of Alvelestat, an Oral Neutrophil Elastase Inhibitor, on Elevated Elastase and Collagen Turnover Biomarkers in Patients with Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation

Annie Im, Jacqueline Parkin, Noa G. Holtzman, William Moore, Lauren M. Curtis, Cody Peer, William D. Figg, Sr., Jeremy J. Rose, Laura Parsons-Wandell, Frances T. Hakim, Steven Z. Pavletic

Blood (2021) 138 (Supplement 1): 1815.

https://doi.org/10.1182/blood-2021-151324

Published: 2021

Journal Articles

A randomized phase 2 trial of pomalidomide in subjects failing prior therapy for chronic graft-versus-host disease

Blood (2021) 137 (7): 896–907.

https://doi.org/10.1182/blood.2020006892

Published: 2021

Includes: Supplemental data

Journal Articles

Phase 1 Study of Alvelestat, an Oral Neutrophil Elastase Inhibitor, in Patients with Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation

Annie Im, MD, Noa G. Holtzman, MD, Lauren M. Curtis, MD, Laura Parsons-Wandell, RN, Jeannette Nashed, BSN MSN CRNP, Cody Peer, PhD, William D. Figg, PhD, Amisha Barochia, MBBS, MHS, Jeremy J. Rose, MS, Frances T. Hakim, PhD, Steven Z. Pavletic, MD MS

Blood (2020) 136 (Supplement 1): 18–19.

https://doi.org/10.1182/blood-2020-140481

Published: 2020

Journal Articles

Efficacy and Safety of Baricitinib in Refractory Chronic Graft-Versus-Host Disease (cGVHD): Preliminary Analysis Results of a Phase 1/2 Study

Noa G. Holtzman, MD, Annie Im, MD, Alen Ostojic, MD, Lauren M. Curtis, MD, Laura Parsons-Wandell, RN, Jeannette Nashed, BSN MSN CRNP, Cody Peer, PhD, William D. Figg, Sr., PharmD, M. Teresa Magone, MD, Edward W Cowen, MD, Jacqueline W Mays, DDS, PhD, Frances T. Hakim, PhD, Jeremy J. Rose, MS, Marie C Pouzelles, PhD, Naomi Taylor, MD PhD, Steven Z. Pavletic, MD MS

Blood (2020) 136 (Supplement 1): 1.

https://doi.org/10.1182/blood-2020-140392

Published: 2020

Journal Articles

Single-Cell RNA-Seq Identifies Potentially Pathogenic B Cell Populations That Uniquely Circulate in Patients with Chronic Gvhd

Jonathan C Poe, PhD, Dadong Zhang, PhD, Jichun Xie, PhD, Rachel A. DiCioccio, BS, Xiaodi Qin, MS, Jiyuan Fang, MS, Vincent T. Ho, MD, Jeremy J. Rose, MS, Steven Z. Pavletic, MD MS, Frances T. Hakim, PhD, Wei Jia, MD PhD, Amy N. Suthers, PhD, Mitchell E. Horwitz, MD, David A. Rizzieri, MD, William C. McManigle, MD, Nelson J. Chao, MD, Kouros Owzar, PhD, Stefanie Sarantopoulos, MD PhD

Blood (2019) 134 (Supplement_1): 874.

https://doi.org/10.1182/blood-2019-130928

Published: 2019

Journal Articles

Clinical Characterization and Cytokine Profile of Fatigue in Patients with Chronic Gvhd

Sencer Goklemez, MD, Saligan Leorey, PhD, Filip Pirsl, Seth M. Steinberg, PhD, Sandra A Mitchell, PhD, Frances T. Hakim, PhD, Jeremy J. Rose, MS, Zhigang Kang, MD, Yunkai Yu, Liang Cao, Annie Im, MD, Steven Z. Pavletic, MD MS

Blood (2019) 134 (Supplement_1): 3282.

https://doi.org/10.1182/blood-2019-124055

Published: 2019

Journal Articles

T Cells Expressing an Anti-B-Cell Maturation Antigen (BCMA) Chimeric Antigen Receptor with a Fully-Human Heavy-Chain-Only Antigen Recognition Domain Induce Remissions in Patients with Relapsed Multiple Myeloma

Lekha Mikkilineni, MD, Elisabet E. Manasanch, MD, Norris Lam, BS, Danielle Vanasse, BS, Jennifer N. Brudno, MD, Irina Maric, MD MSci, Jeremy J. Rose, MS, Maryalice Stetler-Stevenson, MD PhD, Hao-Wei Wang, MD PhD, Constance M. Yuan, MD PhD, David F. Stroncek, MD, Jennifer Mann, CRNP, Micaela Ganadan, BSN, RN, Rashmika Patel, Nathan Trinklein, PhD, Ben Buelow, MD PhD, Ronald E. Gress, MD, James N. Kochenderfer, MD

Blood (2019) 134 (Supplement_1): 3230.

https://doi.org/10.1182/blood-2019-129088

Published: 2019

Journal Articles

Low Levels of Neurologic Toxicity with Retained Anti-Lymphoma Activity in a Phase I Clinical Trial of T Cells Expressing a Novel Anti-CD19 CAR

Jennifer Brudno, MD, Steven Hartman, Norris Lam, BS, David F. Stroncek, John M. Rossi, MS, Yueh-wei Shen, Allen Xue, PhD, Adrian Bot, MD PhD, Jennifer A Kanakry, MD, Steven Z. Pavletic, MD, Lekha Mikkilineni, MD, Mark Roschewski, MD, Robert M. Dean, MD, Jeremy J. Rose, MS, Rashmika Patel, Brenna Hansen, Steve A. Rosenberg, Ronald E. Gress, MD, James N. Kochenderfer, MD

Blood (2018) 132 (Supplement 1): 697.

https://doi.org/10.1182/blood-2018-99-113731

Published: 2018

Journal Articles

Increased TLR7 Signaling of BCR-Activated B Cells in Chronic Graft-Versus Host Disease (cGVHD)

Amy N. Suthers, PhD, Hsuan Su, MS, Sarah M. Anand, MD, Jonathan C Poe, PhD, Jeremy J. Rose, MS, Frances T. Hakim, PhD, Steven Z. Pavletic, MD, David A. Rizzieri, MD, Mitchell E. Horwitz, MD, Yiping Yang, MD PhD, Nelson J. Chao, MDM.B.A, Stefanie Sarantopoulos, MD PhD

Blood (2017) 130 (Supplement 1): 75.

https://doi.org/10.1182/blood.V130.Suppl_1.75.75

Published: 2017

Journal Articles

An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD

Blood (2017) 130 (19): 2131–2145.

https://doi.org/10.1182/blood-2017-05-782466

Published: 2017

Includes: Supplemental data

Journal Articles

All- Trans Retinoic Acid (ATRA) Targets IRF4 Deficient, NOTCH2-Activated B Cells from Chronic Gvhd Patients

Jonathan C. Poe, PhD, Wei Jia, MD, Hsuan Su, MS, Zhiguo Li, PhD, Frances T. Hakim, PhD, Steven Z. Pavletic, MD, Jeremy J. Rose, MS, David A Rizzieri, MD, Yiping Yang, MD PhD, Benny J. Chen, MD, Sarah Anand, MD, Jerome Ritz, MD, Christian W. Siebel, PhD, Nelson J. Chao, MD, Ivan Maillard, MD PhD, Stefanie Sarantopoulos, MD PhD

Blood (2016) 128 (22): 669.

https://doi.org/10.1182/blood.V128.22.669.669

Published: 2016

Journal Articles

T Cells Expressing a Novel Fully-Human Anti-CD19 Chimeric Antigen Receptor Induce Remissions of Advanced Lymphoma in a First-in-Humans Clinical Trial

Jennifer N. Brudno, MD, Victoria Shi, David Stroncek, MD, Stefania Pittaluga, MD PhD, Jennifer A. Kanakry, MD, Lauren M. Curtis, MD, Juan C. Gea-Banacloche, MD, Steven Pavletic, MD, Mohammad-Hadi Bagheri, MD, Jeremy J. Rose, MS, Rashmika Patel, Brenna Hansen, Ronald E. Gress, MD, James N. Kochenderfer, MD

Blood (2016) 128 (22): 999.

https://doi.org/10.1182/blood.V128.22.999.999

Published: 2016

Journal Articles

Final Results of a Randomized Phase 2 Trial Evaluating Lower-Dose Versus Higher-Dose Pomalidomide as Therapy for Corticosteroid-Refractory Chronic Gvhd

Lauren M. Curtis, MD, David Venzon, PhD, Fran T. Hakim, PhD, Edward W. Cowen, MD MHSc, Jennifer Hsu, RN, Licia Masuch, Jacqueline W. Mays, DDS, MHSc, PhD, Sandra A. Mitchell, CRNP, PhD AOCN, Filip Pirsl, Iskra Pusic, MD, Jeremy J. Rose, MS, Zoya J. Kuzmina, MD PhD, Kristin Baird, MD, Robert Peter Gale, Daniel H. Fowler, MD, Ronald E. Gress, MD, Steven Z. Pavletic, MD

Blood (2016) 128 (22): 507.

https://doi.org/10.1182/blood.V128.22.507.507

Published: 2016

Journal Articles

A Randomized Phase 2 Placebo Controlled Trial of Clobetasol Rinse for Treatment of Oral Chronic Graft-Versus-Host Disease

Jacqueline W. Mays, DDS, MHSc, PhD, Lauren M. Curtis, MD, Carol Bassim, DMD, MS, Seth M. Steinberg, PhD, David Venzon, PhD, Jeremy J. Rose, MS, Monica Cho, Christopher G. Kanakry, MD, Fahd Yazdanie, Daniele Avila, NP, Kristin Baird, MD, Jennifer Hsu, RN, Licia Masuch, George Grimes, RPh, Judith Starling, RPh, Daniel H. Fowler, MD, Ronald E. Gress, MD, Fran T. Hakim, PhD, Steven Z. Pavletic, MD

Blood (2016) 128 (22): 826.

https://doi.org/10.1182/blood.V128.22.826.826

Published: 2016

Journal Articles

T cells expressing an anti–B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma

Syed Abbas Ali, Victoria Shi, Irina Maric, Michael Wang, David F. Stroncek, Jeremy J. Rose, Jennifer N. Brudno, Maryalice Stetler-Stevenson, Steven A. Feldman, Brenna G. Hansen, Vicki S. Fellowes, Frances T. Hakim, Ronald E. Gress, James N. Kochenderfer

Blood (2016) 128 (13): 1688–1700.

https://doi.org/10.1182/blood-2016-04-711903

Published: 2016

Includes: Supplemental data

Journal Articles

Pilot Study of Radiation-Targeted Donor Lymphocyte Infusion for Cancer Progression after Allogeneic Hematopoietic Stem Cell Transplantation

Nancy M. Hardy, MD, Deborah Citrin, MD, Frances T. Hakim, PhD, Daniele N. Avila, CRNP, Bazetta Blacklock-Schuver, RN, Stephanie Cotton, RN, Monica Cho, Daniel H. Fowler, MD, Juan C. Gea-Banacloche, MD, Noa G. Holtzman, MD, Karen A. Kurdziel, MD, Sarfraz Memon, MD, Steven Z. Pavletic, MD, Stefania Pittaluga, MD PhD, Jeremy J. Rose, BA, Claude Sportes, MD, Jennifer S. Wilder, RN, Ronald E. Gress, MD, Michael R. Bishop, MD

Blood (2015) 126 (23): 1962.

https://doi.org/10.1182/blood.V126.23.1962.1962

Published: 2015

Journal Articles

Remissions of Multiple Myeloma during a First-in-Humans Clinical Trial of T Cells Expressing an Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor

Syed Abbas Ali, MD, Victoria Shi, Michael Wang, MD, David Stroncek, MD, Irina Maric, Jennifer N Brudno, MD, Maryalice Stetler-Stevenson, Jeremy J. Rose, BA, Steven Feldman, Brenna Hansen, Frances T. Hakim, PhD, Ronald E. Gress, MD, James N. Kochenderfer, MD

Blood (2015) 126 (23): LBA-1.

https://doi.org/10.1182/blood.V126.23.LBA-1.LBA-1

Published: 2015

Journal Articles

Allogeneic T-Cells Expressing an Anti-CD19 Chimeric Antigen Receptor Cause Remissions of B-Cell Malignancies after Allogeneic Hematopoietic Stem Cell Transplantation without Causing Graft-Versus-Host Disease

Blood (2015) 126 (23): 99.

https://doi.org/10.1182/blood.V126.23.99.99

Published: 2015

Journal Articles

Upregulation of Interferon-Inducible and Damage Response Receptors in Chronic Graft-Versus-Host Disease

Frances T. Hakim, PhD, Sarfraz Memon, MD, Ping Jin, PhD, Matin M. Imanguli, DDS, MD, Najibah Rehman, MD, Xiao-Yi Yan, MS, Jeremy J. Rose, BA, Jacqueline W. Mays, DDS, PhD, Susan Dhamala, BA, Veena Kapoor, William Telford, PhD, David C. Halverson, MD, Kristin Baird, MD, Daniel H. Fowler, MD, David Stroncek, MD, Edward W. Cowen, MD MHSc, Steven Z. Pavletic, MD, Ronald E. Gress, MD

Blood (2015) 126 (23): 922.

https://doi.org/10.1182/blood.V126.23.922.922

Published: 2015

Journal Articles

Targeting the Human Notch 2-BCR Axis: A Driver of B-Cell Hyper-Responsiveness in Active Chronic Graft-Versus Host Disease (cGVHD)

Jonathan C. Poe, PhD, Wei Jia, MD, Zhiguo Li, PhD, Frances T. Hakim, PhD, Steven Z. Pavletic, MD, Jeremy J. Rose, BA, David A. Rizzieri, MD, Yiping Yang, MD PhD, Benny J. Chen, MD, Michael Green, MD, Sarah Anand, MD, Christian W. Siebel, PhD, Ivan Maillard, MD PhD, Nelson J. Chao, MD, Stefanie Sarantopoulos, MD PhD

Blood (2015) 126 (23): 145.

https://doi.org/10.1182/blood.V126.23.145.145

Published: 2015

NARROW

Effects of Alvelestat, an Oral Neutrophil Elastase Inhibitor, on Elevated Elastase and Collagen Turnover Biomarkers in Patients with Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation

A randomized phase 2 trial of pomalidomide in subjects failing prior therapy for chronic graft-versus-host disease

Phase 1 Study of Alvelestat, an Oral Neutrophil Elastase Inhibitor, in Patients with Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation

Efficacy and Safety of Baricitinib in Refractory Chronic Graft-Versus-Host Disease (cGVHD): Preliminary Analysis Results of a Phase 1/2 Study

Single-Cell RNA-Seq Identifies Potentially Pathogenic B Cell Populations That Uniquely Circulate in Patients with Chronic Gvhd

Clinical Characterization and Cytokine Profile of Fatigue in Patients with Chronic Gvhd

T Cells Expressing an Anti-B-Cell Maturation Antigen (BCMA) Chimeric Antigen Receptor with a Fully-Human Heavy-Chain-Only Antigen Recognition Domain Induce Remissions in Patients with Relapsed Multiple Myeloma

Low Levels of Neurologic Toxicity with Retained Anti-Lymphoma Activity in a Phase I Clinical Trial of T Cells Expressing a Novel Anti-CD19 CAR

Increased TLR7 Signaling of BCR-Activated B Cells in Chronic Graft-Versus Host Disease (cGVHD)

An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD

All- Trans Retinoic Acid (ATRA) Targets IRF4 Deficient, NOTCH2-Activated B Cells from Chronic Gvhd Patients

T Cells Expressing a Novel Fully-Human Anti-CD19 Chimeric Antigen Receptor Induce Remissions of Advanced Lymphoma in a First-in-Humans Clinical Trial

Final Results of a Randomized Phase 2 Trial Evaluating Lower-Dose Versus Higher-Dose Pomalidomide as Therapy for Corticosteroid-Refractory Chronic Gvhd

A Randomized Phase 2 Placebo Controlled Trial of Clobetasol Rinse for Treatment of Oral Chronic Graft-Versus-Host Disease

T cells expressing an anti–B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma

Pilot Study of Radiation-Targeted Donor Lymphocyte Infusion for Cancer Progression after Allogeneic Hematopoietic Stem Cell Transplantation

Remissions of Multiple Myeloma during a First-in-Humans Clinical Trial of T Cells Expressing an Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor

Allogeneic T-Cells Expressing an Anti-CD19 Chimeric Antigen Receptor Cause Remissions of B-Cell Malignancies after Allogeneic Hematopoietic Stem Cell Transplantation without Causing Graft-Versus-Host Disease

Upregulation of Interferon-Inducible and Damage Response Receptors in Chronic Graft-Versus-Host Disease

Targeting the Human Notch 2-BCR Axis: A Driver of B-Cell Hyper-Responsiveness in Active Chronic Graft-Versus Host Disease (cGVHD)

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American Society of Hematology

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American Society of Hematology

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