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Journal Articles

Prolonged cytopenias after BCMA CAR‑T are associated with impaired endogenous T cell recovery characterized by decreased CD8+ T cell diversity

Free
Abigail Chutnik, Zachary Avigan, Ramy Mahmoud, Alessandro Lagana, Matthew Croken, Meenakshi Mehrotra, Zahra Moinfar, Adriana Rossi, Shambavi Richard, Gurbakhash Kaur, Joshua Richter, Larysa Sanchez, Cesar Rodriguez Valdes, Hearn Cho, Sundar Jagannath, Mesude Bicak, Nina Bhardwaj, Jane Houldsworth, Santiago Thibaud, Samir Parekh
Journal: Blood
Blood (2025) 146 (Supplement 1): 2290.
https://doi.org/10.1182/blood-2025-2290
Published: 2025
Journal Articles

Utility and sensitivity of wett-SA53 to measure dysgeusia associated with talquetamab, a GPRC5D×CD3 bispecific antibody, in Relapsed/Refractory multiple myeloma: Preliminary data from the talisman study

Free
Rakesh Popat, Niels W.C.J. van de Donk, Beth Faiman, Junichiro Yuda, Kihyun Kim, Abel Costa, Alexa Laheij, Richard Doty, James Omel, Brea Lipe, Larysa Sanchez, Ajai Chari, Alexander Lin, Hervé Sroussi, Mariana Fernandez, Katy Gray, Gloria Aguilar, Kasey Bolyard, Jennifer Schultz, Keqin Qi, Diana Cortes-Selva, Jing Zhang, Christoph Heuck, Kelly Hawks, Ken Tian, Monique Franca, Leo Rasche
Journal: Blood
Blood (2025) 146 (Supplement 1): 5821.
https://doi.org/10.1182/blood-2025-5821
Published: 2025
Journal Articles

Spatially resolved transcriptomics reveals immunosuppressive niches and clonal diversity in extramedullary disease in multiple myeloma refractory to immunotherapy

Free
Junia Vieira, Reyka Jayasinghe, Tarek Mouhieddine, Jordan Lu, Hajer Merarda, Darwin D'Souza, Hyo Jeong Nam, Adolfo Aleman, Meghana Ram, Zhihong Chen, Seunghee Kim-Schulze, Gaurav Bhatt, Julie Fortier, Michael Slade, Alina Dulau Florea, Rachel Brody, Larysa Sanchez, Cesar Rodriguez Valdes, Joshua Richter, Shambavi Richard, Adriana Rossi, Sundar Jagannath, Ravi Vij, Li Ding, Samir Parekh, Alessandro Lagana
Journal: Blood
Blood (2025) 146 (Supplement 1): 3949.
https://doi.org/10.1182/blood-2025-3949
Published: 2025
Journal Articles

Updated efficacy and safety results of JNJ-5322, a novel, next-generation BCMA×GPRC5D×CD3 trispecific antibody, in patients with Relapsed/Refractory multiple myeloma

Free
Amrita Krishnan, Martin Kaiser, Rakesh Popat, Jeffrey Matous, Alfred Garfall, Gala Vega, Aurore Perrot, Sébastien Anguille, Albert Oriol, Nicolas Kint, Jo Caers, Saad Usmani, Lionel Karlin, Larysa Sanchez, Cindy Varga, Wilfried Roeloffzen, Laura Rosiñol Dachs, Darren Pan, Paula Rodriguez-Otero, María-Victoria Mateos, Tadao Ishida, Kentaro Fukushima, Pansy Minnick, M. Damiette Smit, Nikki Daskalakis, Thomas Prior, Deeksha Vishwamitra, Emily DeSantis, Ashley Nguyen, Brandi Hilder, Joseph Weidman, Caroline Hodin, Daniel Jonathan, Sangmin Lee, Cyrille Touzeau, Hans Lee, Niels W.C.J. Van De Donk, Monique Minnema
Journal: Blood
Blood (2025) 146 (Supplement 1): 4042.
https://doi.org/10.1182/blood-2025-4042
Published: 2025
Journal Articles

S100A8/A9 drives T cell exhaustion and compromises the therapeutic efficacy of bispecific antibodies in multiple myeloma.

Free
Adolfo Aleman, Oliver Van Oekelen, Shriya Desai, Sidorela Reci, Leah Grossman, Rudra Prasad Dutta, Mathieu Desaunay, Junia Vieira, Rongbao Zhao, Rahul Sanawar, Mani Mohindru, Tarek Mouhieddine, Alessandro Lagana, Marta Larrayoz, Poulikos Poulikakos, Gurbakhash Kaur, Larysa Sanchez, Cesar Rodriguez Valdes, Santiago Thibaud, Adriana Rossi, Shambavi Richard, Joshua Richter, Hearn Cho, Jose A. Martinez-Climent, Amit Verma, Sundar Jagannath, Samir Parekh
Journal: Blood
Blood (2025) 146 (Supplement 1): 916.
https://doi.org/10.1182/blood-2025-916
Published: 2025
Journal Articles

Development of predictive relapse indicators for myeloma T cell engagers (PRIME) model for myeloma patients receiving BCMA- and GPRC5D-targeting T cell engagers

Free
Tarek Mouhieddine, Tianxiang Sheng, Junia Vieira, Adolfo Aleman, Zachary Avigan, Ariel Siegel, Mujahid Quidwai, Jordan Lu, Mohammad Rattu, Santiago Thibaud, Gurbakhash Kaur, Shambavi Richard, Adriana Rossi, Hearn Cho, Alessandro Lagana, Samantha Stclair, Dalia Abdel Azim, Larysa Sanchez, Joshua Richter, Cesar Rodriguez Valdes, Christian Salib, Erin Moshier, Samir Parekh, Sundar Jagannath
Journal: Blood
Blood (2025) 146 (Supplement 1): 3996.
https://doi.org/10.1182/blood-2025-3996
Published: 2025
Journal Articles

Combined PD-1 and Tim-3 Blockade Improves the in Vitro Anti-Myeloma Activity of T Cells of Patients on Talquetamab

Free
Tarek H. Mouhieddine, Junia Vieira, Adolfo Aleman, Leah Grossman, David Melnekoff, Bhaskar Upadhyaya, Samantha St. Clair, Monica Garcia-Barros, Meghana Ram, Santiago Thibaud, Adriana Rossi, Shambavi Richard, Cesar Rodriguez, Joshua Richter, Hearn Jay Cho, Larysa Sanchez, Sundar Jagannath, Ajai Chari, Rachel Brody, Christian Salib, Alessandro Lagana, Samir Parekh
Journal: Blood
Blood (2024) 144 (Supplement 1): 357.
https://doi.org/10.1182/blood-2024-204929
Published: 2024
Journal Articles

Clinical Outcomes in Black Patients with Relapsed/Refractory Multiple Myeloma Following Talquetamab Treatment: Analyses from the Phase 1/2 Monumental-1 Study

Free
Carolina Schinke, Gareth Morgan, Luciano J. Costa, Natalie Callander, Don A. Stevens, Jesus G Berdeja, Brea Lipe, Sagar Lonial, Marie-Christiane Vekemans, Ravi Vij, Philippe Moreau, Paula Rodríguez-Otero, Anna Sureda Balari, Thomas Renaud, Jaszianne Tolbert, Bonnie W Lau, Brandi W Hilder, Tara J Masterson, Michela Campagna, Veronique Vreys, Christoph Heuck, Colleen Kane, Kathleen S Gray, Deeksha Vishwamitra, Indrajeet Singh, Joy Gong, Xiang Qin, Larysa Sanchez
Journal: Blood
Blood (2024) 144 (Supplement 1): 3357.
https://doi.org/10.1182/blood-2024-199797
Published: 2024
Journal Articles

Clinical Outcomes of Subsequent Therapies in Patients with Relapsed/Refractory Multiple Myeloma Following Talquetamab Treatment: Analyses from the Phase 1/2 MonumenTAL-1 Study

Free
Larysa Sanchez, Carolina Schinke, Amrita Krishnan, Jésus G Berdeja, Niels WCJ van de Donk, María Victoria Mateos, Ajai Chari, Samir Parekh, Tarek H. Mouhieddine, Sundar Jagannath, Nizar J Bahlis, Cyrille Touzeau, Albert Oriol, Jesus San-Miguel, Paula Rodriguez Otero, Monique C Minnema, Michela Campagna, Tara J Masterson, Brandi W Hilder, Jaszianne Tolbert, Thomas Renaud, Kathleen Gray, Damiette Smit, Christoph Heuck, Leo Rasche
Journal: Blood
Blood (2023) 142 (Supplement 1): 2007.
https://doi.org/10.1182/blood-2023-182330
Published: 2023
Journal Articles

Early and Consistent CRS Detection Using Wearable Device for Remote Patient Monitoring Following CAR-T Therapy in Relapsed/Refractory Multiple Myeloma (RRMM): Early Results of an Investigator-Initiated Trial

Free
Sridevi Rajeeve, Nicole Zahradka, Matt Wilkes, Darren Pan, Nicholas J Calafat, Kseniya Serebryakova, Katerina Kappes, Hayley Jackson, Nicole Buchenholz, Sarita Agte, Santiago Thibaud, Larysa Sanchez, Shambavi Richard, Joshua Richter, Cesar Rodriguez, Hearn Jay Cho, Ajai Chari, Sundar Jagannath, Adriana C Rossi, Samir Parekh
Journal: Blood
Blood (2023) 142 (Supplement 1): 1007.
https://doi.org/10.1182/blood-2023-181936
Published: 2023
Journal Articles

Timing of Vaccination Impacts Serological Response to COVID-19 Myeloma Patients after BCMA-Targeted CAR T

Free
Oliver Van Oekelen, Morgan Van Kesteren, Adolfo Aleman, Ariel Kogan Zajdman, Lucia Y Chen, Tarek H. Mouhieddine, Bhaskar Upadhyaya, Kseniya Serebryakova, Katerina Kappes, Sarita Agte, Annika Oostenink, Hayley Jackson, Charles Gleason, Komal Srivastava, Santiago Thibaud, Larysa Sanchez, Cesar Rodriguez, Joshua Richter, Hearn Jay Cho, Adriana C Rossi, Shambavi Richard, Carlos Cordon-Cardo, Ania Wajnberg, Florian Krammer, Sundar Jagannath, Viviana Simon, Samir Parekh
Journal: Blood
Blood (2023) 142 (Supplement 1): 3350.
https://doi.org/10.1182/blood-2023-184409
Published: 2023
Journal Articles

Multimodal Single-Cell Transcriptomic and Proteomic Correlatives of Patients Outcomes Following Anti-BCMA Cellular Therapy with Ciltacabtagene Autoleucel (Cilta-cel) in Relapsed Multiple Myeloma

Free
Junia Vieira dos Santos, David Melnekoff, Adolfo Aleman, Sherry Bhalla, Tarek H. Mouhieddine, Oliver Van Oekelen, Sridevi Rajeeve, Bhaskar Upadhyaya, Yogita Ghodke-Puranik, Violetta Leshchenko, Adeeb Rahman, Shaked Afik, Hadas Lewinsky, Santiago Thibaud, Hearn Jay Cho, Joshua Richter, Cesar Rodriguez, Larysa Sanchez, Adriana C Rossi, Shambavi Richard, Ajai Chari, Sundar Jagannath, Samir Parekh, Alessandro Lagana
Journal: Blood
Blood (2023) 142 (Supplement 1): 93.
https://doi.org/10.1182/blood-2023-186395
Published: 2023
Journal Articles

Immune Dynamics Associated with Patient Outcomes Identified By Multimodal Single-Cell Analysis in Multiple Myeloma Patients Receiving Talquetamab Monotherapy

Free
Tarek H. Mouhieddine, Junia Vieira dos Santos, Yogita Ghodke-Puranik, Adolfo Aleman, David Melnekoff, Bhaskar Upadhyaya, Adeeb Rahman, Shaked Afik, Hadas Lewinsky, Santiago Thibaud, Adriana C Rossi, Shambavi Richard, Cesar Rodriguez, Joshua Richter, Hearn Jay Cho, Larysa Sanchez, Sundar Jagannath, Ajai Chari, Alessandro Lagana, Samir Parekh
Journal: Blood
Blood (2023) 142 (Supplement 1): 1927.
https://doi.org/10.1182/blood-2023-185308
Published: 2023
Journal Articles

Interventions and outcomes of patients with multiple myeloma receiving salvage therapy after BCMA-directed CAR T therapy

Free
Clinical Trials & Observations
Oliver Van Oekelen, Karthik Nath, Tarek H. Mouhieddine, Tasmin Farzana, Adolfo Aleman, David T. Melnekoff, Yogita Ghodke-Puranik, Gunjan L. Shah, Alexander Lesokhin, Sergio Giralt, Santiago Thibaud, Adriana Rossi, Cesar Rodriguez, Larysa Sanchez, Joshua Richter, Shambavi Richard, Hearn J. Cho, Ajai Chari, Saad Z. Usmani, Sundar Jagannath, Urvi A. Shah, Sham Mailankody, Samir Parekh
Journal: Blood
Blood (2023) 141 (7): 756–765.
https://doi.org/10.1182/blood.2022017848
Published: 2023
Includes: Supplemental data
Journal Articles

Comparative Effectiveness of Lenalidomide/Dexamethasone-Based Triplet Regimens for Treatment of Relapsed and/or Refractory Multiple Myeloma in Subgroups Defined By Cytogenetic Risk

Free
Larysa Sanchez, Mu Cheng, Dasha Cherepanov, Maral DerSarkissian, Dawn Marie Stull, Fei Huang, Annalise Hilts, Justin Chun, Mei Sheng Duh, Sikander Ailawadhi
Journal: Blood
Blood (2022) 140 (Supplement 1): 4308–4309.
https://doi.org/10.1182/blood-2022-156320
Published: 2022
Journal Articles

Extramedullary Relapse Post CAR-T

Free
Shambavi Richard, Guido Lancman, Adriana Rossi, Ajai Chari, Samir Parekh, Larysa Sanchez, Cesar Rodriguez, Hearn J. Cho, Joshua Richter, Santiago Thibaud, Kiah Purcell, Elizabeth Aronson, Daniel Verina, Juliet Escalon, Karen Louw, Sundar Jagannath
Journal: Blood
Blood (2022) 140 (Supplement 1): 4301–4302.
https://doi.org/10.1182/blood-2022-170119
Published: 2022
Journal Articles

Gain of chr1q Portends Poor Outcomes in Multiple Myeloma Patients Treated with Venetoclax

Free
Alessandro Lagana, Santiago Thibaud, David T. Melnekoff, Paula Restrepo, Violetta Leshchenko, Jonathan McCafferty, Scott Newman, Abbi Kern, David Corrigan, Feras Hantash, Adriana Rossi, Cesar Rodriguez, Larysa Sanchez, Shambavi Richard, Ajai Chari, Hearn J. Cho, Sundar Jagannath, Joshua Richter, Samir Parekh
Journal: Blood
Blood (2022) 140 (Supplement 1): 4388–4390.
https://doi.org/10.1182/blood-2022-166572
Published: 2022
Journal Articles

Immune Recovery Post BCMA CAR-T: Implications for Infection Prophylaxis and Vaccinations

Free
Shambavi Richard, Guido Lancman, Santiago Thibaud, Ajai Chari, Samir Parekh, Adriana Rossi, Hearn J. Cho, Larysa Sanchez, Joshua Richter, Cesar Rodriguez, Elizabeth Aronson, Karen Louw, Kiah Purcell, Daniel Verina, Juliet Escalon, Sundar Jagannath
Journal: Blood
Blood (2022) 140 (Supplement 1): 7444–7446.
https://doi.org/10.1182/blood-2022-170404
Published: 2022
Journal Articles

Comprehensive Characterization of Prolonged Unexplained Cytopenias in Relapsed/Refractory Multiple Myeloma Patients Following BCMA-Directed CAR-T Cell Therapy

Free
Santiago Thibaud, Md. Babu Mia, Oliver Van Oekelen, Tarek H. Mouhieddine, Christoph Schaniel, Yogita Ghodke-Puranik, Adolfo Aleman, Bhaskar Upadhyaya, Guido Lancman, Alessandro Lagana, Shambavi Richard, Adriana Rossi, Ajai Chari, Larysa Sanchez, Cesar Rodriguez, Hearn J. Cho, Joshua Richter, Ronald Hoffman, Sundar Jagannath, Samir Parekh
Journal: Blood
Blood (2022) 140 (Supplement 1): 614–616.
https://doi.org/10.1182/blood-2022-165646
Published: 2022
Journal Articles

Infections and Severe Hypogammaglobulinemia in Multiple Myeloma Patients Treated with Anti-BCMA Bispecific Antibodies

Free
Guido Lancman, Kian Parsa, Cesar Rodriguez, Joshua Richter, Hearn J. Cho, Samir Parekh, Shambavi Richard, Adriana Rossi, Larysa Sanchez, Santiago Thibaud, Sundar Jagannath, Ajai Chari
Journal: Blood
Blood (2022) 140 (Supplement 1): 10073–10074.
https://doi.org/10.1182/blood-2022-163733
Published: 2022