Abstract 5096

[Abstract] Objective To investigate acute T cell lymphoma/leukemia (ATL) cases for Notch1 and FoxP3 expression and the clinical implications.

Methods

The expressions of Notch1 and FoxP3 in lymphoma and bone marrow specimens from 22 cases of ATL were studied by immunohistochemical analysis. The expressions of Notch1 and FoxP3 were analyzed by Image-ProPlus 6.0 and shown in integral optical density (IOD) (X±S).

Results

The neoplastic T cells of 90.91% of cases expressed FoxP3 and 72.73% of cases expressed Notch1, and 63.64% of patients had Notch1 and FoxP3 co-expression. IOD of FoxP3 and Notch1 were 13.57±11.38 and 8.42±3.48, respectively. The comparison of their IOD had no statistical significance (P=0.055).

Conclusion

The expressions of Notch1 and FoxP3 were high in ATL, which may be associated with the clinical outcome of ATL.

Disclosures:

No relevant conflicts of interest to declare.

Topics:
foxp3 gene, leukemia, notch1 gene, t-cell lymphoma, bone marrow specimen, lymphoma, treatment outcome, optics, t-lymphocytes

Author notes

*

Asterisk with author names denotes non-ASH members.

© 2010 by The American Society of Hematology
2010
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