An eight year old female is presented with hemophilia A with hemorrhagic symptoms since three months of age. Family studies revealed sex linked transmission through the maternal lineage.

Chromosome analysis revealed a normal complement with two X chromosomes. Possible genetic mechanisms for this apparent homozygous hemophilic state derived from a carrier woman and normal father are presented.

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© 1961 by American Society of Hematology, Inc.
1961
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