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Simone Cenci
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Journal Articles

Unraveling Pathophysiology and Hematopoiesis of Vexas Syndrome By Multi-Omics Analyses and Targeted Gene Editing

Raffaella Molteni, Martina Fiumara, Corrado Campochiaro, Alessandro Tomelleri, Elisa Diral, Angelica Varesi, Alessandra Weber, Davide Stefanoni, Roberta Alfieri, Luisa Albano, Maddalena Panigada, Eleonora Cantoni, Daniele Canarutto, Luca Basso-Ricci, Pamela Quaranta, Angelo D'Alessandro, Marco Matucci-Cerinic, Raffaella Di Micco, Serena Scala, Alessandro Aiuti, Fabio Ciceri, Ivan Merelli, Lorenzo Dagna, Simone Cenci, Giulio Cavalli, Luigi Naldini, Samuele Ferrari
Journal: Blood
Blood (2023) 142 (Supplement 1): 2692.
https://doi.org/10.1182/blood-2023-179749
Published: 2023
Journal Articles

Targeting the Mitochondrial Protease Clpp Unveils Mitochondrial Vulnerabilities in Multiple Myeloma

Tommaso Perini, Laura Oliva, Maria Materozzi, Rossella Del Pizzo, Laura Cassina, Mehmet K. Samur, Ugo Orfanelli, Enrico Milan, Alessandra Boletta, Nikhil C Munshi, Simone Cenci
Journal: Blood
Blood (2022) 140 (Supplement 1): 7072–7073.
https://doi.org/10.1182/blood-2022-164536
Published: 2022
Journal Articles

A FAM46C-Dependent Molecular Circuit Modulates Antibody Synthesis and Proliferation in Plasma Cell Dyscrasias

Enrico Milan, Massimo Resnati, Elena Riva, Mario Nuvolone, Simone Cenci
Journal: Blood
Blood (2022) 140 (Supplement 1): 857.
https://doi.org/10.1182/blood-2022-162234
Published: 2022
Journal Articles

Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease

Raffaella Molteni, Riccardo Biavasco, Davide Stefanoni, Travis Nemkov, Jorge Domínguez-Andrés, Rob J. Arts, Ivan Merelli, Davide Mazza, Samuel Zambrano, Maddalena Panigada, Eleonora Cantoni, Isak W. Tengesdal, Philippe Maksud, Francesco Piras, Daniela Cesana, Laura Cassina, Gianfranco Distefano, Alessia Loffreda, Daniela Gnani, Giacomo De Luca, Alessandro Tomelleri, Corrado Campochiaro, Leo A. B. Joosten, Charles A. Dinarello, Anna Kajaste-Rudnitski, Julien Haroche, Simone Cardaci, Simone Cenci, Lorenzo Dagna, Claudio Doglioni, Marina Ferrarini, Elisabetta Ferrero, Alessandra Boletta, Angelo D’Alessandro, Eugenio Montini, Mihai G. Netea, Giulio Cavalli
Journal: Blood
Blood (2021) 138 (17): 1554–1569.
https://doi.org/10.1182/blood.2020009594
Published: 2021
Includes: Supplemental data
Journal Articles

Tryptophan Deprivation Promotes an Adaptive Response and Contributes to Bioenergetics in Multiple Myeloma

Alessandra Romano, MDPhD, Nunziatina Laura Parrinello, Katia Todoerti, PhD, Piera La Cava, Fabrizio Puglisi, Cesarina Giallongo, PhD, Daniele Tibullo, Giuseppina Camiolo, Giuseppe Sapienza, MD, Vittorio Del Fabro, MD, Concetta Conticello, Francesco Piazza, Marilena Carrino, PhD, Giuseppe A. Palumbo, MD, Simone Cenci, MD, Antonino Neri, MD, Francesco Di Raimondo, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4511.
https://doi.org/10.1182/blood-2018-99-116447
Published: 2018
Journal Articles

Arginine Deprivation and Autophagy Sustain Bioenergetics in Multiple Myeloma

Alessandra Romano, MDPhD, Laura Oliva, PhD, Jose Manuel Manteiga, Todoerti Katia, Lorenzo Canziani, Matteo Trudu, Francesca Fontana, Michela Ghizzinardi, Ugo Orfanelli, Magda Marcatti, MD, Fabio Ciceri, MD, Giovanni Tonon, MD PhD, Antonino Neri, MD, Claudio Cerichione, MD PhD, Francesco Di Raimondo, MD, Simone Cenci, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3051.
https://doi.org/10.1182/blood.V130.Suppl_1.3051.3051
Published: 2017
Journal Articles

Arginine Deprivation Sustains Plasma Cell Fitness Via GCN2: A Novel Immuno-Metabolic Check-Point

Alessandra Romano, MDPhD, Ugo Orfanelli, Michela Ghizzinardi, Nunziatina Laura Parrinello, Piera La Cava, Todoerti Katia, Laura Oliva, PhD, Francesca Paradiso, Floriana Cremasco, Daniele Tibullo, Cesarina Giallongo, Concetta Conticello, MD, Magda Marcatti, MD, Fabio Ciceri, MD, Antonino Neri, MD, Claudio Cerichione, MD PhD, Francesco Di Raimondo, MD, Simone Cenci, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1752.
https://doi.org/10.1182/blood.V130.Suppl_1.1752.1752
Published: 2017
Journal Articles

The amyloidogenic light chain is a stressor that sensitizes plasma cells to proteasome inhibitor toxicity

Laura Oliva, Ugo Orfanelli, Massimo Resnati, Andrea Raimondi, Andrea Orsi, Enrico Milan, Giovanni Palladini, Paolo Milani, Fulvia Cerruti, Paolo Cascio, Simona Casarini, Paola Rognoni, Thierry Touvier, Magda Marcatti, Fabio Ciceri, Silvia Mangiacavalli, Alessandro Corso, Giampaolo Merlini, Simone Cenci
Journal: Blood
Blood (2017) 129 (15): 2132–2142.
https://doi.org/10.1182/blood-2016-08-730978
Published: 2017
Includes: Supplemental data
Journal Articles

Immune Suppression By High-Density Neutrophils Predicts Short Progression-Free Survival in Multiple Myeloma

Alessandra Romano, MD PhD, Jose Manteiga, PhD, Vittorio Simeon, PhD, Nunziatina L Parrinello, Cesarina Giallongo, Piera La Cava, Concetta Conticello, MD, Daniele Tibullo, PhD, Francesca Fontana, Fabio Ciceri, MD, Floriana Cremasco, Monica Fabbri, Pellegrino Musto, Simone Cenci, MD, Francesco Di Raimondo, MD
Journal: Blood
Blood (2016) 128 (22): 4459.
https://doi.org/10.1182/blood.V128.22.4459.4459
Published: 2016
Journal Articles

Metabolomics Identifies Potential Biomarkers of Multiple Myeloma Development and Progression

Francesca Fontana, MD, PhD, Josè Manuel garcia Manteiga, PhD, Magda Marcatti, MD, Francesca Lorentino, MD, Giovanni Tonon, MD, PhD, Fabio Ciceri, MD, Roberto Sitia, MD, Simone Cenci, MD
Journal: Blood
Blood (2012) 120 (21): 3985.
https://doi.org/10.1182/blood.V120.21.3985.3985
Published: 2012
Journal Articles

Assessing Proteostasis and Proteasome Stress In Light Chain Amyloidosis

Laura Oliva, PhD, Giovanni Palladini, MD, Fulvia Cerruti, PhD, Niccolò Pengo, MS, Paolo Cascio, PhD, Giampaolo Merlini, MD, Roberto Sitia, MD, Simone Cenci, MD
Journal: Blood
Blood (2010) 116 (21): 3992.
https://doi.org/10.1182/blood.V116.21.3992.3992
Published: 2010
Journal Articles

The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition

Giada Bianchi, Laura Oliva, Paolo Cascio, Niccolò Pengo, Francesca Fontana, Fulvia Cerruti, Andrea Orsi, Elena Pasqualetto, Alexandre Mezghrani, Valeria Calbi, Giovanni Palladini, Nicola Giuliani, Kenneth C. Anderson, Roberto Sitia, Simone Cenci
Journal: Blood
Blood (2009) 113 (13): 3040–3049.
https://doi.org/10.1182/blood-2008-08-172734
Published: 2009
Includes: Supplemental data
Journal Articles

Proteasome Stress Causes Apoptotic Sensitivity of Multiple Myeloma Cells to Proteasome Inhibition

Giada Bianchi, Laura Oliva, Paolo Cascio, Niccolo’ Pengo, Andrea Orsi, Francesca Fontana, Elena Pasqualetto, Alexandre Mezghrani, Fulvia Cerruti, Valeria Calbi, Giovanni Palladini, Nicola Giuliani, Dharminder Chauhan, Kenneth C. Anderson, Roberto Sitia, Simone Cenci
Journal: Blood
Blood (2008) 112 (11): 247.
https://doi.org/10.1182/blood.V112.11.247.247
Published: 2008
Journal Articles

Direct Assessment of Proteasomal Degradation as a Potential Predictor of Responsiveness to Bortezomib in Multiple Myeloma.

Giada Bianchi, MD, Andrea Orsi, PhD, Simone Cenci, MD, Paolo Cascio, PhD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD, Roberto Sitia, MD
Journal: Blood
Blood (2006) 108 (11): 3525.
https://doi.org/10.1182/blood.V108.11.3525.3525
Published: 2006
Journal Articles

Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines

M. Neale Weitzmann, Simone Cenci, Leonard Rifas, Christopher Brown, Roberto Pacifici
Journal: Blood
Blood (2000) 96 (5): 1873–1878.
https://doi.org/10.1182/blood.V96.5.1873
Published: 2000