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Research Article September 4 2025

Acalabrutinib treatment for older (≥80 years old) and/or frail patients with CLL: primary end point analysis of the CLL-Frail trial

Florian Simon,Rudy Ligtvoet,Jan-Paul Bohn,Thomas Nösslinger,Julia von Tresckow,Rüdiger Liersch,Tobias Gaska,Kathleen Jentsch-Ulrich,Michael Gärtner,Thomas Wolff,Ingo Schwaner,Dominik Wolf,Christof Schneider,Ursula Vehling-Kaiser,Matthias Ritgen,Christian Spoer,Michael J. Eckart,Thomas Decker,Geothy Chakupurakal,Björn Schöttker,Jens Kisro,Karl-Anton Kreuzer,Eugen Tausch,Stephan Stilgenbauer,Sandra Robrecht,Janina Stumpf,Anna Fink,Moritz Fürstenau,Kirsten Fischer,Valentin Goede,Michael J Hallek,Barbara F. Eichhorst

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Review Article September 4 2025

Platelet heterogeneity in disease: the many and the diverse?

Rainer Kaiser,Afra Anjum,Leo Nicolai

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Research Article September 3 2025

Off-the-shelf dual CAR-iNKT cell immunotherapy eradicates medullary and leptomeningeal high-risk KMT2A-rearranged leukemia

Hongwei Ren,Natalina Elliott,Bryan Lye,Mohammad Umer Sharif Shohan,Joe Wilson Cross,Lucy May Field,Kanagaraju Ponnusamy,Siobhan Rice,Thomas Jackson,Ilia Leontari,Nouhad El Ouazzani,Rebecca Thomas,Sarah Inglott,Jack Bartram,Owen Smith, Professor,Jonathan Bond,Irene Roberts,Christina Halsey,Rachael Bashford-Rogers,Thomas A Milne,Anindita Roy,Anastasios Karadimitris

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Research Article August 27 2025

CD371-Targeted CAR T cells Secreting Interleukin-18 Exhibit Robust Expansion and Clear Refractory Acute Myeloid Leukemia

Mark B. Geyer,Susan DeWolf,Xiaoli Mi,Kenyon Weis,Brian C. Shaffer,Briana Cadzin,Devin McAvoy,Zoe A Katsamakis,Rachel Lorenc,Alexander M Lewis,Brianna Gipson,M. Adriana Cuibus,Narina N. Girotra,Kenton Wu,Natalie Smith,Erin R. Burns,Jasmine S. Um,Sarah Yoo,Behzad Kharabi Masouleh,Pallavi K. Galera,Kinga Hosszu,Jagrutiben Chaudhari,Xiuyan Wang,Qianqian Lin,Kevin J. Curran,Jae H Park,David A Scheinberg,Marcel R.M. van den Brink,Omar Abdel-Wahab,Renier J. Brentjens,Anthony F. Daniyan

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Research Article August 27 2025

An immunostimulatory CELMoD combination overcomes resistance to T-cell engagers caused by a high multiple myeloma burden

Erin W Meermeier,Kirsten Pfeffer,Caleb K Stein,Meaghen Sharik,Megan Tien Du,Yuliza Tafoya Alvarado,Chang-Xin Shi,Yuan Xiao Zhu,Peter Leif Bergsagel,Marta Chesi

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Review Article August 26 2025

Platelet Heterogeneity: Variety Makes Immune and Vascular Function Better

Michael Malloy,Kathleen E McGrath,Craig N Morrell

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Research Article August 26 2025

Chronic NK cell activation results in a dysfunctional, tissue resident-like state mediated by KLF2 deficiency

Jacob Myers,Rih-Sheng Huang,Shee Kwan Phung,Jeremy M. Chacón,Laura E Bendzick,Anna Jo Weis,Mihir Shetty,Taylor DePauw,Melissa J Khaw,Juan E Abrahante Llorens,Stephen D O'Flanagan,K Maude Ashby,John R Lozada,Stephen C. Jameson,Justin H Hwang,Frank Cichocki,Martin Felices,Jeffrey S. Miller

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Review Article August 26 2025

Novel Strategies Targeting Mutant Calreticulin in Essential Thrombocythemia and Myelofibrosis

Gabriel S Salzman,Ann Mullally

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Research Article August 26 2025

LEF1 Intragenic Deletion Induces a Dominant-Negative isoform and unveils a Wnt/β3-Catenin Vulnerability in T-ALL

Manon Delafoy,Mickaël Frédéric Bonnet,Etienne Lengliné,Agata Cieslak,Aurore Touzart,Estelle Balducci,Mathieu Simonin,Véronique Lheritier,Marie-Emilie Dourthe,Benoit Heid-Picard,Sylvain Latour,Hervé Dombret,Philippe Rousselot,André Baruchel,Nicolas Boissel,Guillaume P. Andrieu,Vahid Asnafi

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Research Article August 20 2025

Factor VIIa-released extracellular vesicles attenuate joint bleed-induced hemophilic arthropathy

Padmavathi Kavadipula,Shiva Keshava,Kaushik Das,Jhansi Magisetty,Christian DeJong,Josthna Penchalaneni,Usha Pendurthi,L. Vijaya Mohan Rao

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Research Article August 19 2025

Layilin inhibits integrin activation, and its loss results in platelet hyperactivation via Rac1 in inflammatory bowel disease

Rebecca A Mellema,Kimberly A Queisser,Abigail Ajanel,Nansy Albtoush,Lydia Smith,Matt Rondina,Julie Will,John F Valentine,Aaron C. Petrey

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Review Article August 4 2025

How I Manage Chronic Myeloid Leukemia During Pregnancy

Elisabetta Abruzzese,Ekaterina Chelysheva

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Review Article July 15 2025

The Treatment of Marginal Zone Lymphoma

Juan Pablo Alderuccio,Ariela Noy

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Research Article July 10 2025

Boosting CAR T-Cell Efficacy by Blocking Proteasomal Degradation of Membrane Antigens

Leonie Rieger,Kilian Irlinger,Franziska Füchsl,Marlene Tietje,Anna Purcarea,Nicolas Mathis Barbian,Melanie Faber,Carolin Vogelsang,Lisa Pfeuffer,Sonja Stotz,Oleksandra Karpiuk,Tobias Schulze,Abirami Augsburger,Nadine Glaisner,Verena Konetzki,Sabrina Friedel,Andrej Besse,Lenka Besse,Christoph Driessen,Maike Buchner,Kristina Schwamborn,Katja Steiger,Piero Giansanti,Sebastian Theurich,Johannes M. Waldschmidt,Klaus Martin Kortüm,Michael Hudecek,Hermann Einsele,Marion Högner,Bernhard Kuster,Angela Krackhardt,Judith S. Hecker,Florian Bassermann

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Review Article May 15 2025

How I Evaluate and Treat Resistance and Relapse in CML

Simona Soverini,Fausto Castagnetti

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Review Article May 12 2025

How I approach hematopoietic stem cell transplantation for CML in a TKI world

Yves Chalandon,Federico Simonetta,Stavroula Masouridi-Levrat

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Review Article April 16 2025

How I individualize treatment for chronic-phase CML

Ariel Monet Leyte-Vidal,Neil P. Shah

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Review Article March 25 2025

How I treat chronic myeloid leukemia in children and adolescents

Jing Chen,Meinolf Suttorp,Nobuko Hijiya

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Acalabrutinib treatment for older (≥80 years old) and/or frail patients with CLL: primary end point analysis of the CLL-Frail trial

Platelet heterogeneity in disease: the many and the diverse?

Off-the-shelf dual CAR-iNKT cell immunotherapy eradicates medullary and leptomeningeal high-risk KMT2A-rearranged leukemia

CD371-Targeted CAR T cells Secreting Interleukin-18 Exhibit Robust Expansion and Clear Refractory Acute Myeloid Leukemia

An immunostimulatory CELMoD combination overcomes resistance to T-cell engagers caused by a high multiple myeloma burden

Platelet Heterogeneity: Variety Makes Immune and Vascular Function Better

Chronic NK cell activation results in a dysfunctional, tissue resident-like state mediated by KLF2 deficiency

Novel Strategies Targeting Mutant Calreticulin in Essential Thrombocythemia and Myelofibrosis

LEF1 Intragenic Deletion Induces a Dominant-Negative isoform and unveils a Wnt/β3-Catenin Vulnerability in T-ALL

Factor VIIa-released extracellular vesicles attenuate joint bleed-induced hemophilic arthropathy

Layilin inhibits integrin activation, and its loss results in platelet hyperactivation via Rac1 in inflammatory bowel disease

How I Manage Chronic Myeloid Leukemia During Pregnancy

The Treatment of Marginal Zone Lymphoma

Boosting CAR T-Cell Efficacy by Blocking Proteasomal Degradation of Membrane Antigens

How I Evaluate and Treat Resistance and Relapse in CML

How I approach hematopoietic stem cell transplantation for CML in a TKI world

How I individualize treatment for chronic-phase CML

How I treat chronic myeloid leukemia in children and adolescents

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American Society of Hematology

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