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Journal Articles

Smaart Criz: Sickle Cell Mechanisms of Activation, Adhesion, Rheology, and Thrombosis (SMAART) in Response to P-Selectin Inhibition

Gianna G. Guzzardo, Meera Chitlur, Patrick C. Hines, Aliya U. Zaidi, Rasa Borhan, Kelsey Cinciarelli, Alexander K Glaros

Blood (2023) 142 (Supplement 1): 2528.

https://doi.org/10.1182/blood-2023-189008

Published: 2023

Journal Articles

The Role of Red Blood Cell Vascular Adhesion Biomarkers in Understanding Sickle Cell Disease Associated Chronic Pain

Olufunke Y. Martin, Rasa Borhan, Aliya U. Zaidi, Deepika S. Darbari, Patrick C. Hines, Andrew D. Campbell

Blood (2023) 142 (Supplement 1): 1137.

https://doi.org/10.1182/blood-2023-190689

Published: 2023

Journal Articles

Assessment of Biomarker Response to Clinical Administration of Adakveo in a “Real World” Clinical Setting: A Model for Therapeutic Monitoring in Sickle Cell Disease (SCD)

Jennell White, Corrine Packer-Pencle, Xiufeng Gao, Andrekia Williams-Montgomery, Gershwin Theophilus Blyden, Lanetta Bronté-Hall, Patrick C. Hines

Blood (2023) 142 (Supplement 1): 5282.

https://doi.org/10.1182/blood-2023-191195

Published: 2023

Journal Articles

Red Blood Cell Deformability and Morphological Dynamic Sickling As a Metric to Monitor Pharmacodynamic Response to Voxelotor

Marta Ferranti, Jordan Antongiorgi, Robert Goodrich, Xiufeng Gao, Ke Liu, Nnamdi Okeke, Michael Tarasev, Patrick C. Hines

Blood (2023) 142 (Supplement 1): 5260.

https://doi.org/10.1182/blood-2023-190246

Published: 2023

Journal Articles

Healthcare Utilization and Cost of Care Analysis of Patients with Sickle Cell Disease with High Vs. Low Biomarkers: A Retrospective Chart Review

Ryan Dingle, Jennell White, Kerry Bellemare, Lanetta Bronté-Hall, Patrick C. Hines

Blood (2023) 142 (Supplement 1): 5285.

https://doi.org/10.1182/blood-2023-191230

Published: 2023

Journal Articles

Assessing Real-Time Sickling Kinetics in Individual Cells from Erythrocyte Populations of Subjects with Different HbA, HbS and HbF Percentages

Aliya U. Zaidi, Xiufeng Gao, Robert Goodrich, Marta Ferranti, Rasa Borhan, Ke Liu, Nnamdi Okeke, Michael Tarasev, Mariama Kabore, Courtney D. Fitzhugh, Priya Sethu Chockalingam, Patrick C. Hines

Blood (2023) 142 (Supplement 1): 1118.

https://doi.org/10.1182/blood-2023-190404

Published: 2023

Journal Articles

Initial Results in a Phase 1b Trial of PB-04 in Sickle Cell Disease Demonstrate Fetal Hemoglobin Induction, Additive Activity with Hydroxyurea, and Improved Red Blood Cell Sickling Parameters

Kevin H.M. Kuo, Sylvia Titi Singer, Gershwin Theophilus Blyden, Lanetta Bronté-Hall, Aidan Faller, Abdullah Kutlar, Frans A. Kuypers, Aliya U. Zaidi, Patrick C. Hines, Niren Patel, Sandra Larkin, Hanny Al-Samkari, Sujit Sheth, Seyed Mehdi Nouraie, Susan Perrine

Blood (2023) 142 (Supplement 1): 1148.

https://doi.org/10.1182/blood-2023-184627

Published: 2023

Journal Articles

Dynamic Sickling Assay: Using Enzymatically Induced Hypoxia to Assess Real-Time Sickling Scalable from Large Erythrocyte Populations to Individual Cells

Michael Tarasev, Xiufeng Gao, Marta Ferranti, Robert Goodrich, Allie Edenstrom, Aliya Zaidi, Patrick C. Hines

Blood (2022) 140 (Supplement 1): 4976–4977.

https://doi.org/10.1182/blood-2022-170885

Published: 2022

Journal Articles

Real World Applications of Clinical Whole Blood Adhesion (VCAM and P-selectin) Biomarkers in a Pediatric SCD Population

Olufunke Y. Martin, Stefanie L. Margulies, Deepika S. Darbari, Patrick C. Hines, Andrew D. Campbell

Blood (2022) 140 (Supplement 1): 5459–5460.

https://doi.org/10.1182/blood-2022-170351

Published: 2022

Journal Articles

Ex Vivo Evaluation of Red Blood Cell Adhesion and Whole Blood Thrombosis in Pyruvate Kinase Deficiency

Patrick C. Hines, Xiufeng Gao, Andrew Herppich, Wendy Hollon, Meera B. Chitlur, Janet L. Kwiatkowski, Michael Tarasev

Blood (2021) 138 (Supplement 1): 923.

https://doi.org/10.1182/blood-2021-149744

Published: 2021

Journal Articles

Evaluation of Longitudinal Pain Study in Sickle Cell Disease (ELIPSIS) by patient-reported outcomes, actigraphy, and biomarkers

Debra D. Pittman, Patrick C. Hines, David Beidler, Denis Rybin, Andrew L. Frelinger, III, Alan D. Michelson, Ke Liu, Xiufeng Gao, Jennell White, Ahmar U. Zaidi, Robert J. Charnigo, Michael U. Callaghan

Blood (2021) 137 (15): 2010–2020.

https://doi.org/10.1182/blood.2020006020

Published: 2021

Includes: Supplemental data

Journal Articles

Hemolytic Biomarkers Predict Adhesiveness of Sickle Blood Cells in a Clinical Adhesion Bioassay

Jennell White, PhD, Xiufeng Gao, MD, Michael Tarasev, Michael.tarasev@functionalfluidics.com, Ke Liu, PhD, Michael U. Callaghan, MD, Patrick C. Hines, MDPhD

Blood (2020) 136 (Supplement 1): 31.

https://doi.org/10.1182/blood-2020-143402

Published: 2020

Journal Articles

Evaluation of Coagulation and Inflammatory Markers in Pediatric Patients on Extracorporeal Membrane Oxygenation (ECMO)

Katherine Regling, DO, Katherine Cashen, DO, Manisha Gadgeel, MBBS, MS, Yue Xi, PhD, Andrew Herppich, Michael Tarasev, Patrick C. Hines, MDPhD, Meera B. Chitlur, MD

Blood (2020) 136 (Supplement 1): 14.

https://doi.org/10.1182/blood-2020-140900

Published: 2020

Journal Articles

A Standardized Clinical Flow Adhesion Assay of Whole Blood Adhesion to VCAM-1 Predicts Severe SCD Phenotypes in a 2-Yr Prospective Observational Follow-up of the Original Elipsis Cohort

Patrick C. Hines, MD PhD, Ahmar Urooj Zaidi, MD, Xiufeng Gao, MD, Ke Liu, PhD, Muhammad O. Shareef, Michael Callaghan, Jennell White, PhD

Blood (2019) 134 (Supplement_1): 3562.

https://doi.org/10.1182/blood-2019-126371

Published: 2019

Journal Articles

PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation

Martin K. Safo, PhD, Piyusha P Pagare, PhD, Mohini Ghatge, PhD, Carla Casu, PhD, Valentina Ghiaccio, PhD, Nancy Anabaraonye, Xiaomeng Xu, MS, Stefano Rivella, PhD, Patrick C. Hines, MD PhD, Ke Liu, PhD, Yan Zhang, PhD, Jürgen Venitz, MD PhD, Osheiza Abdulmalik, DVM

Blood (2019) 134 (Supplement_1): 73.

https://doi.org/10.1182/blood-2019-128646

Published: 2019

Journal Articles

Longitudinal Evaluation of a Standardized P-Selectin Flow Adhesion Bioassay: Potential Role for the Assessment and Prediction of Vaso-Occlusive Episodes in Sickle Cell Disease

Ke Liu, PhD, Xiufeng Gao, MD, Jennell White, PhD, Michael U. Callaghan, MD, Patrick C. Hines, MD PhD

Blood (2018) 132 (Supplement 1): 1096.

https://doi.org/10.1182/blood-2018-99-120084

Published: 2018

Journal Articles

A Longitudinal Study to Identify and Assess Adhesion Indices during Vaso-Occlusive Crises in Adults and Adolescents with Sickle Cell Disease

Jennell White, PhD, Xiufeng Gao, MD, Ke Liu, PhD, Michael U. Callaghan, MD, Patrick C. Hines, MD PhD

Blood (2018) 132 (Supplement 1): 1097.

https://doi.org/10.1182/blood-2018-99-120311

Published: 2018

Journal Articles

Elipsis: A Longitudinal Study of Electronic Patient-Reported Outcomes, Actigraphy and Biomarkers to Identify and Assess at-Home Vaso-Occlusive Crises in Adults and Adolescents with Sickle Cell Disease

Michael U. Callaghan, Patrick C. Hines, MD PhD, Debra D Pittman, MS, David Beidler, PhD, Denis Rybin, PhD, Ahmar Urooj Zaidi, MD BSc, Jennell White, PhD, Ke Liu, PhD, Bryan Hannan, MS, Xiufeng Gao, MD, Andreas M Pleil, PhD, Alexandra Barsdorf, PhD, Martin David, Pharm D, Melanie Simmons, PMP, PSM, Andrew L Frelinger, III, PhD, Alan D Michelson, MD, Nick Clarke, PhD, Robert J Charnigo, MS

Blood (2017) 130 (Supplement 1): 973.

https://doi.org/10.1182/blood.V130.Suppl_1.973.973

Published: 2017

Journal Articles

Sevuparin Blocks Sickle Blood Cell Adhesion and Sickle-Leukocyte Rolling on Immobilized L-Selectin in a Dose Dependent Manner

Maria Lindgren, PhD, Jennell White, PhD, Ke Liu, PhD, Lena Jendeberg, PhD, Patrick C. Hines, MD PhD

Blood (2016) 128 (22): 2482.

https://doi.org/10.1182/blood.V128.22.2482.2482

Published: 2016

Journal Articles

Evaluation of Purified Poloxamer-188 (vepoloxamer) on Sickle Red Blood Cell (RBC) Membrane Function Properties

Jennell White, PhD, Patrick C. Hines, MD PhD, Ke Liu, PhD, Lennette J. Benjamin, MD, Xiufeng Gao, Martin Emanuele, PhD

Blood (2015) 126 (23): 2180.

https://doi.org/10.1182/blood.V126.23.2180.2180

Published: 2015

NARROW

Smaart Criz: Sickle Cell Mechanisms of Activation, Adhesion, Rheology, and Thrombosis (SMAART) in Response to P-Selectin Inhibition

The Role of Red Blood Cell Vascular Adhesion Biomarkers in Understanding Sickle Cell Disease Associated Chronic Pain

Assessment of Biomarker Response to Clinical Administration of Adakveo in a “Real World” Clinical Setting: A Model for Therapeutic Monitoring in Sickle Cell Disease (SCD)

Red Blood Cell Deformability and Morphological Dynamic Sickling As a Metric to Monitor Pharmacodynamic Response to Voxelotor

Healthcare Utilization and Cost of Care Analysis of Patients with Sickle Cell Disease with High Vs. Low Biomarkers: A Retrospective Chart Review

Assessing Real-Time Sickling Kinetics in Individual Cells from Erythrocyte Populations of Subjects with Different HbA, HbS and HbF Percentages

Initial Results in a Phase 1b Trial of PB-04 in Sickle Cell Disease Demonstrate Fetal Hemoglobin Induction, Additive Activity with Hydroxyurea, and Improved Red Blood Cell Sickling Parameters

Dynamic Sickling Assay: Using Enzymatically Induced Hypoxia to Assess Real-Time Sickling Scalable from Large Erythrocyte Populations to Individual Cells

Real World Applications of Clinical Whole Blood Adhesion (VCAM and P-selectin) Biomarkers in a Pediatric SCD Population

Ex Vivo Evaluation of Red Blood Cell Adhesion and Whole Blood Thrombosis in Pyruvate Kinase Deficiency

Evaluation of Longitudinal Pain Study in Sickle Cell Disease (ELIPSIS) by patient-reported outcomes, actigraphy, and biomarkers

Hemolytic Biomarkers Predict Adhesiveness of Sickle Blood Cells in a Clinical Adhesion Bioassay

Evaluation of Coagulation and Inflammatory Markers in Pediatric Patients on Extracorporeal Membrane Oxygenation (ECMO)

A Standardized Clinical Flow Adhesion Assay of Whole Blood Adhesion to VCAM-1 Predicts Severe SCD Phenotypes in a 2-Yr Prospective Observational Follow-up of the Original Elipsis Cohort

PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation

Longitudinal Evaluation of a Standardized P-Selectin Flow Adhesion Bioassay: Potential Role for the Assessment and Prediction of Vaso-Occlusive Episodes in Sickle Cell Disease

A Longitudinal Study to Identify and Assess Adhesion Indices during Vaso-Occlusive Crises in Adults and Adolescents with Sickle Cell Disease

Elipsis: A Longitudinal Study of Electronic Patient-Reported Outcomes, Actigraphy and Biomarkers to Identify and Assess at-Home Vaso-Occlusive Crises in Adults and Adolescents with Sickle Cell Disease

Sevuparin Blocks Sickle Blood Cell Adhesion and Sickle-Leukocyte Rolling on Immobilized L-Selectin in a Dose Dependent Manner

Evaluation of Purified Poloxamer-188 (vepoloxamer) on Sickle Red Blood Cell (RBC) Membrane Function Properties

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American Society of Hematology

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American Society of Hematology

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