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Renier J. Brentjens
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Journal Articles

The Intestinal Microbiota Correlates with Response and Toxicity after CAR T Cell Therapy in Patients with B-Cell Malignancies

Melody Smith, Anqi Dai, Guido Ghilardi, Kimberly Amelsberg, Sean M Devlin, Raymone Pajarillo, John B Slingerland, Silvia Beghi, Pamela S Herrera, Paul A Giardina, Annelie Clurman, Emmanuel A Dwomoh, Gabriel K Armijo, Antonio L.C. Gomes, Eric R Littmann, Jonas Schluter, Emily Fontana, Ying Taur, Jae H Park, Maria Lia Palomba, Elizabeth Halton, Josel D Ruiz, Tania Jain, Martina Pennisi, Aishat Olaide Afuye, Miguel-Angel Perales, Craig W. Freyer, Alfred L Garfall, Shannon H Gier, Sunita Nasta, Daniel J Landsburg, James N Gerson, Jakub Svoboda, Justin Cross, Elise A Chong, Sergio A Giralt, Saar Gill, Isabelle Rivière, David L Porter, Stephen J Schuster, Michel Sadelain, Noelle V Frey, Renier J Brentjens, Carl H June, Eric G Pamer, Jonathan U Peled, Marco Ruella, Marcel van den Brink, Andrea Facciabene
Journal: Blood
Blood (2021) 138 (Supplement 1): 253.
https://doi.org/10.1182/blood-2021-153945
Published: 2021
Journal Articles

Five-Year Experience Using Bridging Radiotherapy Prior to Chimeric Antigen Receptor (CAR) T-Cell Therapies for B-Cell Malignancies at Memorial Sloan Kettering Cancer Center

Emily A. Silverman, Harper Hubbeling, M. Lia Palomba, N. Ari Wijetunga, Kathryn Tringale, Emily Lebow, Ana Alarcon Tomas, Roni Shouval, Connie Lee Batlevi, Renier J Brentjens, Parastoo B. Dahi, Sergio A Giralt, Richard J Lin, Jae H Park, Michael Scordo, Craig S. Sauter, Gunjan L. Shah, Miguel-Angel Perales, Carla Hajj, Joachim Yahalom, Brandon S. Imber
Journal: Blood
Blood (2021) 138 (Supplement 1): 2507.
https://doi.org/10.1182/blood-2021-151179
Published: 2021
Journal Articles

Phase I First-in-Class Trial of MCARH109, a G Protein Coupled Receptor Class C Group 5 Member D (GPRC5D) Targeted CAR T Cell Therapy in Patients with Relapsed or Refractory Multiple Myeloma

Sham Mailankody, Claudia Diamonte, Lisa Fitzgerald, Peter Kane, Xiuyan Wang, Devanjan S. Sikder, Brigitte Senechal, Vladimir P. Bermudez, Diana Frias, Justina Morgan, Patrick Grant, Terence J Purdon, Kinga Hosszu, Sean M Devlin, Urvi A Shah, Jonathan Landa, Alexander Lesokhin, Neha Korde, Hani Hassoun, Carlyn Tan, Malin Hultcrantz, Gunjan L. Shah, Heather J Landau, David J. Chung, Michael Scordo, Mikhail Roshal, Ola Landgren, Ahmet Dogan, Sergio A Giralt, Jae H Park, Isabelle Rivière, Renier J Brentjens, Eric L Smith
Journal: Blood
Blood (2021) 138 (Supplement 1): 827.
https://doi.org/10.1182/blood-2021-153204
Published: 2021
Journal Articles

Lesion Characteristics and Patterns of Failure in Diffuse Large B Cell Lymphoma Patients Treated with Bridging Radiotherapy Prior to Chimeric Antigen Receptor T Cell Therapy

Harper Hubbeling, Emily A. Silverman, Neil Ari Wijetunga, M. Lia Palomba, Kathryn Tringale, Emily Lebow, Ana Alarcon Tomas, Roni Shouval, Connie Lee Batlevi, Renier J Brentjens, Parastoo B. Dahi, Sergio A Giralt, Richard J Lin, Jae H Park, Michael Scordo, Craig S. Sauter, Gunjan L Shah, Miguel-Angel Perales, Carla Hajj, Joachim Yahalom, Brandon S. Imber
Journal: Blood
Blood (2021) 138 (Supplement 1): 1429.
https://doi.org/10.1182/blood-2021-149702
Published: 2021
Journal Articles

A Phase II Study of Prophylactic Anakinra to Prevent CRS and Neurotoxicity in Patients Receiving CD19 CAR T Cell Therapy for Relapsed or Refractory Lymphoma

Jae H Park, Craig S. Sauter, M. Lia Palomba, Gunjan L Shah, Parastoo B Dahi, Richard J Lin, Michael Scordo, Connie Lee Batlevi, Miguel-Angel Perales, Peter Kane, Aishat Olaide Afuye, Elena Mead, Bianca Santomasso, Elizabeth Halton, Michel Sadelain, Renier J Brentjens
Journal: Blood
Blood (2021) 138 (Supplement 1): 96.
https://doi.org/10.1182/blood-2021-150431
Published: 2021
Journal Articles

Interventions and outcomes of adult patients with B-ALL progressing after CD19 chimeric antigen receptor T-cell therapy

Clinical Trials & Observations
Kitsada Wudhikarn, Jessica R. Flynn, Isabelle Rivière, Mithat Gönen, Xiuyan Wang, Brigitte Senechal, Kevin J. Curran, Mikhail Roshal, Peter G. Maslak, Mark B. Geyer, Elizabeth F. Halton, Claudia Diamonte, Marco L. Davila, Michel Sadelain, Renier J. Brentjens, Jae H. Park
Journal: Blood
Blood (2021) 138 (7): 531–543.
https://doi.org/10.1182/blood.2020009515
Published: 2021
Includes: Supplemental data
Journal Articles

A Phase I Study of CD19-Targeted 19(T2)28z1xx CAR T Cells in Adult Patients with Relapsed or Refractory B-Cell Malignancies

Jae H. Park, MD, Isabelle Riviere, PhD, Devanjan S. Sikder, Vladimir P. Bermudez, Brigitte Senechal, Xiuyan Wang, PhD, Thomas H. Auchincloss, Claudia Diamonte, RN, Elizabeth Halton, NP-BC AOCNP, M. Lia Palomba, MD, Renier J. Brentjens, MD PhD, Michel Sadelain, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 43–44.
https://doi.org/10.1182/blood-2020-143088
Published: 2020
Journal Articles

Toxicity and response after CD19-specific CAR T-cell therapy in pediatric/young adult relapsed/refractory B-ALL

Clinical Trials & Observations
Kevin J. Curran, Steven P. Margossian, Nancy A. Kernan, Lewis B. Silverman, David A. Williams, Neerav Shukla, Rachel Kobos, Christopher J. Forlenza, Peter Steinherz, Susan Prockop, Farid Boulad, Barbara Spitzer, Maria I. Cancio, Jaap Jan Boelens, Andrew L. Kung, Yasmin Khakoo, Victoria Szenes, Jae H. Park, Craig S. Sauter, Glenn Heller, Xiuyan Wang, Brigitte Senechal, Richard J. O’Reilly, Isabelle Riviere, Michel Sadelain, Renier J. Brentjens
Journal: Blood
Blood (2019) 134 (26): 2361–2368.
https://doi.org/10.1182/blood.2019001641
Published: 2019
Includes: Supplemental data
Journal Articles

Optimal Dual-Targeted CAR Construct Simultaneously Targeting Bcma and GPRC5D Prevents Bcma-Escape Driven Relapse in Multiple Myeloma

Carlos Fernandez de Larrea, MD PhD, Mette Staehr, PhD, Andrea Lopez, Yunxin Chen, MBBS, Terence J Purdon, MS, Khong Y. Ng, PhD, Hans Wendel, MD, Renier J. Brentjens, MD PhD, Eric L Smith, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 136.
https://doi.org/10.1182/blood-2019-126145
Published: 2019
Journal Articles

Hematological Count Recovery in Patients Undergoing Treatment with Chimeric Antigen Receptor T Cells (CAR T)

Tania Jain, MD, Andrea Knezevic, MS, Martina Pennisi, Josel D Ruiz, MPH, Sean M. Devlin, PhD, Molly A. Maloy, MS, Elizabeth Halton, NP-BC AOCNP, Claudia Diamonte, RN, Michael Scordo, MD, Craig S. Sauter, MD, Elena Mead, MD, Bianca Santomasso, MD PhD, M. Lia Palomba, MD, Gunjan L. Shah, MDMS, Connie Lee Batlevi, MD PhD, Eric L Smith, MD PhD, Sergio A. Giralt, MD, Renier J. Brentjens, MD PhD, Jae H. Park, MD, Miguel-Angel Perales, MD, Sham Mailankody, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 4455.
https://doi.org/10.1182/blood-2019-127480
Published: 2019
Journal Articles

Comparing Gradings of Immune Effector Cells Toxicities: Application of Astct Consensus Grading System and Implications for Clinical Management

Martina Pennisi, Tania Jain, MD, Elena Mead, MD, Bianca Santomasso, MD PhD, Mari Lynne Silverberg, Yakup Batlevi, PhD, Roni Shouval, Molly A. Maloy, MS, Sean M. Devlin, PhD, Connie Lee Batlevi, MD PhD, Renier J. Brentjens, MD PhD, Parastoo B. Dahi, MD, Claudia Diamonte, RN, Jessica Flynn, BS, Sergio A Giralt, MD, Elizabeth Halton, NP-BC AOCNP, Maria Lia Palomba, MD, Miriam Sanchez-Escamilla, MD, Craig S. Sauter, MD, Michael Scordo, MD, Gunjan L. Shah, MD, Jae H. Park, MD, Miguel-Angel Perales, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4458.
https://doi.org/10.1182/blood-2019-126022
Published: 2019
Journal Articles

Easix and Modified-Easix Are Early Predictors of Severe Cytokine Release Syndrome and Neurotoxicity in Patients Treated with Chimeric Antigen Receptor T Cells

Martina Pennisi, Miriam Sanchez-Escamilla, MD, Jessica Flynn, BS, Molly A. Maloy, MS, Mari Lynne Silverberg, Yakup Batlevi, PhD, Roni Shouval, Connie Lee Batlevi, MD PhD, Renier J. Brentjens, MD PhD, Sean M. Devlin, PhD, Parastoo B. Dahi, MD, Claudia Diamonte, RN, Sergio A Giralt, MD, Elizabeth Halton, NP-BC AOCNP, Tania Jain, MD, Elena Mead, MD, Maria Lia Palomba, MD, Bianca Santomasso, MD PhD, Craig S. Sauter, MD, Michael Scordo, MD, Gunjan L. Shah, MD, Jae H. Park, MD, Miguel-Angel Perales, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1947.
https://doi.org/10.1182/blood-2019-126208
Published: 2019
Journal Articles

Clinical Factors Associated with Improved Survival Following Allogeneic HSCT after CD19 CAR Therapy in Adult Patients with Relapsed B-ALL

Jae H. Park, MD, Jessica Flynn, BS, Mithat Gonen, Yvette Bernal, MS, Claudia Diamonte, RN, Elizabeth Halton, NP-BC AOCNP, Xiuyan Wang, PhD, Isabelle Riviere, PhD, Michel Sadelain, MD PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1348.
https://doi.org/10.1182/blood-2019-129343
Published: 2019
Journal Articles

CD19 CAR T cells following autologous transplantation in poor-risk relapsed and refractory B-cell non-Hodgkin lymphoma

Clinical Trials & Observations
Craig S. Sauter, Brigitte Senechal, Isabelle Rivière, Ai Ni, Yvette Bernal, Xiuyan Wang, Terence Purdon, Malloury Hall, Ashvin N. Singh, Victoria Z. Szenes, Sarah Yoo, Ahmet Dogan, Yongzeng Wang, Craig H. Moskowitz, Sergio Giralt, Matthew J. Matasar, Miguel-Angel Perales, Kevin J. Curran, Jae Park, Michel Sadelain, Renier J. Brentjens
Journal: Blood
Blood (2019) 134 (7): 626–635.
https://doi.org/10.1182/blood.2018883421
Published: 2019
Includes: Supplemental data
Journal Articles

Clinical Responses and Pharmacokinetics of MCARH171, a Human-Derived Bcma Targeted CAR T Cell Therapy in Relapsed/Refractory Multiple Myeloma: Final Results of a Phase I Clinical Trial

Sham Mailankody, MBBS, Arnab Ghosh, MBBS, PhD, Mette Staehr, PhD, Terence J Purdon, MS, Mikhail Roshal, MD PhD, Elizabeth Halton, NP-BC AOCNP, Claudia Diamonte, RN, John Pineda, RN, Pavan Anant, BS, Yvette Bernal, MS, Analisa Wills, Neha Korde, MD, Nikoletta Lendvai, MDPhD, Alexander M. Lesokhin, MD, Hani Hassoun, MD, Malin Hultcrantz, MD PhD, Heather J. Landau, MD, Gunjan L. Shah, MD, Michael Scordo, MD, David J. Chung, MDPhD, Oscar B Lahoud, MD, Pallavi Khattar, MD, Carlos Fernandez de Larrea, MD PhD, Qi Gao, Achim Jungbluth, MDPhD, Jae H. Park, MD, Kevin J. Curran, MD, Craig S. Sauter, MD, Maria Lia Palomba, MD, Brigitte Senechal, PhD, Xiuyan Wang, PhD, Ahmet Dogan, MD PhD, Sergio Giralt, MD, Isabelle Riviere, PhD, Ola Landgren, MD PhD, Renier J. Brentjens, MD PhD, Eric L. Smith, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 959.
https://doi.org/10.1182/blood-2018-99-119717
Published: 2018
Journal Articles

Resource Utilization Early after Chimeric Antigen Receptor (CAR) T Cell Infusion for Hematologic Malignancies

Gunjan L. Shah, MDMS, Jae H. Park, MD, Craig S. Sauter, MD, Elaine Duck, RN MS MA, Elizabeth Halton, NP-BC AOCNP, Maria Lia Palomba, MD, Connie Lee Batlevi, MD, Anas Younes, MD, Mark Blaine Geyer, MD, Eric L. Smith, MD PhD, Sham Mailankody, MBBS, Elena Mead, MD, Bianca Santomasso, MD PhD, Miguel-Angel Perales, MD, Paul Sabbatini, MD, Sergio Giralt, MD, Renier J. Brentjens, MD PhD, Peter Bach, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 616.
https://doi.org/10.1182/blood-2018-99-114093
Published: 2018
Journal Articles

Prediction of CAR T-Related Toxicities in R/R DLBCL Patients Treated with Axicabtagene Ciloleucel Using Point of Care Cytokine Measurements

Rawan Faramand, MD, Hiroshi Kotani, MD PhD, Dylan Morrissey, Bin Yu, Frederick L. Locke, MD, Michael D. Jain, MDPhD, Julio C. Chavez, MD, Xuefeng Wang, PhD, Asmita Mishra, MD, Christina A Bachmeier, PharmD, Renier J. Brentjens, MD PhD, Sarah Yoo, Jae H. Park, MD, Marco L. Davila, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 95.
https://doi.org/10.1182/blood-2018-99-116539
Published: 2018
Journal Articles

Intestinal Microbiota Composition Prior to CAR T Cell Infusion Correlates with Efficacy and Toxicity

Melody Smith, MD, Eric R. Littmann, BA, John B. Slingerland, BSc, Annelie Clurman, BA, Ann E. Slingerland, BSc, Ying Taur, MD MPH, Jonas Schluter, PhD, Jae H. Park, MD, Roisin O'Cearbhaill, MD, Sham Mailankody, MBBS, Eric L. Smith, MD PhD, Maria Lia Palomba, MD, Oladapo Yeku, MD PhD, Jonathan U. Peled, MD, Elizabeth Halton, NP-BC AOCNP, Claudia Diamonte, RN, Jason Chan, Malloury Hall, BA, Pavan Anant, BS, Peter Kane, BA, Sergio Giralt, MD, Isabelle Riviere, PhD, Renier J. Brentjens, MD PhD, Eric G. Pamer, MD, Marcel R.M. van den Brink, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3492.
https://doi.org/10.1182/blood-2018-99-118628
Published: 2018
Journal Articles

CAR T Cell Therapy Targeting G Protein-Coupled Receptor Class C Group 5 Member D (GPRC5D), a Novel Target for the Immunotherapy of Multiple Myeloma

Eric L. Smith, MD PhD, Kimberly Harrington, Mette Staehr, PhD, Reed Masakayan, MS, Jon Jones, BS, Thomas Long, PhD, Majid Ghoddusi, DVM, PhD, Terence J Purdon, MS, Trevor Do, Xiuyan Wang, PhD, Minh Pham, Jessica M Brown, Elizabeth Peguero, Carlos Fernández De Larrea, MD PhD, Pei Wang, PhD, Hong Liu, MD PhD, Yiyang Xu, PhD, Sarah Garrett, Steven Almo, PhD, Isabelle Riviere, PhD, Cheng Liu, PhD, Blythe Duke Sather, PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 589.
https://doi.org/10.1182/blood-2018-99-110471
Published: 2018
Journal Articles

A Phase I First-in-Human Clinical Trial of CD19-Targeted 19-28z/4-1BBL "Armored" CAR T Cells in Patients with Relapsed or Refractory NHL and CLL Including Richter's Transformation

Jae H. Park, MD, Maria Lia Palomba, MD, Connie Lee Batlevi, MD, Isabelle Riviere, PhD, Xiuyan Wang, PhD, Brigitte Senechal, PhD, Richard R. Furman, MD, Yvette Bernal, MS, Malloury Hall, BA, John Pineda, RN, Claudia Diamonte, RN, Elizabeth Halton, NP-BC AOCNP, Renier J. Brentjens, MD PhD, Michel Sadelain, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 224.
https://doi.org/10.1182/blood-2018-99-117737
Published: 2018