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Keli L. Hippen
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Journal Articles

Repurposing a novel anti-cancer RXR agonist to attenuate murine acute GVHD and maintain graft-versus-leukemia responses

Govindarajan Thangavelu, Chao Wang, Michael Loschi, Asim Saha, Mark J. Osborn, Scott N. Furlan, Kazutoshi Aoyama, Cameron McDonald-Hyman, Ethan G. Aguilar, Amanda S. Janesick, Roshantha A. Chandraratna, Yosef Refaeli, Angela Panoskaltsis-Mortari, Kelli P. MacDonald, Geoffrey R. Hill, Robert Zeiser, Ivan Maillard, Jonathan S. Serody, William J. Murphy, David H. Munn, Bruce Blumberg, Chrysothemis Brown, Vijay Kuchroo, Leslie S. Kean, Keli L. Hippen, Randolph J. Noelle, Bruce R. Blazar
Journal: Blood
Blood (2021) 137 (8): 1090–1103.
https://doi.org/10.1182/blood.2020005628
Published: 2021
Includes: Supplemental data
Journal Articles

In Vitro Induction of Human Regulatory T-Cells (iTregs) Using Conditions of Low Tryptophan Plus Kynurenines

Keli L. Hippen, PhD, Margaret L. MacMillan, MD, Amanda Lemire, BS, Asim Saha, PhD, Eric Hanse, Colin Lord, Ameeta Kelekar, PhD, Roddy S. O'Connor, PhD, James L. Riley, PhD, Carl H June, MD, Leslie Kean, MD PhD, Jeffrey S. Miller, MD, John E. Wagner, MD, David H. Munn, MD, Bruce R. Blazar, MD
Journal: Blood
Blood (2016) 128 (22): 1229.
https://doi.org/10.1182/blood.V128.22.1229.1229
Published: 2016
Journal Articles

miR-146b antagomir–treated human Tregs acquire increased GVHD inhibitory potency

Yunjie Lu, Keli L. Hippen, Amanda L. Lemire, Jian Gu, Weizhi Wang, Xuhao Ni, Parvathi Ranganathan, Bruce L. Levine, James L. Riley, Carl H. June, Laurence A. Turka, David H. Munn, Ramiro Garzon, Ling Lu, Bruce R. Blazar
Journal: Blood
Blood (2016) 128 (10): 1424–1435.
https://doi.org/10.1182/blood-2016-05-714535
Published: 2016
Includes: Supplemental data
Journal Articles

Umbilical cord blood–derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect

Claudio G. Brunstein, Jeffrey S. Miller, David H. McKenna, Keli L. Hippen, Todd E. DeFor, Darin Sumstad, Julie Curtsinger, Michael R. Verneris, Margaret L. MacMillan, Bruce L. Levine, James L. Riley, Carl H. June, Chap Le, Daniel J. Weisdorf, Philip B. McGlave, Bruce R. Blazar, John E. Wagner
Journal: Blood
Blood (2016) 127 (8): 1044–1051.
https://doi.org/10.1182/blood-2015-06-653667
Published: 2016
Includes: Supplemental data
Journal Articles

Protein Kinase C-Theta Interacts with mTORC2 and Vimentin to Limit Regulatory T-Cell Function

Cameron McDonald-Hyman, BA, Govindarajan Thangavelu, PhD, James Muller, Guoan Zhang, PhD, Sudha Kumari, PhD, Asim Saha, PhD, Brent H. Koehn, PhD, Jason S. Mitchell, PhD, Brian T Fife, PhD, Jonathan S. Serody, MD, Mark J. Osborn, PhD, Keli L. Hippen, PhD, Ameeta Kelekar, PhD, David H. Munn, MD, Amnon Altman, PhD, Thomas A. Neubert, PhD, Michael L. Dustin, PhD, Bruce R. Blazar, MD
Journal: Blood
Blood (2015) 126 (23): 849.
https://doi.org/10.1182/blood.V126.23.849.849
Published: 2015
Journal Articles

Megatal, Crispr/Cas9, and Talen T-Cell Receptor Gene Editing

Mark J. Osborn, PhD, Beau R Webber, PhD, Friederike Knipping, Cara-lin Lonetree, Anthony DeFeo, Amber McElroy, Colby Starker, PhD, Richard Gabriel, Sarah Merkel, Keli L. Hippen, PhD, Daniel Voytas, PhD, Christof von Kalle, MD, Manfred Schmidt, PhD, Jeffrey S. Miller, MD, Jordan Jarjour, PhD, Alexander Astrakhan, PhD, Andrew M Scharenberg, MD, Jakub Tolar, MD, PhD, Bruce R. Blazar, MD
Journal: Blood
Blood (2015) 126 (23): 2045.
https://doi.org/10.1182/blood.V126.23.2045.2045
Published: 2015
Journal Articles

Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes

Keli L. Hippen, Christoph Bucher, Dawn K. Schirm, Amanda M. Bearl, Ty Brender, Kathy A. Mink, Kimberly S. Waggie, Regis Peffault de Latour, Anne Janin, Julie M. Curtsinger, Stacey R. Dillon, Jeffrey S. Miller, Gerard Socie, Bruce R. Blazar
Journal: Blood
Blood (2012) 119 (2): 619–628.
https://doi.org/10.1182/blood-2011-07-368027
Published: 2012
Includes: Supplemental data
Journal Articles

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

Clinical Trials & Observations
Claudio G. Brunstein, Jeffrey S. Miller, Qing Cao, David H. McKenna, Keli L. Hippen, Julie Curtsinger, Todd DeFor, Bruce L. Levine, Carl H. June, Pablo Rubinstein, Philip B. McGlave, Bruce R. Blazar, John E. Wagner
Journal: Blood
Blood (2011) 117 (3): 1061–1070.
https://doi.org/10.1182/blood-2010-07-293795
Published: 2011
Includes: Supplemental data
Journal Articles

Adoptive Transfer of Umbilical Cord Blood (UCB)-Derived Regulatory T Cells (Tregs) to Recipients of Nonmyeloablative Unrelated Double UCB Transplantation.

Claudio Brunstein, Keli L. Hippen, David H. McKenna, Qing Cao, Julie Curtsinger, Darin Sumstad, Bruce L. Levine, PhD, James L. Riley, Carl H. June, MD, Jeffrey S. Miller, Bruce R. Blazar, John E. Wagner
Journal: Blood
Blood (2009) 114 (22): 513.
https://doi.org/10.1182/blood.V114.22.513.513
Published: 2009
Journal Articles

Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells

Keli L. Hippen, Paul Harker-Murray, Stephen B. Porter, Sarah C. Merkel, Aryel Londer, Dawn K. Taylor, Megan Bina, Angela Panoskaltsis-Mortari, Pablo Rubinstein, Nico Van Rooijen, Tatiana N. Golovina, Megan M. Suhoski, Jeffrey S. Miller, John E. Wagner, Carl H. June, James L. Riley, Bruce R. Blazar
Journal: Blood
Blood (2008) 112 (7): 2847–2857.
https://doi.org/10.1182/blood-2008-01-132951
Published: 2008
Includes: Supplemental data