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Journal Articles

Gene Therapy Expressing Platelet-Derived Factor VIII for Correction of Hemophilia Α with a History of Inhibitors

David A. Wilcox, Myriam Armant, Lynn Malec, Qizhen Shi, Bryon D. Johnson, Huiqing Xu, Lily M. Du, Lisa J. Duffy, Frederic D. Bushman, James H. Jerkins, Peiman Hematti, Ruta Brazauskas, Shawn M. Jobe, Parameswaran N. Hari, Mary Eapen

Blood (2023) 142 (Supplement 1): 2249.

https://doi.org/10.1182/blood-2023-172845

Published: 2023

Journal Articles

The Tfh/Tfr Pathway Is Pivotal in FVIII Inhibitor Development in Mice

Weiqing Jing, Jocelyn Schroeder, Juan Chen, Yuanhua Cai, Saurabh Kumar, Alexander Dent, Qizhen Shi

Blood (2023) 142 (Supplement 1): 3971.

https://doi.org/10.1182/blood-2023-180998

Published: 2023

Journal Articles

Platelet α IIb β 3 Receptor Antagonist Impedes the Hemostatic Efficacy of Platelet-Specific FVIII Gene Therapy in Hemophilia a Mice

Hongyin Yu, Jocelyn A. Schroeder, Jeremy Mattson, Qizhen Shi

Blood (2022) 140 (Supplement 1): 2712.

https://doi.org/10.1182/blood-2022-168343

Published: 2022

Journal Articles

Blocking hemophilic arthropathy

Qizhen Shi, Hartmut Weiler

Blood (2022) 139 (18): 2734–2735.

https://doi.org/10.1182/blood.2022015776

Published: 2022

Journal Articles

Pre-Existing Anti-FVIII Immunity Alters Therapeutic Platelet-Targeted FVIII Engraftment in the System Preconditioned with Busulfan Alone through Cytotoxic CD8 T Cells

Weiqing Jing, Christina Baumgartner, Feng Xue, Jocelyn A. Schroeder, Qizhen Shi

Blood (2021) 138 (Supplement 1): 444.

https://doi.org/10.1182/blood-2021-153722

Published: 2021

Journal Articles

Platelet-Targeted Gene Therapy Induces Robust Immune Tolerance Even in a Primed Model Via Peripheral Clonal Deletion of CD4 and CD8 T Cells and Expansion of Treg Cells

Jing Li, MD PhD, Juan Chen, PhD, Jocelyn A. Schroeder, Qizhen Shi, MDPhD

Blood (2020) 136 (Supplement 1): 2.

https://doi.org/10.1182/blood-2020-140851

Published: 2020

Journal Articles

Fludarabine in Combination with Busulfan As Pretransplant Conditioning for Platelet Gene Therapy in Murine Hemophilia a with Inhibitors

Yingyu Chen, PhD, Jing Li, MD PhD, Jocelyn A. Schroeder, Weiqing Jing, MD PhD, Jianda Hu, PhD, Qizhen Shi, MD PhD

Blood (2019) 134 (Supplement_1): 1108.

https://doi.org/10.1182/blood-2019-127410

Published: 2019

Journal Articles

Animal Models Demonstrate a Critical Role of Factor VIII in Par4- and Platelet-Mediated Pathology

Michelle Castillo, BS, Quihui Yang, MD PhD, Dosia McKinney, Qizhen Shi, MD PhD, Rashmi Sood, PhD

Blood (2019) 134 (Supplement_1): 1057.

https://doi.org/10.1182/blood-2019-123290

Published: 2019

Journal Articles

Induction of Activated T Follicular Helper Cells Is Critical for Anti-FVIII Inhibitor Development in Hemophilia a Mice

Weiqing Jing, MD PhD, Juan Chen, PhD, Yuanhua Cai, MD, Yingyu Chen, PhD, Jocelyn A. Schroeder, Weiguo Cui, MD PhD, Qizhen Shi, MD PhD

Blood (2019) 134 (Supplement_1): 92.

https://doi.org/10.1182/blood-2019-123777

Published: 2019

Journal Articles

In Vivo Enrichment of Genetically Manipulated Platelets for Murine Haemophilia B Gene Therapy

Yingyu Chen, PhD, Jocelyn A. Schroeder, Jianda Hu, PhD, Qizhen Shi, MD

Blood (2018) 132 (Supplement 1): 3483.

https://doi.org/10.1182/blood-2018-99-112245

Published: 2018

Journal Articles

A Murine Model of Type 2N VWD Was Developed By CRISPR/Cas9 Gene Editing and Recapitulates Human Type 2N VWD

Robert R Montgomery, MD, Scot A Fahs, Jeremy G Mattson, Hartmut Weiler, PhD, Qizhen Shi, MD

Blood (2018) 132 (Supplement 1): 221.

https://doi.org/10.1182/blood-2018-99-110324

Published: 2018

Journal Articles

The Severe Spontaneous Bleeding Phenotype in a Novel Hemophilia a Rat Model with an Inversion Mutation Is Rescued By Platelet-Targeted FVIII Expression

Qizhen Shi, MD, Jeremy G Mattson, Scot A Fahs, Robert R Montgomery, MD

Blood (2018) 132 (Supplement 1): 219.

https://doi.org/10.1182/blood-2018-99-112165

Published: 2018

Journal Articles

Platelet-Targeted Hyperfunctional Factor IX (FIX) Gene Therapy for Hemophilia B Mice with Pre-Existing Anti-FIX Immunity

Jocelyn A. Schroeder, Jeremy G Mattson, Paul Edward Monahan, MD, Qizhen Shi, MD

Blood (2018) 132 (Supplement 1): 220.

https://doi.org/10.1182/blood-2018-99-111718

Published: 2018

Journal Articles

Platelet-Targeted Gene Therapy of Hemophilia a Using Hematopoietic Stem Cells Derived from Genome-Edited Induced Pluripotent Stem Cells

Dawei Wang, Guowei Zhang, Junjie Gu, Xiaohu Shao, Xiaohong Pan, Shuxian Yao, Ying Jin, Qizhen Shi, MD PhD, Zhu Chen, PhD, Sai-Juan Chen, PhD

Blood (2017) 130 (Supplement 1): 2063.

https://doi.org/10.1182/blood.V130.Suppl_1.2063.2063

Published: 2017

Journal Articles

Platelet-Targeted Gene Transfer Induces Immune Tolerance in a Primed Model

Jing Li, MD PhD, Juan Chen, PhD, Jocelyn Schroeder, Jianda Hu, MD PhD, Qizhen Shi, MD PhD

Blood (2017) 130 (Supplement 1): 4612.

https://doi.org/10.1182/blood.V130.Suppl_1.4612.4612

Published: 2017

Journal Articles

Platelet-Targeted Gene Transfer Prevents Graft Rejection and Induces Immune Tolerance Even in a Primed Model

Xiaofeng Luo, MD, PhD, Jing Li, MD PhD, Juan Chen, PhD, Jocelyn A. Schroeder, Jianda Hu, MD PhD, Qizhen Shi, MD PhD

Blood (2016) 128 (22): 2315.

https://doi.org/10.1182/blood.V128.22.2315.2315

Published: 2016

Journal Articles

E35, a Novel Analog of Emodin, Selectively Eliminates Acute Leukemia Stem and Progenitor Cells

Yingyu Chen, PhD, Jing Zheng, PhD, Zhenxing Lin, Jing Li, PhD, Qizhen Shi, MD PhD, Jianda Hu, MD PhD

Blood (2016) 128 (22): 5213.

https://doi.org/10.1182/blood.V128.22.5213.5213

Published: 2016

Journal Articles

The Impact of VWF on FVIII Immune Responses in Hemophilia a Mice with Pre-Existing Anti-FVIII Immunity

Juan Chen, PhD, Jocelyn A. Schroeder, Xiaofeng Luo, MD PhD, Robert R. Montgomery, MD, Qizhen Shi, MD PhD

Blood (2016) 128 (22): 84.

https://doi.org/10.1182/blood.V128.22.84.84

Published: 2016

Journal Articles

Platelet-Derived Codon-Optimized Hyperfunctional FIX Gene Therapy of Hemophilia B Mice

Jocelyn A. Schroeder, Mary A. Jozwiak, Paul E. Monahan, MD, Qizhen Shi, MD PhD

Blood (2016) 128 (22): 3751.

https://doi.org/10.1182/blood.V128.22.3751.3751

Published: 2016

Journal Articles

The immunogenicity of platelet-derived FVIII in hemophilia A mice with or without preexisting anti-FVIII immunity

Yingyu Chen, Jocelyn A. Schroeder, Juan Chen, Xiaofeng Luo, Christina K. Baumgartner, Robert R. Montgomery, Jianda Hu, Qizhen Shi

Blood (2016) 127 (10): 1346–1354.

https://doi.org/10.1182/blood-2015-08-662916

Published: 2016

Includes: Supplemental data

NARROW

Gene Therapy Expressing Platelet-Derived Factor VIII for Correction of Hemophilia Α with a History of Inhibitors

The Tfh/Tfr Pathway Is Pivotal in FVIII Inhibitor Development in Mice

Platelet α IIb β 3 Receptor Antagonist Impedes the Hemostatic Efficacy of Platelet-Specific FVIII Gene Therapy in Hemophilia a Mice

Blocking hemophilic arthropathy

Pre-Existing Anti-FVIII Immunity Alters Therapeutic Platelet-Targeted FVIII Engraftment in the System Preconditioned with Busulfan Alone through Cytotoxic CD8 T Cells

Platelet-Targeted Gene Therapy Induces Robust Immune Tolerance Even in a Primed Model Via Peripheral Clonal Deletion of CD4 and CD8 T Cells and Expansion of Treg Cells

Fludarabine in Combination with Busulfan As Pretransplant Conditioning for Platelet Gene Therapy in Murine Hemophilia a with Inhibitors

Animal Models Demonstrate a Critical Role of Factor VIII in Par4- and Platelet-Mediated Pathology

Induction of Activated T Follicular Helper Cells Is Critical for Anti-FVIII Inhibitor Development in Hemophilia a Mice

In Vivo Enrichment of Genetically Manipulated Platelets for Murine Haemophilia B Gene Therapy

A Murine Model of Type 2N VWD Was Developed By CRISPR/Cas9 Gene Editing and Recapitulates Human Type 2N VWD

The Severe Spontaneous Bleeding Phenotype in a Novel Hemophilia a Rat Model with an Inversion Mutation Is Rescued By Platelet-Targeted FVIII Expression

Platelet-Targeted Hyperfunctional Factor IX (FIX) Gene Therapy for Hemophilia B Mice with Pre-Existing Anti-FIX Immunity

Platelet-Targeted Gene Therapy of Hemophilia a Using Hematopoietic Stem Cells Derived from Genome-Edited Induced Pluripotent Stem Cells

Platelet-Targeted Gene Transfer Induces Immune Tolerance in a Primed Model

Platelet-Targeted Gene Transfer Prevents Graft Rejection and Induces Immune Tolerance Even in a Primed Model

E35, a Novel Analog of Emodin, Selectively Eliminates Acute Leukemia Stem and Progenitor Cells

The Impact of VWF on FVIII Immune Responses in Hemophilia a Mice with Pre-Existing Anti-FVIII Immunity

Platelet-Derived Codon-Optimized Hyperfunctional FIX Gene Therapy of Hemophilia B Mice

The immunogenicity of platelet-derived FVIII in hemophilia A mice with or without preexisting anti-FVIII immunity

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American Society of Hematology

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American Society of Hematology

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