Normal white blood cells and cells from patients with leukemia are able to incorporate C14-DL-leucine into proteins in vitro. Cells from individuals with chronic myelogenous leukemia were able to incorporate significantly greater amounts of the amino acid, and they were able to maintain this incorporation for a longer period of time than the control cells.

Both types of cells had the same in vitro survival time of four days, following storage at 3 C.

The incorporation was partially decreased in the presence of dinitrophenol, as well as in an atmosphere of nitrogen.

Topics:
leucine, leukocytes, amino acids, atmosphere, unit of pressure, dinitrophenols, leukemia, leukemia, myelocytic, chronic, nitrogen, time factors
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© 1957 by American Society of Hematology, Inc.
1957
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