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Journal Articles

Preclinical and Clinical Use of AB1, a DNMT1 Protein Depleter, to Upregulate Fetal Hemoglobin in Townes Sickle Cell Disease (SCD) Mice and Patients with SCD

Nirmish Shah, Girindra Raval, Abdullah Kutlar, Niren Patel, Mayuko Takezaki, Biaoru Li, Manickam Alagar, Hongyan Xu, Kelly Blackburn, Santhosh Vadivelu, Robert Schaub, David Santos, Betty Pace

Blood (2023) 142 (Supplement 1): 276.

https://doi.org/10.1182/blood-2023-188165

Published: 2023

Journal Articles

Initial Results in a Phase 1b Trial of PB-04 in Sickle Cell Disease Demonstrate Fetal Hemoglobin Induction, Additive Activity with Hydroxyurea, and Improved Red Blood Cell Sickling Parameters

Kevin H.M. Kuo, Sylvia Titi Singer, Gershwin Theophilus Blyden, Lanetta Bronté-Hall, Aidan Faller, Abdullah Kutlar, Frans A. Kuypers, Aliya U. Zaidi, Patrick C. Hines, Niren Patel, Sandra Larkin, Hanny Al-Samkari, Sujit Sheth, Seyed Mehdi Nouraie, Susan Perrine

Blood (2023) 142 (Supplement 1): 1148.

https://doi.org/10.1182/blood-2023-184627

Published: 2023

Journal Articles

Proteomics of Plasma from Patients with Sickle Cell Disease with and without Chronic Pain: A Pilot Biomarker Discovery Study

Mycal Casey, Brandon Gramazio, Florence Urum, Niren Patel, Wenbo Zhi, Abdullah Kutlar

Blood (2022) 140 (Supplement 1): 5414–5415.

https://doi.org/10.1182/blood-2022-168950

Published: 2022

Journal Articles

ETA Receptor Blockade and Vascular Function in Patients with Sickle Cell Disease

Daniel Adamkiewicz, Hongyan Xu, PhD, Latanya Bowman, RN, Leigh Wells, MSN, Niren Patel, MBBS, Ryan Harris, PhD CEP, FACSM, Jennifer Pollock, PhD, David M. Pollock, PhD, Steffen E. Meiler, MD, Abdullah Kutlar, MD

Blood (2020) 136 (Supplement 1): 25–26.

https://doi.org/10.1182/blood-2020-142477

Published: 2020

Journal Articles

Downregulation of Cytoskeletal Protein Kazrin in Lung Endothelial Cells of Preclinical Sickle Cell Disease Mouse Model - Essential Role of Endothelial Barrier Function

Umapathy N Siddaramappa, PhD, Niren Patel, MBBS, Betty S. Pace, MD, Abdullah Kutlar, MD

Blood (2019) 134 (Supplement_1): 2258.

https://doi.org/10.1182/blood-2019-130924

Published: 2019

Journal Articles

Correlation of Serum Ferritin Levels with Liver Iron Concentration By MRI Measurement in Sickle Cell Patients with Transfusional Iron Overload

Germame Ajebo, MD, Abhishek A. Mangaonkar, MD, Imran Ahmad, MD MPH, Nadine Barrett, MSN, Leigh Wells, MSN, Niren Patel, MBBS, Hongyan Xu, PhD, Abdullah Kutlar, MD

Blood (2018) 132 (Supplement 1): 4926.

https://doi.org/10.1182/blood-2018-99-119597

Published: 2018

Journal Articles

Characteristics and Potential Biomarkers of Adult Sickle Cell Patients with Chronic Pain

Camila Albo, Sanjiv Kumar, PhD, Michael Pope, Bachelors/MDcal Student, Kyle Michael Kidwell, Bachelors/MDcal Student, Niren Patel, MBBS, Leigh Wells, MSN, Latanya Bowman, RN, Nadine Barrett, MSN, Xu Hongyan, PhD, Abdullah Kutlar, MD

Blood (2018) 132 (Supplement 1): 857.

https://doi.org/10.1182/blood-2018-99-115084

Published: 2018

Journal Articles

Erythroferrone (ERFE) and Hepcidin Levels in Sickle Cell Disease with and without Transfusional Iron Overload

Fahim Thawer, Abdullah Kutlar, MD, Latanya Bowman, RN, Leigh Wells, MSN, Xu Hongyan, PhD, Niren Patel, MBBS, Pritam Bora, BA

Blood (2017) 130 (Supplement 1): 3518.

https://doi.org/10.1182/blood.V130.Suppl_1.3518.3518

Published: 2017

Journal Articles

Evolution of Chronic Pain in Sickle Cell Disease

Michael Pope, BA, Camila Albo, Kyle Michael Kidwell, BS, Hongyan Xu, PhD, Latanya Bowman, BSN, Leigh Wells, MSN, Nadine Barrett, MSN, Sabine Fields, BSN, Pritam Bora, BA, E. Leila Jerome Clay, MD, Niren Patel, MBBS, Abdullah Kutlar, MD

Blood (2016) 128 (22): 1297.

https://doi.org/10.1182/blood.V128.22.1297.1297

Published: 2016

Journal Articles

Characteristics of Sickle Cell Patients with Frequent ED Visits and Hospitalizations: Demographic, Clinical, Laboratory and Psycho-Social Aspects

Kyle Michael Kidwell, BS, Camila Albo, Michael Pope, BA, Latanya Bowman, BSN, Hongyan Xu, PhD, Leigh Wells, MSN, Nadine Barrett, MSN, Sabine Fields, BSN, Pritam Bora, BA, Niren Patel, MBBS, Amy Allison, PhD, Abdullah Kutlar, MD

Blood (2016) 128 (22): 2501.

https://doi.org/10.1182/blood.V128.22.2501.2501

Published: 2016

Journal Articles

Coinheritance of Alpha -3.7 Deletion and Hb Questembert [ 131 alpha-2 Tct > CCT](Ser131>Pro)] in an African American Patient Results in an Alpha Thalassemia Phenotype

Asiya Shakir, MD, Betty Pace, MD, Niren Patel, MBBS, Ferdane Kutlar, MD, Abdullah Kutlar, MD, Afshin Ameri, MD

Blood (2015) 126 (23): 4597.

https://doi.org/10.1182/blood.V126.23.4597.4597

Published: 2015

Journal Articles

Characteristics and Potential Biomarkers for Chronic Pain in Patients with Sickle Cell Disease

Nina Kuei, BS, Niren Patel, MBBS, Hongyan Xu, PhD, Leigh Wells, MS, Latanya Bowman, BS, Pritam Bora, Kavita Natrajan, MBBS, Abdullah Kutlar, MD

Blood (2015) 126 (23): 986.

https://doi.org/10.1182/blood.V126.23.986.986

Published: 2015

Journal Articles

TCD with Transfusions Changing to Hydroxyurea (TWiTCH): Hydroxyurea Therapy As an Alternative to Transfusions for Primary Stroke Prevention in Children with Sickle Cell Anemia

Russell E. Ware, MD PhD, Barry R Davis, MD PhD, William H Schultz, MHS PA, Clark Brown, MD PhD, Banu Aygun, MD, Sharada A. Sarnaik, MD, Isaac Odame, MD, Beng Fuh, MD, Alex George, MD, PhD, William Owen, MD, Lori Luchtman-Jones, MD, Zora R. Rogers, MD, Lee Hilliard, MD, Cynthia Gauger, MD, Connie M. Piccone, MD, Margaret T. Lee, MD, Janet Kwiatkowski, MD, Sherron Jackson, MD, Scott T. Miller, MD, Carla W Roberts, MD, Matthew M. Heeney, MD FRCP(C), Theodosia A. Kalfa, MD PhD, Stephen C Nelson, MD, Hamayun Imran, MD, Kerri A Nottage, MD MPH, Ofelia A. Alvarez, MD, Melissa Rhodes, MD, Alexis A. Thompson, MD, Jennifer Rothman, MD, Kathleen J. Helton, MD, Donna Roberts, MD, Jamie Coleman, MD, Melanie J Bonner, PhD, Abdullah Kutlar, MD, Niren Patel, MD, John C Wood, MD PhD, Linda Piller, MD, Peng Wei, PhD, Judy Luden, CCRP, Nicole A. Mortier, MHS, PA-C, Susan Stuber, MA, Naomi L.C. Luban, MD, Alan R. Cohen, MD, Sara L Pressel, MS, Robert J. Adams, MD MS

Blood (2015) 126 (23): 3.

https://doi.org/10.1182/blood.V126.23.3.3

Published: 2015

Journal Articles

Diagnostic Challenges in a Low a 2 β-Thalassemia Case

Niren Patel, MBBS, Natalia Dixon, MD, Lina Zhuang, MD, Shanequa Bryant, Ferdane Kutlar, MD, Abdullah Kutlar, MD

Blood (2014) 124 (21): 4898.

https://doi.org/10.1182/blood.V124.21.4898.4898

Published: 2014

Journal Articles

Plasma Biomarkers of Iron Regulation, Overload, and Inflammation in Sickle Cell Disease

Abhishek Mangaonkar, MBBS, Niren Patel, MBBS, Hongyan Xu, PhD, Kavita Natrajan, MBBS, Betsy Clair, Leigh G Wells, MSN, RN, FNP-BC, Latanya Bowman, RN, Nadine Barret, MSN, RN, FNP-BC, Abdullah Kutlar, MD

Blood (2014) 124 (21): 1380.

https://doi.org/10.1182/blood.V124.21.1380.1380

Published: 2014

Journal Articles

Genetic Association Studies of Pain Phenotypes in Adult SCD Patients

Abdullah Kutlar, MD, Leigh G Wells, MSN, RN, FNP-BC, Hongyan Xu, PhD, Latanya Bowman, RN, Pritam Bora, Arati Rani Chand, MBBS, Betsy Clair, Steffen E Meiler, MD, Xiaoling Wang, PhD, Kavita Natrajan, MBBS, Niren Patel, MBBS, Roger B Fillingim, PhD

Blood (2014) 124 (21): 2708.

https://doi.org/10.1182/blood.V124.21.2708.2708

Published: 2014

Journal Articles

Homozygous Expression of a Novel Senegalese-Type Partial Deletion of the Beta and Delta Genes Causes a Delta 0 Beta + Thalassemia.

Hernan Sabio, MD, MS, Natalia Dixon, MD, Ferdane Kutlar, MD, Niren Patel, MBBS, Hanfang Zhang, MD, PhD, Lina Zhuang, MD, Abdullah Kutlar, MD

Blood (2012) 120 (21): 2128.

https://doi.org/10.1182/blood.V120.21.2128.2128

Published: 2012

Journal Articles

Improving the Accuracy of BCR-ABL Transcript Quantitation: Pitfalls of Using a Common Standard for b3a2 and b2a2 Transcripts

Hanfang Zhang, MD, PhD, Linda Fletcher, Niren Patel, MBBS, Shanequa Bryant, Honglin Li, PhD, Ferdane Kutlar, MD, Anand P. Jillella, MD, Vamsi Kota, MBBS, Betsy Clair, Abdullah Kutlar, MD

Blood (2012) 120 (21): 4423.

https://doi.org/10.1182/blood.V120.21.4423.4423

Published: 2012

Journal Articles

Resveratrol Regulates Fetal Hemoglobin Production by Inhibiting KLF1 and BCL11A in KU812 Cells

Davies G Agyekum, Zhong Chen, MD, Haiyan Xiao, Megan Yu, Niren Patel, MBBS, Betty S Pace, MD, Steffen E. Meiler, MD

Blood (2012) 120 (21): 1000.

https://doi.org/10.1182/blood.V120.21.1000.1000

Published: 2012

Journal Articles

Diagnostic Challenge Presented by “Hb F only” Pattern In Newborn Screening for Hemoglobinopathies: Approach to Accurate Diagnosis

Niren Patel, MBBS, Hanfang Zhang, MD, PhD, Lina Zhuang, MD, Rupa Redding-Lallinger, MD, Ruth Luddy, MD, Abdullah Kutlar, MD, Ferdane Kutlar, MD

Blood (2010) 116 (21): 5173.

https://doi.org/10.1182/blood.V116.21.5173.5173

Published: 2010

NARROW

Preclinical and Clinical Use of AB1, a DNMT1 Protein Depleter, to Upregulate Fetal Hemoglobin in Townes Sickle Cell Disease (SCD) Mice and Patients with SCD

Initial Results in a Phase 1b Trial of PB-04 in Sickle Cell Disease Demonstrate Fetal Hemoglobin Induction, Additive Activity with Hydroxyurea, and Improved Red Blood Cell Sickling Parameters

Proteomics of Plasma from Patients with Sickle Cell Disease with and without Chronic Pain: A Pilot Biomarker Discovery Study

ETA Receptor Blockade and Vascular Function in Patients with Sickle Cell Disease

Downregulation of Cytoskeletal Protein Kazrin in Lung Endothelial Cells of Preclinical Sickle Cell Disease Mouse Model - Essential Role of Endothelial Barrier Function

Correlation of Serum Ferritin Levels with Liver Iron Concentration By MRI Measurement in Sickle Cell Patients with Transfusional Iron Overload

Characteristics and Potential Biomarkers of Adult Sickle Cell Patients with Chronic Pain

Erythroferrone (ERFE) and Hepcidin Levels in Sickle Cell Disease with and without Transfusional Iron Overload

Evolution of Chronic Pain in Sickle Cell Disease

Characteristics of Sickle Cell Patients with Frequent ED Visits and Hospitalizations: Demographic, Clinical, Laboratory and Psycho-Social Aspects

Coinheritance of Alpha -3.7 Deletion and Hb Questembert [ 131 alpha-2 Tct > CCT](Ser131>Pro)] in an African American Patient Results in an Alpha Thalassemia Phenotype

Characteristics and Potential Biomarkers for Chronic Pain in Patients with Sickle Cell Disease

TCD with Transfusions Changing to Hydroxyurea (TWiTCH): Hydroxyurea Therapy As an Alternative to Transfusions for Primary Stroke Prevention in Children with Sickle Cell Anemia

Diagnostic Challenges in a Low a 2 β-Thalassemia Case

Plasma Biomarkers of Iron Regulation, Overload, and Inflammation in Sickle Cell Disease

Genetic Association Studies of Pain Phenotypes in Adult SCD Patients

Homozygous Expression of a Novel Senegalese-Type Partial Deletion of the Beta and Delta Genes Causes a Delta 0 Beta + Thalassemia.

Improving the Accuracy of BCR-ABL Transcript Quantitation: Pitfalls of Using a Common Standard for b3a2 and b2a2 Transcripts

Resveratrol Regulates Fetal Hemoglobin Production by Inhibiting KLF1 and BCL11A in KU812 Cells

Diagnostic Challenge Presented by “Hb F only” Pattern In Newborn Screening for Hemoglobinopathies: Approach to Accurate Diagnosis

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American Society of Hematology

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