Experimental Research on the Proliferative and Differentiative Activity of the Erythroblast in Chronic Erythremia, the Chronic Form of Di Guglielmo’s Disease

Using the method of culture in vitro, the authors have studied the proliferative and differentiative activities of the erythroblastic tissue in chronic erythremic myelosis.

The results of the research allowed the authors to reach the following conclusions:

1. the erythroblastic cells of chronic erythremic myelosis reveal indisputable differentiative activity in vitro;

2. the rate of maturation of the erythremic erythroblasts is slower than normal;

3. the proliferation of the erythroblastic tissue in chronic erythremic myelosis is normal;

4. in the genesis of the erythroblastic hyperplasia in chronic erythremic myelosis, the most evident factor is a defect of maturation of the erythroblasts.