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Journal Articles

Practical and Flexible Genome Profiling Study Using the Halo-Shape Annealing and Defer-Ligation Enrichment (HANDLE) System: HM-Screen-JAPAN02

Naoko Hosono, Takahiro Yamauchi, Chi Sung-Gi, Hironori Arai, Kentaro Fukushima, Daisuke Ikeda, Satoshi Iyama, Akihiko Gotoh, Takayuki Ikezoe, Chikashi Yoshida, Goichi Yoshimoto, Junya Kanda, Naoto Takahashi, Emiko Sakaida, Kensuke Usuki, Yosuke Minami

Blood (2023) 142 (Supplement 1): 2279.

https://doi.org/10.1182/blood-2023-184546

Published: 2023

Journal Articles

NGS Profile and the Mathematical Prediction Model for Venetoclax Combination Therapy in HM-Screen-Japan 02 Study

Tomoaki Ueda, Kentaro Fukushima, Naoki Hosen, Sunggi Chi, Hiroshi Haeno, Goichi Yoshimoto, Hironori Arai, Daisuke Ikeda, Kensuke Usuki, Naoto Takahashi, Naoko Hosono, Takahiro Yamauchi, Takeshi Kondo, Kazuhito Yamamoto, Junya Kuroda, Yosuke Minami

Blood (2023) 142 (Supplement 1): 5761.

https://doi.org/10.1182/blood-2023-180339

Published: 2023

Journal Articles

A Practice-Oriented Genome Profiling Study with the Novel Halo-Shape Annealing and Defer-Ligation Enrichment (HANDLE) System : HM-Screen-JAPAN02

Blood (2022) 140 (Supplement 1): 10722–10724.

https://doi.org/10.1182/blood-2022-159351

Published: 2022

Journal Articles

CHOP Plus Sequential Mogamulizumab As First-Line Therapy for Untreated Adult T-Cell Leukemia-Lymphoma

Kazuki Tanimoto, Koji Kato, Takatoshi Aoki, Goichi Yoshimoto, Ilseung Choi, Masanori Kadowaki, Yasuhiro Sugio, Takuro Kuriyama, Noriaki Kawano, Ritsuro Suzuki, Kohta Miyawaki, Hideho Henzan, Noriyuki Saito, Takanori Ohta, Toshihiro Miyamoto, Koichi Akashi

Blood (2021) 138 (Supplement 1): 1393.

https://doi.org/10.1182/blood-2021-151937

Published: 2021

Journal Articles

Evaluation of TIM-3-Positive LSCs Post Allo-SCT Is a Highly Sensitive Strategy to Predict AML Relapses

Teppei Sakoda, MD, Yoshikane Kikushige, MD PhD, Takuya Harada, MD, Hidetoshi Irifune, MD, Masayasu Hayashi, MD PhD, Goichi Yoshimoto, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2019) 134 (Supplement_1): 2702.

https://doi.org/10.1182/blood-2019-127779

Published: 2019

Journal Articles

Multicenter, Open-Label, 3-Arm Study of Gilteritinib, Gilteritinib Plus Azacitidine, or Azacitidine Alone in Newly Diagnosed FLT 3 Mutated ( FLT3 mut+ ) Acute Myeloid Leukemia (AML) Patients Ineligible for Intensive Induction Chemotherapy: Findings from the Safety Cohort

Jordi Esteve, MD PhD, Rik Schots, Teresa Bernal Del Castillo, MD PhD, Je-Hwan Lee, MD PhD, Eunice S. Wang, MD, Shira Dinner, MD, Mark D. Minden, MD PhD, Olga Salamero, MD, Jorge Sierra, MD, Goichi Yoshimoto, MD PhD, Kamel Laribi, MD, Janusz Halka, MD, Pau Montesinos, MD PhD, Shufang Liu, Elizabeth Shima Rich, MD PhD, Erkut Bahceci, MD

Blood (2018) 132 (Supplement 1): 2736.

https://doi.org/10.1182/blood-2018-99-110976

Published: 2018

Journal Articles

Evaluation of TIM-3+ LSCs Is a Highly Sensitive MRD Monitoring Strategy to Predict AML Relapse after Allogenic Stem Cell Transplantation

Masayasu Hayashi, MD PhD, Teppei Sakoda, MD, Yoshikane Kikushige, MD PhD, Hidetoshi Irifune, MD, Goichi Yoshimoto, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2018) 132 (Supplement 1): 1390.

https://doi.org/10.1182/blood-2018-99-116640

Published: 2018

Journal Articles

Comparative Analysis of Tyrosine Kinase Inhibitors-Related Pulmonary Hypertension in the Patients Treated By Imatinib, Dasatinib and Nilotinib

Mariko Minami, MD, Toshihiro Miyamoto, MD PhD, Takeshi Arita, MD PhD, Tomohiko Kamimura, MD PhD, Junichiro Yuda, MD, Yoshikane Kikushige, MD PhD, Yasuo Mori, MDPhD, Goichi Yoshimoto, MD PhD, Kenjiro Kamezaki, MD PhD, Koji Kato, MD PhD, Motoaki Shiratsuchi, MDPhD, Katsuto Takenaka, MD PhD, Hiromi Iwasaki, MDPhD, Satoshi Yamasaki, MD PhD, Tsuyoshi Muta, MD PhD, Kazuki Tanimoto, MD PhD, Ryosuke Ogawa, MD PhD, Tetsuya Eto, MD PhD, Koichi Akashi, MD PhD

Blood (2015) 126 (23): 1583.

https://doi.org/10.1182/blood.V126.23.1583.1583

Published: 2015

Journal Articles

Prior Use of Mogamulizumab to Allogenic Hematopoietic Stem Cell Transplantation Induces Severe Acute Graft-Versus-Host Disease

Blood (2015) 126 (23): 1940.

https://doi.org/10.1182/blood.V126.23.1940.1940

Published: 2015

Journal Articles

Incidence and Differential Diagnosis of Human Herpes Virus-6 Associated Encephalitis/Myelitis in Allogeneic Stem Cell Transplantation That Mimics Calcineurin Inhibitor-Induced Pain Syndrome

Goichi Yoshimoto, MDPhD, Toshihiro Miyamoto, MD PhD, Koji Kato, MD PhD, Yasuo Mori, MDPhD, Kenjiro Kamezaki, MDPhD, Katsuto Takenaka, MDPhD, Hiromi Iwasaki, MD PhD, Koichi Akashi, MD PhD

Blood (2015) 126 (23): 1912.

https://doi.org/10.1182/blood.V126.23.1912.1912

Published: 2015

Journal Articles

Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis

Takuro Kuriyama, Katsuto Takenaka, Kentaro Kohno, Takuji Yamauchi, Shinya Daitoku, Goichi Yoshimoto, Yoshikane Kikushige, Junji Kishimoto, Yasunobu Abe, Naoki Harada, Toshihiro Miyamoto, Hiromi Iwasaki, Takanori Teshima, Koichi Akashi

Blood (2012) 120 (19): 4058–4067.

https://doi.org/10.1182/blood-2012-02-408864

Published: 2012

Includes: Supplemental data

Journal Articles

Hemophagocytic Lymphohistiocytosis Is Caused by Engulfment of Hematopoietic Stem Cells by Macrophages Through Stem Cell-Specific Suppression of CD47 Under Influence of Cytokine Deregulation

Takuro Kuriyama, MD, Katsuto Takenaka, MD, PhD, Kentaro Kohno, MD, Goichi Yoshimoto, MD, PhD, Junji Kishimoto, PhD, Yasunobu Abe, MD, PhD, Toshihiro Miyamoto, MD, PhD, Koichi Akashi, MD, PhD.

Blood (2011) 118 (21): 522.

https://doi.org/10.1182/blood.V118.21.522.522

Published: 2011

Journal Articles

Minimal Residual Disease Negative Status At the End of Induction Therapy Is a Potent Prognostic Marker in Adult Non-Ph Acute Lymphoblastic Leukemia: Results of the ALL MRD2002 Study

Koji Nagafuji, MD, PhD, Toshihiro Miyamoto, MD, PhD, Tetsuya Eto, MD, PhD, Tomohiko Kamimura, MD, Shuichi Taniguchi, MD, PhD, Takashi Okamura, MD, PhD, Eiichi Ohtsuka, MD, PhD, Takashi Yoshida, MD, Masakazu Higuchi, MD, PhD, Goichi Yoshimoto, MD, PhD, Tomoaki Fujisaki, MD, PhD, Yasunobu Abe, MD, PhD, Yasushi Takamatsu, MD, PhD, Shouhei Yokota, MD, PhD, Koichi Akashi, MD, PhD., Mine Harada, MD, PhD

Blood (2011) 118 (21): 2581.

https://doi.org/10.1182/blood.V118.21.2581.2581

Published: 2011

Journal Articles

FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD–specific STAT5 activation

Goichi Yoshimoto, Toshihiro Miyamoto, Siamak Jabbarzadeh-Tabrizi, Tadafumi Iino, Jennifer L. Rocnik, Yoshikane Kikushige, Yasuo Mori, Takahiro Shima, Hiromi Iwasaki, Katsuto Takenaka, Koji Nagafuji, Shin-ichi Mizuno, Hiroaki Niiro, Gary D. Gilliland, Koichi Akashi

Blood (2009) 114 (24): 5034–5043.

https://doi.org/10.1182/blood-2008-12-196055

Published: 2009

Includes: Supplemental data

Journal Articles

Human FLT3/FLK2 Targets Hematopoietic Stem Cells and Granulocyte/Macrophage Progenitors.

Yoshikane Kikushige, Goichi Yoshimoto, Toshihiro Miyamoto, Fumihiko Ishikawa, Hiromi Iwasaki, Koichi Akashi

Blood (2007) 110 (11): 1263.

https://doi.org/10.1182/blood.V110.11.1263.1263

Published: 2007

Journal Articles

Anti-Apoptotic MCL-1 Plays a Critical Role in Maintenance of Normal and Malignant Human Hematopoietic Stem Cells through FLT3 Signaling.

Goichi Yoshimoto, MD, Toshihiro Miyamoto, MD, PhD, Tadafumi Iino, MD, Yoshikane Kikushige, MD, Hiroaki Niiro, MD, PhD, Hiromi Iwasaki, MD, PhD, Mine Harada, MD, PhD, Koichi Akashi, MD, PhD

Blood (2006) 108 (11): 11.

https://doi.org/10.1182/blood.V108.11.11.11

Published: 2006

Journal Articles

Prospective Isolation of Human Eosinophil-Committed Progenitors.

Yasuo Mori, MD, Hiromi Iwasaki, MD,PhD, Goichi Yoshimoto, MD, Aki Okeda, MD, Toshihiro Miyamoto, MD,PhD, Shin-ichi Mizuno, MD,PhD, Mine Harada, MD,PhD, Kiyoshi Takatsu, MD,PhD, Koichi Akashi, MD,PhD

Blood (2006) 108 (11): 1285.

https://doi.org/10.1182/blood.V108.11.1285.1285

Published: 2006

Journal Articles

hFlt3 Expression Marks Long-Term Hematopoietic Stem Cells, but Not the Pathway Common to Granulocyte/Monocyte and Lymphoid Lineages in Human Hematopoiesis.

Yoshikane Kikushige, MD, Goichi Yoshimoto, MD, Toshihiro Miyamoto, MD, Fumihiko Ishikawa, MD, Hiromi Iwasaki, MD, Mine Harada, MD, Koichi Akashi, MD

Blood (2006) 108 (11): 1654.

https://doi.org/10.1182/blood.V108.11.1654.1654

Published: 2006

Journal Articles

Long-Term Engraftment and Self-Renewal of AML Stem Cells in the Newborn NOD-scid/IL2rgnull Immunodeficient Mouse Model.

Shuro Yoshida, MD, Fumihiko Ishikawa, MD, PhD, Masaki Yasukawa, MD, PhD, Toshihiro Miyamoto, MD, PhD, Goichi Yoshimoto, MD, Noriaki Kawano, MD, Kazuya Shimoda, MD, Koichi Akashi, MD, PhD, Leonard D. Shultz, PhD, Mine Harada, MD

Blood (2005) 106 (11): 1261.

https://doi.org/10.1182/blood.V106.11.1261.1261

Published: 2005

Journal Articles

Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chain null mice

Fumihiko Ishikawa, Masaki Yasukawa, Bonnie Lyons, Shuro Yoshida, Toshihiro Miyamoto, Goichi Yoshimoto, Takeshi Watanabe, Koichi Akashi, Leonard D. Shultz, Mine Harada

Blood (2005) 106 (5): 1565–1573.

https://doi.org/10.1182/blood-2005-02-0516

Published: 2005

Includes: Supplemental data

NARROW

Practical and Flexible Genome Profiling Study Using the Halo-Shape Annealing and Defer-Ligation Enrichment (HANDLE) System: HM-Screen-JAPAN02

NGS Profile and the Mathematical Prediction Model for Venetoclax Combination Therapy in HM-Screen-Japan 02 Study

A Practice-Oriented Genome Profiling Study with the Novel Halo-Shape Annealing and Defer-Ligation Enrichment (HANDLE) System : HM-Screen-JAPAN02

CHOP Plus Sequential Mogamulizumab As First-Line Therapy for Untreated Adult T-Cell Leukemia-Lymphoma

Evaluation of TIM-3-Positive LSCs Post Allo-SCT Is a Highly Sensitive Strategy to Predict AML Relapses

Multicenter, Open-Label, 3-Arm Study of Gilteritinib, Gilteritinib Plus Azacitidine, or Azacitidine Alone in Newly Diagnosed FLT 3 Mutated ( FLT3 mut+ ) Acute Myeloid Leukemia (AML) Patients Ineligible for Intensive Induction Chemotherapy: Findings from the Safety Cohort

Evaluation of TIM-3+ LSCs Is a Highly Sensitive MRD Monitoring Strategy to Predict AML Relapse after Allogenic Stem Cell Transplantation

Comparative Analysis of Tyrosine Kinase Inhibitors-Related Pulmonary Hypertension in the Patients Treated By Imatinib, Dasatinib and Nilotinib

Prior Use of Mogamulizumab to Allogenic Hematopoietic Stem Cell Transplantation Induces Severe Acute Graft-Versus-Host Disease

Incidence and Differential Diagnosis of Human Herpes Virus-6 Associated Encephalitis/Myelitis in Allogeneic Stem Cell Transplantation That Mimics Calcineurin Inhibitor-Induced Pain Syndrome

Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis

Hemophagocytic Lymphohistiocytosis Is Caused by Engulfment of Hematopoietic Stem Cells by Macrophages Through Stem Cell-Specific Suppression of CD47 Under Influence of Cytokine Deregulation

Minimal Residual Disease Negative Status At the End of Induction Therapy Is a Potent Prognostic Marker in Adult Non-Ph Acute Lymphoblastic Leukemia: Results of the ALL MRD2002 Study

FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD–specific STAT5 activation

Human FLT3/FLK2 Targets Hematopoietic Stem Cells and Granulocyte/Macrophage Progenitors.

Anti-Apoptotic MCL-1 Plays a Critical Role in Maintenance of Normal and Malignant Human Hematopoietic Stem Cells through FLT3 Signaling.

Prospective Isolation of Human Eosinophil-Committed Progenitors.

hFlt3 Expression Marks Long-Term Hematopoietic Stem Cells, but Not the Pathway Common to Granulocyte/Monocyte and Lymphoid Lineages in Human Hematopoiesis.

Long-Term Engraftment and Self-Renewal of AML Stem Cells in the Newborn NOD-scid/IL2rgnull Immunodeficient Mouse Model.

Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chain null mice

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