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Paolo Cascio
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Journal Articles

Nuclear respiratory factor 1 promotes cell survival in multiple myeloma under proteasome inhibition therapy

Open Access
Tiziana Bruno, Maria Chiara Cappelletto, Clelia Cortile, Stefano Di Giovenale, Bruno Amadio, Francesca De Nicola, Italia Falcone, Stefano Giuliani, Belinda Palermo, Valeria Catena, Ludovica Ciuffreda, Fulvia Cerruti, Paolo Cascio, Roberta Merola, Serena Masi, Valentina De Pascale, Ombretta Annibali, Silvia Ferraro, +39, Svitlana Gumenyuk, Francesco Pisani, Francesco Marchesi, Andrea Mengarelli, Maurizio Fanciulli, Giacomo Corleone
Journal: Blood
Blood blood.2025028441.
https://doi.org/10.1182/blood.2025028441
Published: 2025
Includes: Supplemental data
Journal Articles

The amyloidogenic light chain is a stressor that sensitizes plasma cells to proteasome inhibitor toxicity

Free
Laura Oliva, Ugo Orfanelli, Massimo Resnati, Andrea Raimondi, Andrea Orsi, Enrico Milan, Giovanni Palladini, Paolo Milani, Fulvia Cerruti, Paolo Cascio, Simona Casarini, Paola Rognoni, Thierry Touvier, Magda Marcatti, Fabio Ciceri, Silvia Mangiacavalli, Alessandro Corso, Giampaolo Merlini, Simone Cenci
Journal: Blood
Blood (2017) 129 (15): 2132–2142.
https://doi.org/10.1182/blood-2016-08-730978
Published: 2017
Includes: Supplemental data
Journal Articles

Assessing Proteostasis and Proteasome Stress In Light Chain Amyloidosis

Free
Laura Oliva, PhD, Giovanni Palladini, MD, Fulvia Cerruti, PhD, Niccolò Pengo, MS, Paolo Cascio, PhD, Giampaolo Merlini, MD, Roberto Sitia, MD, Simone Cenci, MD
Journal: Blood
Blood (2010) 116 (21): 3992.
https://doi.org/10.1182/blood.V116.21.3992.3992
Published: 2010
Journal Articles

The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition

Free
Giada Bianchi, Laura Oliva, Paolo Cascio, Niccolò Pengo, Francesca Fontana, Fulvia Cerruti, Andrea Orsi, Elena Pasqualetto, Alexandre Mezghrani, Valeria Calbi, Giovanni Palladini, Nicola Giuliani, Kenneth C. Anderson, Roberto Sitia, Simone Cenci
Journal: Blood
Blood (2009) 113 (13): 3040–3049.
https://doi.org/10.1182/blood-2008-08-172734
Published: 2009
Includes: Supplemental data
Journal Articles

Proteasome Stress Causes Apoptotic Sensitivity of Multiple Myeloma Cells to Proteasome Inhibition

Free
Giada Bianchi, Laura Oliva, Paolo Cascio, Niccolo’ Pengo, Andrea Orsi, Francesca Fontana, Elena Pasqualetto, Alexandre Mezghrani, Fulvia Cerruti, Valeria Calbi, Giovanni Palladini, Nicola Giuliani, Dharminder Chauhan, Kenneth C. Anderson, Roberto Sitia, Simone Cenci
Journal: Blood
Blood (2008) 112 (11): 247.
https://doi.org/10.1182/blood.V112.11.247.247
Published: 2008
Journal Articles

Direct Assessment of Proteasomal Degradation as a Potential Predictor of Responsiveness to Bortezomib in Multiple Myeloma.

Free
Giada Bianchi, MD, Andrea Orsi, PhD, Simone Cenci, MD, Paolo Cascio, PhD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD, Roberto Sitia, MD
Journal: Blood
Blood (2006) 108 (11): 3525.
https://doi.org/10.1182/blood.V108.11.3525.3525
Published: 2006
Journal Articles

Proteasome activity restricts lentiviral gene transfer into hematopoietic stem cells and is down-regulated by cytokines that enhance transduction

Free
Francesca Romana Santoni de Sio, Paolo Cascio, Anna Zingale, Mauro Gasparini, Luigi Naldini
Journal: Blood
Blood (2006) 107 (11): 4257–4265.
https://doi.org/10.1182/blood-2005-10-4047
Published: 2006
Includes: Supplemental data