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Research Article November 14 2025
CPX-351 versus daunorubicin, cytarabine plus gemtuzumab ozogamicin in older adults with non-adverse risk AML: NCRI AML18
Steven Knapper,Laura W Dillon,Malavika Babu,Abin Thomas,Ian Thomas,Christopher S Hourigan,Georgia M Andrew,Richard James Dillon,Amanda Frances Gilkes,Nuria Marquez-Almuina,Sophie King,Nicholas McCarthy,Reem Bahr,Rasha W Al-Ali,Louisa Stone,Tom Coats,Jennifer L Byrne,Simone Green,Ulrik Malthe Overgaard,Rob S. Sellar,Mike Dennis,Priyanka Mehta,Robert K Hills,Sylvie D Freeman,Nigel H. Russell
Research Article November 14 2025
Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation
Tianyi Ling,Cristiana O'Brien,Jonathan St-Germain,Vincent Rondeau,Mary Shi,Jacob M Berman,Adrianna Kinga Cepa,Paula Saez Raez,Mark Wunderlich,Katharine Carter,Cody Stillwell,Christina R Sexton,Rachel Culp-Hill,Julie A. Reisz,Saeer A Adeel,Andy G. X. Zeng,Suraj Bansal,Emily Tsao,He Tian Tony Chen,John E. Dick,Mark D Minden,Andrea Arruda,Maria L Amaya,Anastasia N Tikhonova,Kristin Hope,Angelo D'Alessandro,Brian Raught,Courtney L Jones
Research Article November 14 2025
Highly discriminative globin gene activation by the non-canonical BAF chromatin remodeling complex
Research Article November 6 2025
Engineered coagulation factor VIII with enhanced secretion and coagulation potential for hemophilia A gene therapy
Research Article November 5 2025
Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy
Sven Turkalj,Felix A. Radtke,Bilyana Stoilova,Rabea Mecklenbrauck,Angus J. Groom,Niels Asger Jakobsen,Curtis A. Lachowiez,Marlen Metzner,Batchimeg Usukhbayar,Mirian Angulo Salazar,Zhihong Zeng,Sanam Loghavi,Jennifer Marvin-Peek,Verena Körber,Farhad Ravandi,Ghayas C. Issa,Tapan M. Kadia,Vasiliki Symeonidou,Anne P. de Groot,Hagop M Kantarjian,Koichi Takahashi,Marina Konopleva,Courtney D. DiNardo,Paresh Vyas
Research Article November 5 2025
Dynamic rRNA Methylation Regulates Translation in the Hematopoietic System and is Essential for Stem Cell Fitness
Ofri Rabany,Sivan Ben Dror,Maram Arafat,Hadar Aharoni levitanus,Yudit Halperin,Virginie Marchand,Nikolai Romanovski,Noga Ussishkin,Maayan Livneh Golany,Adi Reches,Judith Wexler,Nina Mayorek,Galya Monderer-Rothkoff,Sagiv Shifman,Widad Mâmmer Bouhou,Michael VanInsberghe,Cornelius Pauli,Carsten Müller-Tidow,Ola Karmi,Yoav Livneh,Alexander van Oudenaarden,Yuri Motorin,Daphna Nachmani
Research Article November 5 2025
Multinational Assessment of Absolute Neutrophil Counts and White Blood Cell Counts Among Healthy Duffy Null Adults
Stephen P Hibbs,Israel Chipare,Amr J. Halawani,Sophie E Legge,Geoffrey Fell,Daniel Dees,David J Roberts,Nicholas S Gleadall,Olga Shamardina,Abdulrahman A Alhamzi,Edwig Shingenge,Mohammed Jebril Alabdly,Hilary T Charuma,Mohammed A Nushaily,Judith M Sinvula,Menelik Russo,Michelle Sholzberg,Sara Paparini,Vanessa Apea,Maureen O. Achebe,Nancy Berliner,Lauren Merz
Research Article November 5 2025
PIKfyve inhibition in myeloma disrupts autophagy and the lysosome, increasing MHC expression and cholesterol metabolism
Cecilia Bonolo De Campos,Ruijuan He,Tessa Josephine Pelino,Dor David Abelman,Zhihua Li,Daniel K C Lee,Ding Yan Wang,Michael St. Paul,Jeffrey Bruce,Craig D Simpson,Leanne Wybenga-Groot,Michael F. Moran,Rodger E Tiedemann,Trevor Pugh,Tak W. Mak,Olga Issakova,Nikolai Sepetov,Suzanne Trudel,A Keith Stewart
Research Article November 5 2025
Guanine nucleotides drive ribosome biogenesis and glycolytic reprogramming in acute myeloid leukemia stem cells
Research Article November 5 2025
Silencing of BCL11A by Disrupting Enhancer-Dependent Epigenetic Insulation
Research Article October 29 2025
The XPO7-NPAT axis represents key vulnerabilities in TP53-mutated acute myeloid leukemia
Research Article October 29 2025
Brexucabtagene autoleucel for BTKi-naive relapsed/refractory mantle cell lymphoma: primary analysis of ZUMA-2 Cohort 3
Tom van Meerten,Marie José Kersten,Gloria Iacoboni,Georg R. Hess,Pim G.N.J. Mutsaers,Alejandro Martin Martin Garcia-Sancho,Andre Goy,Eva Gine,Brian T. Hill,Wen-Kai Weng,Patrick M. Reagan,Krish Patel,Ahmed Galal,Charles Herbaux,Robin Sanderson,Edouard Forcade,Max S. Topp,Roch Houot,Dan Zheng,Wangshu Zhang,Justyna Kanska,Rhine R Shen,Rita Damico Khalid,Ioana Kloos,Martin Dreyling,Michael L Wang
Letter October 29 2025
High-grade/large B-cell lymphoma-11q has a very good prognosis in children and young people without a predisposition
Leila Ronceray,Minke Henrina Willemina Huibers,Katrin Reutter,Oussama Abla,Mara Andres,Olga Balagué,Monika Csoka,Gil Gilad,Melanie M Hagleitner,Daiki Hori,Lisa Lyngsie Hjalgrim,Janez Jazbec,Wolfram Klapper,Atsuko Nakazawa,Jaime Verdu-Amorós,Hannah von Mersi,Wilhelm Woessmann,Ana C Xavier,Birgit Burkhardt,Itziar Salaverria,Andishe Attarbaschi
Research Article October 27 2025
Menin inhibition enhances graft-versus-leukemia effects by T-cell activation and endogenous retrovirus induction in AML
Viktor Fetsch,Lennard Frederik Schwöbel,Ezgi Ozyerli-Goknar, PhD,Anna-Verena Stell,Marco Punta,Thomas Plenge,Tabea Klaus,Manoj K. Gupta,Geoffroy Andrieux,Khalid Shoumariyeh,Sophie Pfeiffer,Eyleen Corrales,Lina Schlenke,Hosna Baniadam,Simon M. Brandl,Massimo Andreis,Michal Remen,Alina Hartmann,Kathleen Grueter,Melissa Zwick,Natalie Köhler,Monika Kuban,Eric Metzger,Christoph Rummelt,Justus Duyster,Melanie Börries,Maike Hofmann,Julian Färber,Lukas M Braun,Alexander Zähringer,Michael Lübbert,Cristina Toffalori,Luca Vago,Florian H Heidel,Susana Minguet,Petya Apostolova,Tobias Feuchtinger,Kristina Maas-Bauer,Franziska Blaeschke,Michael W.M. Kühn,Marc Timmers,Tobias Wertheimer,Florian Perner,Robert Zeiser
Research Article October 27 2025
Multiselective RAS(ON) inhibition targets oncogenic RAS and overcomes RAS-mediated resistance to FLT3i and BCL2i in AML
Bogdan Popescu,Matthew F Jones,Madison Piao,Elaine Tran,Andrew Koh,Isabelle Lomeli,Cheryl A. C. Peretz,Natalia Murad,Sydney Abelson,Carolina E. Morales,Jose M Rivera,Alexa Rane Batingana,Jeevitha D'Souza,Yana Pikman,Michael L. Cheng,Aaron C Logan,Benjamin J. Huang,Elliot Stieglitz,Catherine C. Smith
Research Article October 24 2025
Age‐adapted chemotherapy and MRD‐oriented transplant for Ph-negative acute lymphoblastic leukemia: the GRAALL-2014 trial
Nicolas Boissel,Sylvie Chevret,Françoise Rigal-Huguet,Thibaut TL Leguay,Mathilde Hunault,Carlos Graux,Yves Chalandon,Eric Delabesse,Yosr Hicheri,Patrice Chevallier,Marie Balsat,Cedric Pastoret,Martine Escoffre-Barbe,Florence Pasquier,Magalie Joris,Anne Thiebaut,Anne Huynh,Nathalie Dhedin,Emilie Lemasle,Caroline Bonmati,Sebastien Maury,Gaelle Guillerm,Ana Berceanu,Urs Schanz,Thomas Cluzeau,Pascal Turlure,Philippe Rousselot,Bernard De Prijck,Nathalie Grardel,Marie-Christine Béné,Marina Lafage-Pochitaloff,Wendy Cuccuini,Norbert H Ifrah,Véronique Lheritier,Vahid Asnafi,Emmanuelle Clappier,Hervé Dombret
Research Article October 23 2025
Therapeutic base editing to generate a gain-of-function F9 variant for hemophilia B
Brief Report October 21 2025
Fully Human anti-GPRC5D CAR T-Cell Therapy RD118 Induces Durable Remissions in Relapsed/Refractory Multiple Myeloma
Research Article October 21 2025
CPX-351 in Down syndrome-associated Myeloid Leukemia: Results and Prognostic Factors from the Phase 3 ML-DS 2018 Trial
Stephanie Laszig,Antonia Diederichs,Emilia Salzmann-Manrique,Konstantin Schuschel,José Goncalves-Dias,Hasan Issa,Milica Miladinovic,Eva Rettinger,Sibylle Wehner,Hermann Kreyenberg,Melanie Bremm,Sabine Hünecke,Helena Kerp,Katharina Waack-Buchholz,Felicitas R Thol,Bianca F Goemans,Barbara De Moerloose,Heidrun Boztug,Nastassja Keora Scheidegger,Katarzyna Pawinska-Wasikowska,Dirk Reinhardt,Jan-Henning Klusmann
Research Article October 20 2025
The Proteostasis Network is a Therapeutic Target in Acute Myeloid Leukemia
Review Article October 17 2025
Diagnosis and Management of AML in Pediatric Patients: Consensus Recommendations from an International Expert Panel
C. Michel Zwaan,Sarah K Tasian,Richard Aplenc,Lisa Eidenschink Brodersen,Barbara Buldini,Barbara De Moerloose,Michael N Dworzak,Linda Fogelstrand,Brenda ES Gibson,Bianca F Goemans,Henrik Hasle,Betsy A Hirsch,Gertjan JL Kaspers,Jan-Henning Klusmann,Matthew A Kutny,Thomas Lehrnbecher,Franco Locatelli,Shoeil Meshinchi,Arnaud Petit,Martina Pigazzi,Anne Tierens,E Anders Kolb,Dirk Reinhardt,Daisuke Tomizawa,Todd M Cooper
Research Article October 16 2025
A CD22-Specific T-Cell Receptor Enables Effective Adoptive T-Cell Therapy for B-cell malignancies
Simone Rhein,Neşe Çakmak-Görür,Corinna Grunert,Sarah Hayder Jalal Al-Tabatabaee,Nazli Serin,Matthias Leisegang,Stefanos Timiliotis,Luisa Sophie Ohlmeier,Cäcilia Freund,Gerald Willimsky,Frank Konietschke,Elisa Kieback,Sarah K Tasian,Bjoern Chapuy,Ulrich Keller,Thomas Blankenstein,Antonio Pezzutto,Antonia Busse
Research Article October 16 2025
Ramantamig (JNJ-79635322), a novel T-cell-engaging trispecific antibody targeting BCMA, GPRC5D, and CD3, in multiple myeloma models
Research Article October 16 2025
Impact of Modernizing Eligibility Criteria on Enrollment and Representation in Acute Myeloid Leukemia Clinical Trials
Andrew Hantel,Yating Wang,Angel Cronin,Irum Khan,Ivy Elizabeth Abraham,Ann-Kathrin Eisfeld,Anand A Patel,Wendy A Stock,Sarah Monick,Thomas P Walsh,Erin Gallagher,Marlise R. Luskin,Ana Maria Avila Rodriguez,Carlos Galvez,Peter G. Doukas,Jessica K Altman,Madelyn Burkart,Amani Erra,Maryam Zia,Melissa L. Larson,Ami Dave,Stephanie B. Tsai,Ahmed Aleem,Nepheli Ioanna Raptis,Christopher S Lathan,Hajime Uno,Daniel J. DeAngelo,Gregory A. Abel
Research Article October 10 2025
Challenging the Concept of Functional High-Risk Myeloma through Transcriptional and Genetic Profiling
Research Article October 8 2025
Distinct Biological Subtypes of Chronic GVHD after Pediatric Hematopoietic Cell Transplantation
Bernard Ng,Andrew C. Harris,Sayeh Abdossamadi,Geraldine Aubert,Rajinder P. Bajwa,Monica Bhatia,Henrique Bittencourt,Nataliya Prokopenko Buxbaum,Emi H. Caywood,Sonali Chaudhury,Joseph H Chewning,Sung Won Choi,Ashley Chopek,Julia Chu,Donald Coulter,Shahinaz M Gadalla,Richard T Hogg,David A Jacobsohn,Amanda K Johnson,Michael Joyce,Kimberly A. Kasow,Michael Kent,Carrie L. Kitko,Donna Lau,Anita Lawitschka,Victor Anthony Lewis,Amanda M Li,Laura Michelle McLaughlin,David Mitchell,Eneida R. Nemecek,Vaishnavi Parthasarathy,Anna B Pawlowska,Filip Pirsl,Michael A. Pulsipher,Muna Qayed,Jacob Rozmus,Süreyya Savaşan,Tal Schechter,Shalini Shenoy,Alima Suleimenova,Dong Jun Zheng,Elena Ostroumov,Andrew Gilman,Ramon I Klein Geltink,Daniel Wolff,Geoffrey D.E. Cuvelier,Kirk R. Schultz
Research Article October 8 2025
Circulating tumor cells predict myeloma outcomes in patients treated with daratumumab, bortezomib, lenalidomide, and dexamethasone
Luca Bertamini,Cathelijne Fokkema,Paula Rodriguez-Otero,Mark van Duin,Evangelos Terpos,Mattia D'Agostino,Vincent H.J. van der Velden,Niels W.C.J. van de Donk,Michel Delforge,Christoph Driessen,Roman Hajek,Hermann Einsele,Annette Juul Vangsted,Diego Vieyra,Ricardo M Attar,Anna Sitthi-Amorn,Robin Carson,Fredrik Schjesvold,Pawel Robak,Meral Beksac,Andrew Spencer,Annemiek Broijl,Tom Cupedo,Philippe Moreau,Mario Boccadoro,Pieter Sonneveld
Research Article October 8 2025
Phase 2 trial of rituximab with either pentostatin or bendamustine for multiply relapsed or refractory hairy cell leukemia
Research Article October 8 2025
Inflammation perturbs hematopoiesis by remodeling specific compartments of the bone marrow niche
Brief Report October 8 2025
MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia
Dorien Pastoors,Marije Havermans,Roger Mulet-Lazaro,Leonie Smeenk,Sophie Ottema,Claudia A.J. Erpelinck-Verschueren,Stanley van Herk,Maikel Anthonissen,Tim Grob,Shruthi Subramanian,Julie A I Thoms,John E Pimanda,Bas J Wouters,Berna H Beverloo,Torsten Haferlach,Claudia Haferlach,Johannes Zuber,Eric Bindels,Ruud Delwel
Research Article October 7 2025
Genomic Determinants of Response and Resistance to Pirtobrutinib in Relapsed/Refractory Chronic Lymphocytic Leukemia
Jennifer R. Brown,Bastien Nguyen,Sai Prasad Desikan,Helen Won,Shady I. Tantawy,Samuel C McNeely,Narasimha Marella,Hetal S Randeria,Lauren M Hanson,Andrew Parker,Salome Calado Botelho,Jennifer A. Woyach,Krish Patel,Constantine S Tam,Toby A. Eyre,Chan Y Cheah,Nirav N Shah,Paolo Ghia,Wojciech Jurczak,Minna Balbas,Binoj Chandrasekharan Nair,Paolo B. Abada,Chunxiao Wang,Denise Wang,Lindsey Elizabeth Roeker,Varsha Gandhi,William G. Wierda
Research Article October 7 2025
A Notch trans-activation to cis-inhibition switch underlies hematopoietic stem cell aging
Research Article October 1 2025
Mucosal calprotectin is associated with severity of aGI-GVHD and poor outcomes after allogeneic stem cell transplantation
Ekin Ece Gurer Kluge,Elisabeth Meedt,Julia Feicht,Kedi Cao,Andreas Hiergeist,Andreas Mamilos,Daniela Hirsch,Matthias Hoepting, Dr. med,Anna-Sophia Kattner, Dr. med,Carina Matos,Sigrid Bülow,Erik Thiele Orberg,Philipp Beckhove,Arne Kandulski,Matthias Evert,Kai Hildner,Marina Kreutz,Matthias Edinger,Daniel Wolff,Wolfgang Herr,Hendrik Poeck,André Gessner,Daniela Andrea Weber,Birte Kehr,Ernst Holler, Prof. Dr. med,Sakhila Ghimire
Research Article October 1 2025
Fetal context conveys heritable protection against MLL-rearranged AML that depends on MLL3
Brief Report September 30 2025
Genome-wide analysis defines genetic determinants of MPN subtypes and identifies a sex-specific association at CDH22/CD40
William J Tapper,Ahmed A.Z. Dawoud,Joannah Score,Andrew J Chase,E. Joanna Baxter,Joanne Ewing,Louise Wallis,Paola Guglielmelli,Dolors Colomer,Beatriz Bellosillo,Monste Gomez,Juan Carlos Hernandez-Boluda,Carlos Besses,Francisco Cervantes,Steffen Koschmieder,Anthony R Green,Andreas Reiter,Alessandro M. Vannucchi,Claire N. Harrison,Nicholas C.P. Cross
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