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Leslie A Crews
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Journal Articles

Deregulation of Splicing in Pediatric Acute Myeloid Stem and Progenitor Cells

Phoebe Mondala, Inge Van Der Werf, Larisa Balaian, Kathleen Steel, Luisa Ladel, Cayla Mason, Raymond Diep, Jacqueline Cloos, Gertjan Kaspers, Markus J van Roosmalen, Ruben Van Boxtel, Warren Chan, Adam Mark, Mary Donohoe, James La Clair, Peggy Wentworth, Kathleen Fisch, Leslie A Crews, Thomas Whisenant, Michael Burkart, Catriona Jamieson
Journal: Blood
Blood (2021) 138 (Supplement 1): 2227.
https://doi.org/10.1182/blood-2021-154120
Published: 2021
Journal Articles

ADAR1 Splicing Modulation As a Mechanism to Eradicate Immunologically Silent Leukemia Stem Cells

Leslie A Crews, Phoebe Mondala, Cayla Mason, Larisa Balaian, Wenxue Ma, Jessica Pham, Christina Wu, Peggy Wentworth, James La Clair, Michael Burkart, Catriona Jamieson
Journal: Blood
Blood (2021) 138 (Supplement 1): 3321.
https://doi.org/10.1182/blood-2021-154233
Published: 2021
Journal Articles

Selective Targeting of Alternative Splicing Deregulation in Pediatric Acute Myeloid Stem and Progenitor Cells

Inge Van Der Werf, MSc, Phoebe Mondala, BS, Raymond Diep, BS, Larissa Balaian, PhD, Cayla Mason, BS, Jacqueline Cloos, PhD, Gertjan J.L. Kaspers, Prof. MD PhD, Jim La Clair, Peggy Wentworth, Leslie A Crews, PhD, Thomas Whisenant, PhD, Kathleen Fisch, PhD, Michael Burkart, PhD, Catriona Jamieson, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 8.
https://doi.org/10.1182/blood-2020-136596
Published: 2020
Journal Articles

Inflammatory Cytokine Responsive Enzymatic Mutagenesis Fuels Myeloproliferative Neoplasm Pre-Leukemia Stem Cell Evolution

Catriona Jamieson, MD PhD, Qingfei Jiang, PhD, Frida Holm, PhD, Jane Isquith, MS, Adam Mark, Cayla Mason, BS, Wenxue Ma, MD PhD, Raymond H Diep, Jessica Pham, B.S., Eduardo Reynoso Moreno, PhD, Chanond A Nasamran, Xu Guorong, Amanda Birmingham, Leslie A Crews, PhD, Ludmil Alexandrov, Gabriel Pineda, PhD, Thomas Whisenant, Kathleen M Fisch
Journal: Blood
Blood (2019) 134 (Supplement_1): 3780.
https://doi.org/10.1182/blood-2019-131510
Published: 2019
Journal Articles

Comparative Inflammasome Analysis of Bone Marrow Stroma in Aging and Myelofibrosis

Larissa Balaian, PhD, Leslie A Crews, PhD, Cayla Mayson, BS, Frida Holm, PhD, Raymond H Diep, Heather Leu, BS, Anna Kulidjian, MD, Edward D. Ball, MD, Catriona Jamieson, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4331.
https://doi.org/10.1182/blood-2018-99-118993
Published: 2018
Journal Articles

Genetic Modulation of Adenosine-to-Inosine RNA Editing Selectively Disrupts Inflammasome and Extracellular Matrix Genes in Multiple Myeloma

Leslie A Crews, PhD, Phoebe Mondala, BS, Elisa Lazzari, PhD, Gabriel Pineda, PhD, Christina Wu, PhD, Caitlin L. Costello, MD, Catriona Jamieson, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1324.
https://doi.org/10.1182/blood-2018-99-120326
Published: 2018
Journal Articles

Decoding the RNA Editome of Normal Versus Malignant Progenitor Cell Aging Short Title: RNA Editing in Normal Aging and MDS/AML Stem Cells

Leslie A Crews, PhD, Qingfei Jiang, PhD, Larisa Balaian, PhD, Heather Leu, BS, Nathan Delos Santos, Angela C Court, Anil Sadarangani, PhD, Sheldon Morris, MD, Rainer F. Storb, MD, Anna Kulidjian, MD, Edward D. Ball, MD, Catriona Jamieson, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1519.
https://doi.org/10.1182/blood.V128.22.1519.1519
Published: 2016
Journal Articles

RNA Splicing Modulation Impairs Acute Myeloid Leukemia Stem Cell Maintenance

Leslie A Crews, PhD, Larissa Balaian, PhD, Heather Leu, BS, Nathaniel Delos Santos, Angela C Court, Anil Sadarangani, PhD, Maria A. Zipeto, PhD, James J La Clair, Reymundo Villa, Sheldon Morris, MD, Rainer F. Storb, MD, Anna Kulidjian, MD, Edward D. Ball, MD, Michael D Burkart, PhD, Catriona Jamieson, MD PhD
Journal: Blood
Blood (2015) 126 (23): 567.
https://doi.org/10.1182/blood.V126.23.567.567
Published: 2015
Journal Articles

Targeting Cancer Stem Cell Survival in Plasma Cell Leukemia with a Pan-BCL2 Inhibitor

Elisa Lazzari, MA, Leslie A Crews, PhD, Christina Wu, PhD, Heather Leu, BS, Raffaella Chiaramonte, PhD, Mark D. Minden, MD PhD, Caitlin L. Costello, MD, Catriona Jamieson, MD PhD
Journal: Blood
Blood (2015) 126 (23): 5351.
https://doi.org/10.1182/blood.V126.23.5351.5351
Published: 2015
Journal Articles

Inflammatory Cytokine-Responsive ADAR1 Impairs Let-7 Biogenesis and Promotes Leukemia Stem Cell Generation

Maria Anna Zipeto, PhD, Angela Court Recart, Nathaniel Delos Santos, Qingfei Jiang, PhD, Leslie A Crews, PhD, Catriona HM Jamieson, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4014.
https://doi.org/10.1182/blood.V126.23.4014.4014
Published: 2015
Journal Articles

Regulation of Self-Renewal through Modulation of Let-7 Stem Cell Regulatory Family of microRNAs in Chronic Myeloid Leukemia Stem Cells

Maria Anna Zipeto, PhD, Qingfei Jiang, PhD, Leslie A Crews, PhD, Angela Court Recart, Catriona HM Jamieson, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4527.
https://doi.org/10.1182/blood.V124.21.4527.4527
Published: 2014
Journal Articles

Tracking Human Myeloma Cell Therapeutic Resistance Using a Novel Diagnostic Assay for Detection of RNA Editing Biomarkers of Cancer Stem Cell Generation

Elisa Lazzari, MS, Leslie A Crews, PhD, Maria Anna Zipeto, PhD, Shawn Ali, BA, Catriona HM Jamieson, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3406.
https://doi.org/10.1182/blood.V124.21.3406.3406
Published: 2014
Journal Articles

Inhibition Of Inflammation Driven Leukemia Stem Cell Self-Renewal With a Selective JAK2 Antagonist

Angela C Court Recart, BS, MS, Anil Sadarangani, PhD, Elizabeth Chun, MSc, Cayla N Mason, BS, Qingfei Jiang, PhD, Christian L Barrett, Ph.D., Russell Wall, BS, Daniel J Goff, PhD, Ifat Geron, MSc, Alice Shih, Heather S. Leu, B.S., Wenxue Ma, M.D., Ph.D., Mark D. Minden, MD PhD, Kelly A Frazer, Ph.D., Marco A. Marra, PhD, Leslie A Crews, PhD, Catriona HM Jamieson, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1481.
https://doi.org/10.1182/blood.V122.21.1481.1481
Published: 2013
Journal Articles

A Highly Selective SF3B1-Targeted Splicing Inhibitor Reduces Human CD34+ Cell Survival and Self-Renewal In Acute Myeloid Leukemia

Larissa Balaian, Ph.D., Leslie A Crews, PhD, Marianna Zipeto, Kulidjian Anna, MD, Edward D. Ball, M.D., Michael D Burkart, PhD, Catriona HM Jamieson, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1653.
https://doi.org/10.1182/blood.V122.21.1653.1653
Published: 2013