In the original description and isolation of the murine Abelson leukemia virus, we described a “massive degree of meningeal involvement” as a characteristic of the disease process.1,2 As in the Bcr/Abl murine bone marrow transduction and transplantation model, the latent period to tumor appearance was very short. We suggested that the meningeal disease could serve as a model for testing chemotherapy.
1
Abelson HT, Rabstein LS. Lymphosarcoma: virus-induced thymic-independent disease in mice
Cancer Res.
1970
;30
: 2213
-2222.2
Rabstein S, Gazdar AF, Chopra HC, Abelson HT. Early morphological changes associated with infection by a murine nonthymic lymphatic tumor virus.
J Natl Cancer Inst.
1971
;46
: 481
-491.Copyright © 2003 by The American Society of Hematology
2003
