Studies on the Dynamics of the Reaction Between Rh Antibody and Antigen

The anti-D antibody of two human sera was found to be transferred in part from sensitized group A Rh (D)-positive cells to normal group B Rh (D)-positive cells when the cell suspensions were mixed and incubated in a saline medium.

The amount of anti-D antibody transferred from sensitized to normal cells in a given period of time was found to be directly related to the concentration of antibody to which the group A donor cells were originally exposed. It is concluded that the amount of antibody transferred to recipient cells under standard conditions is related to the concentration of antibody on the surface of the donor cells.