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Journal Articles

Stroma-Driven Notch2 Signaling Controls Naïve B Cell Fate By Regulating Microenvironmental Positioning within the Spleen

Blood (2023) 142 (Supplement 1): 2549.

https://doi.org/10.1182/blood-2023-186941

Published: 2023

Journal Articles

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL

Mateusz Antoszewski, Nadine Fournier, Gustavo A. Ruiz Buendía, Joao Lourenco, Yuanlong Liu, Tara Sugrue, Christelle Dubey, Marianne Nkosi, Colin E.J. Pritchard, Ivo J. Huijbers, Gabriela C. Segat, Sandra Alonso-Moreno, Elisabeth Serracanta, Laura Belver, Adolfo A. Ferrando, Giovanni Ciriello, Andrew P. Weng, Ute Koch, Freddy Radtke

Blood (2022) 139 (16): 2483–2498.

https://doi.org/10.1182/blood.2021012077

Published: 2022

Includes: Supplemental data

Journal Articles

Notch signaling promotes disease initiation and progression in murine chronic lymphocytic leukemia

Delphine Tardivon, Mateusz Antoszewski, Nadine Zangger, Marianne Nkosi, Jessica Sordet-Dessimoz, Rudi Hendriks, Ute Koch, Freddy Radtke

Blood (2021) 137 (22): 3079–3092.

https://doi.org/10.1182/blood.2020006701

Published: 2021

Includes: Supplemental data

Journal Articles

Donor T Cells Require Notch Signals but Not Alloantigen Presentation from Specialized Secondary Lymphoid Organ Fibroblasts to Drive Graft-Versus-Host Disease

Eric Perkey, BS, Léolène Carrington, PhD, Jooho Chung, MDPhD, David Granadier, BS, Alexander Dils, Ann Friedman, BS, Anastasia Tikhonova, PhD, Bruce R. Blazar, MD, Ute Koch, PhD, Nathalie Labrecque, PhD, Freddy Radtke, PhD, Chris Siebel, PhD BA, Iannis Aifantis, PhD, Ivan Maillard, MD PhD

Blood (2018) 132 (Supplement 1): 810.

https://doi.org/10.1182/blood-2018-99-110258

Published: 2018

Journal Articles

Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21–mediated tumor suppressor Pdcd4 repression

Fabian Junker, Antoine Chabloz, Ute Koch, Freddy Radtke

Blood (2015) 126 (8): 993–1004.

https://doi.org/10.1182/blood-2014-12-618892

Published: 2015

Includes: Supplemental data

Journal Articles

Delta-like Ligands Expressed By Stromal Cells in Secondary Lymphoid Organs Deliver an Early Pulse of Notch Signaling and Drive T Cell Pathogenicity in Acute Graft-Versus-Host Disease

Jooho Chung, BS, Christen L. Ebens, MDMPH, Vedran Radojcic, MD, Ute Koch, PhD, Ann Friedman, BS, Ivy T. Tran, BS, Qian Chai, PhD, Lucas Onder, PhD, Minhong Yan, PhD, Pavan Reddy, MD, Bruce R. Blazar, MD, Burkhard Ludewig, PhD, Christian W. Siebel, PhD, Freddy Radtke, PhD, Ivan Maillard, MD PhD

Blood (2014) 124 (21): 841.

https://doi.org/10.1182/blood.V124.21.841.841

Published: 2014

Journal Articles

Delta-Like Notch Ligands Expressed By Host Non-Hematopoietic Radioresistant Cells Regulate Graft-Versus-Host Disease and Extrathymic T Cell Development After Bone Marrow Transplantation

Christen L Ebens, MD, MPH, Jooho Chung, BS, Ute Koch, PhD, Ivy T Tran, BS, Ashley R Sandy-Sloat, PhD, Ann Friedman, BS, Bruce R Blazar, MD, Pavan Reddy, MD, Minhong Yan, PhD, Christian W Siebel, PhD, Freddy Radtke, PhD, Ivan Maillard, MD, PhD

Blood (2013) 122 (21): 2003.

https://doi.org/10.1182/blood.V122.21.2003.2003

Published: 2013

Journal Articles

Notch1 regulates angio-supportive bone marrow–derived cells in mice: relevance to chemoresistance

Jeanine M. L. Roodhart, Huanhuan He, Laura G. M. Daenen, Arnaud Monvoisin, Chad L. Barber, Miranda van Amersfoort, Jennifer J. Hofmann, Freddy Radtke, Timothy F. Lane, Emile E. Voest, M. Luisa Iruela-Arispe

Blood (2013) 122 (1): 143–153.

https://doi.org/10.1182/blood-2012-11-459347

Published: 2013

Includes: Supplemental data

Journal Articles

LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance

Sung-Uk Lee, Manami Maeda, Yuichi Ishikawa, Sierra Min Li, Anne Wilson, Adrian M. Jubb, Nagisa Sakurai, Lihong Weng, Emma Fiorini, Freddy Radtke, Minhong Yan, H. Robson MacDonald, Ching-Cheng Chen, Takahiro Maeda

Blood (2013) 121 (6): 918–929.

https://doi.org/10.1182/blood-2012-03-418103

Published: 2013

Includes: Supplemental data

Journal Articles

LRF Maintains HSC Homeostasis by Preventing Lymphoid-Primed LT-HSCs From Excessive Differentiation

Sung-Uk Lee, PhD, Manami Maeda, MD, PhD, Anne E. Wilson, Min Li, PhD, Yuichi Ishikawa, MD, PhD, Adrian M. Judd, PhD, Nagisa Sakurai, PhD, Emma Fiorini, PhD, Freddy Radtke, PhD, Minhong Yan, PhD, Hugh Robson Macdonald, PhD, Ching-Cheng Chen, Takahiro Maeda, MD, PhD

Blood (2011) 118 (21): 44.

https://doi.org/10.1182/blood.V118.21.44.44

Published: 2011

Journal Articles

Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL

Robin Jeannet, Jérôme Mastio, Alejandra Macias-Garcia, Attila Oravecz, Todd Ashworth, Anne-Solen Geimer Le Lay, Bernard Jost, Stéphanie Le Gras, Jacques Ghysdael, Thomas Gridley, Tasuku Honjo, Freddy Radtke, Jon C. Aster, Susan Chan, Philippe Kastner

Blood (2010) 116 (25): 5443–5454.

https://doi.org/10.1182/blood-2010-05-286658

Published: 2010

Includes: Supplemental data

Journal Articles

Notch Repression by LRF Is Necessary for the Maintenance of Adult Hematopoietic Stem Cell Pool.

Sung-UK Lee, PhD, Min Li, PhD, Manami Maeda, Nagisa Sakurai, Yuichi Ishikawa, MD, PhD, Freddy Radtke, Minhong Yan, Hugh Robson Macdonald, Takahiro Maeda, MD, PhD

Blood (2010) 116 (21): 2633.

https://doi.org/10.1182/blood.V116.21.2633.2633

Published: 2010

Journal Articles

LRF Is Indispensable for Hematopoietic Stem Cell Function Via Blocking Notch1-Mediated T Cell-Instructive Signals in the Bone Marrow Niche.

Sung-UK Lee, Manami Maeda, Nagisa Sakurai, Freddy Radtke, Takahiro Maeda

Blood (2009) 114 (22): 81.

https://doi.org/10.1182/blood.V114.22.81.81

Published: 2009

Journal Articles

LRF Regulates Self-Renewal of Hematopoietic Stem Cells by Blocking Notch1-Mediated T Cell Differentiation

Sung-UK Lee, PhD, Manami Maeda, MD, PhD, Nagisa Sakurai, PhD, Julie Teruya-Feldstein, MD, Freddy Radtke, PhD, Takahiro Maeda, MD, PhD

Blood (2008) 112 (11): 75.

https://doi.org/10.1182/blood.V112.11.75.75

Published: 2008

Journal Articles

Simultaneous loss of β- and γ-catenin does not perturb hematopoiesis or lymphopoiesis

Ute Koch, Anne Wilson, Monica Cobas, Rolf Kemler, H. Robson MacDonald, Freddy Radtke

Blood (2008) 111 (1): 160–164.

https://doi.org/10.1182/blood-2007-07-099754

Published: 2008

Includes: Supplemental data

Journal Articles

Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation

Stéphane J. C. Mancini, Ned Mantei, Alexis Dumortier, Ueli Suter, H. Robson MacDonald, Freddy Radtke

Blood (2005) 105 (6): 2340–2342.

https://doi.org/10.1182/blood-2004-08-3207

Published: 2005

Journal Articles

Mouse CD11c + B220 + Gr1 + plasmacytoid dendritic cells develop independently of the T-cell lineage

Isabel Ferrero, Werner Held, Anne Wilson, Fabienne Tacchini-Cottier, Freddy Radtke, H. Robson MacDonald

Blood (2002) 100 (8): 2852–2857.

https://doi.org/10.1182/blood-2002-01-0214

Published: 2002

NARROW

Stroma-Driven Notch2 Signaling Controls Naïve B Cell Fate By Regulating Microenvironmental Positioning within the Spleen

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL

Notch signaling promotes disease initiation and progression in murine chronic lymphocytic leukemia

Donor T Cells Require Notch Signals but Not Alloantigen Presentation from Specialized Secondary Lymphoid Organ Fibroblasts to Drive Graft-Versus-Host Disease

Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21–mediated tumor suppressor Pdcd4 repression

Delta-like Ligands Expressed By Stromal Cells in Secondary Lymphoid Organs Deliver an Early Pulse of Notch Signaling and Drive T Cell Pathogenicity in Acute Graft-Versus-Host Disease

Delta-Like Notch Ligands Expressed By Host Non-Hematopoietic Radioresistant Cells Regulate Graft-Versus-Host Disease and Extrathymic T Cell Development After Bone Marrow Transplantation

Notch1 regulates angio-supportive bone marrow–derived cells in mice: relevance to chemoresistance

LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance

LRF Maintains HSC Homeostasis by Preventing Lymphoid-Primed LT-HSCs From Excessive Differentiation

Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL

Notch Repression by LRF Is Necessary for the Maintenance of Adult Hematopoietic Stem Cell Pool.

LRF Is Indispensable for Hematopoietic Stem Cell Function Via Blocking Notch1-Mediated T Cell-Instructive Signals in the Bone Marrow Niche.

LRF Regulates Self-Renewal of Hematopoietic Stem Cells by Blocking Notch1-Mediated T Cell Differentiation

Simultaneous loss of β- and γ-catenin does not perturb hematopoiesis or lymphopoiesis

Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation

Mouse CD11c + B220 + Gr1 + plasmacytoid dendritic cells develop independently of the T-cell lineage

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American Society of Hematology

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American Society of Hematology

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