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Journal Articles

Red Blood Cell Deformability and Morphological Dynamic Sickling As a Metric to Monitor Pharmacodynamic Response to Voxelotor

Marta Ferranti, Jordan Antongiorgi, Robert Goodrich, Xiufeng Gao, Ke Liu, Nnamdi Okeke, Michael Tarasev, Patrick C. Hines
Journal: Blood
Blood (2023) 142 (Supplement 1): 5260.
https://doi.org/10.1182/blood-2023-190246
Published: 2023
Journal Articles

Assessing Real-Time Sickling Kinetics in Individual Cells from Erythrocyte Populations of Subjects with Different HbA, HbS and HbF Percentages

Aliya U. Zaidi, Xiufeng Gao, Robert Goodrich, Marta Ferranti, Rasa Borhan, Ke Liu, Nnamdi Okeke, Michael Tarasev, Mariama Kabore, Courtney D. Fitzhugh, Priya Sethu Chockalingam, Patrick C. Hines
Journal: Blood
Blood (2023) 142 (Supplement 1): 1118.
https://doi.org/10.1182/blood-2023-190404
Published: 2023
Journal Articles

Evaluation of Longitudinal Pain Study in Sickle Cell Disease (ELIPSIS) by patient-reported outcomes, actigraphy, and biomarkers

Clinical Trials & Observations
Debra D. Pittman, Patrick C. Hines, David Beidler, Denis Rybin, Andrew L. Frelinger, III, Alan D. Michelson, Ke Liu, Xiufeng Gao, Jennell White, Ahmar U. Zaidi, Robert J. Charnigo, Michael U. Callaghan
Journal: Blood
Blood (2021) 137 (15): 2010–2020.
https://doi.org/10.1182/blood.2020006020
Published: 2021
Includes: Supplemental data
Journal Articles

Hemolytic Biomarkers Predict Adhesiveness of Sickle Blood Cells in a Clinical Adhesion Bioassay

Jennell White, PhD, Xiufeng Gao, MD, Michael Tarasev, Michael.tarasev@functionalfluidics.com, Ke Liu, PhD, Michael U. Callaghan, MD, Patrick C. Hines, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 31.
https://doi.org/10.1182/blood-2020-143402
Published: 2020
Journal Articles

A Standardized Clinical Flow Adhesion Assay of Whole Blood Adhesion to VCAM-1 Predicts Severe SCD Phenotypes in a 2-Yr Prospective Observational Follow-up of the Original Elipsis Cohort

Patrick C. Hines, MD PhD, Ahmar Urooj Zaidi, MD, Xiufeng Gao, MD, Ke Liu, PhD, Muhammad O. Shareef, Michael Callaghan, Jennell White, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3562.
https://doi.org/10.1182/blood-2019-126371
Published: 2019
Journal Articles

PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation

Martin K. Safo, PhD, Piyusha P Pagare, PhD, Mohini Ghatge, PhD, Carla Casu, PhD, Valentina Ghiaccio, PhD, Nancy Anabaraonye, Xiaomeng Xu, MS, Stefano Rivella, PhD, Patrick C. Hines, MD PhD, Ke Liu, PhD, Yan Zhang, PhD, Jürgen Venitz, MD PhD, Osheiza Abdulmalik, DVM
Journal: Blood
Blood (2019) 134 (Supplement_1): 73.
https://doi.org/10.1182/blood-2019-128646
Published: 2019
Journal Articles

Regulatory T Cell Selective IL-2-Fc Fusion Proteins for the Treatment of Autoimmune Diseases

Rajat Varma, PhD, Ke Liu, PhD, Kendra Avery, PhD, Rumana Rashid, PhD, Suzanne Schubbert, PhD, Irene Leung, PhD, Christine Bonzon, PhD, Liz Bogaert, PhD, John Desjarlais, Matthew J. Bernett
Journal: Blood
Blood (2018) 132 (Supplement 1): 3709.
https://doi.org/10.1182/blood-2018-99-117622
Published: 2018
Journal Articles

Longitudinal Evaluation of a Standardized P-Selectin Flow Adhesion Bioassay: Potential Role for the Assessment and Prediction of Vaso-Occlusive Episodes in Sickle Cell Disease

Ke Liu, PhD, Xiufeng Gao, MD, Jennell White, PhD, Michael U. Callaghan, MD, Patrick C. Hines, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1096.
https://doi.org/10.1182/blood-2018-99-120084
Published: 2018
Journal Articles

A Longitudinal Study to Identify and Assess Adhesion Indices during Vaso-Occlusive Crises in Adults and Adolescents with Sickle Cell Disease

Jennell White, PhD, Xiufeng Gao, MD, Ke Liu, PhD, Michael U. Callaghan, MD, Patrick C. Hines, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1097.
https://doi.org/10.1182/blood-2018-99-120311
Published: 2018
Journal Articles

Elipsis: A Longitudinal Study of Electronic Patient-Reported Outcomes, Actigraphy and Biomarkers to Identify and Assess at-Home Vaso-Occlusive Crises in Adults and Adolescents with Sickle Cell Disease

Michael U. Callaghan, Patrick C. Hines, MD PhD, Debra D Pittman, MS, David Beidler, PhD, Denis Rybin, PhD, Ahmar Urooj Zaidi, MD BSc, Jennell White, PhD, Ke Liu, PhD, Bryan Hannan, MS, Xiufeng Gao, MD, Andreas M Pleil, PhD, Alexandra Barsdorf, PhD, Martin David, Pharm D, Melanie Simmons, PMP, PSM, Andrew L Frelinger, III, PhD, Alan D Michelson, MD, Nick Clarke, PhD, Robert J Charnigo, MS
Journal: Blood
Blood (2017) 130 (Supplement 1): 973.
https://doi.org/10.1182/blood.V130.Suppl_1.973.973
Published: 2017
Journal Articles

Sevuparin Blocks Sickle Blood Cell Adhesion and Sickle-Leukocyte Rolling on Immobilized L-Selectin in a Dose Dependent Manner

Maria Lindgren, PhD, Jennell White, PhD, Ke Liu, PhD, Lena Jendeberg, PhD, Patrick C. Hines, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2482.
https://doi.org/10.1182/blood.V128.22.2482.2482
Published: 2016
Journal Articles

Evaluation of Purified Poloxamer-188 (vepoloxamer) on Sickle Red Blood Cell (RBC) Membrane Function Properties

Jennell White, PhD, Patrick C. Hines, MD PhD, Ke Liu, PhD, Lennette J. Benjamin, MD, Xiufeng Gao, Martin Emanuele, PhD
Journal: Blood
Blood (2015) 126 (23): 2180.
https://doi.org/10.1182/blood.V126.23.2180.2180
Published: 2015
Journal Articles

Role of a 5′-enhancer in the transcriptional regulation of the human endothelial cell protein C receptor gene

Luigina R. Mollica, James T. B. Crawley, Ke Liu, James B. Rance, Peter N. Cockerill, George A. Follows, Josette-Renee Landry, Dominic J. Wells, David A. Lane
Journal: Blood
Blood (2006) 108 (4): 1251–1259.
https://doi.org/10.1182/blood-2006-02-001461
Published: 2006
Includes: Supplemental data