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Research Article August 20 2024
Efficacy and safety of teclistamab in patients with relapsed/refractory multiple myeloma after BCMA-targeting therapies
Cyrille Touzeau,Amrita Y Krishnan,Philippe Moreau,Aurore Perrot,Saad Z Usmani,Salomon Manier,Michele Cavo,Carmen Martinez Chamorro,Ajay K. Nooka,Thomas G Martin,Lionel Karlin,Xavier Leleu,Nizar J. Bahlis,Britta Besemer,Lixia Pei,Sarah Stein,Shun Xin Wang Lin,Danielle Trancucci,Raluca Verona,Suzette Girgis,Xin Miao,Clarissa Uhlar,Katherine Chastain,Alfred Garfall
Research Article August 20 2024
Spatial transcriptomics reveals profound subclonal heterogeneity and T-cell dysfunction in extramedullary myeloma
Mara John,Moutaz Helal,Johannes Duell,Greta Mattavelli,Emilia Stanojkovska,Nazia Afrin,Alexander Michael Leipold,Maximilian Johannes Steinhardt,Xiang Zhou,David Žihala,Anjana Anilkumar Sithara,Julia Mersi,Johannes M Waldschmidt,Christine Riedhammer,Sofie-Katrin Kadel,Marietta Truger,Rudolf A. Werner,Claudia Haferlach,Hermann Einsele,Kai Kretzschmar,Tomáš Jelínek,Andreas Rosenwald,K. Martin Kortüm,Angela Riedel,Leo Rasche
Review Article August 16 2024
How I approach intersectionality in hematopoietic stem cell transplantation
Research Article August 16 2024
An unbiased lncRNAs dropout CRISPR-Cas9 screen reveals RP11-350G8.5 as a novel therapeutic target for Multiple Myeloma
Katia Grillone,Serena Ascrizzi,Paolo Cremaschi,Jussara Amato, Professor,Nicoletta Polerà,Ottavio Croci,Roberta Rocca,Caterina Riillo,Francesco Conforti,Raffaele Graziano,Diego Brancaccio,Daniele Caracciolo,Stefano Alcaro,Bruno Pagano,Antonio Randazzo,Pierosandro Tagliaferri,Francesco Iorio,Pierfrancesco Tassone
Research Article August 16 2024
Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo
Research Article August 16 2024
Epigenetic Regulation of Non-canonical Menin Targets Modulates Menin Inhibitor Response in Acute Myeloid Leukemia
Research Article August 16 2024
Daratumumab in Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma: DELPHINUS Study
Teena Bhatla,Laura Hogan, MD,David Trent Teachey,Franciso Bautista,John P Moppett,Pablo Velasco,Concetta Micalizzi,Claudia Rossig,Neerav Narendra Shukla,Gil Gilad,Franco Locatelli,André BARUCHEL,Michel Zwaan,Natalie S. Bezler,Alba Rubio-San-Simón,David Taussig,Elizabeth A. Raetz,Zhengwei J Mao,Brent Wood,Diana Alvarez Arias, Dr,Maria Krevvata,Ivo Nnane,Nibedita Bandyopadhyay,Lorena Lopez Solano,Robyn M. Dennis,Robin Carson,Ajay Vora
Research Article August 16 2024
Deletions in the MAL gene result in loss of Mal protein, defining the rare inherited AnWj-negative blood group phenotype
Review Article August 14 2024
The intestinal microbiota and cellular therapy: implications for impact and mechanisms
Research Article August 12 2024
Genetic Risk Stratification and Outcomes Among Treatment-Naive Patients With AML Treated With Venetoclax and Azacitidine
Review Article August 12 2024
Genetic risk classification for adults with AML receiving less-intensive therapies: the 2024 ELN recommendations
Hartmut Döhner,Courtney D. DiNardo,Frederick Appelbaum,Charles Craddock,Hervé Dombret,Benjamin L Ebert,Pierre Fenaux,Lucy A Godley,Robert P Hasserjian,Richard A Larson,Ross L Levine,Yasushi Miyazaki,Dietger Niederwieser,Gert J Ossenkoppele,Christoph Röllig,Jorge Sierra,Eytan M. Stein,Martin S. Tallman,Hwei-Fang Tien,Jianxiang Wang,Agnieszka Wierzbowska,Andrew H. Wei,Bob Löwenberg
Brief Report August 12 2024
Unbalanced MYC break-apart FISH patterns indicate the presence of a MYC rearrangement in HGBCL-DH-BCL2.
Brief Report August 8 2024
Proposals for Revised International Working Group-European LeukemiaNet Criteria for Anemia Response in Myelofibrosis
Ayalew Tefferi,Giovanni Barosi,Francesco Passamonti,Juan Carlos Hernandez-Boluda,Prithviraj Bose,Konstanze Döhner,Martin Ellis,Naseema Gangat,Jacqueline S. Garcia,Heinz Gisslinger,Jason Gotlib,Paola Guglielmelli,Vikas Gupta,Claire N. Harrison,Elizabeth O. Hexner,Gabriela S Hobbs,Jean-Jacques Kiladjian,Steffen Koschmieder,Nicolaus Kröger,Andrew T Kuykendall,Giuseppe Gaetano Loscocco,John O. Mascarenhas,Lucia Masarova,Ruben Mesa,Barbara Mora,Olatoyosi Odenike,Stephen T. Oh,Animesh D Pardanani,Anand A Patel,Naveen Pemmaraju,Alessandro Rambaldi,Raajit K. Rampal,Shireen Sirhan,Natasha Szuber,Moshe Talpaz,Pankit Vachhani,Alessandro M. Vannucchi,Tiziano Barbui
Letter August 5 2024
Directionality of HLA-DP permissive mismatches improves risk prediction in HCT for acute leukemia and MDS
Esteban Arrieta-Bolaños,Lars L. J. van der Burg,Tobias Gedde-Dahl,Marie Robin,Urpu Salmenniemi,Nicolaus Kröger,Ibrahim Yakoub-Agha,Anne Huynh,Charles R Crawley,Eric Deconinick,Claude-Eric Bulabois,Edouard Forcade,Eleni Tholouli,Joost G. K. van der Hem,Peter van Balen,Jorinde Desiree Hoogenboom,Liesbeth C. de Wreede,Florent Malard,Annalisa Ruggeri,Katharina Fleischhauer
Research Article August 5 2024
Asciminib Monotherapy as Frontline Treatment of Chronic-Phase Chronic Myeloid Leukemia: Results from the ASCEND Study
David T. Yeung,Naranie Shanmuganathan,John Reynolds,Susan Branford,Mannu Walia,Agnes SM Yong,Jake Shortt,Lynette Chee,Nicholas Viiala,Ilona Cunningham,David M Ross,Alwyn Bernard D'Souza,Matthew Wright,Rosemary Anne Harrup,Cecily Jane Forsyth,Robin Filshie,Steven W Lane,Peter J Browett,Carolyn S Grove,Andrew A Grigg,Timothy P Hughes
Research Article August 2 2024
NG2 is a target gene of MLL-AF4 and underlies glucocorticoid resistance in MLL-r B-ALL by regulating NR3C1 expression
Belén Lopez-Millan,Alba Rubio-Gayarre,Meritxell Vinyoles,Juan L. Trincado,Mario F. Fraga,Narcís Fernandez-Fuentes,Mercedes Guerrero-Murillo,Alba Martinez-Moreno,Talia Velasco-Hernandez,Aïda Falgàs,Carla Panisello,Gemma Valcarcel,Jose Luis Sardina,Paula López-Martí,Biola M. Javierre,Beatriz Del Valle-Pérez,Antonio García de Herreros,Franco Locatelli,Rob Pieters,Michela Bardini,Giovanni Cazzaniga,Juan Carlos Rodríguez-Manzaneque,Thomas Hanewald,Rolf Marschalek,Thomas A. Milne,Ronald W. Stam,Juan Ramón Ramón Tejedor,Pablo Menendez,Clara Bueno
Research Article July 29 2024
Influence of TP53 Gene Mutations and its Allelic Status in Myelodysplastic Syndromes with Isolated 5q Deletion.
Maria Julia Montoro,Laura Palomo,Claudia Haferlach,Pamela Acha,Onyee Chan,Víctor Navarro,Yasuo Kubota,Felicitas Isabel Schulz,Manja Meggendorfer,Robert Briski,Najla Al-Ali,Blanca Xicoy,Felix Lopez,Francesc Bosch,Teresa González,Lea Naomi Eder,Andrés Jerez,Yu-Hung Hung Wang,Alessia Campagna,Valeria Santini,Teresa Bernal del Castillo,Esperanza Such,Hwei-Fang Tien,Nicolás Díaz Varela,Uwe Platzbecker,Detlef Thomas Haase,María Díez-Campelo,Matteo Giovanni Della Porta,Guillermo Garcia-Manero,Daniel Howard Wiseman,Ulrich Germing,Jaroslaw P. Maciejewski,Rami S Komrokji,Francesc Sole,Torsten Haferlach,David Valcárcel
Review Article July 26 2024
Treatment of Relapsed/Refractory MCL
Research Article July 24 2024
Ruxolitinib for pediatric patients with treatment-naïve and steroid-refractory acute graft-versus-host disease (REACH4)
Research Article July 24 2024
A predictive model for therapy failure in chronic myeloid leukemia patients receiving tyrosine kinase inhibitor therapy
Xiaoshuai Zhang,Bingcheng Liu,Jian Huang,Yanli li Zhang,Na Xu,Robert Peter Gale,Weiming Li,Xiaoli Liu,Huanling Zhu,Ling Pan,Yunfan Yang,Hai Lin,Xin Du,Rong Liang,Chunyan Chen,Xiaodong Wang,Guohui Li,Zhougang Liu,Yanqing Zhang,Zhenfang Liu,Jianda Hu,Chunshui Liu,Fei Li,Wei Yang,Li Meng,Yanqiu Han,Li'e Lin,Zhenyu Zhao,Chuanqing Tu,Caifeng Zheng,Yanliang Bai,Zeping Zhou,Suning Chen,Huiying Qiu,Lijie Yang,Xiuli Sun,Hui Sun,Li Zhou,Zelin Liu,Danyu Wang,Jianxin Guo,Liping Pang,Qingshu Zeng,Xiaohui Suo,Weihua Zhang,Yuanjun Zheng,Xiaojun Huang,Qian Jiang
Research Article July 24 2024
JAK2/mTOR Inhibition Fails to Prevent Acute GVHD Despite Reduced Th1/Th17 cells: Final Phase II Trial Results
Joseph A Pidala,Shernan G Holtan,Kelly Walton,Jongphil Kim,Biwei Cao,Hany Elmariah,Asmita Mishra,Nelli Bejanyan,Taiga Nishihori,Farhad Khimani,Lia E Perez,Rawan G Faramand,Marco L. Davila,Shannon McSain,Jordan Pleskow,Jeffrey Baron,Claudio Anasetti,Carlos M Moran Segura,Daniel J Weisdorf,Bruce R Blazar,Jeffrey S. Miller,Veronika Bachanova,Najla El Jurdi,Brian C Betts
Research Article July 24 2024
Diagnostic Guidelines for Familial Hemophagocytic Lymphohistiocytosis Revisited
Review Article July 24 2024
How I treat post-immunotherapy relapsed B-ALL
Brief Report July 24 2024
Interleukin-1 blockade in patients with Wiskott-Aldrich Syndrome: a retrospective multinational case series
Samuele Naviglio,Maria Pia Cicalese,Elizabeth Rivers,Francesca Ferrua,Carmem M.S. Bonfim,Sabina Cenciarelli,Kai-Ning Cheong,Maura Faraci,Stefano Giardino,Sujal Ghosh,Pamela P. Lee,Paula Teixeira Lyra,Roland Meisel,Valentina Sofia,Antimo Tessitore,Alberto Tommasini,Erica Valencic,Tanja C. Vallée,Stefano Volpi,Austen J Worth,Marco Rabusin,Michael H Albert,Adrian J Thrasher,Alessandro Aiuti
Research Article July 19 2024
Abatacept for acute graft-versus-host disease prophylaxis after unrelated donor hematopoietic cell transplantation
Research Article July 16 2024
JAK2-mutant Clonal Hematopoiesis is Associated with Venous Thromboembolism
Research Article July 16 2024
Mitigation of Checkpoint Inhibitor-Induced Autoimmune Hemolytic Anemia through Modulation of Purinergic Signaling
Research Article July 12 2024
Risk Prediction for Clonal Cytopenia: Multicenter Real-World Evidence
Zhuoer Xie,Rami S Komrokji,Najla Al-Ali,Alexandra Regelson,Susan Geyer,Anand A Patel,Caner Saygin,Amer M. Zeidan,Jan Philipp Bewersdorf,Lourdes M Mendez,Ashwin Kishtagari,Joshua F. Zeidner,Catherine C. Coombs,Yazan F Madanat,Stephen S Chung,Talha Badar,James M Foran,Pinkal Desai,Charlton Tsai,Elizabeth A. Griffiths,Monzr M. Al Malki,Idoroenyi Amanam,Catherine Lai,H. Joachim Deeg,Lionel Ades,Cecilia Arana-Yi,Afaf EG Osman,Shira Naomi Dinner,Yasmin Abaza,Justin Taylor,Namrata S Chandhok,Deborah Soong,Andrew M. Brunner,Hetty E Carraway,Abhay Singh,Chiara Elena,Jacqueline Ferrari,Anna Galli,Sara Pozzi,Eric Padron,Mrinal M. Patnaik,Luca Malcovati,Michael R. Savona,Aref Al-Kali
Research Article July 11 2024
Germline ERG haploinsufficiency defines a new syndrome with cytopenia and hematological malignancy predisposition
Jiarna Rose Zerella,Claire C Homan,Peer Arts,Xuzhu Lin,Sam John Spinelli,Parvathy Venugopal,Milena Babic,Peter Brautigan,Lynda Truong,Luis Alberto Arriola-Martinez,Sarah Moore,Rachel Hollins,Wendy Parker,Hung Nguyen,Karin S Kassahn,Susan Branford,Simone K Feurstein,Lise Larcher,Flore Sicre de Fontbrune,Serwet Demirdas,Sonja de Munnik,Hélène A Poirel,Benedicte Brichard,Sahar Mansour,Kristiana Gordon,ERG Variants Research Network,Marcin W Wlodarski,Ashwin Lakshman Koppayi,Sara Dobbins,Pim G.N.J. Mutsaers,Kim E. Nichols,Ninad Oak,Desiree DeMille,Rong Mao,Ali Crawford,Julie McCarrier,Donald Basel,Josue Flores-Daboub,Michael W Drazer,Kerry Phillips,Nicola Poplawski,Graeme M Birdsey,Daniela Pirri,Pia Ostergaard,Annet Simons,Lucy A Godley,David M Ross,Devendra K. Hiwase,Jean Soulier,Anna L Brown,Catherine L Carmichael,Hamish S Scott,Christopher N Hahn
Research Article July 10 2024
Venetoclax-Obinutuzumab for previously untreated chronic lymphocytic leukemia: 6-year results of the phase 3 CLL14 study
Othman Al-Sawaf,Sandra Robrecht,Can Zhang,Stefano Olivieri,Yi Meng Chang,Anna-Maria Fink,Eugen Tausch,Christof Schneider,Matthias Ritgen,Karl-Anton Kreuzer,Liliya Sivcheva,Carsten Utoft Niemann,Anthony P. Schwarer,Javier Loscertales,Robert Weinkove,Dirk Strumberg,Allanah Kilfoyle,Beenish S. Manzoor,Dureshahwar Jawaid,Nnadozie Emechebe,Jacob Devine,Michelle Boyer,Eva D Runkel,Barbara Eichhorst,Stephan Stilgenbauer,Yanwen Jiang,Michael J Hallek,Kirsten Fischer
Review Article July 8 2024
How I Treat: Differentiation Therapy in Acute Myeloid Leukemia
Research Article July 5 2024
A Phase 1 Clinical Trial of NKTR-255 with CD19-22 CAR-T Cell Therapy for Refractory B-cell Acute Lymphoblastic Leukemia
Hrishikesh Krishna Srinagesh,Clayton Jackson,Parveen Shiraz,Nikeshan Jeyakumar,Mark P Hamilton,Emily Egeler,Sharon Mavroukakis,Adam Kuo,Juancarlos Cancilla,Bita Sahaf,Neha Agarwal,Alyssa M Kanegai,Anne Marijn Kramer,Sally Arai,Sushma Bharadwaj,Saurabh Dahiya,Hitomi Hosoya,Laura J Johnston,Vanessa E Kennedy,Michaela Liedtke,Robert Lowsky,Lekha Mikkilineni,Robert S. Negrin,Andrew R. Rezvani,Surbhi Sidana,Judith A. Shizuru,Melody Smith,Wen-Kai Weng,Steven A Feldman,Matthew J. Frank,Zachary Lee,Mary Tagliaferri,A Mario Q. Marcondes,David B Miklos,Crystal L. Mackall,Lori Muffly
Research Article July 3 2024
Molecular Taxonomy of Myelodysplastic Syndromes and its Clinical Implications
Elsa Bernard,Robert P. Hasserjian,Peter L. Greenberg,Juan Esteban Arango Ossa,Maria Creignou,Heinz Tuechler,Jesús Gutiérrez-Abril,Dylan Domenico,Juan Santiago Medina-Martinez,Max Fine Levine,Konstantinos Liosis,Noushin Farnoud,Maria Sirenko,Martin Jädersten,Ulrich Germing,Guillermo F. Sanz,Arjan A Van de Loosdrecht,Yasuhito Nannya,Olivier Kosmider,Matilde Y Follo,Felicitas R. Thol,Lurdes Zamora,Ronald Feitosa Pinheiro,Andrea Pellagatti,Harold Kunal Elias,Detlef Thomas Haase,Christina Ganster,Lionel Ades,Magnus Tobiasson,Laura Palomo,Matteo Giovanni Della Porta,Pierre Fenaux,Monika Belickova,Michael R. Savona,Virginia Klimek,Fabio P S Santos,Jacqueline Boultwood,Ioannis Kotsianidis,Valeria Santini,Francesc Sole,Uwe Platzbecker,Michael Heuser,Peter Valent,Carlo Finelli,Maria Teresa Voso,Lee Yung Shih,Michaela Fontenay,Joop H Jansen,José Cervera,Norbert Gattermann,Benjamin L Ebert,Rafael Bejar,Luca Malcovati,Seishi Ogawa,Mario Cazzola,Eva S Hellstrom-Lindberg,Elli Papaemmanuil
Research Article July 1 2024
Use of HSC Targeted LNP to Generate a Mouse Model of Lethal α-Thalassemia and Treatment via Lentiviral Gene Therapy
Maxwell Elliott Chappell,Laura Breda,Lucas Tricoli,Amaliris Guerra,Danuta Jadwiga Jarocha,Carlo Castruccio Castracani,Tyler Ellis Papp,Naoto Tanaka,Nolan Hamilton,Michael Paul Triebwasser,Valentina Ghiaccio,Megan Fedorky,Kandace Gollomp,Veronica Bochenek,Aoife M Roche,John K Everett,Emma J Cook,Frederic D. Bushman,Nattiya Teawtrakul,Stavros Glentis,Antonis Kattamis, Prof,Barbara L Mui,Ying K. Tam,Drew Weissman,Osheiza Abdulmalik,Hamideh Parhiz,Stefano Rivella
Research Article June 28 2024
Optimizing Drug Combinations for T-PLL: Restoring DNA Damage and P53-Mediated Apoptotic Responses
Jana von Jan,Sanna Timonen,Till Braun,Qu Jiang,Aleksandr Ianevski,Yayi Peng,Kathleen McConnell,Paola Sindaco,Tony Andreas Müller,Sabine Pützer,Hanna Klepzig,Dennis Jungherz,Annika Dechow,Linus Wahnschaffe,Anil K Giri,Matti Kankainen,Heikki Kuusanmäki,Heidi A Neubauer, PhD,Richard H Moriggl,Paolo Mazzeo,Nicole Schmidt,Raphael Koch,Michael J Hallek,Amel Chebel,David Armisen,Laurent Genestier,Emmanuel Bachy,Anjali Mishra,Alexandra Schrader,Tero Aittokallio,Satu Mustjoki,Marco Herling
Review Article June 28 2024
How I treat iron overload in adult myelodysplastic syndrome
Review Article June 21 2024
How I Treat Infant Acute Lymphoblastic Leukemia
Research Article June 20 2024
Soluble Glycoprotein VI Predicts Abdominal Aortic Aneurysm Growth Rate and is a Novel Therapeutic Target
Tyler W. Benson,Mindy M. Pike,Anthony R. Spuzzillo,Sarah M Hicks,Michael Pham,Doran S. Mix,Seth Brunner,Caris A. Wadding-Lee,Kelsey A. Conrad,Hannah M Russell,Courtney L Jennings,Taylor M. Coughlin,Anu Aggarwal,Sean Patrick Lyden,Kevin Mani,Martin Bjorck,Anders Wanhainen,Rohan Bhandari,Loren Lipworth,Cassianne Robinson-Cohen,Francis John Caputo,Sharon Shim,Odayme Quesada,Benjamin Tourdot,Todd L Edwards,Michael Tranter,Elizabeth E Gardiner,Nigel Mackman,Scott J Cameron,A. Phillip Owens III
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