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Research Article August 26 2025

LEF1 Intragenic Deletion Induces a Dominant-Negative isoform and unveils a Wnt/β3-Catenin Vulnerability in T-ALL

Manon Delafoy,Mickaël Frédéric Bonnet,Etienne Lengliné,Agata Cieslak,Aurore Touzart,Estelle Balducci,Mathieu Simonin,Véronique Lheritier,Marie-Emilie Dourthe,Benoit Heid-Picard,Sylvain Latour,Hervé Dombret,Philippe Rousselot,André Baruchel,Nicolas Boissel,Guillaume P. Andrieu,Vahid Asnafi

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Research Article August 20 2025

Factor VIIa-released extracellular vesicles attenuate joint bleed-induced hemophilic arthropathy

Padmavathi Kavadipula,Shiva Keshava,Kaushik Das,Jhansi Magisetty,Christian DeJong,Josthna Penchalaneni,Usha Pendurthi,L. Vijaya Mohan Rao

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Research Article August 19 2025

Layilin inhibits integrin activation, and its loss results in platelet hyperactivation via Rac1 in inflammatory bowel disease

Rebecca A Mellema,Kimberly A Queisser,Abigail Ajanel,Nansy Albtoush,Lydia Smith,Matt Rondina,Julie Will,John F Valentine,Aaron C. Petrey

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Research Article August 19 2025

A T-cell-based metric of immune age predicts outcomes in older patients with myeloma receiving daratumumab-based therapy

Wassilis S.C. Bruins,Febe Smits,Carolien Duetz,Kaz Groen,Charlotte L.B.M. Korst,A. Vera de Jonge, dr.,Christie P.M. Verkleij,Rosa Rentenaar,Meliha Cosovic,Merve Eken,Inoka Twickler,Paola M. Homan-Weert,Pieter Sonneveld,Philippe Moreau,Jürgen Claesen,Niels W.C.J. van de Donk,Sonja Zweegman,Tuna Mutis

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Research Article August 19 2025

A phase 2 study of zanubrutinib in combination with rituximab and lenalidomide in de novo diffuse large B-cell lymphoma

Pengpeng Xu,YUE ZHU,Zi-Yang Shi,Li Wang,Shu Cheng,Ying Qian,Yan Zhao,Yang He,Hongmei Yi,Binshen Ouyang,Xu-Feng Jiang,Biao Li,Qi Song,Rong-Ji Mu,Weili Zhao

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Research Article August 19 2025

Proteomic subtypes enrich current acute myeloid leukemia nomenclature and reflect intrinsic pathogenesis alongside aging

Wenyan Cheng,Xiao Yi,Zhenyi Wang,Jian-Feng Li,Jun-Yi Zhang,Rui-Hong Zhang,Qian-Qian Zhang,Xiangqin Weng,Ting Huang,Yong-Mei Zhu,Chao Wang,Wei Yin,Jia-Nan Zhang,Hui-Yi Wu,Jun-Min Li,Hongming Zhu,Li Chen,Wen-Fang Wang,Yuting Dai,Chen-Xu Gao,Xuan Liu,Shan Wang,Shengyue Wang,Bo Jiao,Zhu Chen,Hai Fang,Tong Yin,Yang Shen,Sai-Juan Chen

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Research Article August 14 2025

Pooled CAR-T screening in nonhuman primates identifies designs with enhanced proliferation, trafficking, and persistence

Lucy H. Maynard,Eric J Cavanaugh,Haiying Zhu,Carly E Starke,Sarah M Doherty,Teresa K Einhaus,Ailyn C. Pérez-Osorio,Laurence Stensland,Cameron Blair,Aoife M Roche,John K. Everett,Robert D Murnane,Michelle E Hoffman,Veronica Nelson,Sarah Althea Herrin,Chad Littlewood,Kaycee Camou,Erica Wilson,Christopher Wessel,Frederic Bushman,Keith R Jerome,Hans-Peter Kiem,Christopher William Peterson

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Research Article August 14 2025

Cryo-EM structure of the tissue factor/factor VIIa complex with a factor X mimetic reveals a novel allosteric mechanism

Josepha C Sedzro,Amanda L. Photenhauer,Fabienne Birkle,Katarina Meze,Alex Mortenson,Cade Duckworth,Po-Chao Wen,Sarah Kearns,Michael A. Cianfrocco,Emad Tajkhorshid,Melanie D. Ohi,James H. Morrissey

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Research Article August 14 2025

Improved diagnostic screening and classification of clonal mast cell diseases by ultrasensitive KIT p.D816V detection

Paula Navarro-Navarro,María González-Tablas,Alba Pérez-Pons,Laura Sánchez-Muñoz,Ana Henriques,Iván Álvarez-Twose,Paula Nafria,David Araco-Sánchez,Cristina Morales-Cabeza,Horacio Caligaris,Lei Chen,David González-de-Olano,Óscar González-López,Luis Escribano Mora,Andrés C. García-Montero,María Jara-Acevedo,Alberto Orfao

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Review Article August 4 2025

How I Manage Chronic Myeloid Leukemia During Pregnancy

Elisabetta Abruzzese,Ekaterina Chelysheva

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Research Article August 1 2025

Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues, ameliorating GVHD post-HSCT

Duneia McManus,Sabrina N Copsel,Brent J Pfeiffer,Dietlinde Wolf,Henry Barreras,Symon Ma,Ali Khodor,Seitaro Komai,Marina Burgos da Silva,Hajar Hazime,Miguel Gallardo,Sarah Grace R Lime,Marcel R.M. van den Brink,Jung-Hyun Park,Maria T Abreu,Geoffrey R Hill,Victor L Perez,Robert B Levy

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Research Article July 25 2025

Donor-derived CD7 CAR T cells for pediatric and adult relapsed/refractory T-ALL/LBL: a phase 2 trial

Jing Pan,Liping Zhao,Yibing Zhang,Samuel Seery,Yue Tan,Biping Deng,Lingling Shan,Zhuojun Ling,Fan Wu,Quangang Wang,Xinjian Yu,Qinlong Zheng,Xiuwen Xu,Ying Yuan,Zhenglong Tian,Yanlei Zhang,Shuixiu Peng,Alex H. H. Chang,Xiaoming Feng

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Research Article July 23 2025

TCA cycle mode switch determines the fate of pirtobrutinib-tolerant persister cells in mantle cell lymphoma

Wei Wang,Qingsong Cai,Yang Liu,Lei Nie,Heng-Huan Lee,Fangfang Yan,Yue Fei,Yixin Yao,Yijing Li,Lin Tan,Philip L Lorenzi,Ying-Nai Wang,Jun Yao,Zhihong Chen,Joseph McIntosh,Cheng-tai Yu,Preetesh Jain,Vivian Jiang,Jovanny Vargas,Xiaolin Li,Tianci Zhang,Shaoying Li,David Santos,Selvi Thirumurthi,Erin Heather Seeley,Lukas Mikolaj Simon,Christopher R. Flowers,Chi Young Ok,Michael L Wang

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Review Article July 15 2025

The Treatment of Marginal Zone Lymphoma

Juan Pablo Alderuccio,Ariela Noy

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Research Article July 10 2025

Boosting CAR T-Cell Efficacy by Blocking Proteasomal Degradation of Membrane Antigens

Leonie Rieger,Kilian Irlinger,Franziska Füchsl,Marlene Tietje,Anna Purcarea,Nicolas Mathis Barbian,Melanie Faber,Carolin Vogelsang,Lisa Pfeuffer,Sonja Stotz,Oleksandra Karpiuk,Tobias Schulze,Abirami Augsburger,Nadine Glaisner,Verena Konetzki,Sabrina Friedel,Andrej Besse,Lenka Besse,Christoph Driessen,Maike Buchner,Kristina Schwamborn,Katja Steiger,Piero Giansanti,Sebastian Theurich,Johannes M. Waldschmidt,Klaus Martin Kortüm,Michael Hudecek,Hermann Einsele,Marion Högner,Bernhard Kuster,Angela Krackhardt,Judith S. Hecker,Florian Bassermann

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Research Article July 3 2025

Restoring p53 wild-type conformation in TP53-Y220C-mutant acute myeloid leukemia

Bing Z Carter,Po Yee Mak,Edward Ayoub,Xiaogang Wu,Baozhen Ke,Yuki Nishida,Andrew Futreal,Lauren B Ostermann,Andrea D Bedoy,Steffen Boettcher,Courtney D. DiNardo,Anna Puzio-Kuter,Masha V Poyurovsky,Arnold J. Levine,Michael Andreeff

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Review Article May 15 2025

How I Evaluate and Treat Resistance and Relapse in CML

Simona Soverini,Fausto Castagnetti

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Review Article May 12 2025

How I approach hematopoietic stem cell transplantation for CML in a TKI world

Yves Chalandon,Federico Simonetta,Stavroula Masouridi-Levrat

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Review Article April 16 2025

How I individualize treatment for chronic-phase CML

Ariel Monet Leyte-Vidal,Neil P. Shah

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Review Article March 25 2025

How I treat chronic myeloid leukemia in children and adolescents

Jing Chen,Meinolf Suttorp,Nobuko Hijiya

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First Edition

LEF1 Intragenic Deletion Induces a Dominant-Negative isoform and unveils a Wnt/β3-Catenin Vulnerability in T-ALL

Factor VIIa-released extracellular vesicles attenuate joint bleed-induced hemophilic arthropathy

Layilin inhibits integrin activation, and its loss results in platelet hyperactivation via Rac1 in inflammatory bowel disease

A T-cell-based metric of immune age predicts outcomes in older patients with myeloma receiving daratumumab-based therapy

A phase 2 study of zanubrutinib in combination with rituximab and lenalidomide in de novo diffuse large B-cell lymphoma

Proteomic subtypes enrich current acute myeloid leukemia nomenclature and reflect intrinsic pathogenesis alongside aging

Pooled CAR-T screening in nonhuman primates identifies designs with enhanced proliferation, trafficking, and persistence

Cryo-EM structure of the tissue factor/factor VIIa complex with a factor X mimetic reveals a novel allosteric mechanism

Improved diagnostic screening and classification of clonal mast cell diseases by ultrasensitive KIT p.D816V detection

How I Manage Chronic Myeloid Leukemia During Pregnancy

Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues, ameliorating GVHD post-HSCT

Donor-derived CD7 CAR T cells for pediatric and adult relapsed/refractory T-ALL/LBL: a phase 2 trial

TCA cycle mode switch determines the fate of pirtobrutinib-tolerant persister cells in mantle cell lymphoma

The Treatment of Marginal Zone Lymphoma

Boosting CAR T-Cell Efficacy by Blocking Proteasomal Degradation of Membrane Antigens

Restoring p53 wild-type conformation in TP53-Y220C-mutant acute myeloid leukemia

How I Evaluate and Treat Resistance and Relapse in CML

How I approach hematopoietic stem cell transplantation for CML in a TKI world

How I individualize treatment for chronic-phase CML

How I treat chronic myeloid leukemia in children and adolescents

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