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Takahiro Shima
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Journal Articles

Guanine nucleotides drive ribosome biogenesis and glycolytic reprogramming in acute myeloid leukemia stem cells

Open Access
Gentaro Kawano, Riichiro Ikeda, Daisuke Ishihara, Takahiro Shima, Teppei Sakoda, Shunsuke Yamamoto, Yu Kochi, Yuichiro Semba, Sanae Ashitani, Yasuo Mori, Koji Kato, Takahiro Maeda, Toshihiro Miyamoto, Tomoyoshi Soga, Koichi Akashi, Yoshikane Kikushige
Journal: Blood
Blood blood.2025030209.
https://doi.org/10.1182/blood.2025030209
Published: 2025
Includes: Supplemental data
Journal Articles

Monotherapy update from Phase 1 portion in Phase1/2 trial of the menin-MLL inhibitor enzomenib (DSP-5336) in patients with relapsed or refractory acute leukemia

Free
Naval Daver, Joshua Zeidner, Justin Watts, Junichiro Yuda, Mark Levis, Pau Montesinos, Cristina Papayannidis, Kentaro Fukushima, Takahiro Shima, Emmanuel Raffoux, Uma Borate, Neil Palmisiano, Joseph Brandwein, Mael Heiblig, Yasushi Miyazaki, Takayuki Ikezoe, Melissa Ooi, Shang-Ju Wu, Eunice Wang, Susana Vives, Stephen Strickland, Dimitri Breems, Naoko Hosono, Yoshiaki Ogawa, Koichi Onodera, Andrew Brunner, Gina Keiffer, Timothy Pardee, Paul Shami, Alireza Eghtedar, Hongliang Cai, Bo Xu, Priya Robson, Akinobu Watanabe, Matthew Hitron, Jatin Shah, Hagop Kantarjian, Harry Erba
Journal: Blood
Blood (2025) 146 (Supplement 1): 763.
https://doi.org/10.1182/blood-2025-763
Published: 2025
Journal Articles

Efficacy of upfront blinatumomab combined with reduced-intensity chemotherapy for newly diagnosed adult Philadelphia chromosome–negative B-lineage acute lymphoblastic leukemia: Interim analysis of two prospective studies of JSCT ALL/MRD2023 and ALL/MRD2019 in Japan

Free
Takahiro Shima, Koji Nagafuji, Toshihiro Miyamoto, Shuichi Ota, Yuna Katsuoka, Satoshi Yoshihara, Naoyuki Uchida, Senji Kasahara, Hiroki Hosoi, Mitsumasa Watanabe, Hitoji Uchiyama, Junya Kanda, Takeru Asano, Yuichiro Nawa, Ken Takase, Atsushi Satake, Junya Kuroda, Tetsuya Eto, Yutaka Imamura, Yasuhiko Miyazaki, Akio Mori, Satoshi Yamamoto, Takahiro Nagashima, Shinichi Masuda, Yoshiki Nakae, Hitoshi Minamiguchi, Yuta Katayama, Tatsunori Ishikawa, Shiro Fujii, Tomoaki Fujisaki, Katsuto Takenaka, Goichi Yoshimoto, Ilseung Choi, Masao Ogata, Koji Kato, Naoki Harada, Mika Kuroiwa, Masahiro Onozawa, Hisashi Yamamoto, Junichi Kitagawa, Taku Tsukamoto, Noboru Asada, Ryota Imanaka, Kazushi Tanimoto, Shuro Yoshida, Yuichiro Semba, Yoshikane Kikushige, Yoshikiyo Ito, Takahiro Maeda, Koichi Akashi
Journal: Blood
Blood (2025) 146 (Supplement 1): 5116.
https://doi.org/10.1182/blood-2025-5116
Published: 2025
Journal Articles

Platelet decrease and efficacy of platelet-rich plasma return for CAR-T lymphocyte apheresis in low-weight patients

Free
Takahiro Shima, Tomoko Henzan, Ikumi Yamanaka, Yuichiro Semba, Shunsuke Yamamoto, Utako Oba, Yuhki Koga, Shouichi Ohga, Takahiro Maeda, Koichi Akashi
Journal: Blood
Blood (2025) 146 (Supplement 1): 7702.
https://doi.org/10.1182/blood-2025-7702
Published: 2025
Journal Articles

Pre-CAR-T GTE Scoring of Electroencephalogram Abnormalities As Predictive Biomarkers for Icans

Free
Hidetaka Nakagaki, Takuji Yamauchi, Takahiko Mukaino, Ayumi Sakata, Eriko Watanabe, Mitsuru Watanabe, Daisuke Ishihara, Hiroshi Imanaga, Kensuke Sasaki, Teppei Sakoda, Fumiaki Jinnouchi, Kohta Miyawaki, Takahiro Shima, Yoshikane Kikushige, Yasuo Mori, Yuya Kunisaki, Taeko Hotta, Hiroshi Shigeto, Noriko Isobe, Koichi Akashi, Koji Kato
Journal: Blood
Blood (2024) 144 (Supplement 1): 2081.
https://doi.org/10.1182/blood-2024-199102
Published: 2024
Journal Articles

Phase 1 Results: First-in-Human Phase 1/2 Study of the Menin-MLL Inhibitor Enzomenib (DSP-5336) in Patients with Relapsed or Refractory Acute Leukemia

Free
Joshua F Zeidner, Junichiro Yuda, Justin M. Watts, Mark J. Levis, Harry P. Erba, Kentaro Fukushima, Takahiro Shima, Neil D. Palmisiano, Eunice S. Wang, Uma Borate, Joseph Brandwein, Cristina Papayannidis, Pau Montesinos, Gina Keiffer, Yasushi Miyazaki, Naoko Hosono, Takayuki Ikezoe, Yoshiaki Ogawa, Timothy S Pardee, Stephen Anthony Strickland, Koichi Onodera, Shang-Ju Wu, Melissa G Ooi, Emmanuel Raffoux, Susana Vives, Alireza Eghtedar, Hongliang Cai, Curtis Allred, Bo Xu, Priya Robson, Akinobu Watanabe, Matthew Hitron, Jatin Shah, Hagop M. Kantarjian, Naval Daver
Journal: Blood
Blood (2024) 144 (Supplement 1): 213.
https://doi.org/10.1182/blood-2024-194827
Published: 2024
Journal Articles

Phase 1/2 First-in-Human Study of the Menin-MLL Inhibitor DSP-5336 in Patients with Relapsed or Refractory Acute Leukemia

Free
Naval Daver, Joshua F. Zeidner, Junichiro Yuda, Justin M. Watts, Mark J. Levis, Kentaro Fukushima, Takayuki Ikezoe, Yoshiaki Ogawa, Joseph Brandwein, Eunice S. Wang, Yasushi Miyazaki, Timothy Pardee, Naoko Hosono, Takahiro Shima, Hisayuki Yokoyama, Noboru Asada, Joseph Jurcic, Hongliang Cai, Akinobu Watanabe, Matthew Hitron, Emily Brooks, Bo Xu, Jatin Shah, Hagop M. Kantarjian, Harry P. Erba
Journal: Blood
Blood (2023) 142 (Supplement 1): 2911.
https://doi.org/10.1182/blood-2023-179252
Published: 2023
Journal Articles

Fever with Significant Procalcitonin Increase Following Gemtuzumab Ozogamicin Infusion in Hematologic Malignancy Patients without Evidence of Infection

Free
Chiaki Kubara, Takahiro Shima, Yasuo Mori, Koji Kato, Koichi Akashi
Journal: Blood
Blood (2023) 142 (Supplement 1): 7281.
https://doi.org/10.1182/blood-2023-180039
Published: 2023
Journal Articles

Impact of Anti-Thymocyte Globulin on Procalcitonin Levels Comparison during Fever in Allogeneic Stem Cell Transplantation Conditioning

Free
Takahiro Shima, Mariko Minami, Yasuo Mori, Shin-ichi Mizuno, Toshihiro Miyamoto, Koji Kato, Koichi Akashi
Journal: Blood
Blood (2023) 142 (Supplement 1): 6985.
https://doi.org/10.1182/blood-2023-174235
Published: 2023
Journal Articles

Interleukin-18 and Soluble Interleukin-2 Receptor Are Useful Markers for Enhanced Diagnosis of Intravascular Lymphoma

Free
Takahiro Shima, Yusuke Yamauchi, Masahiro Ohtsu, Hiroki Mitoma, Koji Kato, Koichi Akashi
Journal: Blood
Blood (2023) 142 (Supplement 1): 6117.
https://doi.org/10.1182/blood-2023-181258
Published: 2023
Journal Articles

Platelet Decrease and Efficacy of Platelet-Rich Plasma Return for Peripheral Blood Stem Cell Apheresis

Free
Takahiro Shima, MD PhD, Teppei Sakoda, MD, Tomoko Henzan, MD, Yuya Kunisaki, MD PhD, Takahiro Maeda, MD PhD, Koichi Akashi, MD PhD, Toshihiro Miyamoto, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29–30.
https://doi.org/10.1182/blood-2020-142316
Published: 2020
Journal Articles

Aromatase is a novel neosubstrate of cereblon responsible for immunomodulatory drug–induced thrombocytopenia

Free
Taro Tochigi, Toshihiro Miyamoto, Kiwamu Hatakeyama, Teppei Sakoda, Daisuke Ishihara, Hidetoshi Irifune, Takahiro Shima, Koji Kato, Takahiro Maeda, Takumi Ito, Hiroshi Handa, Koichi Akashi, Yoshikane Kikushige
Journal: Blood
Blood (2020) 135 (24): 2146–2158.
https://doi.org/10.1182/blood.2019003749
Published: 2020
Includes: Supplemental data
Journal Articles

Hippo kinase loss contributes to del(20q) hematologic malignancies through chronic innate immune activation

Free
Samuel A. Stoner, Ming Yan, Katherine Tin Heng Liu, Kei-Ichiro Arimoto, Takahiro Shima, Huan-You Wang, Daniel T. Johnson, Rafael Bejar, Catriona Jamieson, Kun-Liang Guan, Dong-Er Zhang
Journal: Blood
Blood (2019) 134 (20): 1730–1744.
https://doi.org/10.1182/blood.2019000170
Published: 2019
Includes: Supplemental data
Journal Articles

Hippo Kinase Inactivation Contributes to Del(20q) Malignancies and Cooperates with JAK2-V617F to Promote Myelofibrosis in Mice

Free
Samuel A Stoner, Ming Yan, PhD, Katherine Liu, Takahiro Shima, MD PhD, Huan-You Wang, MD PhD, Kei-Ichiro Arimoto, PhD, Rafael Bejar, MD PhD, Catriona Jamieson, MD PhD, Kun-Liang Guan, PhD, Dong-Er Zhang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 99.
https://doi.org/10.1182/blood-2018-99-115591
Published: 2018
Journal Articles

FIP1L1 Regulates Alternative Polyadenylation of Leukemia-Associated Genes in Acute Myeloid Leukemia

Free
Amanda G Davis, BS, Takahiro Shima, MD PhD, Ruijia Wang, PhD, Dinghai Zheng, PhD, Bin Tian, PhD, Dong-Er Zhang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3882.
https://doi.org/10.1182/blood-2018-99-119582
Published: 2018
Journal Articles

CPSF1-Mediated Acute Myeloid Leukemia Fusion 3'UTR Alternation Is a Potential Therapeutic Target

Free
Takahiro Shima, MD PhD, Amanda G Davis, Daniel T Johnson, Yu Kochi, MD, Sayuri Miyauchi, DDS, PhD, Samuel A Stoner, Junichiro Yuda, MD, Toshihiro Miyamoto, MD PhD, Jie-Hua Zhou, MD, Edward D. Ball, MD, Koichi Akashi, MD PhD, Dong-Er Zhang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 885.
https://doi.org/10.1182/blood-2018-99-119199
Published: 2018
Journal Articles

RUNX1 Deficiency Cooperates with SRSF2 Mutation to Further Disrupt RNA Splicing and Exacerbate Myelodysplastic Syndromes in Mouse Models

Free
Yi-Jou Huang, BS, Ming Yan, PhD, Jia-Yu Chen, PhD, Liang Chen, PhD, Eunhee Kim, PhD, Takahiro Shima, MD PhD, Amanda G Davis, BS, Sayuri Miyauchi, DDS, PhD, Samuel A Stoner, Xiang-Dong Fu, PhD, Omar I Abdel-Wahab, MD, Dong-Er Zhang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1796.
https://doi.org/10.1182/blood-2018-99-119104
Published: 2018
Journal Articles

RUNX1 Deficiency and SRSF2 Mutation Cooperate to Promote Myelodysplastic Syndrome Development

Free
Yi-Jou Huang, BS, Ming Yan, PhD, Eunhee Kim, PhD, Amanda G Davis, BS, Takahiro Shima, MD PhD, Sayuri Miyauchi, DDS, PhD, Xiang-Dong Fu, PhD, Omar Abdel-Wahab, MD, Dong-Er Zhang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 119.
https://doi.org/10.1182/blood.V130.Suppl_1.119.119
Published: 2017
Journal Articles

Characterization of the Post-Transcriptional Regulation of AML1-ETO Expression in t(8;21) Leukemia Cells

Free
Daniel T Johnson, BS, Takahiro Shima, MD PhD, Amanda G Davis, BS, Dong-Er Zhang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3790.
https://doi.org/10.1182/blood.V130.Suppl_1.3790.3790
Published: 2017
Journal Articles

CPSF1 Regulates AML1-ETO Fusion Gene Polyadenylation and Stability in t(8;21) Acute Myelogenous Leukemia

Free
Takahiro Shima, MD PhD, Amanda G Davis, Sayuri Miyauchi, DDS, PhD, Yu Kochi, MD, Daniel T Johnson, Samuel A Stoner, BS, Yuda Junichiro, MD, Toshihiro Miyamoto, MD PhD, Jie-Hua Zhou, MD, Edward D Ball, MD, Koichi Akashi, MD PhD, Dong-Er Zhang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2498.
https://doi.org/10.1182/blood.V130.Suppl_1.2498.2498
Published: 2017