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Journal Articles

Novel, potent, and orally bioavailable LSD1 inhibitors induce fetal hemoglobin synthesis in a sickle cell disease mouse model

Yu Wang, Lei Yu, Kaiwen Deng, Mathivanan Packiarajan, Angelo Aguilar, Sojin An, Greggory Myers, Hoon Oh, Sharon A. Singh, Uhn-soo Cho, Shaomeng Wang, Yuanfang Guan, Andrew White, Rami Khoriaty, James Douglas Engel

Blood blood.2024028006.

https://doi.org/10.1182/blood.2024028006

Published: 2025

Includes: Supplemental data

Journal Articles

TR4 and BCL11A repress γ-globin transcription via independent mechanisms

Yu Wang, Greggory Myers, Lei Yu, Kaiwen Deng, Ginette Balbin-Cuesta, Sharon A. Singh, Yuanfang Guan, Rami Khoriaty, James Douglas Engel

Blood (2024) 144 (26): 2762–2772.

https://doi.org/10.1182/blood.2024024599

Published: 2024

Includes: Supplemental data

Journal Articles

The LSD1 Inhibitor RN1 Rescues Congenital Dyserythropoietic Anemia Type II

Lei Yu, Yu Wang, Richard King, Greggory Myers, Beth McGee, Ann Friedman, Ginette Balbin-Cuesta, Zesen Lin, Claire Drysdale, Xiaofang Liu, Claire Kerpet, Kaiwen Deng, Aaron Robida, James Engel, Rami Khoriaty

Blood (2024) 144 (Supplement 1): 938.

https://doi.org/10.1182/blood-2024-201649

Published: 2024

Journal Articles

The Saga Complex Member TADA2B Is a Novel Regulator of γ-Globin Production

Claire Drysdale, Rami Khoriaty, Greggory Myers

Blood (2024) 144 (Supplement 1): 170.

https://doi.org/10.1182/blood-2024-206049

Published: 2024

Journal Articles

Disruption of the Malate-Aspartate Shuttle Leads to Anemia

Narges Pourmandi, Greggory Myers, Kelsey Temprine, Amanda Sankar, Costas Lyssiotis, Yatrik Shah, Rami Khoriaty, James Engel

Blood (2024) 144 (Supplement 1): 5245.

https://doi.org/10.1182/blood-2024-212276

Published: 2024

Journal Articles

Identifying Novel Regulators of γ-Globin Expression Using a Genome-Scale CRISPR Activation Screen

Ginette Balbin-Cuesta, Greggory Myers, Zesen Lin, Claire Kerpet, Beth McGee, Katherine Rybkin, Richard King, Claire Drysdale, Ann Friedman, Lei Yu, Masaki Ito, Rilie Saba, Ayse Bilge Ozel, Rami Khoriaty

Blood (2023) 142 (Supplement 1): 1100.

https://doi.org/10.1182/blood-2023-182203

Published: 2023

Journal Articles

Identification of CNOT4 As a Positive Regulator of Erythroid Cell Growth Using a Genome Wide CRISPR Knock-out Screen

Claire Drysdale, Greggory Myers, Lei Yu, Ann Friedman, Claire Kerpet, Ginette Balbin-Cuesta, Zesen Lin, Ayse Bilge Ozel, James Engel, Rami Khoriaty

Blood (2023) 142 (Supplement 1): 2447.

https://doi.org/10.1182/blood-2023-182187

Published: 2023

Journal Articles

Disruption of the Malate-Aspartate Shuttle Leads to Anemia

Narges Pourmandi, Greggory Myers, Kelsey Temprine, Amanda Sankar, Noah Nelson, Yatrik Shah, Costas Lyssiotis, James Engel, Rami Khoriaty

Blood (2023) 142 (Supplement 1): 3823.

https://doi.org/10.1182/blood-2023-188220

Published: 2023

Journal Articles

Direct and Indirect Functions of TR4 in the Control of Fetal Hemoglobin Silencing

Yu Wang, Lei Yu, Greggory Myers, Sharon A Singh, James Engel

Blood (2023) 142 (Supplement 1): 555.

https://doi.org/10.1182/blood-2023-181113

Published: 2023

Journal Articles

Whole-Genome CRISPR-Cas9 Screening Identifies Genes Required for Human and Mouse Erythroid Development

Greggory Myers, Ann Friedman, Lei Yu, Claire Kerpet, Masaki Ito, Rilie Saba, Ginette Balbin-Cuesta, Zesen Lin, Claire Drysdale, Ayse Bilge Ozel, James Engel, Rami Khoriaty

Blood (2023) 142 (Supplement 1): 3828.

https://doi.org/10.1182/blood-2023-181929

Published: 2023

Journal Articles

Whole-Genome CRISPR-Cas9 Screen Identifies ZBTB7A As a Potential Therapeutic Target for Cda-II

Lei Yu, Greggory Myers, Beth McGee, Xiaofang Liu, Gallagher Patrick, Richard King, Ann Friedman, Ginette Balbin-Cuesta, Zesen Lin, Claire Drysdale, Claire Kerpet, Singh Sharon, James Engel, Rami Khoriaty

Blood (2023) 142 (Supplement 1): 12.

https://doi.org/10.1182/blood-2023-182246

Published: 2023

Journal Articles

A Genome Scale CRISPR Screen Identifies Novel Genes That Regulate Erythropoietin Production

Zesen Lin, Ginette Balbin-Cuesta, Greggory Myers, Lei Yu, Claire Drysdale, Vi Tang, Ayse Bilge Ozel, Ann Friedman, Beth McGee, Masaki Ito, Rilie Saba, Claire Kerpet, Richard King, Gallagher Patrick, James Engel, Rami Khoriaty

Blood (2023) 142 (Supplement 1): 3820.

https://doi.org/10.1182/blood-2023-182427

Published: 2023

Journal Articles

The CDK-Inhibitor p27 Kip1 Regulates Fetal Hemoglobin Expression

Ginette Balbin-Cuesta, Greggory Myers, Claire Kerpet, Beth McGee, Katherine Rybkin, Zesen Lin, Claire Drysdale, Ann Friedman, Sharon A Singh, Lei Yu, Ayse Bilge Ozel, Rami Khoriaty

Blood (2023) 142 (Supplement 1): 556.

https://doi.org/10.1182/blood-2023-181197

Published: 2023

Journal Articles

p53-Independent Pathways in Diamond Blackfan Anemia

Kaiwen Deng, Lei Yu, Susan Hammoud, Alejandra Sanchez-Martinez, Xiaofang Liu, Ghazi-Abullah Saroya, Greggory Myers, Yu Wang, Ginette Balbin-Cuesta, Yuanfang Guan, Vesa Kaartinen, Rami Khoriaty, James Douglas Engel, Sharon A Singh

Blood (2022) 140 (Supplement 1): 11474.

https://doi.org/10.1182/blood-2022-165705

Published: 2022

Journal Articles

Identifying Novel Regulators of Erythroid Maturation and Proliferation Using a Genome-Scale CRISPR Activation Screen

Ginette Balbin-Cuesta, Katherine Rybkin, Greggory Myers, Rami Khoriaty

Blood (2022) 140 (Supplement 1): 8170–8171.

https://doi.org/10.1182/blood-2022-170108

Published: 2022

Journal Articles

Identification of Novel Regulators of Erythropoiesis Using Whole-Genome CRISPR-Cas9 Screening

Greggory Myers, Lei Yu, Ginette Balbin-Cuesta, Ayse Bilge Ozel, James Douglas Engel, Rami Khoriaty

Blood (2022) 140 (Supplement 1): 8155–8156.

https://doi.org/10.1182/blood-2022-170101

Published: 2022

Journal Articles

An erythroid-to-myeloid cell fate conversion is elicited by LSD1 inactivation

Lei Yu, Greggory Myers, Chia-Jui Ku, Emily Schneider, Yu Wang, Sharon A. Singh, Natee Jearawiriyapaisarn, Andrew White, Takashi Moriguchi, Rami Khoriaty, Masayuki Yamamoto, Michael G. Rosenfeld, Julien Pedron, John H. Bushweller, Kim-Chew Lim, James Douglas Engel

Blood (2021) 138 (18): 1691–1704.

https://doi.org/10.1182/blood.2021011682

Published: 2021

Includes: Supplemental data

Journal Articles

A Genome Scale CRISPR Screen Identifies the ER Cargo Receptor That Facilitates the Efficient Secretion of Erythropoietin

Zesen Lin, B.S., Greggory Myers, Beth McGee, Richard King, MD, Vi Tang, B.S., Ann Friedman, B.S., Brian Emmer, MD, Rami Khoriaty

Blood (2019) 134 (Supplement_1): 340.

https://doi.org/10.1182/blood-2019-131208

Published: 2019

Journal Articles

Inhibition of LSD1 by small molecule inhibitors stimulates fetal hemoglobin synthesis

Cuong Quang Le, Greggory Myers, Alawi Habara, Natee Jearawiriyapaisarn, George J. Murphy, David H. K. Chui, Martin H. Steinberg, James Douglas Engel, Shuaiying Cui

Blood (2019) 133 (22): 2455–2459.

https://doi.org/10.1182/blood.2018892737

Published: 2019

Includes: Supplemental data

Journal Articles

LSD1 Inhibitors Induce Fetal Hemoglobin in Primary Human Erythroid Cells

Cuong LE, PhD, Greggory Myers, Alawi Habara, MBBS, MSc, David H.K. Chui, MD, Martin H. Steinberg, MD, James Douglas Engel, PhD, Shuaiying Cui, PhD

Blood (2018) 132 (Supplement 1): 1066.

https://doi.org/10.1182/blood-2018-99-117675

Published: 2018

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Novel, potent, and orally bioavailable LSD1 inhibitors induce fetal hemoglobin synthesis in a sickle cell disease mouse model

TR4 and BCL11A repress γ-globin transcription via independent mechanisms

The LSD1 Inhibitor RN1 Rescues Congenital Dyserythropoietic Anemia Type II

The Saga Complex Member TADA2B Is a Novel Regulator of γ-Globin Production

Disruption of the Malate-Aspartate Shuttle Leads to Anemia

Identifying Novel Regulators of γ-Globin Expression Using a Genome-Scale CRISPR Activation Screen

Identification of CNOT4 As a Positive Regulator of Erythroid Cell Growth Using a Genome Wide CRISPR Knock-out Screen

Disruption of the Malate-Aspartate Shuttle Leads to Anemia

Direct and Indirect Functions of TR4 in the Control of Fetal Hemoglobin Silencing

Whole-Genome CRISPR-Cas9 Screening Identifies Genes Required for Human and Mouse Erythroid Development

Whole-Genome CRISPR-Cas9 Screen Identifies ZBTB7A As a Potential Therapeutic Target for Cda-II

A Genome Scale CRISPR Screen Identifies Novel Genes That Regulate Erythropoietin Production

The CDK-Inhibitor p27 Kip1 Regulates Fetal Hemoglobin Expression

p53-Independent Pathways in Diamond Blackfan Anemia

Identifying Novel Regulators of Erythroid Maturation and Proliferation Using a Genome-Scale CRISPR Activation Screen

Identification of Novel Regulators of Erythropoiesis Using Whole-Genome CRISPR-Cas9 Screening

An erythroid-to-myeloid cell fate conversion is elicited by LSD1 inactivation

A Genome Scale CRISPR Screen Identifies the ER Cargo Receptor That Facilitates the Efficient Secretion of Erythropoietin

Inhibition of LSD1 by small molecule inhibitors stimulates fetal hemoglobin synthesis

LSD1 Inhibitors Induce Fetal Hemoglobin in Primary Human Erythroid Cells

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